Standard name Systematic name Name description Description
DSL1 YNL258C Peripheral membrane protein needed for Golgi-to-ER retrograde traffic Peripheral membrane protein needed for Golgi-to-ER retrograde traffic; mediates Sey1p-independent homotypic ER fusion; forms Dsl1 tethering complex with Sec39p and Tip20p that forms a stable complex with ER SNAREs Sec20p, Ufe1p and Use1p and is functionally conserved from yeast to mammalian cells; component of the ER target site that interacts with coatomer; interacts with different subunits of COPI vesicle coat; interacts with Cin5p; homolog of fly and human ZW10 gene
Visualize the interactome of DSL1
Links to external databases:
  SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)

CYCLoPs localization & abundance

WT1 WT2 WT3
Cort. Patches 0.121 0.154 0.124
Cytoplasm 0.121 0.141 0.258
ER 0.773 0.769 0.560
Mito 0.167 0.051 NaN
Cell Periphery NaN 0.109 0.124
Vac/Vac Memb NaN 0.058 0.053

GFP localization & abundance

GFP localization GFP abundance
ER 8970

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
DSL1 0 0 0 0 0

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
TIP20 YGL145W Peripheral membrane protein required for COPI vesicle fusion to the ER physical 16 5 9 Two-hybrid, Two-hybrid, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS, Two-hybrid, Co-fractionation, Affinity Capture-Western, Reconstituted Complex, Affinity Capture-MS, Two-hybrid, Two-hybrid, Reconstituted Complex
SEC39 YLR440C Component of the Dsl1p tethering complex physical 15 5 7 Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS, Two-hybrid, Two-hybrid, Affinity Capture-MS, Affinity Capture-MS, Co-purification, Co-purification, Two-hybrid, Two-hybrid, Affinity Capture-MS, PCA, Affinity Capture-MS
SEC20 YDR498C Membrane glycoprotein v-SNARE physical 8 3 4 Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS, Two-hybrid, Two-hybrid, Affinity Capture-MS, Affinity Capture-MS
USE1 YGL098W Essential SNARE protein localized to the ER physical 7 3 3 Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Two-hybrid, Two-hybrid
RET2 YFR051C Delta subunit of the coatomer complex (COPI) physical 5 4 3 Two-hybrid, Affinity Capture-Western, Two-hybrid, Co-crystal Structure, Reconstituted Complex
SLY1 YDR189W Hydrophilic protein involved in ER/Golgi vesicle trafficking genetic 5 3 3 Dosage Rescue, Synthetic Lethality, Synthetic Lethality, Synthetic Rescue, Synthetic Lethality
COP1 YDL145C Alpha subunit of COPI vesicle coatomer complex genetic 4 3 4 Synthetic Lethality, Synthetic Growth Defect, Negative Genetic, Synthetic Lethality
UFE1 YOR075W t-SNARE protein required for retrograde vesicular traffic physical 4 3 4 Affinity Capture-Western, Affinity Capture-MS, Reconstituted Complex, Affinity Capture-MS
RET2 YFR051C Delta subunit of the coatomer complex (COPI) genetic 3 3 2 Synthetic Growth Defect, Phenotypic Enhancement, Synthetic Lethality
SEC39 YLR440C Component of the Dsl1p tethering complex genetic 3 2 2 Dosage Rescue, Dosage Rescue, Synthetic Rescue
RIC1 YLR039C Protein involved in retrograde transport to the cis-Golgi network genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
SEY1 YOR165W Dynamin-like GTPase that mediates homotypic ER fusion genetic 3 3 1 Synthetic Growth Defect, Phenotypic Enhancement, Negative Genetic
YKT6 YKL196C Vesicle membrane protein (v-SNARE) with acyltransferase activity physical 3 2 1 Affinity Capture-MS, Affinity Capture-MS, Co-purification
SEC28 YIL076W Epsilon-COP subunit of the coatomer physical 2 2 2 Protein-peptide, PCA
SEC21 YNL287W Gamma subunit of coatomer genetic 2 2 2 Dosage Rescue, Synthetic Lethality
SEC22 YLR268W R-SNARE protein genetic 2 2 2 Synthetic Lethality, Negative Genetic
COP1 YDL145C Alpha subunit of COPI vesicle coatomer complex physical 2 1 2 Affinity Capture-Western, Affinity Capture-Western
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator physical 2 1 2 Affinity Capture-RNA, Affinity Capture-RNA
TIP20 YGL145W Peripheral membrane protein required for COPI vesicle fusion to the ER genetic 2 1 2 Synthetic Lethality, Synthetic Lethality
SEC20 YDR498C Membrane glycoprotein v-SNARE genetic 2 1 2 Synthetic Lethality, Synthetic Lethality
SEC27 YGL137W Essential beta'-coat protein of the COPI coatomer physical 2 2 1 PCA, Co-localization
PSE1 YMR308C Karyopherin/importin that interacts with the nuclear pore complex genetic 2 2 1 Negative Genetic, Positive Genetic
DRS2 YAL026C Trans-golgi network aminophospholipid translocase (flippase) genetic 2 1 1 Negative Genetic, Negative Genetic
TRS85 YDR108W Component of transport protein particle (TRAPP) complex III genetic 2 1 1 Negative Genetic, Negative Genetic
IFA38 YBR159W Microsomal beta-keto-reductase genetic 2 1 1 Negative Genetic, Negative Genetic
IRE1 YHR079C Serine-threonine kinase and endoribonuclease genetic 2 1 1 Positive Genetic, Positive Genetic
CHO2 YGR157W Phosphatidylethanolamine methyltransferase (PEMT) genetic 2 1 1 Negative Genetic, Negative Genetic
FKH1 YIL131C Forkhead family transcription factor regulation 1 1 1 ChEC-Seq experiments
SFP1 YLR403W Regulates transcription of ribosomal protein and biogenesis genes regulation 1 1 1 DNA to cDNA expression microarray evidence
ACT1 YFL039C Actin, structural protein in cytoskeleton genetic 1 1 1 Negative Genetic
CCR4 YAL021C Component of the CCR4-NOT transcriptional complex physical 1 1 1 Affinity Capture-RNA
CSE2 YNR010W Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
CHK1 YBR274W Serine/threonine kinase and DNA damage checkpoint effector genetic 1 1 1 Negative Genetic
USE1 YGL098W Essential SNARE protein localized to the ER genetic 1 1 1 Negative Genetic
UFE1 YOR075W t-SNARE protein required for retrograde vesicular traffic genetic 1 1 1 Negative Genetic
NTR2 YKR022C Essential protein that forms a dimer with Ntr1p physical 1 1 1 Two-hybrid
SEC28 YIL076W Epsilon-COP subunit of the coatomer genetic 1 1 1 Synthetic Lethality
ERG6 YML008C Delta(24)-sterol C-methyltransferase physical 1 1 1 PCA
PLN1 YKR046C Perilipin, involved in formation and stability of lipid droplets physical 1 1 1 PCA
LDO16 YMR148W Protein of unknown function with possible role in spore wall assembly physical 1 1 1 PCA
GOS1 YHL031C v-SNARE protein involved in Golgi transport physical 1 1 1 Affinity Capture-Western
SBP1 YHL034C Protein that binds eIF4G and has a role in repression of translation physical 1 1 1 Affinity Capture-RNA
PUF3 YLL013C Protein of the mitochondrial outer surface physical 1 1 1 Affinity Capture-RNA
ISW1 YBR245C ATPase subunit of imitation-switch (ISWI) class chromatin remodelers physical 1 1 1 Affinity Capture-RNA
SEC27 YGL137W Essential beta'-coat protein of the COPI coatomer genetic 1 1 1 Synthetic Lethality
RER1 YCL001W Protein involved in retention of membrane proteins physical 1 1 1 PCA
SEC61 YLR378C Conserved ER protein translocation channel physical 1 1 1 Affinity Capture-MS
ERV14 YGL054C COPII-coated vesicle protein genetic 1 1 1 Dosage Rescue
PGA3 YML125C Putative cytochrome b5 reductase, localized to the plasma membrane genetic 1 1 1 Negative Genetic
MRE11 YMR224C Nuclease subunit of the MRX complex with Rad50p and Xrs2p genetic 1 1 1 Negative Genetic
PSD1 YNL169C Phosphatidylserine decarboxylase of the mitochondrial inner membrane genetic 1 1 1 Negative Genetic
MDM32 YOR147W Mitochondrial inner membrane protein with similarity to Mdm31p genetic 1 1 1 Negative Genetic
TTI1 YKL033W Subunit of the ASTRA complex, involved in chromatin remodeling genetic 1 1 1 Negative Genetic
TTI2 YJR136C Subunit of the ASTRA complex, involved in chromatin remodeling genetic 1 1 1 Negative Genetic
PYC2 YBR218C Pyruvate carboxylase isoform genetic 1 1 1 Negative Genetic
RSC9 YML127W Component of the RSC chromatin remodeling complex genetic 1 1 1 Negative Genetic
RET3 YPL010W Zeta subunit of the coatomer complex (COPI) genetic 1 1 1 Negative Genetic
SWC5 YBR231C Component of the SWR1 complex genetic 1 1 1 Negative Genetic
RTT103 YDR289C Protein involved in transcription termination by RNA polymerase II genetic 1 1 1 Negative Genetic
SEN1 YLR430W ATP-dependent 5' to 3' RNA/DNA and DNA helicase genetic 1 1 1 Negative Genetic
UBP3 YER151C Ubiquitin-specific protease that cleaves Ub-protein fusions genetic 1 1 1 Negative Genetic
SEC26 YDR238C Essential beta-coat protein of the COPI coatomer genetic 1 1 1 Negative Genetic
ICE2 YIL090W Integral ER membrane protein with type-III transmembrane domains genetic 1 1 1 Negative Genetic
INO4 YOL108C Transcription factor involved in phospholipid synthesis genetic 1 1 1 Positive Genetic
TAF10 YDR167W Subunit (145 kDa) of TFIID and SAGA complexes genetic 1 1 1 Positive Genetic
MIR1 YJR077C Mitochondrial phosphate carrier genetic 1 1 1 Positive Genetic
ESL2 YKR096W hEST1A/B (SMG5/6)-like protein genetic 1 1 1 Positive Genetic
KCH1 YJR054W Potassium transporter that mediates K+ influx genetic 1 1 1 Positive Genetic
ESA1 YOR244W Catalytic subunit of the histone acetyltransferase complex (NuA4) genetic 1 1 1 Positive Genetic
HIR1 YBL008W Subunit of the HIR complex genetic 1 1 1 Negative Genetic
MPS3 YJL019W Nuclear envelope protein genetic 1 1 1 Negative Genetic
FIP1 YJR093C Subunit of cleavage polyadenylation factor (CPF) genetic 1 1 1 Positive Genetic
STU2 YLR045C Microtubule polymerase of the XMAP215/Dis1 family genetic 1 1 1 Positive Genetic
ROX3 YBL093C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Positive Genetic
YCS4 YLR272C Subunit of the condensin complex genetic 1 1 1 Positive Genetic
GPI13 YLL031C ER membrane localized phosphoryltransferase genetic 1 1 1 Positive Genetic
NOP1 YDL014W Histone glutamine methyltransferase, modifies H2A at Q105 in nucleolus genetic 1 1 1 Positive Genetic
SDD4 YPR022C Putative transcription factor, as suggested by computational analysis genetic 1 1 1 Positive Genetic
ASK10 YGR097W Regulator of the Fps1p glycerol channel genetic 1 1 1 Negative Genetic
BOS1 YLR078C v-SNARE (vesicle specific SNAP receptor) genetic 1 1 1 Synthetic Growth Defect
BRF1 YGR246C TFIIIB B-related factor genetic 1 1 1 Negative Genetic
BRE5 YNR051C Ubiquitin protease cofactor genetic 1 1 1 Negative Genetic
DBP5 YOR046C Cytoplasmic ATP-dependent RNA helicase of the DEAD-box family genetic 1 1 1 Positive Genetic
BBP1 YPL255W Protein required for the spindle pole body (SPB) duplication genetic 1 1 1 Positive Genetic
CYT1 YOR065W Cytochrome c1 genetic 1 1 1 Positive Genetic
ATG15 YCR068W Phospholipase genetic 1 1 1 Negative Genetic