Standard name Systematic name Name description Description
GPA2 YER020W Nucleotide binding alpha subunit of the heterotrimeric G protein Nucleotide binding alpha subunit of the heterotrimeric G protein; interacts with the receptor Gpr1p, has signaling role in response to nutrients; required for the recruitment of Ras-GTP at the plasma membrane and in the nucleus
Visualize the interactome of GPA2
Links to external databases:
  SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)

CYCLoPs localization & abundance

WT1 WT2 WT3
Cell Periphery 0.843 0.796 0.895
Cort. Patches 0.142 0.306 0.222
Cytoplasm 0.104 0.215 NaN
Mito 0.239 0.097 0.348
Bud NaN 0.075 NaN

GFP localization & abundance

GFP localization GFP abundance
cell periphery 4570

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
GPA2 0 1 0 9 0

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
RAS2 YNL098C GTP-binding protein genetic 7 4 7 Dosage Rescue, Phenotypic Suppression, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Phenotypic Enhancement
GPR1 YDL035C Plasma membrane G protein coupled receptor (GPCR) genetic 6 4 5 Synthetic Rescue, Dosage Rescue, Phenotypic Enhancement, Phenotypic Suppression, Phenotypic Enhancement, Synthetic Rescue
GPB2 YAL056W Multistep regulator of cAMP-PKA signaling physical 5 3 4 Affinity Capture-Western, Two-hybrid, Two-hybrid, Reconstituted Complex, Two-hybrid
GPR1 YDL035C Plasma membrane G protein coupled receptor (GPCR) physical 5 2 4 Affinity Capture-Western, Two-hybrid, Two-hybrid, Two-hybrid, Two-hybrid
IME2 YJL106W Serine/threonine protein kinase involved in activation of meiosis physical 5 3 2 Affinity Capture-Western, Reconstituted Complex, Two-hybrid, Two-hybrid, Two-hybrid
SCH9 YHR205W AGC family protein kinase genetic 3 2 2 Synthetic Growth Defect, Synthetic Lethality, Synthetic Lethality
FKH2 YNL068C Forkhead family transcription factor regulation 2 2 2 chromatin immunoprecipitation-chip evidence, ChEC-Seq experiments
CYR1 YJL005W Adenylate cyclase genetic 2 2 2 Synthetic Rescue, Dosage Rescue
WHI3 YNL197C RNA binding protein that modulates mRNA stability physical 2 2 2 Protein-RNA, Affinity Capture-RNA
SIR2 YDL042C Conserved NAD+ dependent histone deacetylase of the Sirtuin family genetic 2 2 2 Phenotypic Enhancement, Phenotypic Suppression
MEP3 YPR138C Ammonium permease of high capacity and low affinity physical 2 1 2 PCA, PCA
MCK1 YNL307C Dual-specificity ser/thr and tyrosine protein kinase physical 2 2 1 Affinity Capture-Western, Biochemical Activity
GLC7 YER133W Type 1 S/T protein phosphatase (PP1) catalytic subunit genetic 2 1 1 Synthetic Lethality, Synthetic Lethality
GPB1 YOR371C Multistep regulator of cAMP-PKA signaling physical 2 1 1 Affinity Capture-Western, Affinity Capture-Western
FOB1 YDR110W Nucleolar protein that binds the rDNA replication fork barrier site genetic 2 1 1 Phenotypic Enhancement, Phenotypic Enhancement
MET32 YDR253C Zinc-finger DNA-binding transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
MET4 YNL103W Leucine-zipper transcriptional activator regulation 1 1 1 chromatin immunoprecipitation-chip evidence
XBP1 YIL101C Transcriptional repressor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
YAP6 YDR259C Basic leucine zipper (bZIP) transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
YAP1 YML007W Basic leucine zipper (bZIP) transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
REB1 YBR049C RNA polymerase I enhancer binding protein regulation 1 1 1 chromatin immunoprecipitation-chip evidence
MED4 YOR174W Subunit of the RNA polymerase II mediator complex regulation 1 1 1 chromatin immunoprecipitation-chip evidence
MED6 YHR058C Subunit of the RNA polymerase II mediator complex regulation 1 1 1 chromatin immunoprecipitation-chip evidence
TUP1 YCR084C General repressor of transcription in complex with Cyc8p regulation 1 1 1 chromatin immunoprecipitation-chip evidence
GLN3 YER040W Transcriptional activator in nitrogen catabolite repression system regulation 1 1 1 chromatin immunoprecipitation-chip evidence
CCR4 YAL021C Component of the CCR4-NOT transcriptional complex physical 1 1 1 Affinity Capture-RNA
ASC1 YMR116C G-protein beta subunit and guanine dissociation inhibitor for Gpa2p physical 1 1 1 Affinity Capture-Western
CYR1 YJL005W Adenylate cyclase physical 1 1 1 Reconstituted Complex
FAB1 YFR019W 1-phosphatidylinositol-3-phosphate 5-kinase genetic 1 1 1 Negative Genetic
GIM5 YML094W Subunit of the heterohexameric cochaperone prefoldin complex genetic 1 1 1 Positive Genetic
FLC2 YAL053W Putative calcium channel involved in calcium release under hypotonic physical 1 1 1 PCA
CDC13 YDL220C Single stranded DNA-binding protein found at TG1-3 telomere G-tails genetic 1 1 1 Positive Genetic
FAR8 YMR029C Protein involved in recovery from arrest in response to pheromone physical 1 1 1 Affinity Capture-MS
ASA1 YPR085C Subunit of the ASTRA complex, involved in chromatin remodeling genetic 1 1 1 Negative Genetic
IDH1 YNL037C Subunit of mitochondrial NAD(+)-dependent isocitrate dehydrogenase physical 1 1 1 Affinity Capture-MS
PMA2 YPL036W Plasma membrane H+-ATPase physical 1 1 1 Affinity Capture-MS
GUS1 YGL245W Glutamyl-tRNA synthetase (GluRS) physical 1 1 1 Affinity Capture-MS
PLC1 YPL268W Phospholipase C physical 1 1 1 Affinity Capture-Western
KSS1 YGR040W Mitogen-activated protein kinase (MAPK) physical 1 1 1 Affinity Capture-Western
GPB1 YOR371C Multistep regulator of cAMP-PKA signaling genetic 1 1 1 Phenotypic Suppression
GPB2 YAL056W Multistep regulator of cAMP-PKA signaling genetic 1 1 1 Phenotypic Suppression
RGS2 YOR107W Negative regulator of glucose-induced cAMP signaling physical 1 1 1 Reconstituted Complex
GPG1 YGL121C Proposed gamma subunit of the heterotrimeric G protein physical 1 1 1 Two-hybrid
HSC82 YMR186W Cytoplasmic chaperone of the Hsp90 family physical 1 1 1 Affinity Capture-MS
YBL029C-A YBL029C-A Protein of unknown function physical 1 1 1 PCA
RFS1 YBR052C Protein of unknown function physical 1 1 1 PCA
HSP30 YCR021C Negative regulator of the H(+)-ATPase Pma1p physical 1 1 1 PCA
RIM1 YCR028C-A ssDNA-binding protein essential for mitochondrial genome maintenance physical 1 1 1 PCA
SYP1 YCR030C Negative regulator of WASP-Arp23 complex physical 1 1 1 PCA
PST2 YDR032C FMN-dependent NAD(P)H:quinone oxidoreductase physical 1 1 1 PCA
TPO4 YOR273C Polyamine transporter of the major facilitator superfamily physical 1 1 1 PCA
TPO2 YGR138C Polyamine transporter of the major facilitator superfamily physical 1 1 1 PCA
YGR130C YGR130C Component of the eisosome with unknown function physical 1 1 1 PCA
MID2 YLR332W O-glycosylated plasma membrane protein physical 1 1 1 PCA
MEP1 YGR121C Ammonium permease physical 1 1 1 PCA
YLR326W YLR326W Putative protein of unknown function physical 1 1 1 PCA
HNM1 YGL077C Plasma membrane transporter for choline, ethanolamine, and carnitine physical 1 1 1 PCA
WSC2 YNL283C Sensor-transducer of the stress-activated PKC1-MPK1 signaling pathway physical 1 1 1 PCA
YOR1 YGR281W Plasma membrane ATP-binding cassette (ABC) transporter physical 1 1 1 PCA
YGL108C YGL108C Protein of unknown function, predicted to be palmitoylated physical 1 1 1 PCA
PDR12 YPL058C Plasma membrane ATP-binding cassette (ABC) transporter physical 1 1 1 PCA
INA1 YLR413W Protein of unknown function physical 1 1 1 PCA
OSH6 YKR003W Oxysterol-binding phosphatidylserine transferase physical 1 1 1 PCA
MUP1 YGR055W High affinity methionine permease physical 1 1 1 PCA
SLM1 YIL105C Phosphoinositide PI4,5P(2) binding protein, forms a complex with Slm2p physical 1 1 1 PCA
TPO3 YPR156C Polyamine transporter of the major facilitator superfamily physical 1 1 1 PCA
SFK1 YKL051W Protein that regulates phospholipid asymmetry at plasma membrane physical 1 1 1 PCA
TPH3 YJL016W Putative protein of unknown function physical 1 1 1 PCA
WSC3 YOL105C Sensor-transducer of the stress-activated PKC1-MPK1 signaling pathway physical 1 1 1 PCA
OSH7 YHR001W Oxysterol-binding phosphatidylserine transferase physical 1 1 1 PCA
MPT5 YGL178W mRNA-binding protein of the PUF family physical 1 1 1 Affinity Capture-RNA
YGK3 YOL128C Protein kinase related to mammalian GSK-3 glycogen synthase kinases physical 1 1 1 Biochemical Activity
HXT1 YHR094C Low-affinity glucose transporter of the major facilitator superfamily genetic 1 1 1 Phenotypic Enhancement
NOT5 YPR072W Component of the CCR4-NOT core complex, involved in mRNA decapping genetic 1 1 1 Synthetic Rescue
TPK2 YPL203W cAMP-dependent protein kinase catalytic subunit genetic 1 1 1 Synthetic Rescue
PDE2 YOR360C High-affinity cyclic AMP phosphodiesterase genetic 1 1 1 Dosage Rescue
MEP2 YNL142W Ammonium permease involved in regulation of pseudohyphal growth genetic 1 1 1 Phenotypic Suppression
SUT2 YPR009W Zn2Cys6 family transcription factor genetic 1 1 1 Dosage Rescue
RAS1 YOR101W GTPase involved in G-protein signaling in adenylate cyclase activation genetic 1 1 1 Dosage Rescue
SWI4 YER111C DNA binding component of the SBF complex (Swi4p-Swi6p) genetic 1 1 1 Phenotypic Enhancement
VMA21 YGR105W Integral membrane protein required for V-ATPase function genetic 1 1 1 Synthetic Growth Defect
VOA1 YGR106C ER protein that functions in assembly of the V0 sector of V-ATPase genetic 1 1 1 Synthetic Growth Defect
SBA1 YKL117W Co-chaperone that binds and regulates Hsp90 family chaperones genetic 1 1 1 Synthetic Lethality
TSA1 YML028W Thioredoxin peroxidase genetic 1 1 1 Synthetic Growth Defect
JJJ1 YNL227C Co-chaperone that stimulates the ATPase activity of Ssa1p genetic 1 1 1 Positive Genetic
SUR1 YPL057C Mannosylinositol phosphorylceramide (MIPC) synthase catalytic subunit genetic 1 1 1 Negative Genetic
YME1 YPR024W Catalytic subunit of i-AAA protease complex genetic 1 1 1 Positive Genetic
SOD1 YJR104C Cytosolic copper-zinc superoxide dismutase genetic 1 1 1 Phenotypic Enhancement
ORC2 YBR060C Subunit of the origin recognition complex (ORC) genetic 1 1 1 Synthetic Rescue
KNS1 YLL019C Protein kinase involved in negative regulation of PolIII transcription genetic 1 1 1 Synthetic Growth Defect
RHO5 YNL180C Non-essential small GTPase of the Rho/Rac family of Ras-like proteins genetic 1 1 1 Synthetic Growth Defect
BCK2 YER167W Serine/threonine-rich protein involved in PKC1 signaling pathway genetic 1 1 1 Phenotypic Enhancement
FUS3 YBL016W Mitogen-activated serine/threonine protein kinase involved in mating physical 1 1 1 Affinity Capture-Western
GPA1 YHR005C Subunit of G protein involved in pheromone response physical 1 1 1 Affinity Capture-MS
GPA1 YHR005C Subunit of G protein involved in pheromone response genetic 1 1 1 Synthetic Lethality
BIR1 YJR089W Subunit of chromosomal passenger complex (CPC) genetic 1 1 1 Positive Genetic
CLN3 YAL040C G1 cyclin involved in cell cycle progression genetic 1 1 1 Phenotypic Enhancement
FTR1 YER145C High affinity iron permease physical 1 1 1 PCA
CYC1 YJR048W Cytochrome c, isoform 1 genetic 1 1 1 Negative Genetic
FLC1 YPL221W Flavin adenine dinucleotide transporter physical 1 1 1 PCA
DUR3 YHL016C Plasma membrane transporter for both urea and polyamines physical 1 1 1 PCA