Standard name Systematic name Name description Description
PPH22 YDL188C Catalytic subunit of protein phosphatase 2A, PP2A Catalytic subunit of protein phosphatase 2A, PP2A; functionally redundant with Pph21p; C-terminally methylated; forms alternate complexes with several regulatory subunits; involved in signal transduction and regulation of mitosis; protein abundance increases in response to DNA replication stress; dephosphorylates Tel1p/Mec1p-phosphorylated Cdc13p to promote telomerase release from telomeres at G2/M; PPH22 has a paralog, PPH21, that arose from the whole genome duplication
Visualize the interactome of PPH22
Links to external databases:
  SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)

CYCLoPs localization & abundance

WT1 WT2 WT3
Cytoplasm 0.918 0.91 0.919
Vac/Vac Memb 0.121 0.08 0.081

GFP localization & abundance

GFP localization GFP abundance
cytoplasm, nucleus 4110

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
PPH22 2 2 0 1 0

Enzyme information

Catalyzed reactions in Yeast8

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
PPH21 YDL134C Catalytic subunit of protein phosphatase 2A, PP2A genetic 14 4 14 Synthetic Growth Defect, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Phenotypic Enhancement, Negative Genetic, Phenotypic Enhancement, Synthetic Lethality, Negative Genetic, Synthetic Growth Defect, Synthetic Lethality, Synthetic Lethality, Synthetic Growth Defect
CDC55 YGL190C Regulatory subunit B of protein phosphatase 2A (PP2A) physical 13 3 12 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Reconstituted Complex, Reconstituted Complex, Affinity Capture-Western
TPD3 YAL016W Regulatory subunit A of the heterotrimeric PP2A complex physical 8 2 7 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS
TAP42 YMR028W Essential protein involved in the TOR signaling pathway physical 6 4 6 Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex, Two-hybrid, Affinity Capture-MS
ZDS1 YMR273C Protein with a role in regulating Swe1p-dependent polarized growth physical 4 2 4 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western
CDC55 YGL190C Regulatory subunit B of protein phosphatase 2A (PP2A) genetic 3 3 3 Synthetic Rescue, Synthetic Growth Defect, Dosage Rescue
PPH3 YDR075W Catalytic subunit of protein phosphatase PP4 complex genetic 3 3 3 Phenotypic Enhancement, Synthetic Lethality, Negative Genetic
RTS1 YOR014W B-type regulatory subunit of protein phosphatase 2A (PP2A) genetic 3 2 3 Negative Genetic, Phenotypic Enhancement, Negative Genetic
TIP41 YPR040W Tap42p-interacting protein physical 3 2 3 Two-hybrid, Two-hybrid, Affinity Capture-Western
SIT4 YDL047W Ceramide-activated, type 2A-related serine-threonine phosphatase genetic 3 2 3 Phenotypic Enhancement, Phenotypic Enhancement, Dosage Rescue
RTS1 YOR014W B-type regulatory subunit of protein phosphatase 2A (PP2A) physical 3 1 3 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS
SSB2 YNL209W Cytoplasmic ATPase that is a ribosome-associated molecular chaperone physical 3 2 2 Affinity Capture-MS, Affinity Capture-MS, Co-purification
CDC5 YMR001C Polo-like kinase required for mitotic exit genetic 3 2 2 Dosage Lethality, Dosage Lethality, Dosage Rescue
HMT1 YBR034C Nuclear SAM-dependent mono- and asymmetric methyltransferase physical 3 2 1 Affinity Capture-Western, PCA, PCA
RRD2 YPL152W Peptidyl-prolyl cis/trans-isomerase physical 2 2 2 Reconstituted Complex, Affinity Capture-Western
RRD2 YPL152W Peptidyl-prolyl cis/trans-isomerase genetic 2 2 2 Dosage Rescue, Negative Genetic
PTC1 YDL006W Type 2C protein phosphatase (PP2C) genetic 2 2 2 Positive Genetic, Dosage Rescue
TDH2 YJR009C Glyceraldehyde-3-phosphate dehydrogenase (GAPDH), isozyme 2 physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
ZDS2 YML109W Protein with a role in regulating Swe1p-dependent polarized growth physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
RTS3 YGR161C Putative component of the protein phosphatase type 2A complex physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
RVB1 YDR190C ATP-dependent DNA helicase, also known as pontin physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
RVB2 YPL235W ATP-dependent DNA helicase, also known as reptin physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
SIN4 YNL236W Subunit of the RNA polymerase II mediator complex genetic 2 1 2 Negative Genetic, Negative Genetic
HIR2 YOR038C Subunit of HIR nucleosome assembly complex genetic 2 1 2 Negative Genetic, Negative Genetic
BUB3 YOR026W Kinetochore checkpoint WD40 repeat protein genetic 2 1 2 Negative Genetic, Negative Genetic
SWE1 YJL187C Protein kinase that regulates the G2/M transition physical 2 2 1 Reconstituted Complex, Biochemical Activity
OMA1 YKR087C Metalloendopeptidase of the mitochondrial inner membrane genetic 2 2 1 Phenotypic Suppression, Synthetic Rescue
MOB1 YIL106W Component of the mitotic exit network genetic 2 1 1 Dosage Lethality, Dosage Lethality
RAP1 YNL216W Essential DNA-binding transcription regulator that binds many loci regulation 1 1 1 chromatin immunoprecipitation-chip evidence
REB1 YBR049C RNA polymerase I enhancer binding protein regulation 1 1 1 chromatin immunoprecipitation-chip evidence
HXK2 YGL253W Hexokinase isoenzyme 2 regulation 1 1 1 quantitative western immunoblotting evidence
CDC13 YDL220C Single stranded DNA-binding protein found at TG1-3 telomere G-tails regulation 1 1 1 qualitative western immunoblotting evidence
AME1 YBR211C Essential kinetochore protein associated with microtubules and SPBs genetic 1 1 1 Negative Genetic
ESA1 YOR244W Catalytic subunit of the histone acetyltransferase complex (NuA4) genetic 1 1 1 Negative Genetic
AMN1 YBR158W Modulator of cell separation and mitotic exit genetic 1 1 1 Synthetic Rescue
CDC42 YLR229C Small rho-like GTPase genetic 1 1 1 Positive Genetic
ACT1 YFL039C Actin, structural protein in cytoskeleton genetic 1 1 1 Synthetic Haploinsufficiency
NAB2 YGL122C Nuclear polyadenylated RNA-binding protein physical 1 1 1 Affinity Capture-RNA
APC1 YNL172W Largest subunit of the Anaphase-Promoting Complex/Cyclosome physical 1 1 1 Biochemical Activity
BET2 YPR176C Beta subunit of Type II geranylgeranyltransferase genetic 1 1 1 Negative Genetic
CDC28 YBR160W Cyclin-dependent kinase (CDK) catalytic subunit genetic 1 1 1 Synthetic Rescue
DCP1 YOL149W Subunit of the Dcp1p-Dcp2p decapping enzyme complex genetic 1 1 1 Positive Genetic
CDC16 YKL022C Subunit of the anaphase-promoting complex/cyclosome (APC/C) physical 1 1 1 Biochemical Activity
ERG13 YML126C 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) synthase physical 1 1 1 Affinity Capture-MS
ESP1 YGR098C Separase/separin, a caspase-like cysteine protease physical 1 1 1 Biochemical Activity
DYN1 YKR054C Cytoplasmic heavy chain dynein genetic 1 1 1 Phenotypic Suppression
LST8 YNL006W Protein required for the transport of Gap1p genetic 1 1 1 Synthetic Rescue
MCD1 YDL003W Essential alpha-kleisin subunit of the cohesin complex physical 1 1 1 Biochemical Activity
MED6 YHR058C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
POL12 YBL035C B subunit of DNA polymerase alpha-primase complex genetic 1 1 1 Negative Genetic
PRE1 YER012W Beta 4 subunit of the 20S proteasome physical 1 1 1 Affinity Capture-MS
PRE10 YOR362C Alpha 7 subunit of the 20S proteasome physical 1 1 1 Affinity Capture-MS
PRE2 YPR103W Beta 5 subunit of the 20S proteasome physical 1 1 1 Affinity Capture-MS
PRE4 YFR050C Beta 7 subunit of the 20S proteasome physical 1 1 1 Affinity Capture-MS
PRE5 YMR314W Alpha 6 subunit of the 20S proteasome physical 1 1 1 Affinity Capture-MS
PRE6 YOL038W Alpha 4 subunit of the 20S proteasome physical 1 1 1 Affinity Capture-MS
PRE7 YBL041W Beta 6 subunit of the 20S proteasome physical 1 1 1 Affinity Capture-MS
PRE8 YML092C Alpha 2 subunit of the 20S proteasome physical 1 1 1 Affinity Capture-MS
PRE9 YGR135W Alpha 3 subunit of the 20S proteasome physical 1 1 1 Affinity Capture-MS
PUP1 YOR157C Beta 2 subunit of the 20S proteasome physical 1 1 1 Affinity Capture-MS
PUP2 YGR253C Alpha 5 subunit of the 20S proteasome physical 1 1 1 Affinity Capture-MS
PUP2 YGR253C Alpha 5 subunit of the 20S proteasome genetic 1 1 1 Negative Genetic
PUP3 YER094C Beta 3 subunit of the 20S proteasome physical 1 1 1 Affinity Capture-MS
SCL1 YGL011C Alpha 1 subunit of the 20S proteasome physical 1 1 1 Affinity Capture-MS
SPS1 YDR523C STE20-family GCKIII protein kinase physical 1 1 1 Affinity Capture-MS
ULA1 YPL003W Protein that activates Rub1p (NEDD8) before neddylation physical 1 1 1 Affinity Capture-MS
RPA135 YPR010C RNA polymerase I second largest subunit A135 physical 1 1 1 Affinity Capture-MS
RPB11 YOL005C RNA polymerase II subunit B12.5 physical 1 1 1 Affinity Capture-MS
YCK1 YHR135C Palmitoylated plasma membrane-bound casein kinase I (CK1) isoform physical 1 1 1 Affinity Capture-MS
TFA1 YKL028W TFIIE large subunit physical 1 1 1 Affinity Capture-MS
TFA2 YKR062W TFIIE small subunit physical 1 1 1 Affinity Capture-MS
SSE1 YPL106C ATPase component of heat shock protein Hsp90 chaperone complex physical 1 1 1 Affinity Capture-MS
SGO1 YOR073W Component of the spindle checkpoint physical 1 1 1 Affinity Capture-MS
SPO12 YHR152W Nucleolar protein of unknown function physical 1 1 1 Two-hybrid
SCJ1 YMR214W One of several homologs of bacterial chaperone DnaJ physical 1 1 1 Affinity Capture-MS
SPB4 YFL002C Putative ATP-dependent RNA helicase physical 1 1 1 Affinity Capture-MS
SIZ1 YDR409W SUMO E3 ligase physical 1 1 1 Affinity Capture-MS
ULP2 YIL031W Peptidase that deconjugates Smt3/SUMO-1 peptides from proteins physical 1 1 1 Affinity Capture-MS
VAM6 YDL077C Guanine nucleotide exchange factor for the GTPase Gtr1p physical 1 1 1 Affinity Capture-MS
PUF2 YPR042C PUF family mRNA-binding protein physical 1 1 1 Affinity Capture-RNA
RRD1 YIL153W Peptidyl-prolyl cis/trans-isomerase genetic 1 1 1 Dosage Rescue
SCH9 YHR205W AGC family protein kinase genetic 1 1 1 Synthetic Rescue
SSD1 YDR293C Translational repressor genetic 1 1 1 Synthetic Rescue
PTP1 YDL230W Phosphotyrosine-specific protein phosphatase genetic 1 1 1 Negative Genetic
STE20 YHL007C Cdc42p-activated signal transducing kinase genetic 1 1 1 Positive Genetic
YAK1 YJL141C Serine-threonine protein kinase genetic 1 1 1 Positive Genetic
TDA1 YMR291W Protein kinase of unknown cellular role genetic 1 1 1 Negative Genetic
VMA3 YEL027W Proteolipid subunit c of the V0 domain of vacuolar H(+)-ATPase genetic 1 1 1 Negative Genetic
WHI3 YNL197C RNA binding protein that modulates mRNA stability genetic 1 1 1 Positive Genetic
STB3 YDR169C Ribosomal RNA processing element (RRPE)-binding protein genetic 1 1 1 Synthetic Rescue
SIS2 YKR072C Negative regulatory subunit of protein phosphatase 1 (Ppz1p) genetic 1 1 1 Dosage Rescue
TEM1 YML064C GTPase involved in initiation of Mitotic Exit Network (MEN) genetic 1 1 1 Dosage Lethality
RRI1 YDL216C Catalytic subunit of the COP9 signalosome (CSN) complex genetic 1 1 1 Negative Genetic
RTG3 YBL103C bHLH/Zip transcription factor for retrograde (RTG) and TOR pathways genetic 1 1 1 Negative Genetic
SWI4 YER111C DNA binding component of the SBF complex (Swi4p-Swi6p) genetic 1 1 1 Positive Genetic
SSN3 YPL042C Component of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
RPO31 YOR116C RNA polymerase III largest subunit C160 genetic 1 1 1 Synthetic Growth Defect
TAF1 YGR274C TFIID subunit, involved in RNA pol II transcription initiation genetic 1 1 1 Synthetic Lethality
SIW14 YNL032W Inositol phosphatase involved in inositol pyrophosphate metabolism genetic 1 1 1 Phenotypic Suppression
SWI1 YPL016W Subunit of the SWI/SNF chromatin remodeling complex genetic 1 1 1 Positive Genetic
SOM1 YEL059C-A Subunit of the mitochondrial inner membrane peptidase (IMP) genetic 1 1 1 Positive Genetic
YGL235W YGL235W Putative protein of unknown function genetic 1 1 1 Positive Genetic
SCS7 YMR272C Sphingolipid alpha-hydroxylase genetic 1 1 1 Positive Genetic
RPB3 YIL021W RNA polymerase II third largest subunit B44 genetic 1 1 1 Negative Genetic
SMX3 YPR182W Core Sm protein Sm F genetic 1 1 1 Negative Genetic
VBA3 YCL069W Permease of basic amino acids in the vacuolar membrane genetic 1 1 1 Negative Genetic
VMS1 YDR049W Peptidyl-tRNA hydrolase that releases stalled peptides from ribosomes, genetic 1 1 1 Negative Genetic
SAC3 YDR159W mRNA export factor genetic 1 1 1 Negative Genetic
SHE9 YDR393W Protein required for normal mitochondrial morphology genetic 1 1 1 Negative Genetic
YPS6 YIR039C Putative GPI-anchored aspartic protease genetic 1 1 1 Negative Genetic
TVP38 YKR088C Integral membrane protein genetic 1 1 1 Negative Genetic
TSA1 YML028W Thioredoxin peroxidase genetic 1 1 1 Negative Genetic
RCF1 YML030W Cytochrome c oxidase subunit genetic 1 1 1 Negative Genetic
VPS9 YML097C Guanine nucleotide exchange factor (GEF) and ubiquitin receptor genetic 1 1 1 Negative Genetic
RMD9 YGL107C Mitochondrial protein that controls mitochondrial gene expression genetic 1 1 1 Negative Genetic
RPS23A YGR118W Ribosomal protein 28 (rp28) of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
SUV3 YPL029W ATP-dependent RNA helicase genetic 1 1 1 Negative Genetic
VMA13 YPR036W Subunit H of the V1 peripheral membrane domain of V-ATPase genetic 1 1 1 Negative Genetic
SPE2 YOL052C S-adenosylmethionine decarboxylase genetic 1 1 1 Positive Genetic
SIP2 YGL208W One of three alternate beta subunits of the Snf1 kinase complex genetic 1 1 1 Positive Genetic
VPS15 YBR097W Serine/threonine protein kinase involved in vacuolar protein sorting genetic 1 1 1 Negative Genetic
SPE1 YKL184W Ornithine decarboxylase genetic 1 1 1 Positive Genetic
SWI6 YLR182W Transcription cofactor genetic 1 1 1 Positive Genetic
URE2 YNL229C Nitrogen catabolite repression transcriptional regulator genetic 1 1 1 Phenotypic Enhancement
HTA2 YBL003C Histone H2A physical 1 1 1 Affinity Capture-MS
MET18 YIL128W Component of cytosolic iron-sulfur protein assembly (CIA) machinery genetic 1 1 1 Negative Genetic
MKT1 YNL085W Protein similar to nucleases that forms a complex with Pbp1p physical 1 1 1 Affinity Capture-MS
MRPL6 YHR147C Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Negative Genetic
MAF1 YDR005C Highly conserved negative regulator of RNA polymerase III genetic 1 1 1 Synthetic Growth Defect
PPH21 YDL134C Catalytic subunit of protein phosphatase 2A, PP2A physical 1 1 1 Affinity Capture-MS
GCN5 YGR252W Catalytic subunit of ADA and SAGA histone acetyltransferase complexes genetic 1 1 1 Synthetic Lethality
FAR11 YNL127W Protein involved in recovery from cell cycle arrest physical 1 1 1 PCA
NOB1 YOR056C Protein involved in proteasomal and 40S ribosomal subunit biogenesis genetic 1 1 1 Negative Genetic
ATP2 YJR121W Beta subunit of the F1 sector of mitochondrial F1F0 ATP synthase genetic 1 1 1 Synthetic Rescue
CDC13 YDL220C Single stranded DNA-binding protein found at TG1-3 telomere G-tails physical 1 1 1 Biochemical Activity
CDC13 YDL220C Single stranded DNA-binding protein found at TG1-3 telomere G-tails genetic 1 1 1 Phenotypic Enhancement
IRA2 YOL081W GTPase-activating protein genetic 1 1 1 Positive Genetic
PHO85 YPL031C Cyclin-dependent kinase genetic 1 1 1 Dosage Lethality
GRR1 YJR090C F-box protein component of an SCF ubiquitin-ligase complex genetic 1 1 1 Synthetic Lethality
DUN1 YDL101C Cell-cycle checkpoint S/T protein kinase genetic 1 1 1 Synthetic Growth Defect
CIN8 YEL061C Bipolar kinesin motor protein genetic 1 1 1 Synthetic Growth Defect
PPE1 YHR075C Protein with carboxyl methyl esterase activity physical 1 1 1 Affinity Capture-MS
GPG1 YGL121C Proposed gamma subunit of the heterotrimeric G protein physical 1 1 1 Affinity Capture-MS
MIH1 YMR036C Protein tyrosine phosphatase physical 1 1 1 Biochemical Activity
MIH1 YMR036C Protein tyrosine phosphatase genetic 1 1 1 Synthetic Growth Defect
PAP2 YOL115W Non-canonical poly(A) polymerase genetic 1 1 1 Negative Genetic
FKH2 YNL068C Forkhead family transcription factor genetic 1 1 1 Positive Genetic
DEF1 YKL054C RNAPII degradation factor physical 1 1 1 Affinity Capture-MS
DBF2 YGR092W Ser/Thr kinase involved in transcription and stress response genetic 1 1 1 Positive Genetic
KKQ8 YKL168C Putative serine/threonine protein kinase with unknown cellular role genetic 1 1 1 Negative Genetic
CPR2 YHR057C Peptidyl-prolyl cis-trans isomerase (cyclophilin) genetic 1 1 1 Positive Genetic
PKC1 YBL105C Protein serine/threonine kinase genetic 1 1 1 Dosage Rescue
ATG34 YOL083W Receptor protein involved in selective autophagy during starvation genetic 1 1 1 Negative Genetic
MNS1 YJR131W Alpha-1,2-mannosidase genetic 1 1 1 Negative Genetic
APC9 YLR102C Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) physical 1 1 1 Biochemical Activity
CDC27 YBL084C Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) physical 1 1 1 Biochemical Activity
CBF1 YJR060W Basic helix-loop-helix (bHLH) protein genetic 1 1 1 Negative Genetic
BUB1 YGR188C Protein kinase involved in the cell cycle checkpoint into anaphase genetic 1 1 1 Negative Genetic
KAR3 YPR141C Minus-end-directed microtubule motor genetic 1 1 1 Negative Genetic
NNF2 YGR089W Protein that exhibits physical and genetic interactions with Rpb8p genetic 1 1 1 Positive Genetic
MOG1 YJR074W Conserved nuclear protein that interacts with GTP-Gsp1p physical 1 1 1 Affinity Capture-MS
KCS1 YDR017C Inositol hexakisphosphate and inositol heptakisphosphate kinase genetic 1 1 1 Negative Genetic
PAM1 YDR251W Essential protein of unknown function genetic 1 1 1 Dosage Rescue
PMR1 YGL167C High affinity Ca2+/Mn2+ P-type ATPase genetic 1 1 1 Negative Genetic
MSS1 YMR023C Mitochondrial protein genetic 1 1 1 Positive Genetic
INM2 YDR287W Inositol monophosphatase genetic 1 1 1 Negative Genetic
GSH1 YJL101C Gamma glutamylcysteine synthetase genetic 1 1 1 Negative Genetic
ARV1 YLR242C Cortical ER protein genetic 1 1 1 Negative Genetic
NCR1 YPL006W Vacuolar membrane protein involved with Npc2p in sterol trafficking genetic 1 1 1 Negative Genetic
COQ2 YNR041C Para hydroxybenzoate polyprenyl transferase genetic 1 1 1 Negative Genetic
HTS1 YPR033C Cytoplasmic and mitochondrial histidine tRNA synthetase genetic 1 1 1 Negative Genetic
MTC3 YGL226W Protein of unknown function genetic 1 1 1 Negative Genetic