Standard name Systematic name Name description Description
GRR1 YJR090C F-box protein component of an SCF ubiquitin-ligase complex F-box protein component of an SCF ubiquitin-ligase complex; modular substrate specificity factor which associates with core SCF (Cdc53p, Skp1p and Hrt1p/Rbx1p) to form the SCF(Grr1) complex; SCF(Grr1) acts as a ubiquitin-protein ligase directing ubiquitination of substrates such as: Gic2p, Mks1p, Mth1p, Cln1p, Cln2p and Cln3p; involved in carbon catabolite repression, glucose-dependent divalent cation transport, glucose transport, morphogenesis, and sulfite detoxification
Visualize the interactome of GRR1
Links to external databases:
  SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)

CYCLoPs localization & abundance

WT1 WT2 WT3
no data no data no data

GFP localization & abundance

GFP localization GFP abundance
no data no data

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
GRR1 4 1 0 0 0

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
SKP1 YDR328C Evolutionarily conserved kinetochore protein physical 24 5 17 Affinity Capture-MS, Two-hybrid, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex, Reconstituted Complex, Reconstituted Complex, Two-hybrid, Two-hybrid, Reconstituted Complex, Affinity Capture-Western, Two-hybrid, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS, Reconstituted Complex, Affinity Capture-Western, Co-purification
CLN2 YPL256C G1 cyclin involved in regulation of the cell cycle physical 12 5 10 Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-Western, Two-hybrid, Affinity Capture-MS, Reconstituted Complex, Biochemical Activity, Affinity Capture-Western, Affinity Capture-Western
CDC53 YDL132W Cullin physical 10 3 9 Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-Western
RGT1 YKL038W Glucose-responsive transcription factor genetic 5 2 5 Phenotypic Enhancement, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue
CLN1 YMR199W G1 cyclin involved in regulation of the cell cycle physical 4 4 4 Affinity Capture-MS, Reconstituted Complex, Biochemical Activity, Affinity Capture-Western
PFK27 YOL136C 6-phosphofructo-2-kinase physical 4 4 3 Reconstituted Complex, Two-hybrid, Affinity Capture-Western, Affinity Capture-MS
HRT1 YOL133W RING-H2 domain core subunit of multiple ubiquitin ligase complexes physical 4 3 3 Affinity Capture-Western, Two-hybrid, Two-hybrid, Reconstituted Complex
CLN2 YPL256C G1 cyclin involved in regulation of the cell cycle genetic 4 3 3 Synthetic Rescue, Phenotypic Suppression, Phenotypic Suppression, Dosage Rescue
CLN1 YMR199W G1 cyclin involved in regulation of the cell cycle genetic 3 2 3 Synthetic Rescue, Phenotypic Suppression, Phenotypic Suppression
CDC55 YGL190C Regulatory subunit B of protein phosphatase 2A (PP2A) genetic 3 2 2 Synthetic Lethality, Synthetic Lethality, Dosage Rescue
MTH1 YDR277C Negative regulator of the glucose-sensing signal transduction pathway physical 3 2 2 Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-MS
HOF1 YMR032W F-BAR protein that regulates actin cytoskeleton organization physical 3 3 1 Two-hybrid, PCA, FRET
MKS1 YNL076W Pleiotropic negative transcriptional regulator physical 3 2 1 Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex
CDC28 YBR160W Cyclin-dependent kinase (CDK) catalytic subunit physical 2 2 2 Biochemical Activity, Reconstituted Complex
SKP1 YDR328C Evolutionarily conserved kinetochore protein genetic 2 2 2 Dosage Lethality, Dosage Rescue
TYE7 YOR344C Serine-rich protein that contains a bHLH DNA binding motif physical 2 2 2 Reconstituted Complex, Affinity Capture-MS
SSY5 YJL156C Serine protease of SPS plasma membrane amino acid sensor system genetic 2 2 2 Dosage Rescue, Synthetic Rescue
CDC34 YDR054C Ubiquitin-conjugating enzyme (E2) genetic 2 2 2 Dosage Lethality, Synthetic Rescue
GIC2 YDR309C Rho-family GTPase interacting protein and Cdc42p effector physical 2 2 2 Two-hybrid, Affinity Capture-MS
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator physical 2 1 2 Affinity Capture-RNA, Affinity Capture-RNA
TIS11 YLR136C mRNA-binding protein expressed during iron starvation physical 2 1 2 Affinity Capture-Western, Affinity Capture-Western
SSN2 YDR443C Subunit of the RNA polymerase II mediator complex physical 2 1 2 Two-hybrid, Two-hybrid
FZF1 YGL254W Transcription factor involved in sulfite metabolism genetic 2 1 2 Dosage Rescue, Dosage Rescue
BMH2 YDR099W 14-3-3 protein, minor isoform physical 2 2 1 Two-hybrid, Affinity Capture-Western
REG1 YDR028C Regulatory subunit of type 1 protein phosphatase Glc7p physical 2 2 1 Two-hybrid, Affinity Capture-Western
NPR2 YEL062W Subunit of the Iml1p/SEACIT complex physical 2 2 1 Affinity Capture-MS, Affinity Capture-Western
PGD1 YGL025C Subunit of the RNA polymerase II mediator complex physical 2 2 1 Reconstituted Complex, Two-hybrid
GIS4 YML006C CAAX box containing protein of unknown function physical 2 2 1 Two-hybrid, Affinity Capture-Western
ARP4 YJL081C Nuclear actin-related protein involved in chromatin remodeling genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
ESA1 YOR244W Catalytic subunit of the histone acetyltransferase complex (NuA4) genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
ADA2 YDR448W Transcription coactivator genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
RSR1 YGR152C Ras-type GTPase genetic 2 1 1 Synthetic Rescue, Synthetic Rescue
SWC4 YGR002C Component of the Swr1p complex that incorporates Htz1p into chromatin genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
YAF9 YNL107W Subunit of NuA4 histone H4 acetyltransferase and SWR1 complexes genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
FKH2 YNL068C Forkhead family transcription factor regulation 1 1 1 ChEC-Seq experiments
YAP6 YDR259C Basic leucine zipper (bZIP) transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
TFC7 YOR110W RNA pol III transcription initiation factor complex (TFIIIC) subunit regulation 1 1 1 chromatin immunoprecipitation-chip evidence
REB1 YBR049C RNA polymerase I enhancer binding protein regulation 1 1 1 chromatin immunoprecipitation-chip evidence
SRL3 YKR091W Repressor of transcription at Start regulation 1 1 1 qualitative western immunoblotting evidence
SSN2 YDR443C Subunit of the RNA polymerase II mediator complex regulation 1 1 1 qualitative western immunoblotting evidence
GCD6 YDR211W Catalytic epsilon subunit of the translation initiation factor eIF2B physical 1 1 1 Affinity Capture-MS
CCR4 YAL021C Component of the CCR4-NOT transcriptional complex physical 1 1 1 Affinity Capture-RNA
BEM2 YER155C Rho GTPase activating protein (RhoGAP) genetic 1 1 1 Synthetic Rescue
CDC12 YHR107C Component of the septin ring that is required for cytokinesis genetic 1 1 1 Synthetic Growth Defect
CPR1 YDR155C Cytoplasmic peptidyl-prolyl cis-trans isomerase (cyclophilin) physical 1 1 1 Affinity Capture-MS
BZZ1 YHR114W SH3 domain protein implicated in regulating actin polymerization physical 1 1 1 Two-hybrid
CAF20 YOR276W Phosphoprotein of the mRNA cap-binding complex physical 1 1 1 Affinity Capture-RNA
FOL2 YGR267C GTP-cyclohydrolase I, catalyzes first step in folic acid biosynthesis physical 1 1 1 Affinity Capture-MS
CDC53 YDL132W Cullin genetic 1 1 1 Dosage Lethality
POR1 YNL055C Mitochondrial porin (voltage-dependent anion channel) physical 1 1 1 Affinity Capture-MS
HTB2 YBL002W Histone H2B physical 1 1 1 Affinity Capture-MS
PFK1 YGR240C Alpha subunit of heterooctameric phosphofructokinase physical 1 1 1 Affinity Capture-MS
PDC6 YGR087C Minor isoform of pyruvate decarboxylase physical 1 1 1 Affinity Capture-MS
SAH1 YER043C S-adenosyl-L-homocysteine hydrolase physical 1 1 1 Affinity Capture-MS
UBI4 YLL039C Ubiquitin physical 1 1 1 Affinity Capture-MS
PDC5 YLR134W Minor isoform of pyruvate decarboxylase physical 1 1 1 Affinity Capture-MS
HRT1 YOL133W RING-H2 domain core subunit of multiple ubiquitin ligase complexes genetic 1 1 1 Synthetic Lethality
REG1 YDR028C Regulatory subunit of type 1 protein phosphatase Glc7p genetic 1 1 1 Dosage Rescue
HEK2 YBL032W RNA binding protein involved in asymmetric localization of ASH1 mRNA physical 1 1 1 Affinity Capture-RNA
NAB2 YGL122C Nuclear polyadenylated RNA-binding protein physical 1 1 1 Affinity Capture-RNA
NPR2 YEL062W Subunit of the Iml1p/SEACIT complex genetic 1 1 1 Dosage Lethality
STP1 YDR463W Transcription factor physical 1 1 1 Affinity Capture-Western
STP2 YHR006W Transcription factor physical 1 1 1 Affinity Capture-Western
SBP1 YHL034C Protein that binds eIF4G and has a role in repression of translation physical 1 1 1 Affinity Capture-RNA
YIR016W YIR016W Putative protein of unknown function physical 1 1 1 Two-hybrid
PRP3 YDR473C Splicing factor physical 1 1 1 Two-hybrid
RRI2 YOL117W Subunit of the COP9 signalosome (CSN) complex physical 1 1 1 Two-hybrid
SHE3 YBR130C Protein adaptor between Myo4p and the She2p-mRNA complex physical 1 1 1 Two-hybrid
SBE2 YDR351W Protein required for bud growth physical 1 1 1 Affinity Capture-Western
SFG1 YOR315W Nuclear protein putative transcription factor physical 1 1 1 Affinity Capture-Western
TIS11 YLR136C mRNA-binding protein expressed during iron starvation genetic 1 1 1 Synthetic Rescue
YHR131C YHR131C Putative protein of unknown function physical 1 1 1 Affinity Capture-Western
YKR045C YKR045C Putative protein of unknown function physical 1 1 1 Affinity Capture-Western
YNL144C YNL144C Putative protein of unknown function physical 1 1 1 Affinity Capture-Western
SSY5 YJL156C Serine protease of SPS plasma membrane amino acid sensor system physical 1 1 1 Two-hybrid
NDD1 YOR372C Transcriptional activator essential for nuclear division physical 1 1 1 Affinity Capture-Western
ISW1 YBR245C ATPase subunit of imitation-switch (ISWI) class chromatin remodelers physical 1 1 1 Affinity Capture-RNA
SRL3 YKR091W Repressor of transcription at Start physical 1 1 1 Affinity Capture-Western
RRP6 YOR001W Nuclear exosome exonuclease component physical 1 1 1 Affinity Capture-MS
MPS3 YJL019W Nuclear envelope protein physical 1 1 1 Affinity Capture-MS
HXT1 YHR094C Low-affinity glucose transporter of the major facilitator superfamily genetic 1 1 1 Dosage Rescue
HXT2 YMR011W High-affinity glucose transporter of the major facilitator superfamily genetic 1 1 1 Dosage Rescue
HXT3 YDR345C Low affinity glucose transporter of the major facilitator superfamily genetic 1 1 1 Dosage Rescue
HXT4 YHR092C High-affinity glucose transporter genetic 1 1 1 Dosage Rescue
SKS1 YPL026C Putative serine/threonine protein kinase genetic 1 1 1 Dosage Rescue
SSU1 YPL092W Plasma membrane sulfite pump involved in sulfite metabolism genetic 1 1 1 Dosage Rescue
SNF3 YDL194W Plasma membrane low glucose sensor, regulates glucose transport genetic 1 1 1 Synthetic Lethality
PLP1 YDR183W Protein that interacts with CCT (chaperonin containing TCP-1) complex genetic 1 1 1 Synthetic Rescue
PAC10 YGR078C Part of the heteromeric co-chaperone GimC/prefoldin complex genetic 1 1 1 Synthetic Lethality
TUB3 YML124C Alpha-tubulin genetic 1 1 1 Synthetic Lethality
RAD27 YKL113C 5' to 3' exonuclease, 5' flap endonuclease genetic 1 1 1 Synthetic Lethality
NUP133 YKR082W Subunit of Nup84p subcomplex of nuclear pore complex (NPC) genetic 1 1 1 Synthetic Lethality
NUP120 YKL057C Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC) genetic 1 1 1 Synthetic Lethality
RTG2 YGL252C Sensor of mitochondrial dysfunction genetic 1 1 1 Phenotypic Suppression
RPD3 YNL330C Histone deacetylase, component of both the Rpd3S and Rpd3L complexes genetic 1 1 1 Dosage Lethality
HMT1 YBR034C Nuclear SAM-dependent mono- and asymmetric methyltransferase genetic 1 1 1 Negative Genetic
PPH21 YDL134C Catalytic subunit of protein phosphatase 2A, PP2A genetic 1 1 1 Synthetic Lethality
PPH22 YDL188C Catalytic subunit of protein phosphatase 2A, PP2A genetic 1 1 1 Synthetic Lethality
TYR1 YBR166C Prephenate dehydrogenase involved in tyrosine biosynthesis genetic 1 1 1 Synthetic Lethality
SNF1 YDR477W AMP-activated S/T protein kinase genetic 1 1 1 Synthetic Lethality
TRP1 YDR007W Phosphoribosylanthranilate isomerase genetic 1 1 1 Synthetic Growth Defect
RAV1 YJR033C Subunit of RAVE complex (Rav1p, Rav2p, Skp1p) genetic 1 1 1 Synthetic Growth Defect
SIN4 YNL236W Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Phenotypic Enhancement
SGS1 YMR190C RecQ family nucleolar DNA helicase genetic 1 1 1 Positive Genetic
COF1 YLL050C Cofilin, involved in pH-dependent actin filament depolarization physical 1 1 1 Affinity Capture-MS
CCT3 YJL014W Subunit of the cytosolic chaperonin Cct ring complex physical 1 1 1 Affinity Capture-MS
GAC1 YOR178C Regulatory subunit for Glc7p type-1 protein phosphatase (PP1) physical 1 1 1 Affinity Capture-Western
ELM1 YKL048C Serine/threonine protein kinase genetic 1 1 1 Synthetic Growth Defect
CDC4 YFL009W F-box protein required for both the G1/S and G2/M phase transitions genetic 1 1 1 Synthetic Growth Defect
GIS4 YML006C CAAX box containing protein of unknown function genetic 1 1 1 Dosage Lethality
CLN3 YAL040C G1 cyclin involved in cell cycle progression physical 1 1 1 Affinity Capture-Western
CLN3 YAL040C G1 cyclin involved in cell cycle progression genetic 1 1 1 Dosage Lethality
CDC34 YDR054C Ubiquitin-conjugating enzyme (E2) physical 1 1 1 Affinity Capture-MS
FOB1 YDR110W Nucleolar protein that binds the rDNA replication fork barrier site physical 1 1 1 Two-hybrid
DSE3 YOR264W Daughter cell-specific protein, may help establish daughter fate physical 1 1 1 Two-hybrid
BUD4 YJR092W Anillin-like protein involved in bud-site selection physical 1 1 1 Affinity Capture-Western
GAP1 YKR039W General amino acid permease genetic 1 1 1 Synthetic Growth Defect
FIR1 YER032W Protein involved in 3' mRNA processing physical 1 1 1 Affinity Capture-Western
FLO11 YIR019C GPI-anchored cell surface glycoprotein (flocculin) genetic 1 1 1 Phenotypic Suppression
ARO7 YPR060C Chorismate mutase genetic 1 1 1 Synthetic Lethality