Standard name Systematic name Name description Description
APC2 YLR127C Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C); which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; component of the catalytic core of the APC/C; has similarity to cullin Cdc53p
Visualize the interactome of APC2
Links to external databases:
SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)

CYCLoPs localization & abundance

WT1 WT2 WT3
Cytoplasm 0.176 0.086 0.261
ER 0.059 NaN NaN
Mito 0.294 0.396 0.076
Nucleolus 0.118 NaN NaN
Nucleus 0.529 0.410 0.534
SpindlePole 0.059 NaN 0.109
Vac/Vac Memb 0.118 0.259 NaN
Budneck NaN NaN 0.084

GFP localization & abundance

GFP localization GFP abundance
cytoplasm, nucleus 432

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
APC2 3 2 1 0 0

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
CDC16 YKL022C Subunit of the anaphase-promoting complex/cyclosome (APC/C) physical 20 2 17 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-Western
CDC23 YHR166C Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) physical 11 2 9 Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western
APC1 YNL172W Largest subunit of the Anaphase-Promoting Complex/Cyclosome physical 9 4 6 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Co-fractionation, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Reconstituted Complex
CDC27 YBL084C Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) physical 8 2 8 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS
DOC1 YGL240W Processivity factor physical 7 3 7 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Two-hybrid, Affinity Capture-Western
APC4 YDR118W Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) physical 7 2 6 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western
APC11 YDL008W Catalytic core subunit, Anaphase-Promoting Complex/Cyclosome (APC/C) physical 5 4 5 Affinity Capture-MS, Affinity Capture-MS, Two-hybrid, Affinity Capture-Western, Reconstituted Complex
SWM1 YDR260C Subunit of the anaphase-promoting complex (APC) physical 5 1 4 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS
MND2 YIR025W Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) physical 4 2 4 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western
APC5 YOR249C Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) physical 4 1 4 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS
ARP4 YJL081C Nuclear actin-related protein involved in chromatin remodeling genetic 3 2 2 Synthetic Lethality, Synthetic Lethality, Positive Genetic
CDC23 YHR166C Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
PDS1 YDR113C Securin genetic 2 2 2 Synthetic Rescue, Synthetic Lethality
SMC3 YJL074C Subunit of the multiprotein cohesin complex genetic 2 2 2 Synthetic Lethality, Negative Genetic
SSE1 YPL106C ATPase component of heat shock protein Hsp90 chaperone complex genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
OKP1 YGR179C Outer kinetochore protein required for accurate chromosome segregation genetic 2 2 2 Negative Genetic, Positive Genetic
APC9 YLR102C Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
CDC27 YBL084C Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) genetic 2 1 1 Negative Genetic, Negative Genetic
APC5 YOR249C Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) genetic 2 1 1 Negative Genetic, Negative Genetic
EAF1 YDR359C Component of the NuA4 histone acetyltransferase complex genetic 2 1 1 Synthetic Lethality, Synthetic Lethality
EAF5 YEL018W Non-essential subunit of the NuA4 acetyltransferase complex genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
EAF7 YNL136W Subunit of the NuA4 histone acetyltransferase complex genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
EPL1 YFL024C Subunit of NuA4, an essential histone H4/H2A acetyltransferase complex genetic 2 1 1 Synthetic Lethality, Synthetic Lethality
ESA1 YOR244W Catalytic subunit of the histone acetyltransferase complex (NuA4) genetic 2 1 1 Synthetic Lethality, Synthetic Lethality
SWC4 YGR002C Component of the Swr1p complex that incorporates Htz1p into chromatin genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
YAF9 YNL107W Subunit of NuA4 histone H4 acetyltransferase and SWR1 complexes genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
YNG2 YHR090C Subunit of NuA4, an essential histone acetyltransferase complex genetic 2 1 1 Synthetic Lethality, Synthetic Lethality
CDC48 YDL126C AAA ATPase with protein-unfoldase activity genetic 2 1 1 Negative Genetic, Negative Genetic
RPN12 YFR052W Subunit of the 19S regulatory particle of the 26S proteasome lid genetic 2 1 1 Negative Genetic, Negative Genetic
HSF1 YGL073W Trimeric heat shock transcription factor genetic 2 1 1 Negative Genetic, Negative Genetic
CDC20 YGL116W Activator of anaphase-promoting complex/cyclosome (APC/C) genetic 2 1 1 Negative Genetic, Negative Genetic
RPT4 YOR259C ATPase of the 19S regulatory particle of the 26S proteasome genetic 2 1 1 Negative Genetic, Negative Genetic
GCN5 YGR252W Catalytic subunit of ADA and SAGA histone acetyltransferase complexes regulation 1 1 1 chromatin immunoprecipitation-chip evidence
XBP1 YIL101C Transcriptional repressor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
YAP6 YDR259C Basic leucine zipper (bZIP) transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
TFC7 YOR110W RNA pol III transcription initiation factor complex (TFIIIC) subunit regulation 1 1 1 chromatin immunoprecipitation-chip evidence
YAP5 YIR018W Basic leucine zipper (bZIP) iron-sensing transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
APC1 YNL172W Largest subunit of the Anaphase-Promoting Complex/Cyclosome genetic 1 1 1 Negative Genetic
CDC16 YKL022C Subunit of the anaphase-promoting complex/cyclosome (APC/C) genetic 1 1 1 Negative Genetic
FMP48 YGR052W Putative protein of unknown function physical 1 1 1 Affinity Capture-MS
MND2 YIR025W Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) genetic 1 1 1 Synthetic Growth Defect
HRT1 YOL133W RING-H2 domain core subunit of multiple ubiquitin ligase complexes physical 1 1 1 Two-hybrid
APC2 YLR127C Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) physical 1 1 1 Affinity Capture-MS
APC4 YDR118W Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) genetic 1 1 1 Negative Genetic
CDC26 YFR036W Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) physical 1 1 1 Affinity Capture-MS
CDC26 YFR036W Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) genetic 1 1 1 Negative Genetic
RAD51 YER095W Strand exchange protein physical 1 1 1 Two-hybrid
DMC1 YER179W Meiosis-specific recombinase required for double-strand break repair physical 1 1 1 Two-hybrid
SPC110 YDR356W Inner plaque spindle pole body (SPB) component physical 1 1 1 Co-purification
HEK2 YBL032W RNA binding protein involved in asymmetric localization of ASH1 mRNA physical 1 1 1 Affinity Capture-RNA
CDC5 YMR001C Polo-like kinase required for mitotic exit physical 1 1 1 Affinity Capture-MS
BZZ1 YHR114W SH3 domain protein implicated in regulating actin polymerization physical 1 1 1 Two-hybrid
NAB2 YGL122C Nuclear polyadenylated RNA-binding protein physical 1 1 1 Affinity Capture-RNA
CDC28 YBR160W Cyclin-dependent kinase (CDK) catalytic subunit physical 1 1 1 Affinity Capture-MS
ISW1 YBR245C ATPase subunit of imitation-switch (ISWI) class chromatin remodelers physical 1 1 1 Affinity Capture-RNA
CCR4 YAL021C Component of the CCR4-NOT transcriptional complex physical 1 1 1 Affinity Capture-RNA
MOG1 YJR074W Conserved nuclear protein that interacts with GTP-Gsp1p physical 1 1 1 Affinity Capture-MS
CLB2 YPR119W B-type cyclin involved in cell cycle progression genetic 1 1 1 Dosage Lethality
SIC1 YLR079W Cyclin-dependent kinase inhibitor (CKI) genetic 1 1 1 Synthetic Lethality
ROT1 YMR200W Molecular chaperone involved in protein folding in ER genetic 1 1 1 Synthetic Growth Defect
MSN5 YDR335W Karyopherin genetic 1 1 1 Synthetic Growth Defect
CKA1 YIL035C Alpha catalytic subunit of casein kinase 2 (CK2) genetic 1 1 1 Dosage Growth Defect
KIN4 YOR233W Serine/threonine protein kinase genetic 1 1 1 Dosage Growth Defect
PRK1 YIL095W Ser/Thr protein kinase genetic 1 1 1 Dosage Growth Defect
PSK2 YOL045W PAS-domain containing serine/threonine protein kinase genetic 1 1 1 Dosage Growth Defect
SWE1 YJL187C Protein kinase that regulates the G2/M transition genetic 1 1 1 Dosage Growth Defect
STU1 YBL034C Microtubule plus-end-tracking non-motor protein genetic 1 1 1 Positive Genetic
TUB2 YFL037W Beta-tubulin genetic 1 1 1 Positive Genetic
CDC34 YDR054C Ubiquitin-conjugating enzyme (E2) genetic 1 1 1 Positive Genetic
LCB2 YDR062W Component of serine palmitoyltransferase genetic 1 1 1 Positive Genetic
CAB5 YDR196C Subunit of the CoA-Synthesizing Protein Complex (CoA-SPC) genetic 1 1 1 Positive Genetic
SYF1 YDR416W Member of the NineTeen Complex (NTC) genetic 1 1 1 Positive Genetic
SNM1 YDR478W Ribonuclease MRP complex subunit genetic 1 1 1 Positive Genetic
PUP3 YER094C Beta 3 subunit of the 20S proteasome genetic 1 1 1 Positive Genetic
PRP43 YGL120C RNA helicase in the DEAH-box family genetic 1 1 1 Positive Genetic
PRP18 YGR006W Splicing factor and component of snRNP U5 genetic 1 1 1 Positive Genetic
CIA2 YHR122W Component of cytosolic iron-sulfur protein assembly (CIA) machinery genetic 1 1 1 Positive Genetic
ARP3 YJR065C Essential component of the Arp2/3 complex genetic 1 1 1 Positive Genetic
UTP15 YMR093W Nucleolar protein genetic 1 1 1 Positive Genetic
RET3 YPL010W Zeta subunit of the coatomer complex (COPI) genetic 1 1 1 Positive Genetic
BET2 YPR176C Beta subunit of Type II geranylgeranyltransferase genetic 1 1 1 Positive Genetic
LSM1 YJL124C Lsm (Like Sm) protein genetic 1 1 1 Positive Genetic
BRE5 YNR051C Ubiquitin protease cofactor genetic 1 1 1 Positive Genetic
ISW2 YOR304W ATP-dependent DNA translocase involved in chromatin remodeling genetic 1 1 1 Positive Genetic
LRS4 YDR439W Nucleolar protein that forms a complex with Csm1p genetic 1 1 1 Positive Genetic
YLF2 YHL014C Protein of unknown function genetic 1 1 1 Positive Genetic
BUD20 YLR074C C2H2-type zinc finger protein required for ribosome assembly genetic 1 1 1 Positive Genetic
GAS3 YMR215W Putative 1,3-beta-glucanosyltransferase genetic 1 1 1 Positive Genetic
MPS1 YDL028C Dual-specificity kinase genetic 1 1 1 Negative Genetic
UBC1 YDR177W Ubiquitin-conjugating enzyme genetic 1 1 1 Negative Genetic
SCC2 YDR180W Subunit of cohesin loading factor (Scc2p-Scc4p) genetic 1 1 1 Negative Genetic
SMC1 YFL008W Subunit of the multiprotein cohesin complex genetic 1 1 1 Negative Genetic
DNA2 YHR164C ATP-dependent 5'-flap endonuclease and DNA helicase genetic 1 1 1 Negative Genetic
URA6 YKL024C Uridylate kinase genetic 1 1 1 Negative Genetic
POL12 YBL035C B subunit of DNA polymerase alpha-primase complex genetic 1 1 1 Negative Genetic
ORC2 YBR060C Subunit of the origin recognition complex (ORC) genetic 1 1 1 Negative Genetic
RSC6 YCR052W Component of the RSC chromatin remodeling complex genetic 1 1 1 Negative Genetic
RPN5 YDL147W Subunit of the CSN and 26S proteasome lid complexes genetic 1 1 1 Negative Genetic
YRB1 YDR002W Ran GTPase binding protein genetic 1 1 1 Negative Genetic
CDC37 YDR168W Essential Hsp90p co-chaperone genetic 1 1 1 Negative Genetic
SPC19 YDR201W Essential subunit of the Dam1 complex (aka DASH complex) genetic 1 1 1 Negative Genetic
CAK1 YFL029C Cyclin-dependent kinase-activating kinase genetic 1 1 1 Negative Genetic
RPN11 YFR004W Metalloprotease subunit of 19S regulatory particle genetic 1 1 1 Negative Genetic
ECO1 YFR027W Acetyltransferase required for sister chromatid cohesion genetic 1 1 1 Negative Genetic
CDC14 YFR028C Protein phosphatase required for mitotic exit genetic 1 1 1 Negative Genetic
RSC8 YFR037C Component of the RSC chromatin remodeling complex genetic 1 1 1 Negative Genetic
RNA15 YGL044C Component of the cleavage and polyadenylation factor I (CF I) genetic 1 1 1 Negative Genetic
RPT6 YGL048C ATPase of the 19S regulatory particle of the 26S proteasome genetic 1 1 1 Negative Genetic
NUP145 YGL092W Essential protein with distinct roles in two nuclear pore subcomplexes genetic 1 1 1 Negative Genetic
RPN1 YHR027C Non-ATPase base subunit of the 19S RP of the 26S proteasome genetic 1 1 1 Negative Genetic
BRL1 YHR036W Essential nuclear envelope/ER integral membrane protein genetic 1 1 1 Negative Genetic
PHS1 YJL097W Essential 3-hydroxyacyl-CoA dehydratase of the ER membrane genetic 1 1 1 Negative Genetic
CDC6 YJL194W Essential ATP-binding protein required for DNA replication genetic 1 1 1 Negative Genetic
IPA1 YJR141W Protein implicated in pre-mRNA processing and proteasomal degradation genetic 1 1 1 Negative Genetic
PRI2 YKL045W Subunit of DNA primase genetic 1 1 1 Negative Genetic
ASK1 YKL052C Essential subunit of the Dam1 complex (aka DASH complex) genetic 1 1 1 Negative Genetic
RPT1 YKL145W ATPase of the 19S regulatory particle of the 26S proteasome genetic 1 1 1 Negative Genetic
RSC4 YKR008W Component of the RSC chromatin remodeling complex genetic 1 1 1 Negative Genetic
ARP9 YMR033W Component of both the SWI/SNF and RSC chromatin remodeling complexes genetic 1 1 1 Negative Genetic
DCP2 YNL118C Catalytic subunit of Dcp1p-Dcp2p decapping enzyme complex genetic 1 1 1 Negative Genetic
MVD1 YNR043W Mevalonate pyrophosphate decarboxylase genetic 1 1 1 Negative Genetic
RFC4 YOL094C Subunit of heteropentameric Replication factor C (RF-C) genetic 1 1 1 Negative Genetic
RAT1 YOR048C Nuclear 5' to 3' single-stranded RNA exonuclease genetic 1 1 1 Negative Genetic
ARP7 YPR034W Component of both the SWI/SNF and RSC chromatin remodeling complexes genetic 1 1 1 Negative Genetic
RPN7 YPR108W Essential non-ATPase regulatory subunit of the 26S proteasome genetic 1 1 1 Negative Genetic
SGV1 YPR161C Cyclin (Bur2p)-dependent protein kinase genetic 1 1 1 Negative Genetic
ORC4 YPR162C Subunit of the origin recognition complex (ORC) genetic 1 1 1 Negative Genetic
PGA2 YNL149C Essential protein required for maturation of Gas1p and Pho8p genetic 1 1 1 Negative Genetic
AVO1 YOL078W Component of the membrane-bound TORC2 complex genetic 1 1 1 Negative Genetic
MUM2 YBR057C Protein essential for meiotic DNA replication and sporulation genetic 1 1 1 Negative Genetic
UBC4 YBR082C Ubiquitin-conjugating enzyme (E2) genetic 1 1 1 Negative Genetic
SGF29 YCL010C Component of the HAT/Core module of the SAGA, SLIK, and ADA complexes genetic 1 1 1 Negative Genetic
SIN3 YOL004W Component of both the Rpd3S and Rpd3L histone deacetylase complexes genetic 1 1 1 Negative Genetic
SLK19 YOR195W Kinetochore-associated protein genetic 1 1 1 Negative Genetic
RDL1 YOR285W Thiosulfate sulfurtransferase genetic 1 1 1 Negative Genetic
PDE2 YOR360C High-affinity cyclic AMP phosphodiesterase genetic 1 1 1 Negative Genetic
RAD1 YPL022W Single-stranded DNA endonuclease (with Rad10p) genetic 1 1 1 Negative Genetic
RPL21B YPL079W Ribosomal 60S subunit protein L21B genetic 1 1 1 Negative Genetic
YPL150W YPL150W Protein kinase of unknown cellular role genetic 1 1 1 Negative Genetic
YPR084W YPR084W Putative protein of unknown function genetic 1 1 1 Negative Genetic
HDA3 YPR179C Subunit of HDA1 histone deacetylase complex genetic 1 1 1 Negative Genetic
BUD4 YJR092W Anillin-like protein involved in bud-site selection genetic 1 1 1 Negative Genetic
ATG33 YLR356W Mitochondrial mitophagy-specific protein genetic 1 1 1 Negative Genetic
MRPL17 YNL252C Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Negative Genetic
YPL119C-A YPL119C-A Putative protein of unknown function genetic 1 1 1 Negative Genetic
UFE1 YOR075W t-SNARE protein required for retrograde vesicular traffic genetic 1 1 1 Negative Genetic
ENT4 YLL038C Protein of unknown function genetic 1 1 1 Negative Genetic
TMA7 YLR262C-A Protein of unknown function that associates with ribosomes genetic 1 1 1 Negative Genetic
YPR078C YPR078C Putative protein of unknown function genetic 1 1 1 Negative Genetic
SGS1 YMR190C RecQ family nucleolar DNA helicase genetic 1 1 1 Positive Genetic
HRQ1 YDR291W 3'-5' DNA helicase of the conserved RecQ family genetic 1 1 1 Positive Genetic
APC11 YDL008W Catalytic core subunit, Anaphase-Promoting Complex/Cyclosome (APC/C) genetic 1 1 1 Dosage Rescue
ALG1 YBR110W Mannosyltransferase genetic 1 1 1 Negative Genetic
AEP3 YPL005W Peripheral mitochondrial inner membrane protein genetic 1 1 1 Negative Genetic