Standard name Systematic name Name description Description
MGS1 YNL218W Protein with DNA-dependent ATPase and ssDNA annealing activities Protein with DNA-dependent ATPase and ssDNA annealing activities; involved in maintenance of genome; interacts functionally with DNA polymerase delta; homolog of human Werner helicase interacting protein (WHIP); forms nuclear foci upon DNA replication stress
Visualize the interactome of MGS1
Links to external databases:
  SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)
G2 120

CYCLoPs localization & abundance

WT1 WT2 WT3
Cytoplasm 0.097 0.151 NaN
Mito 0.226 NaN NaN
Nucleus 0.597 0.605 NaN
Vac/Vac Memb 0.226 0.378 NaN

GFP localization & abundance

GFP localization GFP abundance
cytoplasm, nucleus 1180

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
MGS1 1 0 0 0 1

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
SGS1 YMR190C RecQ family nucleolar DNA helicase genetic 7 4 7 Synthetic Lethality, Phenotypic Enhancement, Synthetic Growth Defect, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect
RAD18 YCR066W E3 ubiquitin ligase genetic 5 3 5 Synthetic Lethality, Negative Genetic, Synthetic Lethality, Synthetic Growth Defect, Synthetic Lethality
RAD5 YLR032W DNA helicase/Ubiquitin ligase genetic 5 2 4 Synthetic Growth Defect, Phenotypic Enhancement, Synthetic Growth Defect, Synthetic Growth Defect, Phenotypic Enhancement
POL31 YJR006W Subunit of DNA polymerase delta (polymerase III) genetic 5 3 3 Synthetic Growth Defect, Dosage Lethality, Dosage Lethality, Synthetic Rescue, Synthetic Rescue
POL3 YDL102W Catalytic subunit of DNA polymerase delta genetic 5 4 2 Synthetic Rescue, Phenotypic Enhancement, Dosage Lethality, Synthetic Rescue, Dosage Growth Defect
POL32 YJR043C Third subunit of DNA polymerase delta genetic 4 3 2 Dosage Lethality, Synthetic Rescue, Synthetic Rescue, Dosage Growth Defect
FKH1 YIL131C Forkhead family transcription factor regulation 3 2 3 chromatin immunoprecipitation-chip evidence, chromatin immunoprecipitation-chip evidence, chromatin immunoprecipitation- exonuclease evidence
DNA2 YHR164C ATP-dependent 5'-flap endonuclease and DNA helicase genetic 3 2 3 Dosage Rescue, Dosage Rescue, Negative Genetic
ESC2 YDR363W Sumo-like domain protein genetic 3 2 3 Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect
POL30 YBR088C Proliferating cell nuclear antigen (PCNA) genetic 3 3 2 Dosage Lethality, Synthetic Lethality, Synthetic Rescue
POL30 YBR088C Proliferating cell nuclear antigen (PCNA) physical 3 2 1 Two-hybrid, Two-hybrid, Reconstituted Complex
TOP3 YLR234W DNA Topoisomerase III genetic 2 2 2 Phenotypic Enhancement, Negative Genetic
REV3 YPL167C Catalytic subunit of DNA polymerase zeta genetic 2 2 2 Synthetic Lethality, Synthetic Rescue
RAD51 YER095W Strand exchange protein genetic 2 2 2 Dosage Growth Defect, Dosage Lethality
RFA1 YAR007C Subunit of heterotrimeric Replication Protein A (RPA) genetic 2 2 2 Dosage Lethality, Negative Genetic
RAD9 YDR217C DNA damage-dependent checkpoint protein genetic 2 2 2 Dosage Lethality, Phenotypic Suppression
RAD6 YGL058W Ubiquitin-conjugating enzyme (E2) genetic 2 2 2 Synthetic Lethality, Synthetic Growth Defect
RNH203 YLR154C Ribonuclease H2 subunit genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
SFP1 YLR403W Regulates transcription of ribosomal protein and biogenesis genes regulation 1 1 1 DNA to cDNA expression microarray evidence
TFC7 YOR110W RNA pol III transcription initiation factor complex (TFIIIC) subunit regulation 1 1 1 chromatin immunoprecipitation-chip evidence
MBP1 YDL056W Transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
ACT1 YFL039C Actin, structural protein in cytoskeleton physical 1 1 1 Affinity Capture-MS
ACT1 YFL039C Actin, structural protein in cytoskeleton genetic 1 1 1 Negative Genetic
CCR4 YAL021C Component of the CCR4-NOT transcriptional complex physical 1 1 1 Affinity Capture-RNA
CDC28 YBR160W Cyclin-dependent kinase (CDK) catalytic subunit genetic 1 1 1 Dosage Lethality
CDC12 YHR107C Component of the septin ring that is required for cytokinesis genetic 1 1 1 Negative Genetic
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator physical 1 1 1 Affinity Capture-RNA
ISW1 YBR245C ATPase subunit of imitation-switch (ISWI) class chromatin remodelers physical 1 1 1 Affinity Capture-RNA
MEC1 YBR136W Genome integrity checkpoint protein and PI kinase superfamily member genetic 1 1 1 Dosage Lethality
ARP8 YOR141C Nuclear actin-related protein involved in chromatin remodeling genetic 1 1 1 Negative Genetic
PCM1 YEL058W Essential N-acetylglucosamine-phosphate mutase physical 1 1 1 Affinity Capture-MS
SNF1 YDR477W AMP-activated S/T protein kinase physical 1 1 1 Two-hybrid
TEM1 YML064C GTPase involved in initiation of Mitotic Exit Network (MEN) physical 1 1 1 Two-hybrid
MGS1 YNL218W Protein with DNA-dependent ATPase and ssDNA annealing activities physical 1 1 1 Two-hybrid
YCK2 YNL154C Palmitoylated plasma membrane-bound casein kinase I (CK1) isoform physical 1 1 1 Biochemical Activity
POL31 YJR006W Subunit of DNA polymerase delta (polymerase III) physical 1 1 1 Affinity Capture-Western
NAB2 YGL122C Nuclear polyadenylated RNA-binding protein physical 1 1 1 Affinity Capture-RNA
SSB2 YNL209W Cytoplasmic ATPase that is a ribosome-associated molecular chaperone physical 1 1 1 Co-purification
MPT5 YGL178W mRNA-binding protein of the PUF family physical 1 1 1 Affinity Capture-RNA
VTS1 YOR359W Flap-structured DNA-binding and RNA-binding protein physical 1 1 1 Affinity Capture-RNA
SEC61 YLR378C Conserved ER protein translocation channel physical 1 1 1 Affinity Capture-MS
SIZ1 YDR409W SUMO E3 ligase genetic 1 1 1 Synthetic Rescue
RAD53 YPL153C DNA damage response kinase genetic 1 1 1 Dosage Lethality
RAD17 YOR368W Checkpoint protein genetic 1 1 1 Dosage Lethality
RAD14 YMR201C Subunit of Nucleotide Excision Repair Factor 1 (NEF1) genetic 1 1 1 Dosage Lethality
RMI1 YPL024W Subunit of the RecQ (Sgs1p) - Topo III (Top3p) complex genetic 1 1 1 Negative Genetic
MRE11 YMR224C Nuclease subunit of the MRX complex with Rad50p and Xrs2p genetic 1 1 1 Phenotypic Enhancement
VID22 YLR373C G-quadruplex (G4) DNA binding protein genetic 1 1 1 Negative Genetic
SPT4 YGR063C Spt4p/5p (DSIF) transcription elongation factor complex subunit genetic 1 1 1 Negative Genetic
RAD50 YNL250W Subunit of MRX complex with Mre11p and Xrs2p genetic 1 1 1 Negative Genetic
SWD3 YBR175W Essential subunit of the COMPASS (Set1C) complex genetic 1 1 1 Phenotypic Suppression
SRB2 YHR041C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
YKU80 YMR106C Subunit of telomeric Ku complex (Yku70p-Yku80p) genetic 1 1 1 Positive Genetic
SUS1 YBR111W-A Global transcriptional regulator, component of SAGA, TREX-2 complexes genetic 1 1 1 Positive Genetic
RFC5 YBR087W Subunit of heteropentameric Replication factor C (RF-C) genetic 1 1 1 Dosage Lethality
SRS2 YJL092W DNA helicase and DNA-dependent ATPase genetic 1 1 1 Synthetic Rescue
RAD52 YML032C Protein involved in homologous recombination genetic 1 1 1 Dosage Rescue
UBC13 YDR092W E2 ubiquitin-conjugating enzyme genetic 1 1 1 Synthetic Rescue
RAD30 YDR419W DNA polymerase eta genetic 1 1 1 Synthetic Rescue
REV1 YOR346W Deoxycytidyl transferase genetic 1 1 1 Synthetic Rescue
TAF12 YDR145W Subunit (61/68 kDa) of TFIID and SAGA complexes genetic 1 1 1 Positive Genetic
QRI1 YDL103C UDP-N-acetylglucosamine pyrophosphorylase genetic 1 1 1 Negative Genetic
NSE4 YDL105W Component of the SMC5-SMC6 complex genetic 1 1 1 Negative Genetic
PDC2 YDR081C Transcription factor for thiamine-regulated genes genetic 1 1 1 Negative Genetic
NSE3 YDR288W Component of the SMC5-SMC6 complex genetic 1 1 1 Negative Genetic
TFB1 YDR311W Subunit of TFIIH and nucleotide excision repair factor 3 complexes genetic 1 1 1 Negative Genetic
SMT3 YDR510W Ubiquitin-like protein of the SUMO family genetic 1 1 1 Negative Genetic
NSE1 YLR007W Component of the SMC5-SMC6 complex genetic 1 1 1 Negative Genetic
SMC6 YLR383W Subunit of the SMC5-SMC6 complex genetic 1 1 1 Negative Genetic
NSE5 YML023C Component of the SMC5-SMC6 complex genetic 1 1 1 Negative Genetic
TIM23 YNR017W Essential component of the TIM23 complex genetic 1 1 1 Negative Genetic
TBF1 YPL128C Telobox-containing general regulatory factor genetic 1 1 1 Negative Genetic
YNG2 YHR090C Subunit of NuA4, an essential histone acetyltransferase complex genetic 1 1 1 Negative Genetic
MET18 YIL128W Component of cytosolic iron-sulfur protein assembly (CIA) machinery genetic 1 1 1 Negative Genetic
ILV1 YER086W Threonine deaminase, catalyzes first step in isoleucine biosynthesis genetic 1 1 1 Negative Genetic
CDC13 YDL220C Single stranded DNA-binding protein found at TG1-3 telomere G-tails genetic 1 1 1 Dosage Lethality
CMK1 YFR014C Calmodulin-dependent protein kinase physical 1 1 1 Biochemical Activity
LAF1 YMR102C Sterol-binding beta-propeller protein physical 1 1 1 Two-hybrid
FUS3 YBL016W Mitogen-activated serine/threonine protein kinase involved in mating genetic 1 1 1 Negative Genetic
BIR1 YJR089W Subunit of chromosomal passenger complex (CPC) genetic 1 1 1 Positive Genetic
CSM1 YCR086W Nucleolar protein that mediates homolog segregation during meiosis I physical 1 1 1 Two-hybrid
CSM1 YCR086W Nucleolar protein that mediates homolog segregation during meiosis I genetic 1 1 1 Phenotypic Suppression
MAD2 YJL030W Component of the spindle-assembly checkpoint complex physical 1 1 1 Two-hybrid
APN1 YKL114C Major apurinic/apyrimidinic endonuclease genetic 1 1 1 Dosage Lethality
JNM1 YMR294W Component of the yeast dynactin complex genetic 1 1 1 Synthetic Lethality
BOL1 YAL044W-A Mitochondrial matrix protein involved in Fe-S cluster biogenesis physical 1 1 1 Two-hybrid
CDC8 YJR057W Nucleoside monophosphate and nucleoside diphosphate kinase genetic 1 1 1 Synthetic Growth Defect