Standard name Systematic name Name description Description
MPH1 YIR002C 3'-5' DNA helicase involved in error-free bypass of DNA lesions 3'-5' DNA helicase involved in error-free bypass of DNA lesions; binds flap DNA, stimulates activity of Rad27p and Dna2p; prevents crossovers between ectopic sequences by removing substrates for Mus81-Mms4 or Rad1-Rad10 cleavage; homolog of human FANCM Fanconi anemia protein that is involved in stabilizing and remodeling blocked replication forks; member of SF2 DExD/H superfamily of helicases; nonsense or missense mutations in FANCM can make people more likely to get cancer
Visualize the interactome of MPH1
Links to external databases:
  SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)

CYCLoPs localization & abundance

WT1 WT2 WT3
Cytoplasm 0.067 0.166 0.196
Nucleus 0.821 0.673 0.472
Vac/Vac Memb 0.168 0.181 0.073
Mito NaN 0.161 0.439

GFP localization & abundance

GFP localization GFP abundance
cytoplasm, nucleus no data

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
MPH1 4 0 0 0 1

Enzyme information

Catalyzed reactions in Yeast8

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
SRS2 YJL092W DNA helicase and DNA-dependent ATPase genetic 21 6 19 Synthetic Lethality, Negative Genetic, Synthetic Growth Defect, Phenotypic Enhancement, Phenotypic Enhancement, Synthetic Lethality, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Phenotypic Suppression, Synthetic Growth Defect, Negative Genetic, Synthetic Growth Defect, Dosage Rescue, Phenotypic Suppression, Synthetic Growth Defect, Phenotypic Suppression, Phenotypic Enhancement, Negative Genetic, Phenotypic Enhancement, Negative Genetic
SMC6 YLR383W Subunit of the SMC5-SMC6 complex genetic 13 3 9 Dosage Growth Defect, Synthetic Rescue, Phenotypic Suppression, Synthetic Rescue, Synthetic Rescue, Phenotypic Suppression, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Phenotypic Suppression, Phenotypic Suppression
SMC5 YOL034W Subunit of the SMC5-SMC6 complex physical 12 3 6 Two-hybrid, Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex, Two-hybrid, Affinity Capture-Western, Two-hybrid, Affinity Capture-Western, Two-hybrid, Reconstituted Complex, Two-hybrid, Affinity Capture-Western
SGS1 YMR190C RecQ family nucleolar DNA helicase genetic 11 4 10 Phenotypic Enhancement, Phenotypic Enhancement, Dosage Rescue, Synthetic Growth Defect, Phenotypic Enhancement, Phenotypic Suppression, Phenotypic Suppression, Phenotypic Enhancement, Phenotypic Suppression, Phenotypic Suppression, Phenotypic Enhancement
RAD51 YER095W Strand exchange protein genetic 8 4 7 Synthetic Rescue, Synthetic Rescue, Phenotypic Enhancement, Phenotypic Suppression, Synthetic Rescue, Synthetic Rescue, Phenotypic Suppression, Negative Genetic
MUS81 YDR386W Subunit of structure-specific Mms4p-Mus81p endonuclease genetic 8 5 6 Synthetic Growth Defect, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Dosage Lethality, Phenotypic Suppression, Negative Genetic, Positive Genetic
MMS21 YEL019C Highly conserved SUMO E3 ligase subunit of SMC5-SMC6 complex genetic 8 4 6 Dosage Growth Defect, Phenotypic Suppression, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Phenotypic Enhancement
MTE1 YGR042W Protein of unknown function physical 8 5 4 Reconstituted Complex, Reconstituted Complex, Affinity Capture-MS, PCA, Affinity Capture-Western, Co-localization, PCA, Affinity Capture-MS
FKH1 YIL131C Forkhead family transcription factor physical 8 4 4 Affinity Capture-MS, Two-hybrid, Two-hybrid, Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex, Affinity Capture-MS, Affinity Capture-MS
RAD5 YLR032W DNA helicase/Ubiquitin ligase genetic 7 5 7 Phenotypic Suppression, Synthetic Growth Defect, Phenotypic Enhancement, Phenotypic Suppression, Dosage Growth Defect, Synthetic Rescue, Synthetic Growth Defect
RFA1 YAR007C Subunit of heterotrimeric Replication Protein A (RPA) physical 7 3 7 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Two-hybrid, Two-hybrid, Affinity Capture-MS, Affinity Capture-MS
REV3 YPL167C Catalytic subunit of DNA polymerase zeta genetic 7 4 6 Synthetic Rescue, Phenotypic Enhancement, Phenotypic Enhancement, Synthetic Growth Defect, Synthetic Growth Defect, Phenotypic Suppression, Phenotypic Suppression
MHF1 YOL086W-A Component of the heterotetrameric MHF histone-fold complex physical 7 4 4 Affinity Capture-Western, Affinity Capture-MS, Reconstituted Complex, Affinity Capture-Western, Two-hybrid, Reconstituted Complex, Affinity Capture-MS
MMS4 YBR098W Subunit of structure-specific Mms4p-Mus81p endonuclease genetic 5 3 5 Phenotypic Enhancement, Synthetic Growth Defect, Negative Genetic, Synthetic Growth Defect, Negative Genetic
MGM101 YJR144W Protein with a role in mitochondrial DNA recombinational repair physical 5 3 4 Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-MS, PCA, Affinity Capture-MS
MHF2 YDL160C-A Component of the heterotetrameric MHF histone-fold complex physical 5 3 4 Two-hybrid, Reconstituted Complex, Two-hybrid, Reconstituted Complex, Affinity Capture-MS
RAD52 YML032C Protein involved in homologous recombination genetic 4 4 4 Phenotypic Enhancement, Synthetic Rescue, Phenotypic Suppression, Negative Genetic
CDC13 YDL220C Single stranded DNA-binding protein found at TG1-3 telomere G-tails genetic 4 4 4 Synthetic Rescue, Dosage Lethality, Positive Genetic, Phenotypic Enhancement
ELG1 YOR144C Subunit of an alternative replication factor C complex genetic 4 4 4 Synthetic Growth Defect, Dosage Rescue, Dosage Lethality, Negative Genetic
MAG1 YER142C 3-methyl-adenine DNA glycosylase genetic 4 2 4 Phenotypic Enhancement, Phenotypic Enhancement, Negative Genetic, Negative Genetic
MMS2 YGL087C Ubiquitin-conjugating enzyme variant genetic 4 3 3 Phenotypic Enhancement, Synthetic Growth Defect, Phenotypic Enhancement, Phenotypic Suppression
RIM1 YCR028C-A ssDNA-binding protein essential for mitochondrial genome maintenance physical 3 3 3 Two-hybrid, Affinity Capture-MS, PCA
REV1 YOR346W Deoxycytidyl transferase genetic 3 3 3 Phenotypic Enhancement, Phenotypic Suppression, Negative Genetic
RAD18 YCR066W E3 ubiquitin ligase genetic 3 3 3 Phenotypic Suppression, Synthetic Growth Defect, Positive Genetic
GIM5 YML094W Subunit of the heterohexameric cochaperone prefoldin complex genetic 3 2 3 Phenotypic Suppression, Negative Genetic, Negative Genetic
MSH6 YDR097C Protein required for mismatch repair in mitosis and meiosis physical 3 1 3 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS
SLX4 YLR135W Endonuclease involved in processing DNA genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
RAD54 YGL163C DNA-dependent ATPase that stimulates strand exchange genetic 3 3 2 Synthetic Growth Defect, Positive Genetic, Negative Genetic
MMS1 YPR164W Subunit of E3 ubiquitin ligase complex involved in replication repair genetic 3 3 2 Dosage Lethality, Negative Genetic, Positive Genetic
MTE1 YGR042W Protein of unknown function genetic 3 2 2 Phenotypic Suppression, Synthetic Rescue, Phenotypic Suppression
CLA4 YNL298W Cdc42p-activated signal transducing kinase genetic 3 2 2 Negative Genetic, Negative Genetic, Positive Genetic
HST3 YOR025W Sirtuin, histone H3 deacetylase genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
YAP1 YML007W Basic leucine zipper (bZIP) transcription factor regulation 2 2 2 chromatin immunoprecipitation-chip evidence, DNA to cDNA expression microarray evidence
DNA2 YHR164C ATP-dependent 5'-flap endonuclease and DNA helicase genetic 2 2 2 Dosage Rescue, Phenotypic Suppression
MEC1 YBR136W Genome integrity checkpoint protein and PI kinase superfamily member genetic 2 2 2 Phenotypic Suppression, Negative Genetic
PIF1 YML061C DNA helicase, potent G-quadruplex DNA binder/unwinder genetic 2 2 2 Phenotypic Enhancement, Synthetic Growth Defect
RAD1 YPL022W Single-stranded DNA endonuclease (with Rad10p) genetic 2 2 2 Phenotypic Suppression, Synthetic Growth Defect
RAD55 YDR076W Protein that stimulates strand exchange genetic 2 2 2 Synthetic Rescue, Positive Genetic
RAD57 YDR004W Protein that stimulates strand exchange genetic 2 2 2 Synthetic Rescue, Negative Genetic
SIZ1 YDR409W SUMO E3 ligase genetic 2 2 2 Synthetic Growth Defect, Dosage Rescue
PSO2 YMR137C Nuclease required for DNA single- and double-strand break repair genetic 2 2 2 Synthetic Growth Defect, Phenotypic Enhancement
UBC13 YDR092W E2 ubiquitin-conjugating enzyme genetic 2 2 2 Dosage Rescue, Negative Genetic
MEC3 YLR288C DNA damage and meiotic pachytene checkpoint protein genetic 2 2 2 Synthetic Rescue, Phenotypic Suppression
ESC2 YDR363W Sumo-like domain protein genetic 2 2 2 Synthetic Rescue, Phenotypic Enhancement
MHF2 YDL160C-A Component of the heterotetrameric MHF histone-fold complex genetic 2 2 2 Synthetic Rescue, Synthetic Growth Defect
MHF1 YOL086W-A Component of the heterotetrameric MHF histone-fold complex genetic 2 2 2 Synthetic Rescue, Synthetic Growth Defect
ACT1 YFL039C Actin, structural protein in cytoskeleton genetic 2 1 2 Negative Genetic, Negative Genetic
RFA3 YJL173C Subunit of heterotrimeric Replication Protein A (RPA) physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
RFA2 YNL312W Subunit of heterotrimeric Replication Protein A (RPA) physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
RAD52 YML032C Protein involved in homologous recombination physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
SLT2 YHR030C Serine/threonine MAP kinase genetic 2 1 2 Negative Genetic, Negative Genetic
RAD14 YMR201C Subunit of Nucleotide Excision Repair Factor 1 (NEF1) genetic 2 1 2 Phenotypic Enhancement, Phenotypic Enhancement
VMA9 YCL005W-A Vacuolar H+ ATPase subunit e of the V-ATPase V0 subcomplex genetic 2 1 2 Positive Genetic, Positive Genetic
OSM1 YJR051W Fumarate reductase, catalyzes the reduction of fumarate to succinate genetic 2 1 2 Negative Genetic, Negative Genetic
OCA2 YNL056W Protein of unknown function genetic 2 1 2 Negative Genetic, Negative Genetic
PPT2 YPL148C Phosphopantetheine:protein transferase (PPTase) genetic 2 1 2 Negative Genetic, Negative Genetic
RRM3 YHR031C DNA helicase involved in rDNA replication and Ty1 transposition genetic 2 1 2 Synthetic Growth Defect, Synthetic Growth Defect
DEP1 YAL013W Component of the Rpd3L histone deacetylase complex genetic 2 1 2 Positive Genetic, Positive Genetic
ANP1 YEL036C Subunit of the alpha-1,6 mannosyltransferase complex genetic 2 1 2 Negative Genetic, Negative Genetic
CDC37 YDR168W Essential Hsp90p co-chaperone genetic 2 1 2 Negative Genetic, Negative Genetic
APN1 YKL114C Major apurinic/apyrimidinic endonuclease genetic 2 1 2 Phenotypic Enhancement, Phenotypic Enhancement
HOC1 YJR075W Alpha-1,6-mannosyltransferase genetic 2 1 2 Negative Genetic, Negative Genetic
MNN11 YJL183W Subunit of a Golgi mannosyltransferase complex genetic 2 1 2 Negative Genetic, Negative Genetic
ERD1 YDR414C Predicted membrane protein required for lumenal ER protein retention genetic 2 1 2 Negative Genetic, Negative Genetic
RAD6 YGL058W Ubiquitin-conjugating enzyme (E2) genetic 2 2 1 Synthetic Rescue, Phenotypic Enhancement
POL30 YBR088C Proliferating cell nuclear antigen (PCNA) genetic 2 2 1 Dosage Growth Defect, Synthetic Growth Defect
RNH201 YNL072W Ribonuclease H2 catalytic subunit genetic 2 2 1 Synthetic Lethality, Synthetic Rescue
SSA1 YAL005C ATPase involved in protein folding and NLS-directed nuclear transport physical 2 1 1 Affinity Capture-MS, Affinity Capture-MS
RNH203 YLR154C Ribonuclease H2 subunit genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
SSC1 YJR045C Hsp70 family ATPase genetic 2 1 1 Negative Genetic, Negative Genetic
YHL017W YHL017W Putative protein of unknown function genetic 2 1 1 Negative Genetic, Negative Genetic
DUN1 YDL101C Cell-cycle checkpoint S/T protein kinase genetic 2 1 1 Dosage Lethality, Dosage Lethality
CDC4 YFL009W F-box protein required for both the G1/S and G2/M phase transitions genetic 2 1 1 Negative Genetic, Negative Genetic
BIM1 YER016W Microtubule plus end-tracking protein genetic 2 1 1 Phenotypic Enhancement, Phenotypic Enhancement
FKH1 YIL131C Forkhead family transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
SFP1 YLR403W Regulates transcription of ribosomal protein and biogenesis genes regulation 1 1 1 DNA to cDNA expression microarray evidence
GCN5 YGR252W Catalytic subunit of ADA and SAGA histone acetyltransferase complexes regulation 1 1 1 chromatin immunoprecipitation-chip evidence
MED2 YDL005C Subunit of the RNA polymerase II mediator complex regulation 1 1 1 chromatin immunoprecipitation-chip evidence
BUR6 YER159C Subunit of a heterodimeric NC2 transcription regulator complex regulation 1 1 1 chromatin immunoprecipitation-chip evidence
YAP6 YDR259C Basic leucine zipper (bZIP) transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
TFC7 YOR110W RNA pol III transcription initiation factor complex (TFIIIC) subunit regulation 1 1 1 chromatin immunoprecipitation-chip evidence
SUA7 YPR086W Transcription factor TFIIB regulation 1 1 1 chromatin immunoprecipitation-chip evidence
CKA1 YIL035C Alpha catalytic subunit of casein kinase 2 (CK2) physical 1 1 1 PCA
CKB1 YGL019W Beta regulatory subunit of casein kinase 2 (CK2) physical 1 1 1 PCA
MAK16 YAL025C Essential nuclear protein genetic 1 1 1 Negative Genetic
KRE29 YER038C Subunit of the SMC5-SMC6 complex physical 1 1 1 Affinity Capture-Western
DBP3 YGL078C RNA-Dependent ATPase, member of DExD/H-box family physical 1 1 1 PCA
MDM20 YOL076W Non-catalytic subunit of the NatB N-terminal acetyltransferase genetic 1 1 1 Negative Genetic
IML1 YJR138W GTPase-activating protein (GAP) subunit of the Iml1p/SEACIT complex physical 1 1 1 Affinity Capture-MS
CBC2 YPL178W Small subunit of the heterodimeric cap binding complex with Sto1p physical 1 1 1 PCA
GCD11 YER025W Gamma subunit of the translation initiation factor eIF2 genetic 1 1 1 Positive Genetic
ARP9 YMR033W Component of both the SWI/SNF and RSC chromatin remodeling complexes physical 1 1 1 Affinity Capture-MS
MED4 YOR174W Subunit of the RNA polymerase II mediator complex physical 1 1 1 Affinity Capture-MS
MED4 YOR174W Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Positive Genetic
CFT2 YLR115W Subunit of the mRNA cleavage and polyadenlylation factor (CPF) physical 1 1 1 Affinity Capture-MS
CCR4 YAL021C Component of the CCR4-NOT transcriptional complex physical 1 1 1 Affinity Capture-RNA
KAP104 YBR017C Transportin or cytosolic karyopherin beta 2 genetic 1 1 1 Negative Genetic
BMS1 YPL217C GTPase required for ribosomal subunit synthesis and rRNA processing genetic 1 1 1 Negative Genetic
ARC35 YNR035C Subunit of the ARP2/3 complex genetic 1 1 1 Negative Genetic
CDC14 YFR028C Protein phosphatase required for mitotic exit physical 1 1 1 Affinity Capture-MS
CDC12 YHR107C Component of the septin ring that is required for cytokinesis genetic 1 1 1 Negative Genetic
ERG26 YGL001C C-3 sterol dehydrogenase genetic 1 1 1 Negative Genetic
CIP1 YPL014W Cyclin-dependent kinase inhibitor genetic 1 1 1 Positive Genetic
COX6 YHR051W Subunit VI of cytochrome c oxidase (Complex IV) genetic 1 1 1 Negative Genetic
CPR1 YDR155C Cytoplasmic peptidyl-prolyl cis-trans isomerase (cyclophilin) physical 1 1 1 PCA
CYR1 YJL005W Adenylate cyclase physical 1 1 1 Affinity Capture-MS
CIA2 YHR122W Component of cytosolic iron-sulfur protein assembly (CIA) machinery genetic 1 1 1 Negative Genetic
FKS1 YLR342W Catalytic subunit of 1,3-beta-D-glucan synthase genetic 1 1 1 Negative Genetic
HHF1 YBR009C Histone H4 physical 1 1 1 Affinity Capture-MS
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator physical 1 1 1 Affinity Capture-RNA
HHF2 YNL030W Histone H4 physical 1 1 1 Affinity Capture-MS
HTB2 YBL002W Histone H2B physical 1 1 1 Affinity Capture-MS
ISW1 YBR245C ATPase subunit of imitation-switch (ISWI) class chromatin remodelers physical 1 1 1 Affinity Capture-RNA
KRR1 YCL059C Nucleolar protein required for rRNA synthesis and ribosomal assembly physical 1 1 1 Affinity Capture-MS
DIB1 YPR082C 17-kDa component of the U4/U6aU5 tri-snRNP genetic 1 1 1 Negative Genetic
MCD1 YDL003W Essential alpha-kleisin subunit of the cohesin complex genetic 1 1 1 Negative Genetic
SRS2 YJL092W DNA helicase and DNA-dependent ATPase physical 1 1 1 Two-hybrid
SMC5 YOL034W Subunit of the SMC5-SMC6 complex genetic 1 1 1 Synthetic Rescue
SMC6 YLR383W Subunit of the SMC5-SMC6 complex physical 1 1 1 Affinity Capture-Western
SPO14 YKR031C Phospholipase D physical 1 1 1 Two-hybrid
MPT5 YGL178W mRNA-binding protein of the PUF family physical 1 1 1 Affinity Capture-RNA
PDC5 YLR134W Minor isoform of pyruvate decarboxylase physical 1 1 1 PCA
UTP7 YER082C Nucleolar protein physical 1 1 1 PCA
RPF2 YKR081C Essential protein involved in rRNA maturation and ribosomal assembly physical 1 1 1 PCA
RPL29 YFR032C-A Ribosomal 60S subunit protein L29 physical 1 1 1 PCA
TIF11 YMR260C Translation initiation factor eIF1A physical 1 1 1 PCA
NHP6B YBR089C-A High-mobility group (HMG) protein physical 1 1 1 PCA
TKL1 YPR074C Transketolase physical 1 1 1 PCA
PDA1 YER178W E1 alpha subunit of the pyruvate dehydrogenase (PDH) complex physical 1 1 1 PCA
UBA1 YKL210W Ubiquitin activating enzyme (E1) physical 1 1 1 PCA
SLT2 YHR030C Serine/threonine MAP kinase physical 1 1 1 PCA
SWI3 YJL176C Subunit of the SWI/SNF chromatin remodeling complex physical 1 1 1 Affinity Capture-MS
RTC1 YOL138C Subunit of SEACAT, a subcomplex of the SEA complex physical 1 1 1 Affinity Capture-MS
PIF1 YML061C DNA helicase, potent G-quadruplex DNA binder/unwinder physical 1 1 1 Affinity Capture-MS
MSH3 YCR092C Mismatch repair protein physical 1 1 1 Affinity Capture-MS
SGF73 YGL066W Subunit of DUBm module of SAGA and SLIK physical 1 1 1 Affinity Capture-MS
TOP1 YOL006C Topoisomerase I physical 1 1 1 Affinity Capture-MS
SGS1 YMR190C RecQ family nucleolar DNA helicase physical 1 1 1 Affinity Capture-MS
RFC1 YOR217W Subunit of heteropentameric Replication factor C (RF-C) physical 1 1 1 Affinity Capture-MS
SEF1 YBL066C Putative transcription factor physical 1 1 1 Affinity Capture-MS
MSH2 YOL090W Protein that binds to DNA mismatches physical 1 1 1 Affinity Capture-MS
YAT2 YER024W Carnitine acetyltransferase physical 1 1 1 Affinity Capture-MS
YAT1 YAR035W Outer mitochondrial carnitine acetyltransferase physical 1 1 1 Affinity Capture-MS
SFC1 YJR095W Mitochondrial succinate-fumarate transporter physical 1 1 1 Affinity Capture-MS
PDR12 YPL058C Plasma membrane ATP-binding cassette (ABC) transporter physical 1 1 1 Affinity Capture-MS
MPM1 YJL066C Mitochondrial intermembrane space protein of unknown function physical 1 1 1 Affinity Capture-MS
PCK1 YKR097W Phosphoenolpyruvate carboxykinase physical 1 1 1 Affinity Capture-MS
RGC1 YPR115W Putative regulator of the Fps1p glycerol channel physical 1 1 1 Affinity Capture-MS
SNF2 YOR290C Catalytic subunit of the SWI/SNF chromatin remodeling complex physical 1 1 1 Affinity Capture-MS
SSK1 YLR006C Cytoplasmic phosphorelay intermediate osmosensor and regulator physical 1 1 1 Affinity Capture-MS
POX1 YGL205W Fatty-acyl coenzyme A oxidase physical 1 1 1 Affinity Capture-MS
RIE1 YGR250C RNA binding protein and negative regulator of START physical 1 1 1 Affinity Capture-MS
TRI1 YMR233W Non-essential sumoylated protein of unknown function physical 1 1 1 Affinity Capture-MS
REH1 YLR387C Cytoplasmic 60S subunit biogenesis factor physical 1 1 1 Affinity Capture-MS
RSC2 YLR357W Component of the RSC chromatin remodeling complex physical 1 1 1 Affinity Capture-MS
TMA64 YDR117C Protein of unknown function that associates with ribosomes physical 1 1 1 Affinity Capture-MS
RSC3 YDR303C Component of the RSC chromatin remodeling complex physical 1 1 1 Affinity Capture-MS
POL2 YNL262W Catalytic subunit of DNA polymerase (II) epsilon physical 1 1 1 Affinity Capture-MS
VAC7 YNL054W Integral vacuolar membrane protein physical 1 1 1 Affinity Capture-MS
VAC7 YNL054W Integral vacuolar membrane protein genetic 1 1 1 Negative Genetic
YPT6 YLR262C Rab family GTPase genetic 1 1 1 Negative Genetic
TRS85 YDR108W Component of transport protein particle (TRAPP) complex III genetic 1 1 1 Negative Genetic
SEC28 YIL076W Epsilon-COP subunit of the coatomer genetic 1 1 1 Negative Genetic
TEX1 YNL253W Protein involved in mRNA export genetic 1 1 1 Negative Genetic
TIM18 YOR297C Component of the mitochondrial TIM22 complex genetic 1 1 1 Negative Genetic
RAD24 YER173W Checkpoint protein genetic 1 1 1 Synthetic Rescue
SHP1 YBL058W UBX domain-containing substrate adaptor for Cdc48p genetic 1 1 1 Negative Genetic
MRC1 YCL061C S-phase checkpoint protein required for DNA replication genetic 1 1 1 Negative Genetic
PAA1 YDR071C Polyamine acetyltransferase genetic 1 1 1 Negative Genetic
RIM9 YMR063W Plasma membrane protein of unknown function genetic 1 1 1 Negative Genetic
SHU1 YHL006C Component of Shu complex (aka PCSS complex) genetic 1 1 1 Synthetic Growth Defect
STN1 YDR082W Telomere end-binding and capping protein genetic 1 1 1 Dosage Lethality
YKU70 YMR284W Subunit of the telomeric Ku complex (Yku70p-Yku80p) genetic 1 1 1 Dosage Lethality
YEN1 YER041W Holliday junction resolvase genetic 1 1 1 Synthetic Growth Defect
ULS1 YOR191W Swi2/Snf2-related translocase, SUMO-Targeted Ubiquitin Ligase (STUbL) genetic 1 1 1 Synthetic Growth Defect
RAD30 YDR419W DNA polymerase eta genetic 1 1 1 Phenotypic Suppression
RAD27 YKL113C 5' to 3' exonuclease, 5' flap endonuclease genetic 1 1 1 Phenotypic Suppression
NSE4 YDL105W Component of the SMC5-SMC6 complex genetic 1 1 1 Positive Genetic
TIM22 YDL217C Essential core component of mitochondrial TIM22 complex genetic 1 1 1 Positive Genetic
SEC26 YDR238C Essential beta-coat protein of the COPI coatomer genetic 1 1 1 Positive Genetic
TAF13 YML098W TFIID subunit (19 kDa) genetic 1 1 1 Positive Genetic
PFY1 YOR122C Profilin genetic 1 1 1 Positive Genetic
TPS1 YBR126C Synthase subunit of trehalose-6-P synthase/phosphatase complex genetic 1 1 1 Positive Genetic
STP1 YDR463W Transcription factor genetic 1 1 1 Positive Genetic
PRM4 YPL156C Pheromone-regulated protein proposed to be involved in mating genetic 1 1 1 Positive Genetic
ROM2 YLR371W Guanine nucleotide exchange factor (GEF) for Rho1p and Rho2p genetic 1 1 1 Positive Genetic
RFT1 YBL020W Membrane protein required for translocation of Man5GlcNac2-PP-Dol genetic 1 1 1 Negative Genetic
RIB5 YBR256C Riboflavin synthase genetic 1 1 1 Negative Genetic
MSS4 YDR208W Phosphatidylinositol-4-phosphate 5-kinase genetic 1 1 1 Negative Genetic
TFB1 YDR311W Subunit of TFIIH and nucleotide excision repair factor 3 complexes genetic 1 1 1 Negative Genetic
SNM1 YDR478W Ribonuclease MRP complex subunit genetic 1 1 1 Negative Genetic
WBP1 YEL002C Beta subunit of the oligosaccharyl transferase glycoprotein complex genetic 1 1 1 Negative Genetic
PMI40 YER003C Mannose-6-phosphate isomerase genetic 1 1 1 Negative Genetic
STT3 YGL022W Catalytic subunit of the oligosaccharyltransferase complex of the ER l genetic 1 1 1 Negative Genetic
SRM1 YGL097W Nucleotide exchange factor for Gsp1p genetic 1 1 1 Negative Genetic
RPS2 YGL123W Protein component of the small (40S) subunit genetic 1 1 1 Negative Genetic
UTP8 YGR128C Nucleolar protein required for export of tRNAs from the nucleus genetic 1 1 1 Negative Genetic
RPC25 YKL144C RNA polymerase III subunit C25 genetic 1 1 1 Negative Genetic
SRP102 YKL154W Signal recognition particle (SRP) receptor beta subunit genetic 1 1 1 Negative Genetic
ORC3 YLL004W Subunit of the origin recognition complex (ORC) genetic 1 1 1 Negative Genetic
RLP24 YLR009W Essential protein required for ribosomal large subunit biogenesis genetic 1 1 1 Negative Genetic
RPL10 YLR075W Ribosomal 60S subunit protein L10 genetic 1 1 1 Negative Genetic
SMD2 YLR275W Core Sm protein Sm D2 genetic 1 1 1 Negative Genetic
RSC9 YML127W Component of the RSC chromatin remodeling complex genetic 1 1 1 Negative Genetic
POL1 YNL102W Catalytic subunit of the DNA polymerase I alpha-primase complex genetic 1 1 1 Negative Genetic
SRV2 YNL138W CAP (cyclase-associated protein) genetic 1 1 1 Negative Genetic
PBR1 YNL181W Putative oxidoreductase genetic 1 1 1 Negative Genetic
RAP1 YNL216W Essential DNA-binding transcription regulator that binds many loci genetic 1 1 1 Negative Genetic
RPB11 YOL005C RNA polymerase II subunit B12.5 genetic 1 1 1 Negative Genetic
RPA190 YOR341W RNA polymerase I largest subunit A190 genetic 1 1 1 Negative Genetic
ORC4 YPR162C Subunit of the origin recognition complex (ORC) genetic 1 1 1 Negative Genetic
POL3 YDL102W Catalytic subunit of DNA polymerase delta genetic 1 1 1 Negative Genetic
RSP5 YER125W NEDD4 family E3 ubiquitin ligase genetic 1 1 1 Negative Genetic
RPN11 YFR004W Metalloprotease subunit of 19S regulatory particle genetic 1 1 1 Negative Genetic
SEC22 YLR268W R-SNARE protein genetic 1 1 1 Negative Genetic
TAD3 YLR316C Subunit of tRNA-specific adenosine-34 deaminase genetic 1 1 1 Negative Genetic
SEC62 YPL094C Essential subunit of Sec63 complex genetic 1 1 1 Negative Genetic
TBF1 YPL128C Telobox-containing general regulatory factor genetic 1 1 1 Negative Genetic
YPC1 YBR183W Alkaline ceramidase genetic 1 1 1 Negative Genetic
RRI1 YDL216C Catalytic subunit of the COP9 signalosome (CSN) complex genetic 1 1 1 Negative Genetic
RPA14 YDR156W RNA polymerase I subunit A14 genetic 1 1 1 Negative Genetic
VMA8 YEL051W Subunit D of the V1 peripheral membrane domain of V-ATPase genetic 1 1 1 Negative Genetic
SER3 YER081W 3-phosphoglycerate dehydrogenase and alpha-ketoglutarate reductase genetic 1 1 1 Negative Genetic
UBP9 YER098W Ubiquitin-specific protease that cleaves ubiquitin-protein fusions genetic 1 1 1 Negative Genetic
PRS2 YER099C 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase genetic 1 1 1 Negative Genetic
PMR1 YGL167C High affinity Ca2+/Mn2+ P-type ATPase genetic 1 1 1 Negative Genetic
YGL188C-A YGL188C-A Putative protein of unknown function genetic 1 1 1 Negative Genetic
YGR122W YGR122W Protein that may be involved in pH regulation genetic 1 1 1 Negative Genetic
YHR050W-A YHR050W-A Protein of unknown function genetic 1 1 1 Negative Genetic
MRPL6 YHR147C Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Negative Genetic
TAH1 YCR060W Component of conserved R2TP complex (Rvb1-Rvb2-Tah1-Pih1) genetic 1 1 1 Negative Genetic
SOL2 YCR073W-A Protein with a possible role in tRNA export genetic 1 1 1 Negative Genetic
PBP4 YDL053C Pbp1p binding protein genetic 1 1 1 Negative Genetic
RAD4 YER162C Damaged-DNA binding subunit of Nuclear Excision Repair Factor 2 genetic 1 1 1 Negative Genetic
WWM1 YFL010C WW domain containing protein of unknown function genetic 1 1 1 Negative Genetic
PIB2 YGL023C Phosphatidylinositol 3-phosphate binding protein genetic 1 1 1 Negative Genetic
MRM2 YGL136C Mitochondrial 2' O-ribose methyltransferase genetic 1 1 1 Negative Genetic
TNA1 YGR260W High affinity nicotinic acid plasma membrane permease genetic 1 1 1 Negative Genetic
PUT2 YHR037W Delta-1-pyrroline-5-carboxylate dehydrogenase genetic 1 1 1 Negative Genetic
YCK1 YHR135C Palmitoylated plasma membrane-bound casein kinase I (CK1) isoform genetic 1 1 1 Negative Genetic
NIT1 YIL164C Nitrilase genetic 1 1 1 Negative Genetic
YKE2 YLR200W Subunit of the heterohexameric Gim/prefoldin protein complex genetic 1 1 1 Negative Genetic
YLR297W YLR297W Protein of unknown function genetic 1 1 1 Negative Genetic
YPT7 YML001W Rab family GTPase genetic 1 1 1 Negative Genetic
PEX9 YMR018W Peroxisomal membrane signal receptor for peroxisomal matrix proteins genetic 1 1 1 Negative Genetic
MSB4 YOL112W GTPase-activating protein of the Ras superfamily genetic 1 1 1 Negative Genetic
SFL1 YOR140W Transcriptional repressor and activator genetic 1 1 1 Negative Genetic
RPS10A YOR293W Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
SPS4 YOR313C Protein whose expression is induced during sporulation genetic 1 1 1 Negative Genetic
TRM44 YPL030W tRNA(Ser) Um(44) 2'-O-methyltransferase genetic 1 1 1 Negative Genetic
THP3 YPR045C Protein that may have a role in transcription elongation genetic 1 1 1 Negative Genetic
SPC1 YJR010C-A Subunit of the signal peptidase complex (SPC) genetic 1 1 1 Negative Genetic
VAN1 YML115C Component of the mannan polymerase I genetic 1 1 1 Negative Genetic
SSN8 YNL025C Cyclin-like component of RNA polymerase II holoenzyme genetic 1 1 1 Negative Genetic
PSY2 YNL201C Subunit of protein phosphatase PP4 complex genetic 1 1 1 Negative Genetic
RIM21 YNL294C pH sensor molecule, component of the RIM101 pathway genetic 1 1 1 Negative Genetic
VPS27 YNR006W Endosomal protein that forms a complex with Hse1p genetic 1 1 1 Negative Genetic
PEP4 YPL154C Vacuolar aspartyl protease (proteinase A) genetic 1 1 1 Negative Genetic
SUT2 YPR009W Zn2Cys6 family transcription factor genetic 1 1 1 Negative Genetic
YKU80 YMR106C Subunit of telomeric Ku complex (Yku70p-Yku80p) genetic 1 1 1 Phenotypic Enhancement
RNH1 YMR234W Ribonuclease H1 genetic 1 1 1 Synthetic Lethality
NSE1 YLR007W Component of the SMC5-SMC6 complex genetic 1 1 1 Synthetic Rescue
NSE5 YML023C Component of the SMC5-SMC6 complex genetic 1 1 1 Phenotypic Suppression
RNH202 YDR279W Ribonuclease H2 subunit genetic 1 1 1 Negative Genetic
SHU2 YDR078C Component of Shu complex (aka PCSS complex) genetic 1 1 1 Negative Genetic
RTT107 YHR154W BRCA1 C-terminal domain protein needed for recovery from DNA damage genetic 1 1 1 Negative Genetic
RTT101 YJL047C Cullin subunit of a Roc1p-dependent E3 ubiquitin ligase complex genetic 1 1 1 Negative Genetic
RAD59 YDL059C Protein involved DNA double-strand break repair genetic 1 1 1 Negative Genetic
RAD61 YDR014W Subunit of a complex that inhibits sister chromatid cohesion genetic 1 1 1 Negative Genetic
RAD9 YDR217C DNA damage-dependent checkpoint protein genetic 1 1 1 Phenotypic Suppression
CMR1 YDL156W Nuclear protein with role in transcription, protein quality control physical 1 1 1 Affinity Capture-MS
CMR1 YDL156W Nuclear protein with role in transcription, protein quality control genetic 1 1 1 Positive Genetic
CMD1 YBR109C Calmodulin genetic 1 1 1 Negative Genetic
INO80 YGL150C Nucleosome spacing factor physical 1 1 1 Affinity Capture-MS
IES1 YFL013C Subunit of the INO80 chromatin remodeling complex genetic 1 1 1 Negative Genetic
INO4 YOL108C Transcription factor involved in phospholipid synthesis genetic 1 1 1 Negative Genetic
GPT2 YKR067W Glycerol-3-phosphate/dihydroxyacetone phosphate sn-1 acyltransferase genetic 1 1 1 Negative Genetic
CSN9 YDR179C Subunit of the Cop9 signalosome genetic 1 1 1 Negative Genetic
ABF2 YMR072W Mitochondrial DNA-binding protein genetic 1 1 1 Synthetic Growth Defect
CDC25 YLR310C Membrane bound guanine nucleotide exchange factor genetic 1 1 1 Negative Genetic
GCN5 YGR252W Catalytic subunit of ADA and SAGA histone acetyltransferase complexes genetic 1 1 1 Positive Genetic
FDH1 YOR388C NAD(+)-dependent formate dehydrogenase physical 1 1 1 Affinity Capture-MS
DOT6 YER088C Protein involved in rRNA and ribosome biogenesis physical 1 1 1 Affinity Capture-MS
FPR3 YML074C Nucleolar peptidyl-prolyl cis-trans isomerase (PPIase) genetic 1 1 1 Negative Genetic
AIM41 YOR215C Protein of unknown function physical 1 1 1 Affinity Capture-MS
HTB1 YDR224C Histone H2B physical 1 1 1 Affinity Capture-MS
CDC53 YDL132W Cullin genetic 1 1 1 Negative Genetic
FDO1 YMR144W Protein involved in directionality of mating type switching genetic 1 1 1 Phenotypic Enhancement
KOG1 YHR186C Subunit of TORC1 physical 1 1 1 Affinity Capture-MS
CDC9 YDL164C DNA ligase I found in nucleus and mitochondria genetic 1 1 1 Phenotypic Suppression
COF1 YLL050C Cofilin, involved in pH-dependent actin filament depolarization physical 1 1 1 PCA
DDC1 YPL194W DNA damage checkpoint protein genetic 1 1 1 Negative Genetic
CDC20 YGL116W Activator of anaphase-promoting complex/cyclosome (APC/C) genetic 1 1 1 Negative Genetic
ELM1 YKL048C Serine/threonine protein kinase genetic 1 1 1 Negative Genetic
FHL1 YPR104C Regulator of ribosomal protein (RP) transcription physical 1 1 1 Affinity Capture-MS
DSK2 YMR276W Nuclear-enriched ubiquitin-like polyubiquitin-binding protein genetic 1 1 1 Negative Genetic
CDC15 YAR019C Hippo-like kinase of the Mitotic Exit Network genetic 1 1 1 Positive Genetic
HOG1 YLR113W Mitogen-activated protein kinase involved in osmoregulation genetic 1 1 1 Negative Genetic
MAG1 YER142C 3-methyl-adenine DNA glycosylase physical 1 1 1 Affinity Capture-MS
HHT1 YBR010W Histone H3 genetic 1 1 1 Negative Genetic
CCE1 YKL011C Mitochondrial cruciform cutting endonuclease genetic 1 1 1 Phenotypic Enhancement
KIN28 YDL108W Ser/Thr protein kinase and subunit of TFIIK, a TFIIH subassembly genetic 1 1 1 Negative Genetic
ELG1 YOR144C Subunit of an alternative replication factor C complex physical 1 1 1 Two-hybrid
FKH2 YNL068C Forkhead family transcription factor physical 1 1 1 Affinity Capture-MS
FCF1 YDR339C PINc domain endonuclease physical 1 1 1 Affinity Capture-MS
GDH2 YDL215C NAD(+)-dependent glutamate dehydrogenase physical 1 1 1 Affinity Capture-MS
DHR2 YKL078W Predominantly nucleolar DEAH-box ATP-dependent RNA helicase genetic 1 1 1 Negative Genetic
ADH5 YBR145W Alcohol dehydrogenase isoenzyme V genetic 1 1 1 Negative Genetic
CSM2 YIL132C Subunit of the Shu complex (aka PCSS complex) genetic 1 1 1 Synthetic Growth Defect
MCM10 YIL150C Essential chromatin-associated protein physical 1 1 1 Affinity Capture-MS
CWC24 YLR323C General splicing factor genetic 1 1 1 Negative Genetic
HSP10 YOR020C Mitochondrial matrix co-chaperonin genetic 1 1 1 Positive Genetic
CSM3 YMR048W Replication fork associated factor genetic 1 1 1 Positive Genetic
AIM3 YBR108W Protein that inhibits barbed-end actin filament elongation genetic 1 1 1 Negative Genetic
CHA4 YLR098C DNA binding transcriptional activator physical 1 1 1 Affinity Capture-MS
COG4 YPR105C Essential component of the conserved oligomeric Golgi complex genetic 1 1 1 Positive Genetic
CHL1 YPL008W Probable DNA helicase genetic 1 1 1 Synthetic Growth Defect
CDC21 YOR074C Thymidylate synthase genetic 1 1 1 Negative Genetic
IES3 YLR052W Subunit of the INO80 chromatin remodeling complex physical 1 1 1 Affinity Capture-MS
CSE4 YKL049C Centromeric histone H3-like protein genetic 1 1 1 Negative Genetic
APN1 YKL114C Major apurinic/apyrimidinic endonuclease physical 1 1 1 Affinity Capture-MS
BFR1 YOR198C Component of mRNP complexes associated with polyribosomes physical 1 1 1 PCA
HXK2 YGL253W Hexokinase isoenzyme 2 physical 1 1 1 PCA
MGM1 YOR211C Mitochondrial GTPase, present in complex with Ugo1p and Fzo1p genetic 1 1 1 Positive Genetic
CCZ1 YBR131W Subunit of a heterodimeric guanine nucleotide exchange factor (GEF) genetic 1 1 1 Negative Genetic
CIN1 YOR349W Tubulin folding factor D involved in beta-tubulin (Tub2p) folding genetic 1 1 1 Negative Genetic
GAL4 YPL248C DNA-binding transcription factor required for activating GAL genes genetic 1 1 1 Negative Genetic
MON1 YGL124C Subunit of a heterodimeric guanine nucleotide exchange factor (GEF) genetic 1 1 1 Negative Genetic
ARL3 YPL051W ARF-like small GTPase of the RAS superfamily genetic 1 1 1 Negative Genetic
MON2 YNL297C Protein with a role in endocytosis and vacuole integrity genetic 1 1 1 Negative Genetic
COX19 YLL018C-A Protein required for cytochrome c oxidase assembly genetic 1 1 1 Negative Genetic
CAT2 YML042W Carnitine acetyl-CoA transferase physical 1 1 1 Affinity Capture-MS
ATF1 YOR377W Alcohol acetyltransferase physical 1 1 1 Affinity Capture-MS
ATF1 YOR377W Alcohol acetyltransferase genetic 1 1 1 Negative Genetic
BAP3 YDR046C Amino acid permease genetic 1 1 1 Negative Genetic
MCH1 YDL054C Protein with similarity to mammalian monocarboxylate permeases genetic 1 1 1 Negative Genetic
HRQ1 YDR291W 3'-5' DNA helicase of the conserved RecQ family genetic 1 1 1 Negative Genetic
AIM22 YJL046W Lipoate-protein ligase genetic 1 1 1 Negative Genetic
HTD2 YHR067W Mitochondrial 3-hydroxyacyl-thioester dehydratase genetic 1 1 1 Negative Genetic
CUL3 YGR003W Ubiquitin-protein ligase genetic 1 1 1 Negative Genetic
ACB1 YGR037C Acyl-CoA-binding protein genetic 1 1 1 Negative Genetic
MEF2 YJL102W Mitochondrial elongation factor involved in translational elongation genetic 1 1 1 Negative Genetic
LAG2 YOL025W Protein that negatively regulates the SCF E3-ubiquitin ligase genetic 1 1 1 Negative Genetic
IPT1 YDR072C Inositolphosphotransferase genetic 1 1 1 Negative Genetic
HUR1 YGL168W Protein with a role in DNA repair genetic 1 1 1 Negative Genetic
EST2 YLR318W Reverse transcriptase subunit of the telomerase holoenzyme genetic 1 1 1 Phenotypic Suppression
ERG4 YGL012W C-24(28) sterol reductase genetic 1 1 1 Negative Genetic
ILM1 YJR118C Protein of unknown function genetic 1 1 1 Negative Genetic
BIG1 YHR101C Integral membrane protein of the endoplasmic reticulum genetic 1 1 1 Negative Genetic
EDC1 YGL222C RNA-binding protein that activates mRNA decapping directly genetic 1 1 1 Negative Genetic
COX12 YLR038C Subunit VIb of cytochrome c oxidase genetic 1 1 1 Negative Genetic
MAM3 YOL060C Protein involved in magnesium homeostasis genetic 1 1 1 Negative Genetic
FSH3 YOR280C Putative serine hydrolase genetic 1 1 1 Negative Genetic
ECM18 YDR125C Protein of unknown function physical 1 1 1 PCA
GMC1 YDR506C Protein involved in meiotic progression genetic 1 1 1 Negative Genetic
MMM1 YLL006W ER integral membrane protein, ERMES complex subunit genetic 1 1 1 Negative Genetic
DPI35 YMR130W Putative mitochondrial protein of unknown function genetic 1 1 1 Negative Genetic
LRE1 YCL051W Protein involved in control of cell wall structure and stress response physical 1 1 1 Affinity Capture-MS
GPI11 YDR302W ER membrane protein involved in a late step of GPI anchor assembly genetic 1 1 1 Negative Genetic