Standard name Systematic name Name description Description
SMK1 YPR054W Middle sporulation-specific mitogen-activated protein kinase (MAPK) Middle sporulation-specific mitogen-activated protein kinase (MAPK); required for prospore membrane development and the production of outer spore wall layers; negatively regulates activity of the glucan synthase subunit Gsc2p; activated by Cak1p-mediated phosphorylation of threonine (T207) in the activation loop during meiosis I followed by Ssp2p-promoted autophosphorylation of tyrosine (T209) during meiosis II
Visualize the interactome of SMK1
Links to external databases:
  SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)

CYCLoPs localization & abundance

WT1 WT2 WT3
no data no data no data

GFP localization & abundance

GFP localization GFP abundance
no data no data

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
SMK1 0 3 0 0 0

Enzyme information

Catalyzed reactions in Yeast8

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
SSP2 YOR242C Sporulation specific protein that localizes to the spore wall physical 10 3 5 Reconstituted Complex, Affinity Capture-Western, Reconstituted Complex, Affinity Capture-Western, Reconstituted Complex, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex, Reconstituted Complex
ISC10 YER180C Meiosis-specific MAPK inhibitor physical 3 2 1 Affinity Capture-Western, Reconstituted Complex, Reconstituted Complex
CAK1 YFL029C Cyclin-dependent kinase-activating kinase physical 2 2 2 Two-hybrid, Biochemical Activity
CAK1 YFL029C Cyclin-dependent kinase-activating kinase genetic 2 2 2 Dosage Rescue, Positive Genetic
AMN1 YBR158W Modulator of cell separation and mitotic exit genetic 2 1 2 Negative Genetic, Negative Genetic
DIA2 YOR080W Origin-binding F-box protein genetic 2 1 2 Negative Genetic, Negative Genetic
RPL19B YBL027W Ribosomal 60S subunit protein L19B genetic 2 1 2 Negative Genetic, Negative Genetic
RML2 YEL050C Mitochondrial ribosomal protein of the large subunit (L2) genetic 2 1 2 Negative Genetic, Negative Genetic
SLT2 YHR030C Serine/threonine MAP kinase physical 2 1 1 Affinity Capture-MS, Affinity Capture-MS
FKH1 YIL131C Forkhead family transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
SUM1 YDR310C Transcriptional repressor that regulates middle-sporulation genes regulation 1 1 1 DNA to cDNA expression microarray evidence
GCN5 YGR252W Catalytic subunit of ADA and SAGA histone acetyltransferase complexes regulation 1 1 1 chromatin immunoprecipitation-chip evidence
FKH2 YNL068C Forkhead family transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
MED2 YDL005C Subunit of the RNA polymerase II mediator complex regulation 1 1 1 chromatin immunoprecipitation-chip evidence
RGR1 YLR071C Subunit of the RNA polymerase II mediator complex regulation 1 1 1 chromatin immunoprecipitation-chip evidence
REB1 YBR049C RNA polymerase I enhancer binding protein regulation 1 1 1 chromatin immunoprecipitation-chip evidence
RPD3 YNL330C Histone deacetylase, component of both the Rpd3S and Rpd3L complexes regulation 1 1 1 chromatin immunoprecipitation-chip evidence
PHO2 YDL106C Homeobox transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
NDT80 YHR124W Meiosis-specific transcription factor regulation 1 1 1 northern blot evidence
AMA1 YGR225W Activator of meiotic anaphase promoting complex (APC/C) regulation 1 1 1 qualitative western immunoblotting evidence
CAK1 YFL029C Cyclin-dependent kinase-activating kinase regulation 1 1 1 protein kinase assay evidence
SMK1 YPR054W Middle sporulation-specific mitogen-activated protein kinase (MAPK) regulation 1 1 1 protein kinase assay evidence
COR1 YBL045C Core subunit of the ubiquinol-cytochrome c reductase complex physical 1 1 1 Affinity Capture-MS
SAP185 YJL098W Protein that forms a complex with the Sit4p protein phosphatase physical 1 1 1 Affinity Capture-MS
RSC2 YLR357W Component of the RSC chromatin remodeling complex genetic 1 1 1 Phenotypic Suppression
PRE3 YJL001W Beta 1 subunit of the 20S proteasome physical 1 1 1 Affinity Capture-MS
CCL1 YPR025C Cyclin partner of the cyclin-dependent kinase (CDK) Kin28p genetic 1 1 1 Negative Genetic
CYR1 YJL005W Adenylate cyclase genetic 1 1 1 Synthetic Rescue
MRPL10 YNL284C Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Negative Genetic
PPH3 YDR075W Catalytic subunit of protein phosphatase PP4 complex genetic 1 1 1 Positive Genetic
HSP82 YPL240C Hsp90 chaperone physical 1 1 1 Two-hybrid
MDS3 YGL197W Putative component of the TOR regulatory pathway genetic 1 1 1 Synthetic Rescue
PTC4 YBR125C Cytoplasmic type 2C protein phosphatase (PP2C) genetic 1 1 1 Negative Genetic
RAD52 YML032C Protein involved in homologous recombination genetic 1 1 1 Positive Genetic
PGD1 YGL025C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Dosage Growth Defect
RPB10 YOR210W RNA polymerase subunit ABC10-beta genetic 1 1 1 Negative Genetic
CDC25 YLR310C Membrane bound guanine nucleotide exchange factor genetic 1 1 1 Synthetic Rescue
LTE1 YAL024C Protein similar to GDP/GTP exchange factors genetic 1 1 1 Synthetic Growth Defect
ADO1 YJR105W Adenosine kinase genetic 1 1 1 Positive Genetic
RNR2 YJL026W Ribonucleotide-diphosphate reductase (RNR), small subunit physical 1 1 1 Affinity Capture-MS
QCR2 YPR191W Subunit 2 of ubiquinol cytochrome-c reductase (Complex III) physical 1 1 1 Affinity Capture-MS
CLN1 YMR199W G1 cyclin involved in regulation of the cell cycle genetic 1 1 1 Negative Genetic
MAE1 YKL029C Mitochondrial malic enzyme physical 1 1 1 Affinity Capture-MS
GAL7 YBR018C Galactose-1-phosphate uridyl transferase physical 1 1 1 Affinity Capture-MS
BUD7 YOR299W Member of the ChAPs family (Chs5p-Arf1p-binding proteins) physical 1 1 1 Affinity Capture-MS
BUD7 YOR299W Member of the ChAPs family (Chs5p-Arf1p-binding proteins) genetic 1 1 1 Negative Genetic
STI1 YOR027W Evolutionarily-conserved Hsp90 cochaperone physical 1 1 1 Affinity Capture-MS
YAP7 YOL028C Transcriptional repressor of nitric oxide oxidase physical 1 1 1 Affinity Capture-MS
WWM1 YFL010C WW domain containing protein of unknown function physical 1 1 1 Two-hybrid
TRM112 YNR046W Protein involved in methylation of tRNA, rRNA, and translation factors physical 1 1 1 Reconstituted Complex
UBA1 YKL210W Ubiquitin activating enzyme (E1) physical 1 1 1 Reconstituted Complex
SMK1 YPR054W Middle sporulation-specific mitogen-activated protein kinase (MAPK) physical 1 1 1 Biochemical Activity
YCH1 YGR203W Phosphatase with sequence similarity to Mih1p genetic 1 1 1 Positive Genetic
STU1 YBL034C Microtubule plus-end-tracking non-motor protein genetic 1 1 1 Negative Genetic
SNU114 YKL173W GTPase component of U5 snRNP involved in mRNA splicing via spliceosome genetic 1 1 1 Negative Genetic
TUB4 YLR212C Gamma-tubulin genetic 1 1 1 Synthetic Growth Defect
FKH2 YNL068C Forkhead family transcription factor genetic 1 1 1 Dosage Growth Defect
DBF2 YGR092W Ser/Thr kinase involved in transcription and stress response genetic 1 1 1 Negative Genetic
MSG5 YNL053W Dual-specificity protein phosphatase genetic 1 1 1 Positive Genetic
PMD1 YER132C Protein with an N-terminal kelch-like domain genetic 1 1 1 Synthetic Rescue
CTK3 YML112W Gamma subunit of C-terminal domain kinase I genetic 1 1 1 Positive Genetic
IME2 YJL106W Serine/threonine protein kinase involved in activation of meiosis genetic 1 1 1 Phenotypic Enhancement
RPS24A YER074W Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
RSC1 YGR056W Component of the RSC chromatin remodeling complex genetic 1 1 1 Phenotypic Suppression
AMA1 YGR225W Activator of meiotic anaphase promoting complex (APC/C) physical 1 1 1 Affinity Capture-Western
HSV2 YGR223C Phosphatidylinositol 3,5-bisphosphate-binding protein physical 1 1 1 Reconstituted Complex
BET4 YJL031C Alpha subunit of Type II geranylgeranyltransferase genetic 1 1 1 Negative Genetic
RPL28 YGL103W Ribosomal 60S subunit protein L28 genetic 1 1 1 Negative Genetic
GAB1 YLR459W Subunit of the glycosylphosphatidylinositol transamidase complex genetic 1 1 1 Negative Genetic
NFS1 YCL017C Cysteine desulfurase involved in iron-sulfur cluster biogenesis genetic 1 1 1 Negative Genetic
KCS1 YDR017C Inositol hexakisphosphate and inositol heptakisphosphate kinase genetic 1 1 1 Positive Genetic
MTG1 YMR097C Putative GTPase peripheral to the mitochondrial inner membrane genetic 1 1 1 Negative Genetic
BNA1 YJR025C 3-hydroxyanthranilic acid dioxygenase physical 1 1 1 Reconstituted Complex
GRE3 YHR104W Aldose reductase genetic 1 1 1 Positive Genetic
NDE2 YDL085W Mitochondrial external NADH dehydrogenase physical 1 1 1 Affinity Capture-MS
GSC2 YGR032W Catalytic subunit of 1,3-beta-glucan synthase physical 1 1 1 Affinity Capture-Western
RSM26 YJR101W Mitochondrial ribosomal protein of the small subunit genetic 1 1 1 Negative Genetic
PAU21 YOR394W Protein of unknown function genetic 1 1 1 Dosage Growth Defect