Standard name Systematic name Name description Description
MSG5 YNL053W Dual-specificity protein phosphatase Dual-specificity protein phosphatase; maintains low levels of both basal and induced cell integrity pathway signaling by dephosphorylation of the Slt2p MAPK; reciprocally regulated by Slt2p through phosphorylation; minor role with Ptp2p in the adaptive response to pheromone through the dephosphorylation of the Fus3p MAPK with major contribution by Ptp3p; inhibits the nuclear accumulation of Fus3p; two isoforms exist as the result of alternative translation initiation starts
Visualize the interactome of MSG5
Links to external databases:
SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)
G1(P) 292

CYCLoPs localization & abundance

WT1 WT2 WT3
Cytoplasm 0.955 0.984 0.948
Mito 0.056 NaN NaN

GFP localization & abundance

GFP localization GFP abundance
cytoplasm 538

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
MSG5 4 0 0 10 0

Enzyme information

Catalyzed reactions in Yeast8

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
SLT2 YHR030C Serine/threonine MAP kinase physical 14 6 8 Affinity Capture-MS, Two-hybrid, Affinity Capture-Western, Biochemical Activity, Biochemical Activity, Biochemical Activity, Biochemical Activity, Biochemical Activity, Reconstituted Complex, PCA, Two-hybrid, Reconstituted Complex, Affinity Capture-Western, Biochemical Activity
FUS3 YBL016W Mitogen-activated serine/threonine protein kinase involved in mating physical 6 5 6 Affinity Capture-MS, Co-localization, Biochemical Activity, Reconstituted Complex, Reconstituted Complex, Two-hybrid
KSS1 YGR040W Mitogen-activated protein kinase (MAPK) physical 4 3 4 Reconstituted Complex, Reconstituted Complex, PCA, Two-hybrid
NBP2 YDR162C Protein involved in the HOG (high osmolarity glycerol) pathway genetic 4 1 4 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
KDX1 YKL161C Protein kinase physical 4 4 3 Affinity Capture-MS, PCA, Two-hybrid, Reconstituted Complex
SLT2 YHR030C Serine/threonine MAP kinase genetic 3 3 3 Dosage Rescue, Positive Genetic, Phenotypic Suppression
PTC1 YDL006W Type 2C protein phosphatase (PP2C) genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
PTP2 YOR208W Phosphotyrosine-specific phosphatase genetic 3 2 2 Synthetic Growth Defect, Phenotypic Enhancement, Phenotypic Enhancement
CEG1 YGL130W Guanylyltransferase involved in mRNA 5' capping genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
FKH1 YIL131C Forkhead family transcription factor regulation 2 2 2 chromatin immunoprecipitation-chip evidence, chromatin immunoprecipitation- exonuclease evidence
BCK1 YJL095W MAPKKK acting in the protein kinase C signaling pathway genetic 2 2 2 Positive Genetic, Dosage Rescue
PTC2 YER089C Type 2C protein phosphatase (PP2C) genetic 2 2 2 Phenotypic Enhancement, Negative Genetic
STE50 YCL032W Adaptor protein for various signaling pathways genetic 2 2 2 Phenotypic Enhancement, Positive Genetic
APM3 YBR288C Mu3-like subunit of the clathrin associated protein complex (AP-3) genetic 2 1 2 Negative Genetic, Negative Genetic
CIK1 YMR198W Kinesin-associated protein genetic 2 1 2 Negative Genetic, Negative Genetic
UBP3 YER151C Ubiquitin-specific protease that cleaves Ub-protein fusions genetic 2 1 2 Negative Genetic, Negative Genetic
SSD1 YDR293C Translational repressor genetic 2 1 2 Positive Genetic, Positive Genetic
PSE1 YMR308C Karyopherin/importin that interacts with the nuclear pore complex genetic 2 1 2 Negative Genetic, Negative Genetic
PTP3 YER075C Phosphotyrosine-specific protein phosphatase genetic 2 1 2 Phenotypic Enhancement, Phenotypic Enhancement
BST1 YFL025C GPI inositol deacylase of the endoplasmic reticulum (ER) genetic 2 1 2 Negative Genetic, Negative Genetic
MOT3 YMR070W Transcriptional repressor, activator genetic 2 1 2 Negative Genetic, Negative Genetic
POG1 YIL122W DNA-binding transcriptional activator genetic 2 2 1 Synthetic Rescue, Phenotypic Enhancement
MED7 YOL135C Subunit of the RNA polymerase II mediator complex genetic 2 1 1 Negative Genetic, Negative Genetic
CDC28 YBR160W Cyclin-dependent kinase (CDK) catalytic subunit genetic 2 1 1 Negative Genetic, Negative Genetic
PKC1 YBL105C Protein serine/threonine kinase genetic 2 1 1 Positive Genetic, Positive Genetic
SLU7 YDR088C RNA splicing factor genetic 2 1 1 Negative Genetic, Negative Genetic
SGV1 YPR161C Cyclin (Bur2p)-dependent protein kinase genetic 2 1 1 Negative Genetic, Negative Genetic
SAC7 YDR389W GTPase activating protein (GAP) for Rho1p genetic 2 1 1 Negative Genetic, Negative Genetic
VPS24 YKL041W One of four subunits of the ESCRT-III complex genetic 2 1 1 Negative Genetic, Negative Genetic
SUB1 YMR039C Transcriptional regulator genetic 2 1 1 Negative Genetic, Negative Genetic
CET1 YPL228W RNA 5'-triphosphatase involved in mRNA 5' capping genetic 2 1 1 Negative Genetic, Negative Genetic
SFP1 YLR403W Regulates transcription of ribosomal protein and biogenesis genes regulation 1 1 1 DNA to cDNA expression microarray evidence
STE12 YHR084W Transcription factor that is activated by a MAPK signaling cascade regulation 1 1 1 chromatin immunoprecipitation-chip evidence
TEC1 YBR083W Transcription factor targeting filamentation genes and Ty1 expression regulation 1 1 1 chromatin immunoprecipitation-chip evidence
FKH2 YNL068C Forkhead family transcription factor regulation 1 1 1 ChEC-Seq experiments
MCM1 YMR043W Transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
MED4 YOR174W Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
ASF1 YJL115W Nucleosome assembly factor genetic 1 1 1 Positive Genetic
BEM1 YBR200W Protein containing SH3-domains genetic 1 1 1 Negative Genetic
ASC1 YMR116C G-protein beta subunit and guanine dissociation inhibitor for Gpa2p genetic 1 1 1 Negative Genetic
BUD14 YAR014C Protein involved in bud-site selection genetic 1 1 1 Negative Genetic
CCA1 YER168C ATP (CTP):tRNA-specific tRNA nucleotidyltransferase genetic 1 1 1 Negative Genetic
CDC3 YLR314C Component of the septin ring that is required for cytokinesis genetic 1 1 1 Negative Genetic
ESP1 YGR098C Separase/separin, a caspase-like cysteine protease genetic 1 1 1 Synthetic Growth Defect
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator physical 1 1 1 Affinity Capture-RNA
COG8 YML071C Component of the conserved oligomeric Golgi complex genetic 1 1 1 Negative Genetic
MED6 YHR058C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
CMD1 YBR109C Calmodulin physical 1 1 1 Affinity Capture-MS
DOA4 YDR069C Ubiquitin hydrolase genetic 1 1 1 Negative Genetic
GPT2 YKR067W Glycerol-3-phosphate/dihydroxyacetone phosphate sn-1 acyltransferase genetic 1 1 1 Negative Genetic
MED8 YBR193C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
MNN10 YDR245W Subunit of a Golgi mannosyltransferase complex genetic 1 1 1 Negative Genetic
INP52 YNL106C Polyphosphatidylinositol phosphatase genetic 1 1 1 Dosage Rescue
GCN5 YGR252W Catalytic subunit of ADA and SAGA histone acetyltransferase complexes genetic 1 1 1 Positive Genetic
ACE2 YLR131C Transcription factor required for septum destruction after cytokinesis genetic 1 1 1 Negative Genetic
FLC2 YAL053W Putative calcium channel involved in calcium release under hypotonic genetic 1 1 1 Dosage Rescue
HEK2 YBL032W RNA binding protein involved in asymmetric localization of ASH1 mRNA physical 1 1 1 Affinity Capture-RNA
CNB1 YKL190W Calcineurin B genetic 1 1 1 Phenotypic Suppression
FKH1 YIL131C Forkhead family transcription factor genetic 1 1 1 Positive Genetic
CLN1 YMR199W G1 cyclin involved in regulation of the cell cycle genetic 1 1 1 Negative Genetic
CDC60 YPL160W Cytosolic leucyl tRNA synthetase genetic 1 1 1 Negative Genetic
GLE1 YDL207W Cytoplasmic nucleoporin required for polyadenylated mRNA export genetic 1 1 1 Negative Genetic
CDC4 YFL009W F-box protein required for both the G1/S and G2/M phase transitions genetic 1 1 1 Negative Genetic
KIC1 YHR102W Protein kinase of the PAK/Ste20 family, required for cell integrity genetic 1 1 1 Dosage Rescue
EAP1 YKL204W eIF4E-associated protein, competes with eIF4G for binding to eIF4E genetic 1 1 1 Negative Genetic
TAL1 YLR354C Transaldolase, enzyme in the non-oxidative pentose phosphate pathway physical 1 1 1 Affinity Capture-MS
WHI3 YNL197C RNA binding protein that modulates mRNA stability physical 1 1 1 Protein-RNA
SPC110 YDR356W Inner plaque spindle pole body (SPB) component physical 1 1 1 Affinity Capture-MS
SPC42 YKL042W Central plaque component of spindle pole body (SPB) physical 1 1 1 Affinity Capture-MS
PBS2 YJL128C MAP kinase kinase of the HOG signaling pathway physical 1 1 1 Affinity Capture-MS
PBS2 YJL128C MAP kinase kinase of the HOG signaling pathway genetic 1 1 1 Dosage Rescue
SSB2 YNL209W Cytoplasmic ATPase that is a ribosome-associated molecular chaperone physical 1 1 1 Co-purification
PUF2 YPR042C PUF family mRNA-binding protein physical 1 1 1 Affinity Capture-RNA
YMR1 YJR110W Phosphatidylinositol 3-phosphate (PI3P) phosphatase genetic 1 1 1 Dosage Rescue
STE20 YHL007C Cdc42p-activated signal transducing kinase genetic 1 1 1 Positive Genetic
PFK1 YGR240C Alpha subunit of heterooctameric phosphofructokinase genetic 1 1 1 Positive Genetic
PFK26 YIL107C 6-phosphofructo-2-kinase genetic 1 1 1 Positive Genetic
SSK1 YLR006C Cytoplasmic phosphorelay intermediate osmosensor and regulator genetic 1 1 1 Positive Genetic
RIC1 YLR039C Protein involved in retrograde transport to the cis-Golgi network genetic 1 1 1 Negative Genetic
YPT6 YLR262C Rab family GTPase genetic 1 1 1 Positive Genetic
WHI5 YOR083W Repressor of G1 transcription genetic 1 1 1 Positive Genetic
PHO85 YPL031C Cyclin-dependent kinase genetic 1 1 1 Negative Genetic
SMK1 YPR054W Middle sporulation-specific mitogen-activated protein kinase (MAPK) genetic 1 1 1 Positive Genetic
SRF1 YDL133W Regulator of phospholipase D (Spo14p) genetic 1 1 1 Negative Genetic
SST2 YLR452C GTPase-activating protein for Gpa1p genetic 1 1 1 Negative Genetic
RPD3 YNL330C Histone deacetylase, component of both the Rpd3S and Rpd3L complexes genetic 1 1 1 Positive Genetic
SAT4 YCR008W Ser/Thr protein kinase involved in salt tolerance, nutrient response genetic 1 1 1 Positive Genetic
PHO23 YNL097C Component of the Rpd3L histone deacetylase complex genetic 1 1 1 Negative Genetic
NUP133 YKR082W Subunit of Nup84p subcomplex of nuclear pore complex (NPC) genetic 1 1 1 Negative Genetic
NPL3 YDR432W RNA-binding protein genetic 1 1 1 Synthetic Rescue
PAM17 YKR065C Constituent of the TIM23 complex genetic 1 1 1 Positive Genetic
ROM2 YLR371W Guanine nucleotide exchange factor (GEF) for Rho1p and Rho2p genetic 1 1 1 Positive Genetic
TUS1 YLR425W Guanine nucleotide exchange factor (GEF) that modulates Rho1p activity genetic 1 1 1 Positive Genetic
SLG1 YOR008C Sensor-transducer of the stress-activated PKC1-MPK1 kinase pathway genetic 1 1 1 Positive Genetic
RFT1 YBL020W Membrane protein required for translocation of Man5GlcNac2-PP-Dol genetic 1 1 1 Negative Genetic
WBP1 YEL002C Beta subunit of the oligosaccharyl transferase glycoprotein complex genetic 1 1 1 Negative Genetic
UTR5 YEL035C Protein of unknown function genetic 1 1 1 Negative Genetic
RPB11 YOL005C RNA polymerase II subunit B12.5 genetic 1 1 1 Negative Genetic
SEN54 YPL083C Subunit of the tRNA splicing endonuclease genetic 1 1 1 Negative Genetic
TFB4 YPR056W Subunit of TFIIH complex genetic 1 1 1 Negative Genetic
PRP6 YBR055C Splicing factor genetic 1 1 1 Negative Genetic
SRB6 YBR253W Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
YRB1 YDR002W Ran GTPase binding protein genetic 1 1 1 Negative Genetic
TAF12 YDR145W Subunit (61/68 kDa) of TFIID and SAGA complexes genetic 1 1 1 Negative Genetic
NSE3 YDR288W Component of the SMC5-SMC6 complex genetic 1 1 1 Negative Genetic
STT3 YGL022W Catalytic subunit of the oligosaccharyltransferase complex of the ER l genetic 1 1 1 Negative Genetic
PTI1 YGR156W Essential component of CPF (cleavage and polyadenylation factor) genetic 1 1 1 Negative Genetic
ZPR1 YGR211W Essential protein with two zinc fingers genetic 1 1 1 Negative Genetic
SEC22 YLR268W R-SNARE protein genetic 1 1 1 Negative Genetic
ORC1 YML065W Largest subunit of the origin recognition complex genetic 1 1 1 Negative Genetic
POB3 YML069W Subunit of the heterodimeric FACT complex (Spt16p-Pob3p) genetic 1 1 1 Negative Genetic
RNA1 YMR235C GTPase activating protein (GAP) for Gsp1p genetic 1 1 1 Negative Genetic
RAT1 YOR048C Nuclear 5' to 3' single-stranded RNA exonuclease genetic 1 1 1 Negative Genetic
SMP3 YOR149C Alpha 1,2-mannosyltransferase genetic 1 1 1 Negative Genetic
RPB8 YOR224C RNA polymerase subunit ABC14.5 genetic 1 1 1 Negative Genetic
PRE2 YPR103W Beta 5 subunit of the 20S proteasome genetic 1 1 1 Negative Genetic
SPN1 YPR133C Protein involved in RNA polymerase II transcription genetic 1 1 1 Negative Genetic
SEC23 YPR181C GTPase-activating protein, stimulates the GTPase activity of Sar1p genetic 1 1 1 Negative Genetic
RPS14A YCR031C Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
YGL114W YGL114W Putative protein of unknown function genetic 1 1 1 Negative Genetic
ROF1 YHR177W Putative transcription factor containing a WOPR domain genetic 1 1 1 Negative Genetic
SNT1 YCR033W Set3C histone deacetylase scaffold genetic 1 1 1 Negative Genetic
SLX5 YDL013W Subunit of the Slx5-Slx8 SUMO-targeted Ub ligase (STUbL) complex genetic 1 1 1 Negative Genetic
XRS2 YDR369C FHA domain-containing component of the Mre11 complex genetic 1 1 1 Negative Genetic
RVS167 YDR388W Calmodulin-binding actin-associated protein genetic 1 1 1 Negative Genetic
YBP2 YGL060W Central kinetochore associated protein genetic 1 1 1 Negative Genetic
VAM7 YGL212W Vacuolar SNARE protein genetic 1 1 1 Negative Genetic
YGL230C YGL230C Putative protein of unknown function genetic 1 1 1 Negative Genetic
PRE9 YGR135W Alpha 3 subunit of the 20S proteasome genetic 1 1 1 Negative Genetic
VPS53 YJL029C Component of the GARP (Golgi-associated retrograde protein) complex genetic 1 1 1 Negative Genetic
SAC1 YKL212W Phosphatidylinositol phosphate phosphatase genetic 1 1 1 Negative Genetic
UBX2 YML013W Bridging factor involved in ER-associated protein degradation (ERAD) genetic 1 1 1 Negative Genetic
TOP1 YOL006C Topoisomerase I genetic 1 1 1 Negative Genetic
SIL1 YOL031C Nucleotide exchange factor for the ER lumenal Hsp70 chaperone Kar2p genetic 1 1 1 Negative Genetic
YOR131C YOR131C Putative haloacid dehalogenase-like hydrolase genetic 1 1 1 Negative Genetic
SLA2 YNL243W Adaptor protein that links actin to clathrin and endocytosis genetic 1 1 1 Negative Genetic
STE5 YDR103W Pheromone-responsive MAPK scaffold protein genetic 1 1 1 Phenotypic Enhancement
PHB2 YGR231C Subunit of the prohibitin complex (Phb1p-Phb2p) genetic 1 1 1 Positive Genetic
STE4 YOR212W G protein beta subunit genetic 1 1 1 Dosage Rescue
TUB4 YLR212C Gamma-tubulin genetic 1 1 1 Synthetic Growth Defect
CDH1 YGL003C Activator of anaphase-promoting complex/cyclosome (APC/C) genetic 1 1 1 Positive Genetic
CTK3 YML112W Gamma subunit of C-terminal domain kinase I genetic 1 1 1 Positive Genetic
CAK1 YFL029C Cyclin-dependent kinase-activating kinase genetic 1 1 1 Negative Genetic
DOC1 YGL240W Processivity factor genetic 1 1 1 Negative Genetic
CDC31 YOR257W Calcium-binding component of the spindle pole body (SPB) half-bridge physical 1 1 1 Affinity Capture-MS
DAL81 YIR023W Positive regulator of genes in multiple nitrogen degradation pathways genetic 1 1 1 Negative Genetic
GYP1 YOR070C Cis-golgi GTPase-activating protein (GAP) for yeast Rabs genetic 1 1 1 Negative Genetic
INP53 YOR109W Polyphosphatidylinositol phosphatase genetic 1 1 1 Dosage Rescue
IVY1 YDR229W Phospholipid-binding protein that interacts with both Ypt7p and Vps33p physical 1 1 1 Affinity Capture-MS
ARK1 YNL020C Ser/Thr protein kinase genetic 1 1 1 Negative Genetic
MKK1 YOR231W MAPKK involved in the protein kinase C signaling pathway genetic 1 1 1 Dosage Rescue
DID2 YKR035W-A Class E protein of the vacuolar protein-sorting (Vps) pathway genetic 1 1 1 Negative Genetic
GAB1 YLR459W Subunit of the glycosylphosphatidylinositol transamidase complex genetic 1 1 1 Negative Genetic
MIT1 YEL007W Transcriptional regulator of pseudohyphal growth genetic 1 1 1 Negative Genetic
GPI12 YMR281W ER membrane protein involved in the second step of GPI anchor assembly genetic 1 1 1 Negative Genetic
FLC1 YPL221W Flavin adenine dinucleotide transporter genetic 1 1 1 Dosage Rescue
CDS1 YBR029C Phosphatidate cytidylyltransferase (CDP-diglyceride synthetase) genetic 1 1 1 Negative Genetic
FAD1 YDL045C Flavin adenine dinucleotide (FAD) synthetase genetic 1 1 1 Negative Genetic
ISC1 YER019W Inositol phosphosphingolipid phospholipase C genetic 1 1 1 Positive Genetic
CLB6 YGR109C B-type cyclin involved in DNA replication during S phase genetic 1 1 1 Positive Genetic
CRD1 YDL142C Cardiolipin synthase genetic 1 1 1 Synthetic Lethality
CAX4 YGR036C Dolichyl pyrophosphate (Dol-P-P) phosphatase genetic 1 1 1 Positive Genetic