Standard name Systematic name Name description Description
IST1 YNL265C Protein with positive role in the multivesicular body sorting pathway Protein with positive role in the multivesicular body sorting pathway; functions and forms a complex with Did2p; recruitment to endosomes is mediated by the Vps2p-Vps24p subcomplex of ESCRT-III; also interacts with Vps4p
Visualize the interactome of IST1
Links to external databases:
  SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)

CYCLoPs localization & abundance

WT1 WT2 WT3
Endosome 0.409 0.519 0.469
Mito 0.409 0.229 0.073
Nucleolus 0.182 0.374 0.177
Peroxisome 0.318 0.069 0.052
SpindlePole 0.364 0.183 0.438
Vac/Vac Memb NaN 0.115 0.094

GFP localization & abundance

GFP localization GFP abundance
endosome 4760

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
IST1 0 0 0 0 0

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
DID2 YKR035W-A Class E protein of the vacuolar protein-sorting (Vps) pathway physical 9 5 6 Co-localization, Reconstituted Complex, PCA, Affinity Capture-Western, Affinity Capture-Western, Co-crystal Structure, Reconstituted Complex, Affinity Capture-Western, Affinity Capture-Western
VTA1 YLR181C Multivesicular body (MVB) protein genetic 6 2 6 Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement, Negative Genetic
VPS4 YPR173C AAA-ATPase involved in multivesicular body (MVB) protein sorting physical 5 4 4 Affinity Capture-MS, Co-localization, Reconstituted Complex, Co-purification, Reconstituted Complex
VPS60 YDR486C Protein involved in late endosome to vacuole transport genetic 4 3 4 Phenotypic Enhancement, Phenotypic Enhancement, Negative Genetic, Synthetic Growth Defect
VPS4 YPR173C AAA-ATPase involved in multivesicular body (MVB) protein sorting genetic 3 3 3 Phenotypic Suppression, Phenotypic Enhancement, Negative Genetic
CHM7 YJL049W Yeast homolog of human CHMP7, localizes to the endoplasmic reticulum genetic 3 3 2 Phenotypic Enhancement, Synthetic Growth Defect, Phenotypic Suppression
SNF7 YLR025W One of four subunits of the ESCRT-III complex physical 3 2 2 Co-localization, Affinity Capture-Western, Affinity Capture-Western
VPS60 YDR486C Protein involved in late endosome to vacuole transport physical 2 1 1 Affinity Capture-Western, Affinity Capture-Western
VPS20 YMR077C Myristoylated subunit of the ESCRT-III complex physical 2 1 1 Affinity Capture-Western, Affinity Capture-Western
VPS24 YKL041W One of four subunits of the ESCRT-III complex physical 2 1 1 Affinity Capture-Western, Affinity Capture-Western
DID4 YKL002W Class E Vps protein of the ESCRT-III complex physical 2 1 1 Affinity Capture-Western, Affinity Capture-Western
YAP1 YML007W Basic leucine zipper (bZIP) transcription factor regulation 1 1 1 DNA to cDNA expression microarray evidence
ERB1 YMR049C Constituent of 66S pre-ribosomal particles genetic 1 1 1 Negative Genetic
GCD6 YDR211W Catalytic epsilon subunit of the translation initiation factor eIF2B physical 1 1 1 Affinity Capture-MS
GCD1 YOR260W Gamma subunit of the translation initiation factor eIF2B physical 1 1 1 Affinity Capture-MS
ACT1 YFL039C Actin, structural protein in cytoskeleton genetic 1 1 1 Negative Genetic
GCD2 YGR083C Delta subunit of the translation initiation factor eIF2B physical 1 1 1 Affinity Capture-MS
CCR4 YAL021C Component of the CCR4-NOT transcriptional complex physical 1 1 1 Affinity Capture-RNA
APL3 YBL037W Alpha-adaptin physical 1 1 1 Affinity Capture-MS
GCD7 YLR291C Beta subunit of translation initiation factor eIF2B physical 1 1 1 Affinity Capture-MS
GCN3 YKR026C Alpha subunit of translation initiation factor eIF2B physical 1 1 1 Affinity Capture-MS
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator physical 1 1 1 Affinity Capture-RNA
PRO1 YDR300C Gamma-glutamyl kinase physical 1 1 1 Affinity Capture-MS
RRP40 YOL142W Exosome non-catalytic core component physical 1 1 1 Affinity Capture-MS
RRP46 YGR095C Exosome non-catalytic core component physical 1 1 1 Affinity Capture-MS
SUI3 YPL237W Beta subunit of the translation initiation factor eIF2 physical 1 1 1 Affinity Capture-MS
XKS1 YGR194C Xylulokinase physical 1 1 1 Affinity Capture-MS
VPS27 YNR006W Endosomal protein that forms a complex with Hse1p physical 1 1 1 Co-localization
VPS27 YNR006W Endosomal protein that forms a complex with Hse1p genetic 1 1 1 Negative Genetic
SNF7 YLR025W One of four subunits of the ESCRT-III complex genetic 1 1 1 Synthetic Growth Defect
VTA1 YLR181C Multivesicular body (MVB) protein physical 1 1 1 PCA
IST1 YNL265C Protein with positive role in the multivesicular body sorting pathway physical 1 1 1 PCA
NAB2 YGL122C Nuclear polyadenylated RNA-binding protein physical 1 1 1 Affinity Capture-RNA
MEC1 YBR136W Genome integrity checkpoint protein and PI kinase superfamily member physical 1 1 1 Affinity Capture-MS
TEL1 YBL088C Protein kinase primarily involved in telomere length regulation physical 1 1 1 Affinity Capture-MS
MMS22 YLR320W Subunit of E3 ubiquitin ligase complex involved in replication repair physical 1 1 1 Affinity Capture-MS
SLT2 YHR030C Serine/threonine MAP kinase genetic 1 1 1 Dosage Growth Defect
OPT2 YPR194C Oligopeptide transporter genetic 1 1 1 Synthetic Lethality
MOB2 YFL034C-B Activator of Cbk1p kinase genetic 1 1 1 Positive Genetic
QRI1 YDL103C UDP-N-acetylglucosamine pyrophosphorylase genetic 1 1 1 Negative Genetic
RSP5 YER125W NEDD4 family E3 ubiquitin ligase genetic 1 1 1 Negative Genetic
SAD1 YFR005C Conserved zinc-finger domain protein involved in pre-mRNA splicing genetic 1 1 1 Negative Genetic
SMD1 YGR074W Core Sm protein Sm D1 genetic 1 1 1 Negative Genetic
NUP57 YGR119C FG-nucleoporin component of central core of the nuclear pore complex genetic 1 1 1 Negative Genetic
ORC6 YHR118C Subunit of the origin recognition complex (ORC) genetic 1 1 1 Negative Genetic
PAN1 YIR006C Part of actin cytoskeleton-regulatory complex Pan1p-Sla1p-End3p genetic 1 1 1 Negative Genetic
TAD3 YLR316C Subunit of tRNA-specific adenosine-34 deaminase genetic 1 1 1 Negative Genetic
UTP15 YMR093W Nucleolar protein genetic 1 1 1 Negative Genetic
SRV2 YNL138W CAP (cyclase-associated protein) genetic 1 1 1 Negative Genetic
SEC12 YNR026C Guanine nucleotide exchange factor (GEF) genetic 1 1 1 Negative Genetic
NUT2 YPR168W Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
SWC5 YBR231C Component of the SWR1 complex genetic 1 1 1 Negative Genetic
RPS16B YDL083C Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
RPL11B YGR085C Ribosomal 60S subunit protein L11B genetic 1 1 1 Negative Genetic
TED1 YIL039W GPI-glycan remodelase genetic 1 1 1 Negative Genetic
MOG1 YJR074W Conserved nuclear protein that interacts with GTP-Gsp1p genetic 1 1 1 Negative Genetic
RIC1 YLR039C Protein involved in retrograde transport to the cis-Golgi network genetic 1 1 1 Negative Genetic
RPL21B YPL079W Ribosomal 60S subunit protein L21B genetic 1 1 1 Negative Genetic
RPS6A YPL090C Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
COG8 YML071C Component of the conserved oligomeric Golgi complex physical 1 1 1 Affinity Capture-MS
BUD21 YOR078W Component of small ribosomal subunit (SSU) processosome genetic 1 1 1 Negative Genetic
ILV1 YER086W Threonine deaminase, catalyzes first step in isoleucine biosynthesis genetic 1 1 1 Negative Genetic
BCK1 YJL095W MAPKKK acting in the protein kinase C signaling pathway genetic 1 1 1 Dosage Growth Defect
DID4 YKL002W Class E Vps protein of the ESCRT-III complex genetic 1 1 1 Phenotypic Enhancement
ATG1 YGL180W Protein serine/threonine kinase genetic 1 1 1 Negative Genetic
HSP10 YOR020C Mitochondrial matrix co-chaperonin genetic 1 1 1 Negative Genetic
BOS1 YLR078C v-SNARE (vesicle specific SNAP receptor) genetic 1 1 1 Negative Genetic
BUB1 YGR188C Protein kinase involved in the cell cycle checkpoint into anaphase physical 1 1 1 Affinity Capture-MS
EMC5 YIL027C Member of conserved ER transmembrane complex genetic 1 1 1 Negative Genetic
AUR1 YKL004W Phosphatidylinositol:ceramide phosphoinositol transferase genetic 1 1 1 Negative Genetic
COX10 YPL172C Heme A:farnesyltransferase genetic 1 1 1 Negative Genetic
CHM7 YJL049W Yeast homolog of human CHMP7, localizes to the endoplasmic reticulum physical 1 1 1 Two-hybrid
HPM1 YIL110W AdoMet-dependent methyltransferase genetic 1 1 1 Negative Genetic