Standard name Systematic name Name description Description
PMC1 YGL006W Vacuolar Ca2+ ATPase involved in depleting cytosol of Ca2+ ions Vacuolar Ca2+ ATPase involved in depleting cytosol of Ca2+ ions; prevents growth inhibition by activation of calcineurin in the presence of elevated concentrations of calcium; similar to mammalian PMCA1a
Visualize the interactome of PMC1
Links to external databases:
  SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)

CYCLoPs localization & abundance

WT1 WT2 WT3
Cytoplasm 0.141 0.129 0.088
Endosome 0.058 NaN 0.194
Nucleus 0.101 0.067 NaN
Vac/Vac Memb 0.804 0.825 0.756
Mito NaN 0.062 0.152

GFP localization & abundance

GFP localization GFP abundance
vacuolar membrane 98.9

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
PMC1 0 0 0 0 0

Enzyme information

Catalyzed reactions in Yeast8
r_4237 (Calcium-transporting ATPase 2 (EC 3.6.3.8) (Vacuolar Ca(2+)-ATPase))

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
VCX1 YDL128W Vacuolar membrane antiporter with Ca2+/H+ and K+/H+ exchange activity genetic 10 3 9 Phenotypic Enhancement, Phenotypic Enhancement, Synthetic Lethality, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Lethality, Synthetic Growth Defect, Phenotypic Enhancement, Synthetic Growth Defect, Phenotypic Enhancement
PMR1 YGL167C High affinity Ca2+/Mn2+ P-type ATPase genetic 6 4 5 Synthetic Lethality, Synthetic Growth Defect, Phenotypic Enhancement, Negative Genetic, Negative Genetic, Negative Genetic
CNB1 YKL190W Calcineurin B genetic 3 2 2 Phenotypic Enhancement, Phenotypic Enhancement, Synthetic Lethality
NYV1 YLR093C v-SNARE component of the vacuolar SNARE complex genetic 3 3 1 Synthetic Growth Defect, Synthetic Rescue, Phenotypic Suppression
VPH1 YOR270C Subunit a of the vacuolar-ATPase V0 domain physical 2 2 2 PCA, Affinity Capture-Western
MEH1 YKR007W Subunit of the EGO/GSE complex physical 2 1 2 PCA, PCA
CPT1 YNL130C Cholinephosphotransferase genetic 2 1 2 Negative Genetic, Negative Genetic
NYV1 YLR093C v-SNARE component of the vacuolar SNARE complex physical 2 1 2 Affinity Capture-Western, Affinity Capture-Western
HUR1 YGL168W Protein with a role in DNA repair genetic 2 1 2 Negative Genetic, Negative Genetic
SNA4 YDL123W Protein of unknown function physical 2 1 2 PCA, PCA
YPQ2 YDR352W Putative vacuolar membrane transporter for cationic amino acids physical 2 1 2 PCA, PCA
SOL1 YNR034W Protein with a possible role in tRNA export genetic 2 1 2 Negative Genetic, Negative Genetic
QCR8 YJL166W Subunit 8 of ubiquinol cytochrome-c reductase (Complex III) genetic 2 1 2 Negative Genetic, Negative Genetic
SNF7 YLR025W One of four subunits of the ESCRT-III complex genetic 2 2 1 Dosage Rescue, Synthetic Growth Defect
SNF8 YPL002C Component of the ESCRT-II complex genetic 2 2 1 Dosage Rescue, Synthetic Growth Defect
HOS1 YPR068C Class I histone deacetylase (HDAC) family member genetic 2 1 1 Dosage Lethality, Dosage Lethality
RPD3 YNL330C Histone deacetylase, component of both the Rpd3S and Rpd3L complexes genetic 2 1 1 Dosage Lethality, Dosage Lethality
FKH1 YIL131C Forkhead family transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
IXR1 YKL032C Transcriptional repressor that regulates hypoxic genes during normoxia regulation 1 1 1 DNA to cDNA expression microarray evidence
ACE2 YLR131C Transcription factor required for septum destruction after cytokinesis regulation 1 1 1 chromatin immunoprecipitation-chip evidence
FKH2 YNL068C Forkhead family transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
YAP6 YDR259C Basic leucine zipper (bZIP) transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
CYC8 YBR112C General transcriptional co-repressor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
SKN7 YHR206W Nuclear response regulator and transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
CIN5 YOR028C Basic leucine zipper (bZIP) transcription factor of the yAP-1 family regulation 1 1 1 chromatin immunoprecipitation-chip evidence
SKO1 YNL167C Basic leucine zipper transcription factor of the ATF/CREB family regulation 1 1 1 chromatin immunoprecipitation-chip evidence
ROX1 YPR065W Heme-dependent repressor of hypoxic genes regulation 1 1 1 chromatin immunoprecipitation-chip evidence
GLN3 YER040W Transcriptional activator in nitrogen catabolite repression system regulation 1 1 1 chromatin immunoprecipitation-chip evidence
NDD1 YOR372C Transcriptional activator essential for nuclear division regulation 1 1 1 chromatin immunoprecipitation-chip evidence
CDC73 YLR418C Component of the Paf1p complex genetic 1 1 1 Negative Genetic
CBC2 YPL178W Small subunit of the heterodimeric cap binding complex with Sto1p genetic 1 1 1 Negative Genetic
CCR4 YAL021C Component of the CCR4-NOT transcriptional complex physical 1 1 1 Affinity Capture-RNA
NAB2 YGL122C Nuclear polyadenylated RNA-binding protein physical 1 1 1 Affinity Capture-RNA
FTH1 YBR207W Putative high affinity iron transporter physical 1 1 1 PCA
GTR2 YGR163W Subunit of a TORC1-stimulating GTPase and the EGO/GSE complex physical 1 1 1 PCA
ISW1 YBR245C ATPase subunit of imitation-switch (ISWI) class chromatin remodelers physical 1 1 1 Affinity Capture-RNA
IMG1 YCR046C Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Positive Genetic
IMG2 YCR071C Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Negative Genetic
GCN5 YGR252W Catalytic subunit of ADA and SAGA histone acetyltransferase complexes genetic 1 1 1 Negative Genetic
BCY1 YIL033C Regulatory subunit of the cyclic AMP-dependent protein kinase (PKA) genetic 1 1 1 Negative Genetic
BRE2 YLR015W Subunit of COMPASS (Set1C) complex genetic 1 1 1 Negative Genetic
PMA1 YGL008C Plasma membrane P2-type H+-ATPase genetic 1 1 1 Negative Genetic
GDT1 YBR187W Calcium and manganese transporter with higher affinity for Ca2+ genetic 1 1 1 Synthetic Growth Defect
FCF1 YDR339C PINc domain endonuclease physical 1 1 1 Affinity Capture-MS
BIR1 YJR089W Subunit of chromosomal passenger complex (CPC) genetic 1 1 1 Positive Genetic
DCK1 YLR422W Dock family protein (Dedicator Of CytoKinesis), homolog of human DOCK1 genetic 1 1 1 Positive Genetic
MSN5 YDR335W Karyopherin genetic 1 1 1 Phenotypic Enhancement
ATG27 YJL178C Type I membrane protein involved in autophagy and the Cvt pathway physical 1 1 1 PCA
BFR1 YOR198C Component of mRNP complexes associated with polyribosomes physical 1 1 1 Affinity Capture-RNA
CCZ1 YBR131W Subunit of a heterodimeric guanine nucleotide exchange factor (GEF) genetic 1 1 1 Dosage Rescue
JNM1 YMR294W Component of the yeast dynactin complex genetic 1 1 1 Synthetic Lethality
FMP42 YMR221C Putative protein of unknown function physical 1 1 1 PCA
MON1 YGL124C Subunit of a heterodimeric guanine nucleotide exchange factor (GEF) genetic 1 1 1 Dosage Rescue
COQ9 YLR201C Protein required for ubiquinone biosynthesis and respiratory growth physical 1 1 1 Affinity Capture-MS
AGP2 YBR132C Plasma membrane regulator of polyamine and carnitine transport physical 1 1 1 PCA
MDJ2 YNL328C Constituent of the mitochondrial import motor physical 1 1 1 PCA
GRE3 YHR104W Aldose reductase physical 1 1 1 Affinity Capture-MS
APJ1 YNL077W Hsp40 chaperone with a role in SUMO-mediated protein degradation physical 1 1 1 Affinity Capture-MS
NCR1 YPL006W Vacuolar membrane protein involved with Npc2p in sterol trafficking physical 1 1 1 PCA
MPS3 YJL019W Nuclear envelope protein physical 1 1 1 Affinity Capture-MS
HXT1 YHR094C Low-affinity glucose transporter of the major facilitator superfamily physical 1 1 1 PCA
SFT2 YBL102W Tetra-spanning membrane protein found mostly in the late Golgi physical 1 1 1 PCA
TVP15 YDR100W Integral membrane protein physical 1 1 1 PCA
TMS1 YDR105C Vacuolar membrane protein of unknown function physical 1 1 1 PCA
VBA4 YDR119W Protein of unknown function physical 1 1 1 PCA
VAC8 YEL013W Vacuole-specific Myo2p receptor physical 1 1 1 PCA
VMA8 YEL051W Subunit D of the V1 peripheral membrane domain of V-ATPase physical 1 1 1 PCA
VPS68 YOL129W Vacuolar membrane protein of unknown function physical 1 1 1 PCA
VMA13 YPR036W Subunit H of the V1 peripheral membrane domain of V-ATPase physical 1 1 1 PCA
VPH1 YOR270C Subunit a of the vacuolar-ATPase V0 domain genetic 1 1 1 Synthetic Growth Defect
VMA7 YGR020C Subunit F of the V1 peripheral membrane domain of V-ATPase physical 1 1 1 PCA
VPS35 YJL154C Endosomal subunit of membrane-associated retromer complex physical 1 1 1 PCA
YBT1 YLL048C Transporter of the ATP-binding cassette (ABC) family physical 1 1 1 PCA
YML018C YML018C Protein of unknown function physical 1 1 1 PCA
SPT5 YML010W Spt4p/5p (DSIF) transcription elongation factor complex subunit physical 1 1 1 Affinity Capture-MS
SBP1 YHL034C Protein that binds eIF4G and has a role in repression of translation physical 1 1 1 Affinity Capture-RNA
SSC1 YJR045C Hsp70 family ATPase physical 1 1 1 Affinity Capture-MS
PTC7 YHR076W Type 2C serine/threonine protein phosphatase (PP2C) physical 1 1 1 Affinity Capture-MS
SET4 YJL105W Chromatin-associated protein involved in control of stress response physical 1 1 1 Affinity Capture-MS
TOM22 YNL131W Component of the TOM (Translocase of Outer Membrane) complex physical 1 1 1 Affinity Capture-MS
YPT7 YML001W Rab family GTPase genetic 1 1 1 Dosage Rescue
VAM6 YDL077C Guanine nucleotide exchange factor for the GTPase Gtr1p genetic 1 1 1 Dosage Rescue
SAC1 YKL212W Phosphatidylinositol phosphate phosphatase genetic 1 1 1 Negative Genetic
YNL134C YNL134C NADH-dependent aldehyde reductase genetic 1 1 1 Negative Genetic
YNL040W YNL040W Protein of unknown function genetic 1 1 1 Negative Genetic
VMA21 YGR105W Integral membrane protein required for V-ATPase function genetic 1 1 1 Synthetic Growth Defect
VOA1 YGR106C ER protein that functions in assembly of the V0 sector of V-ATPase genetic 1 1 1 Synthetic Growth Defect
VPS36 YLR417W Component of the ESCRT-II complex genetic 1 1 1 Dosage Rescue
PMC1 YGL006W Vacuolar Ca2+ ATPase involved in depleting cytosol of Ca2+ ions genetic 1 1 1 Synthetic Growth Defect
VPS24 YKL041W One of four subunits of the ESCRT-III complex genetic 1 1 1 Negative Genetic
TFS1 YLR178C Inhibitor of carboxypeptidase Y (Prc1p), and Ras GAP (Ira2p) genetic 1 1 1 Positive Genetic
RPS10A YOR293W Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
SWI3 YJL176C Subunit of the SWI/SNF chromatin remodeling complex genetic 1 1 1 Negative Genetic
RPS11A YDR025W Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
RPS19B YNL302C Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
RTG3 YBL103C bHLH/Zip transcription factor for retrograde (RTG) and TOR pathways genetic 1 1 1 Negative Genetic
SIN3 YOL004W Component of both the Rpd3S and Rpd3L histone deacetylase complexes genetic 1 1 1 Negative Genetic
SNF5 YBR289W Subunit of the SWI/SNF chromatin remodeling complex genetic 1 1 1 Negative Genetic
VPS13 YLL040C Lipid transport protein involved in prospore membrane morphogenesis genetic 1 1 1 Dosage Rescue
COT1 YOR316C Vacuolar transporter that mediates zinc transport into the vacuole physical 1 1 1 PCA
DPP1 YDR284C Diacylglycerol pyrophosphate (DGPP) phosphatase physical 1 1 1 PCA
CTR2 YHR175W Low-affinity copper transporter of the vacuolar membrane physical 1 1 1 PCA
CDC1 YDR182W Putative mannose-ethanolamine phosphate phosphodiesterase genetic 1 1 1 Synthetic Lethality
MRX4 YPL168W Protein that associates with mitochondrial ribosome genetic 1 1 1 Negative Genetic