Standard name Systematic name Name description Description
LOC1 YFR001W Nucleolar protein involved in the asymmetric localization of ASH1 mRNA Nucleolar protein involved in the asymmetric localization of ASH1 mRNA; binds cooperatively with She2p to the E3 zip-code element in the 3'-UTR of the mRNA; constituent of 66S pre-ribosomal particles involved in pre-rRNA processing and nuclear export of the 60S subunit; may facilitate Rpl43p loading; required post-transcriptionally for efficient retrotransposition; absence results in decreased Ty1 Gag:GFP protein levels; relocalizes from nucleus to cytoplasm upon DNA replication stress
Visualize the interactome of LOC1
Links to external databases:
  SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)

CYCLoPs localization & abundance

WT1 WT2 WT3
Cytoplasm 0.119 0.253 0.283
Endosome 0.105 0.073 0.062
Mito 0.165 0.143 NaN
Nucleus 0.109 0.107 0.174
Vac/Vac Memb 0.691 0.612 0.605

GFP localization & abundance

GFP localization GFP abundance
nucleolus, nucleus 3650

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
LOC1 4 0 0 0 0

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
EBP2 YKL172W Required for 25S rRNA maturation and 60S ribosomal subunit assembly physical 8 4 5 Affinity Capture-MS, PCA, Two-hybrid, Two-hybrid, Two-hybrid, Two-hybrid, Two-hybrid, Affinity Capture-Western
PUF6 YDR496C Pumilio-homology domain protein physical 7 3 2 Co-localization, Co-localization, Reconstituted Complex, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex
TIF6 YPR016C Constituent of 66S pre-ribosomal particles physical 6 2 4 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western
SHE2 YKL130C RNA-binding protein that binds specific mRNAs and interacts with She3p physical 6 3 3 Affinity Capture-Western, Co-localization, Reconstituted Complex, Reconstituted Complex, Affinity Capture-Western, Reconstituted Complex
ASH1 YKL185W Component of the Rpd3L histone deacetylase complex physical 5 2 5 Affinity Capture-RNA, Affinity Capture-RNA, Affinity Capture-RNA, Protein-RNA, Affinity Capture-RNA
BRX1 YOL077C Nucleolar protein physical 4 4 4 Affinity Capture-MS, PCA, Two-hybrid, Affinity Capture-Western
NOC2 YOR206W Protein involved in ribosome biogenesis physical 4 4 3 Affinity Capture-MS, PCA, Two-hybrid, Affinity Capture-Western
HAS1 YMR290C ATP-dependent RNA helicase physical 4 3 3 Affinity Capture-MS, Two-hybrid, Affinity Capture-Western, Affinity Capture-MS
PUF6 YDR496C Pumilio-homology domain protein genetic 4 4 2 Phenotypic Enhancement, Synthetic Rescue, Synthetic Growth Defect, Phenotypic Suppression
NUG1 YER006W GTPase that associates with nuclear 60S pre-ribosomes physical 3 3 3 Affinity Capture-MS, Two-hybrid, Affinity Capture-Western
SPB4 YFL002C Putative ATP-dependent RNA helicase physical 3 1 3 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS
RPL25 YOL127W Ribosomal 60S subunit protein L25 physical 3 1 3 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS
DRS1 YLL008W Nucleolar DEAD-box protein required for ribosome assembly and function physical 3 3 2 Affinity Capture-MS, Two-hybrid, Affinity Capture-Western
SPB1 YCL054W AdoMet-dependent methyltransferase physical 3 3 2 Affinity Capture-MS, Two-hybrid, Affinity Capture-Western
DBP10 YDL031W Putative ATP-dependent RNA helicase of the DEAD-box protein family physical 3 3 2 Affinity Capture-MS, Two-hybrid, Affinity Capture-Western
RRP14 YKL082C Essential protein, constituent of 66S pre-ribosomal particles physical 3 2 2 Two-hybrid, Two-hybrid, Affinity Capture-Western
NOP2 YNL061W rRNA m5C methyltransferase physical 3 1 2 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS
NOP4 YPL043W Nucleolar protein physical 3 2 1 Two-hybrid, Two-hybrid, Affinity Capture-Western
NOG1 YPL093W Putative GTPase physical 2 2 2 Affinity Capture-MS, Two-hybrid
RPF1 YHR088W Protein involved in assembly and export of the large ribosomal subunit physical 2 2 2 Affinity Capture-MS, Co-purification
ULP2 YIL031W Peptidase that deconjugates Smt3/SUMO-1 peptides from proteins physical 2 2 2 PCA, Affinity Capture-MS
DBP7 YKR024C Putative ATP-dependent RNA helicase of the DEAD-box family physical 2 2 2 Affinity Capture-MS, Two-hybrid
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator physical 2 2 2 Affinity Capture-RNA, Affinity Capture-Western
FPR4 YLR449W Peptidyl-prolyl cis-trans isomerase (PPIase) physical 2 2 2 PCA, Two-hybrid
NOP7 YGR103W Component of several different pre-ribosomal particles physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
RRP5 YMR229C RNA binding protein involved in synthesis of 18S and 5.8S rRNAs physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
RLP7 YNL002C Nucleolar protein similar to large ribosomal subunit L7 proteins physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
RPL16A YIL133C Ribosomal 60S subunit protein L16A physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
RPL31A YDL075W Ribosomal 60S subunit protein L31A physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
MPT5 YGL178W mRNA-binding protein of the PUF family physical 2 1 2 Affinity Capture-RNA, Affinity Capture-RNA
LOC1 YFR001W Nucleolar protein involved in the asymmetric localization of ASH1 mRNA physical 2 2 1 Two-hybrid, Affinity Capture-Western
MAK21 YDR060W Constituent of 66S pre-ribosomal particles physical 2 2 1 Two-hybrid, Affinity Capture-Western
MAK5 YBR142W Essential nucleolar protein physical 2 2 1 Two-hybrid, Affinity Capture-Western
NOP12 YOL041C Nucleolar protein involved in pre-25S rRNA processing physical 2 2 1 Two-hybrid, Affinity Capture-Western
NOP53 YPL146C Nucleolar protein physical 2 2 1 Two-hybrid, Affinity Capture-Western
PRP43 YGL120C RNA helicase in the DEAH-box family physical 2 2 1 Two-hybrid, Affinity Capture-Western
RRP12 YPL012W Protein required for export of the ribosomal subunits physical 2 2 1 Two-hybrid, Affinity Capture-Western
RPL43B YJR094W-A Ribosomal 60S subunit protein L43B physical 2 2 1 Reconstituted Complex, Affinity Capture-Western
FPR3 YML074C Nucleolar peptidyl-prolyl cis-trans isomerase (PPIase) physical 2 2 1 Two-hybrid, Affinity Capture-Western
DBP5 YOR046C Cytoplasmic ATP-dependent RNA helicase of the DEAD-box family genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
FKH1 YIL131C Forkhead family transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
SFP1 YLR403W Regulates transcription of ribosomal protein and biogenesis genes regulation 1 1 1 DNA to cDNA expression microarray evidence
FKH2 YNL068C Forkhead family transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
HAL9 YOL089C Putative transcription factor containing a zinc finger regulation 1 1 1 DNA to cDNA expression microarray evidence
CAD1 YDR423C AP-1-like basic leucine zipper (bZIP) transcriptional activator regulation 1 1 1 DNA to cDNA expression microarray evidence
DSN1 YIR010W Essential component of the outer kinetochore MIND complex physical 1 1 1 Affinity Capture-MS
GLC7 YER133W Type 1 S/T protein phosphatase (PP1) catalytic subunit physical 1 1 1 Affinity Capture-MS
ERB1 YMR049C Constituent of 66S pre-ribosomal particles physical 1 1 1 Affinity Capture-MS
KAP123 YER110C Karyopherin beta genetic 1 1 1 Negative Genetic
MUS81 YDR386W Subunit of structure-specific Mms4p-Mus81p endonuclease physical 1 1 1 Affinity Capture-MS
RLP24 YLR009W Essential protein required for ribosomal large subunit biogenesis physical 1 1 1 Affinity Capture-MS
SPT5 YML010W Spt4p/5p (DSIF) transcription elongation factor complex subunit physical 1 1 1 Affinity Capture-MS
THP3 YPR045C Protein that may have a role in transcription elongation physical 1 1 1 Affinity Capture-MS
SGV1 YPR161C Cyclin (Bur2p)-dependent protein kinase physical 1 1 1 Affinity Capture-MS
NOC3 YLR002C Subunit of a nuclear complex with Noc2p and pre-replicative complexes physical 1 1 1 Affinity Capture-MS
RPL3 YOR063W Ribosomal 60S subunit protein L3 physical 1 1 1 Affinity Capture-MS
MRT4 YKL009W Protein involved in mRNA turnover and ribosome assembly physical 1 1 1 Affinity Capture-MS
NIP7 YPL211W Nucleolar protein required for 60S ribosome subunit biogenesis physical 1 1 1 Affinity Capture-MS
RPL13B YMR142C Ribosomal 60S subunit protein L13B physical 1 1 1 Affinity Capture-MS
RPL9A YGL147C Ribosomal 60S subunit protein L9A physical 1 1 1 Affinity Capture-MS
YTM1 YOR272W Ribosomal assembly factor and 66S pre-ribosomal particle constituent physical 1 1 1 Affinity Capture-MS
RPL1A YPL220W Ribosomal 60S subunit protein L1A physical 1 1 1 Affinity Capture-MS
RPL30 YGL030W Ribosomal 60S subunit protein L30 physical 1 1 1 Affinity Capture-MS
RPL8B YLL045C Ribosomal 60S subunit protein L8A physical 1 1 1 Affinity Capture-MS
RPL20A YMR242C Ribosomal 60S subunit protein L20A physical 1 1 1 Affinity Capture-MS
RPL5 YPL131W Ribosomal 60S subunit protein L5 physical 1 1 1 Affinity Capture-MS
RPL7A YGL076C Ribosomal 60S subunit protein L7A physical 1 1 1 Affinity Capture-MS
NSA1 YGL111W Constituent of 66S pre-ribosomal particles physical 1 1 1 Affinity Capture-MS
RPL23A YBL087C Ribosomal 60S subunit protein L23A physical 1 1 1 Affinity Capture-MS
RPL4B YDR012W Ribosomal 60S subunit protein L4B physical 1 1 1 Affinity Capture-MS
RPL7B YPL198W Ribosomal 60S subunit protein L7B physical 1 1 1 Affinity Capture-MS
RRP15 YPR143W Nucleolar protein physical 1 1 1 Affinity Capture-MS
RRP1 YDR087C Essential evolutionarily conserved nucleolar protein physical 1 1 1 Affinity Capture-MS
MAK11 YKL021C Protein involved in an early step of 60S ribosomal subunit biogenesis physical 1 1 1 Affinity Capture-MS
NOP15 YNL110C Constituent of 66S pre-ribosomal particles physical 1 1 1 Affinity Capture-MS
UBP10 YNL186W Ubiquitin-specific protease, deubiquitinates Ub-protein moieties physical 1 1 1 PCA
PWP1 YLR196W Protein with WD-40 repeats involved in rRNA processing physical 1 1 1 PCA
NAB2 YGL122C Nuclear polyadenylated RNA-binding protein physical 1 1 1 Affinity Capture-RNA
ORC1 YML065W Largest subunit of the origin recognition complex physical 1 1 1 Affinity Capture-MS
RRP17 YDR412W 5' exoribonuclease required for 5' end processing of pre-60S rRNA physical 1 1 1 Affinity Capture-MS
NOP58 YOR310C Protein involved in producing mature rRNAs and snoRNAs physical 1 1 1 Affinity Capture-MS
RPF2 YKR081C Essential protein involved in rRNA maturation and ribosomal assembly physical 1 1 1 Affinity Capture-MS
SRO9 YCL037C Cytoplasmic RNA-binding protein physical 1 1 1 Affinity Capture-RNA
MLP2 YIL149C Myosin-like protein associated with the nuclear envelope physical 1 1 1 Affinity Capture-MS
VAM6 YDL077C Guanine nucleotide exchange factor for the GTPase Gtr1p physical 1 1 1 Affinity Capture-MS
NOP16 YER002W Constituent of 66S pre-ribosomal particles physical 1 1 1 Two-hybrid
NSA2 YER126C Protein constituent of 66S pre-ribosomal particles physical 1 1 1 Two-hybrid
NSR1 YGR159C Nucleolin, nucleolar protein that binds nuclear localization sequences physical 1 1 1 Two-hybrid
TMA16 YOR252W Protein of unknown function that associates with ribosomes physical 1 1 1 Two-hybrid
PUF3 YLL013C Protein of the mitochondrial outer surface physical 1 1 1 Affinity Capture-RNA
RPC82 YPR190C RNA polymerase III subunit C82 physical 1 1 1 Affinity Capture-MS
RPL8A YHL033C Ribosomal 60S subunit protein L8A physical 1 1 1 Affinity Capture-Western
SSF1 YHR066W Constituent of 66S pre-ribosomal particles physical 1 1 1 Affinity Capture-Western
NOG2 YNR053C Putative GTPase physical 1 1 1 Affinity Capture-Western
NOC4 YPR144C Nucleolar protein physical 1 1 1 Affinity Capture-MS
SND2 YLR065C Protein involved in SRP-independent targeting of substrates to the ER physical 1 1 1 Affinity Capture-MS
SND3 YBR106W Involved in SRP-independent protein targeting to the ER physical 1 1 1 Affinity Capture-MS
PUF4 YGL014W Member of the PUF protein family physical 1 1 1 Affinity Capture-RNA
UTP10 YJL109C Nucleolar protein physical 1 1 1 Affinity Capture-MS
MOG1 YJR074W Conserved nuclear protein that interacts with GTP-Gsp1p physical 1 1 1 Affinity Capture-MS
STE12 YHR084W Transcription factor that is activated by a MAPK signaling cascade physical 1 1 1 Affinity Capture-RNA
RPS0A YGR214W Ribosomal 40S subunit protein S0A physical 1 1 1 Affinity Capture-MS
RPS1A YLR441C Ribosomal protein of the small (40S) subunit physical 1 1 1 Affinity Capture-MS
RPS2 YGL123W Protein component of the small (40S) subunit physical 1 1 1 Affinity Capture-MS
RPS7A YOR096W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPS8A YBL072C Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPS12 YOR369C Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPS18A YDR450W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPS19A YOL121C Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPS20 YHL015W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPS15 YOL040C Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPS22A YJL190C Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPL26A YLR344W Ribosomal 60S subunit protein L26A physical 1 1 1 Affinity Capture-MS
RPS27A YKL156W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPS3 YNL178W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPS14A YCR031C Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RRP6 YOR001W Nuclear exosome exonuclease component physical 1 1 1 Affinity Capture-MS
RRP43 YCR035C Exosome non-catalytic core component physical 1 1 1 Affinity Capture-MS
STP4 YDL048C Protein containing a Kruppel-type zinc-finger domain genetic 1 1 1 Negative Genetic
UBI4 YLL039C Ubiquitin genetic 1 1 1 Negative Genetic
LOS1 YKL205W Nuclear pore protein genetic 1 1 1 Negative Genetic
LTV1 YKL143W Subunit of the EGO/GSE complex genetic 1 1 1 Negative Genetic
TUF1 YOR187W Mitochondrial translation elongation factor Tu (EF-Tu) genetic 1 1 1 Negative Genetic
LSM7 YNL147W Lsm (Like Sm) protein genetic 1 1 1 Negative Genetic
STH1 YIL126W ATPase component of the RSC chromatin remodeling complex genetic 1 1 1 Synthetic Growth Defect
SKN1 YGR143W Protein involved in sphingolipid biosynthesis genetic 1 1 1 Positive Genetic
YCK3 YER123W Palmitoylated vacuolar membrane-localized casein kinase I isoform genetic 1 1 1 Negative Genetic
VPS53 YJL029C Component of the GARP (Golgi-associated retrograde protein) complex genetic 1 1 1 Negative Genetic
RPL38 YLR325C Ribosomal 60S subunit protein L38 genetic 1 1 1 Negative Genetic
SDD3 YOL098C Putative metalloprotease genetic 1 1 1 Negative Genetic
RPL36A YMR194W Ribosomal 60S subunit protein L36A genetic 1 1 1 Dosage Rescue
YPC1 YBR183W Alkaline ceramidase genetic 1 1 1 Negative Genetic
CIC1 YHR052W Essential protein that interacts with proteasome components physical 1 1 1 Affinity Capture-MS
GAR1 YHR089C Protein component of the H/ACA snoRNP pseudouridylase complex physical 1 1 1 PCA
ARX1 YDR101C Nuclear export factor for the ribosomal pre-60S subunit physical 1 1 1 Affinity Capture-Western
HCR1 YLR192C eIF3j component of translation initiation factor 3 (eIF3) genetic 1 1 1 Negative Genetic
CCR4 YAL021C Component of the CCR4-NOT transcriptional complex physical 1 1 1 Affinity Capture-RNA
ECM16 YMR128W Essential DEAH-box ATP-dependent RNA helicase specific to U3 snoRNP physical 1 1 1 Affinity Capture-MS
BMS1 YPL217C GTPase required for ribosomal subunit synthesis and rRNA processing physical 1 1 1 Affinity Capture-MS
LHP1 YDL051W RNA binding protein required for maturation of tRNA and U6 snRNA genetic 1 1 1 Negative Genetic
ASC1 YMR116C G-protein beta subunit and guanine dissociation inhibitor for Gpa2p physical 1 1 1 Affinity Capture-MS
IPI3 YNL182C Component of the Rix1 complex and pre-replicative complexes (pre-RCs) physical 1 1 1 Affinity Capture-MS
FPR1 YNL135C Peptidyl-prolyl cis-trans isomerase (PPIase) genetic 1 1 1 Negative Genetic
HAP2 YGL237C Subunit of the Hap2p/3p/4p/5p CCAAT-binding complex physical 1 1 1 Affinity Capture-MS
KRR1 YCL059C Nucleolar protein required for rRNA synthesis and ribosomal assembly physical 1 1 1 Affinity Capture-MS
CRM1 YGR218W Nuclear export factor, exportin physical 1 1 1 Affinity Capture-MS
HSC82 YMR186W Cytoplasmic chaperone of the Hsp90 family genetic 1 1 1 Synthetic Growth Defect
HRR25 YPL204W Conserved casein kinase, monopolin subunit physical 1 1 1 Affinity Capture-MS
GIM5 YML094W Subunit of the heterohexameric cochaperone prefoldin complex genetic 1 1 1 Negative Genetic
HSP82 YPL240C Hsp90 chaperone genetic 1 1 1 Synthetic Growth Defect
HRK1 YOR267C Protein kinase physical 1 1 1 Affinity Capture-MS
BRR1 YPR057W snRNP protein component of spliceosomal snRNPs genetic 1 1 1 Negative Genetic
DRS2 YAL026C Trans-golgi network aminophospholipid translocase (flippase) genetic 1 1 1 Negative Genetic
EGD2 YHR193C Alpha subunit of the nascent polypeptide-associated complex (NAC) genetic 1 1 1 Synthetic Growth Defect
CAF20 YOR276W Phosphoprotein of the mRNA cap-binding complex physical 1 1 1 Affinity Capture-MS
ELA1 YNL230C Elongin A physical 1 1 1 Affinity Capture-MS
EAP1 YKL204W eIF4E-associated protein, competes with eIF4G for binding to eIF4E physical 1 1 1 Affinity Capture-MS
BRF1 YGR246C TFIIIB B-related factor physical 1 1 1 Affinity Capture-MS
DOM34 YNL001W Protein that facilitates ribosomal subunit dissociation genetic 1 1 1 Dosage Rescue
DBP6 YNR038W Essential protein involved in ribosome biogenesis physical 1 1 1 Two-hybrid
GIS2 YNL255C Translational activator for mRNAs with internal ribosome entry sites physical 1 1 1 Affinity Capture-RNA
APJ1 YNL077W Hsp40 chaperone with a role in SUMO-mediated protein degradation physical 1 1 1 Affinity Capture-MS
LDB18 YLL049W Component of the dynactin complex genetic 1 1 1 Negative Genetic
CGR1 YGL029W Protein involved in nucleolar integrity and processing of pre-rRNA physical 1 1 1 Two-hybrid