| SEC6 |
YIL068C |
Essential 88kDa subunit of the exocyst complex |
physical |
16 |
5 |
13 |
Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex, Affinity Capture-MS, Affinity Capture-Western, Co-fractionation, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Co-localization, Co-localization, Affinity Capture-Western, Reconstituted Complex |
| SEC15 |
YGL233W |
Essential 113 kDa subunit of the exocyst complex |
physical |
13 |
5 |
12 |
Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-Western, Co-fractionation, Co-fractionation, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Co-localization, Affinity Capture-Western, Reconstituted Complex |
| SEC10 |
YLR166C |
Essential 100kDa subunit of the exocyst complex |
physical |
13 |
4 |
11 |
Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Co-localization, Affinity Capture-Western, Reconstituted Complex |
| SEC3 |
YER008C |
Subunit of the exocyst complex |
physical |
12 |
4 |
9 |
Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Co-localization, Co-localization, Affinity Capture-Western, Affinity Capture-MS, Reconstituted Complex, Reconstituted Complex |
| EXO84 |
YBR102C |
Exocyst subunit with dual roles in exocytosis and spliceosome assembly |
physical |
11 |
5 |
10 |
Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, PCA, Affinity Capture-Western, Co-localization, Affinity Capture-Western, Reconstituted Complex, Reconstituted Complex |
| SEC5 |
YDR166C |
Essential 107kDa subunit of the exocyst complex |
physical |
11 |
5 |
10 |
Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS, Co-fractionation, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Co-localization, Reconstituted Complex |
| EXO70 |
YJL085W |
Subunit of the exocyst complex |
physical |
8 |
2 |
7 |
Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western |
| SEC4 |
YFL005W |
Rab family GTPase |
genetic |
8 |
3 |
6 |
Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Dosage Rescue |
| SEC9 |
YGR009C |
t-SNARE protein required for secretory vesicle-plasma membrane fusion |
genetic |
7 |
4 |
6 |
Synthetic Lethality, Synthetic Lethality, Dosage Rescue, Dosage Rescue, Dosage Rescue, Negative Genetic, Synthetic Growth Defect |
| SRO7 |
YPR032W |
Effector of Rab GTPase Sec4p |
genetic |
6 |
2 |
6 |
Dosage Rescue, Synthetic Growth Defect, Synthetic Growth Defect, Dosage Rescue, Dosage Rescue, Dosage Rescue |
| SEC1 |
YDR164C |
Sm-like protein involved in docking and fusion of exocytic vesicles |
genetic |
6 |
4 |
5 |
Synthetic Lethality, Synthetic Lethality, Dosage Lethality, Synthetic Lethality, Negative Genetic, Dosage Rescue |
| SEC6 |
YIL068C |
Essential 88kDa subunit of the exocyst complex |
genetic |
6 |
2 |
4 |
Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic |
| SEC3 |
YER008C |
Subunit of the exocyst complex |
genetic |
5 |
4 |
3 |
Synthetic Growth Defect, Synthetic Lethality, Synthetic Lethality, Dosage Growth Defect, Negative Genetic |
| SEC10 |
YLR166C |
Essential 100kDa subunit of the exocyst complex |
genetic |
5 |
3 |
3 |
Dosage Lethality, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic |
| SEC15 |
YGL233W |
Essential 113 kDa subunit of the exocyst complex |
genetic |
5 |
2 |
3 |
Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic |
| MSO1 |
YNR049C |
Lipid-interacting protein in SNARE complex assembly machinery |
genetic |
4 |
3 |
4 |
Synthetic Lethality, Dosage Lethality, Negative Genetic, Negative Genetic |
| MYO2 |
YOR326W |
Type V myosin motor involved in actin-based transport of cargos |
genetic |
4 |
2 |
4 |
Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Negative Genetic |
| EXO70 |
YJL085W |
Subunit of the exocyst complex |
genetic |
4 |
2 |
3 |
Synthetic Lethality, Negative Genetic, Negative Genetic, Synthetic Lethality |
| SEC2 |
YNL272C |
Guanyl-nucleotide exchange factor for the small G-protein Sec4p |
genetic |
4 |
2 |
3 |
Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Negative Genetic |
| SEC5 |
YDR166C |
Essential 107kDa subunit of the exocyst complex |
genetic |
4 |
2 |
2 |
Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic |
| GDI1 |
YER136W |
GDP dissociation inhibitor |
genetic |
3 |
2 |
2 |
Synthetic Lethality, Negative Genetic, Negative Genetic |
| MSS4 |
YDR208W |
Phosphatidylinositol-4-phosphate 5-kinase |
genetic |
3 |
2 |
2 |
Dosage Rescue, Synthetic Lethality, Dosage Rescue |
| BEM1 |
YBR200W |
Protein containing SH3-domains |
physical |
2 |
2 |
2 |
Affinity Capture-Western, Co-purification |
| SGS1 |
YMR190C |
RecQ family nucleolar DNA helicase |
genetic |
2 |
2 |
2 |
Phenotypic Enhancement, Positive Genetic |
| REB1 |
YBR049C |
RNA polymerase I enhancer binding protein |
regulation |
2 |
1 |
2 |
chromatin immunoprecipitation-chip evidence, chromatin immunoprecipitation-chip evidence |
| CDC42 |
YLR229C |
Small rho-like GTPase |
genetic |
2 |
1 |
2 |
Synthetic Lethality, Synthetic Lethality |
| NEM1 |
YHR004C |
Probable catalytic subunit of Nem1p-Spo7p phosphatase holoenzyme |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| RVS167 |
YDR388W |
Calmodulin-binding actin-associated protein |
physical |
2 |
1 |
2 |
Two-hybrid, Two-hybrid |
| DSS4 |
YPR017C |
Guanine nucleotide dissociation stimulator for Sec4p |
genetic |
2 |
1 |
2 |
Synthetic Lethality, Synthetic Lethality |
| MOG1 |
YJR074W |
Conserved nuclear protein that interacts with GTP-Gsp1p |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| SFH5 |
YJL145W |
Unusual phosphatidylinositol transfer protein (PITP) that binds heme |
genetic |
2 |
1 |
2 |
Dosage Rescue, Dosage Rescue |
| ERG3 |
YLR056W |
C-5 sterol desaturase |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| SEM1 |
YDR363W-A |
19S proteasome regulatory particle lid subcomplex component |
genetic |
2 |
2 |
1 |
Dosage Rescue, Synthetic Rescue |
| ACT1 |
YFL039C |
Actin, structural protein in cytoskeleton |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| BEM2 |
YER155C |
Rho GTPase activating protein (RhoGAP) |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| EXO84 |
YBR102C |
Exocyst subunit with dual roles in exocytosis and spliceosome assembly |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| PHO23 |
YNL097C |
Component of the Rpd3L histone deacetylase complex |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| SDS3 |
YIL084C |
Component of the Rpd3L histone deacetylase complex |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| RXT2 |
YBR095C |
Component of the histone deacetylase Rpd3L complex |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| PFY1 |
YOR122C |
Profilin |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| SNC2 |
YOR327C |
Vesicle membrane receptor protein (v-SNARE) |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| ZPR1 |
YGR211W |
Essential protein with two zinc fingers |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| SRV2 |
YNL138W |
CAP (cyclase-associated protein) |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| SNX4 |
YJL036W |
Sorting nexin |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| VPS51 |
YKR020W |
Component of the GARP (Golgi-associated retrograde protein) complex |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| UBR2 |
YLR024C |
Cytoplasmic ubiquitin-protein ligase (E3) |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| SUB1 |
YMR039C |
Transcriptional regulator |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| MUB1 |
YMR100W |
MYND domain-containing protein |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| AIM29 |
YKR074W |
Protein of unknown function |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| RHO3 |
YIL118W |
Non-essential small GTPase of the Rho/Rac family of Ras-like proteins |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| PHS1 |
YJL097W |
Essential 3-hydroxyacyl-CoA dehydratase of the ER membrane |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| SFP1 |
YLR403W |
Regulates transcription of ribosomal protein and biogenesis genes |
regulation |
1 |
1 |
1 |
DNA to cDNA expression microarray evidence |
| GCN5 |
YGR252W |
Catalytic subunit of ADA and SAGA histone acetyltransferase complexes |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
| MED2 |
YDL005C |
Subunit of the RNA polymerase II mediator complex |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
| TFC7 |
YOR110W |
RNA pol III transcription initiation factor complex (TFIIIC) subunit |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
| POB3 |
YML069W |
Subunit of the heterodimeric FACT complex (Spt16p-Pob3p) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RTF1 |
YGL244W |
Subunit of RNAPII-associated chromatin remodeling Paf1 complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| NSE1 |
YLR007W |
Component of the SMC5-SMC6 complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| NSE3 |
YDR288W |
Component of the SMC5-SMC6 complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RVB1 |
YDR190C |
ATP-dependent DNA helicase, also known as pontin |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| NIP7 |
YPL211W |
Nucleolar protein required for 60S ribosome subunit biogenesis |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RRP1 |
YDR087C |
Essential evolutionarily conserved nucleolar protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| KAP123 |
YER110C |
Karyopherin beta |
genetic |
1 |
1 |
1 |
Positive Genetic |
| PRP19 |
YLL036C |
Splicing factor associated with the spliceosome |
genetic |
1 |
1 |
1 |
Negative Genetic |
| NSE4 |
YDL105W |
Component of the SMC5-SMC6 complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| NOC3 |
YLR002C |
Subunit of a nuclear complex with Noc2p and pre-replicative complexes |
genetic |
1 |
1 |
1 |
Negative Genetic |
| KES1 |
YPL145C |
Sterol/phosphatidylinositol-4-phosphate (PI(4)P) exchanger |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
| NHP2 |
YDL208W |
Protein related to mammalian high mobility group (HMG) proteins |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SAP155 |
YFR040W |
Protein required for function of the Sit4p protein phosphatase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| PAT1 |
YCR077C |
Deadenylation-dependent mRNA-decapping factor |
genetic |
1 |
1 |
1 |
Positive Genetic |
| RPS4B |
YHR203C |
Protein component of the small (40S) ribosomal subunit |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RRP4 |
YHR069C |
Exosome non-catalytic core component |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RPC17 |
YJL011C |
RNA polymerase III subunit C17 |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| GCD11 |
YER025W |
Gamma subunit of the translation initiation factor eIF2 |
genetic |
1 |
1 |
1 |
Positive Genetic |
| RPN1 |
YHR027C |
Non-ATPase base subunit of the 19S RP of the 26S proteasome |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RPN10 |
YHR200W |
Proteasome polyubiquitin receptor |
genetic |
1 |
1 |
1 |
Positive Genetic |
| RPN5 |
YDL147W |
Subunit of the CSN and 26S proteasome lid complexes |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RPN12 |
YFR052W |
Subunit of the 19S regulatory particle of the 26S proteasome lid |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RPT1 |
YKL145W |
ATPase of the 19S regulatory particle of the 26S proteasome |
genetic |
1 |
1 |
1 |
Negative Genetic |
| KAP95 |
YLR347C |
Karyopherin beta |
genetic |
1 |
1 |
1 |
Positive Genetic |
| PRE7 |
YBL041W |
Beta 6 subunit of the 20S proteasome |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CCR4 |
YAL021C |
Component of the CCR4-NOT transcriptional complex |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
| BOI2 |
YER114C |
Protein involved in polar growth |
physical |
1 |
1 |
1 |
PCA |
| BOI2 |
YER114C |
Protein involved in polar growth |
genetic |
1 |
1 |
1 |
Negative Genetic |
| BNI1 |
YNL271C |
Formin |
physical |
1 |
1 |
1 |
PCA |
| NOG2 |
YNR053C |
Putative GTPase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| BUD31 |
YCR063W |
Component of the SF3b subcomplex of the U2 snRNP |
genetic |
1 |
1 |
1 |
Negative Genetic |
| AVO1 |
YOL078W |
Component of the membrane-bound TORC2 complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CKS1 |
YBR135W |
Cyclin-dependent protein kinase regulatory subunit and adaptor |
genetic |
1 |
1 |
1 |
Negative Genetic |
| DCP2 |
YNL118C |
Catalytic subunit of Dcp1p-Dcp2p decapping enzyme complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| EMG1 |
YLR186W |
Methyltransferase for rRNA |
genetic |
1 |
1 |
1 |
Negative Genetic |
| DHH1 |
YDL160C |
Cytoplasmic DEAD-box helicase and mRNA decapping activator |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
| ISW1 |
YBR245C |
ATPase subunit of imitation-switch (ISWI) class chromatin remodelers |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
| LAS17 |
YOR181W |
Actin assembly factor |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MAK5 |
YBR142W |
Essential nucleolar protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MED6 |
YHR058C |
Subunit of the RNA polymerase II mediator complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| IMG2 |
YCR071C |
Mitochondrial ribosomal protein of the large subunit |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MRPL25 |
YGR076C |
Mitochondrial ribosomal protein of the large subunit |
genetic |
1 |
1 |
1 |
Negative Genetic |
| HDA2 |
YDR295C |
Subunit of HDA1 histone deacetylase complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MYO2 |
YOR326W |
Type V myosin motor involved in actin-based transport of cargos |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
| NHP10 |
YDL002C |
Non-essential INO80 chromatin remodeling complex subunit |
genetic |
1 |
1 |
1 |
Negative Genetic |
| NUP159 |
YIL115C |
FG-nucleoporin component of central core of the nuclear pore complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ORC1 |
YML065W |
Largest subunit of the origin recognition complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| GIM3 |
YNL153C |
Subunit of the heterohexameric cochaperone prefoldin complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
| GIM5 |
YML094W |
Subunit of the heterohexameric cochaperone prefoldin complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| PDA1 |
YER178W |
E1 alpha subunit of the pyruvate dehydrogenase (PDH) complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| POL1 |
YNL102W |
Catalytic subunit of the DNA polymerase I alpha-primase complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| INO4 |
YOL108C |
Transcription factor involved in phospholipid synthesis |
genetic |
1 |
1 |
1 |
Negative Genetic |
| NOP14 |
YDL148C |
Nucleolar protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| PUP3 |
YER094C |
Beta 3 subunit of the 20S proteasome |
genetic |
1 |
1 |
1 |
Positive Genetic |
| OPI1 |
YHL020C |
Transcriptional regulator of a variety of genes |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RPP2B |
YDR382W |
Ribosomal protein P2 beta |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SAP30 |
YMR263W |
Component of Rpd3L histone deacetylase complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| LSB3 |
YFR024C-A |
Protein containing a C-terminal SH3 domain |
physical |
1 |
1 |
1 |
Two-hybrid |
| CCT8 |
YJL008C |
Subunit of the cytosolic chaperonin Cct ring complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| PRP9 |
YDL030W |
Subunit of the SF3a splicing factor complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CRN1 |
YLR429W |
Coronin |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ROM2 |
YLR371W |
Guanine nucleotide exchange factor (GEF) for Rho1p and Rho2p |
genetic |
1 |
1 |
1 |
Positive Genetic |
| PTC1 |
YDL006W |
Type 2C protein phosphatase (PP2C) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SBP1 |
YHL034C |
Protein that binds eIF4G and has a role in repression of translation |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
| NEW1 |
YPL226W |
Translation termination and ribosome biogenesis factor |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MKS1 |
YNL076W |
Pleiotropic negative transcriptional regulator |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RPT4 |
YOR259C |
ATPase of the 19S regulatory particle of the 26S proteasome |
genetic |
1 |
1 |
1 |
Negative Genetic |
| DRS2 |
YAL026C |
Trans-golgi network aminophospholipid translocase (flippase) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| HEK2 |
YBL032W |
RNA binding protein involved in asymmetric localization of ASH1 mRNA |
genetic |
1 |
1 |
1 |
Negative Genetic |
| BOI1 |
YBL085W |
Protein involved in polar growth, functionally redundant with Boi2p |
physical |
1 |
1 |
1 |
PCA |
| PUF3 |
YLL013C |
Protein of the mitochondrial outer surface |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
| DNM1 |
YLL001W |
Dynamin-related GTPase involved in mitochondrial organization |
genetic |
1 |
1 |
1 |
Negative Genetic |
| HYP2 |
YEL034W |
Translation elongation factor eIF-5A |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CAF20 |
YOR276W |
Phosphoprotein of the mRNA cap-binding complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| DCS1 |
YLR270W |
Non-essential hydrolase involved in mRNA decapping |
genetic |
1 |
1 |
1 |
Negative Genetic |
| AAT2 |
YLR027C |
Cytosolic aspartate aminotransferase involved in nitrogen metabolism |
genetic |
1 |
1 |
1 |
Negative Genetic |
| LIA1 |
YJR070C |
Deoxyhypusine hydroxylase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MRS6 |
YOR370C |
Rab escort protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| IPA1 |
YJR141W |
Protein implicated in pre-mRNA processing and proteasomal degradation |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RVS167 |
YDR388W |
Calmodulin-binding actin-associated protein |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| HIR1 |
YBL008W |
Subunit of the HIR complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
| BUD7 |
YOR299W |
Member of the ChAPs family (Chs5p-Arf1p-binding proteins) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ATG20 |
YDL113C |
Sorting nexin family member |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MDH2 |
YOL126C |
Cytoplasmic malate dehydrogenase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| LSM8 |
YJR022W |
Lsm (Like Sm) protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| DBF2 |
YGR092W |
Ser/Thr kinase involved in transcription and stress response |
genetic |
1 |
1 |
1 |
Positive Genetic |
| ESS1 |
YJR017C |
Peptidylprolyl-cis/trans-isomerase (PPIase) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| DDI1 |
YER143W |
Aspartic-type endopeptidase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CIT2 |
YCR005C |
Citrate synthase, peroxisomal isozyme involved in glyoxylate cycle |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RAD4 |
YER162C |
Damaged-DNA binding subunit of Nuclear Excision Repair Factor 2 |
genetic |
1 |
1 |
1 |
Negative Genetic |
| PIR5 |
YJL160C |
Putative protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RFT1 |
YBL020W |
Membrane protein required for translocation of Man5GlcNac2-PP-Dol |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RPL9B |
YNL067W |
Ribosomal 60S subunit protein L9B |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RPL22A |
YLR061W |
Ribosomal 60S subunit protein L22A |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ATG23 |
YLR431C |
Peripheral membrane protein required for autophagy and CVT |
genetic |
1 |
1 |
1 |
Negative Genetic |
| BUB1 |
YGR188C |
Protein kinase involved in the cell cycle checkpoint into anaphase |
genetic |
1 |
1 |
1 |
Positive Genetic |
| FRQ1 |
YDR373W |
N-myristoylated calcium-binding protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| OST2 |
YOR103C |
Epsilon subunit of the oligosaccharyltransferase complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
| RTG2 |
YGL252C |
Sensor of mitochondrial dysfunction |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SBH1 |
YER087C-B |
Beta subunit of Sec61p ER translocation complex (Sec61p-Sss1p-Sbh1p) |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
| SBH1 |
YER087C-B |
Beta subunit of Sec61p ER translocation complex (Sec61p-Sss1p-Sbh1p) |
genetic |
1 |
1 |
1 |
Dosage Rescue |
| SEC1 |
YDR164C |
Sm-like protein involved in docking and fusion of exocytic vesicles |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
| SEC22 |
YLR268W |
R-SNARE protein |
physical |
1 |
1 |
1 |
Reconstituted Complex |
| RRN7 |
YJL025W |
Component of the core factor (CF) rDNA transcription factor complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SEC2 |
YNL272C |
Guanyl-nucleotide exchange factor for the small G-protein Sec4p |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
| POL3 |
YDL102W |
Catalytic subunit of DNA polymerase delta |
genetic |
1 |
1 |
1 |
Negative Genetic |
| DOT1 |
YDR440W |
Nucleosomal histone H3-Lys79 methylase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MON1 |
YGL124C |
Subunit of a heterodimeric guanine nucleotide exchange factor (GEF) |
genetic |
1 |
1 |
1 |
Positive Genetic |
| DJP1 |
YIR004W |
ER-associated chaperone involved in protein targeting |
genetic |
1 |
1 |
1 |
Negative Genetic |
| OSH3 |
YHR073W |
Member of an oxysterol-binding protein family |
genetic |
1 |
1 |
1 |
Negative Genetic |
| PRI1 |
YIR008C |
Subunit of DNA primase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| BET4 |
YJL031C |
Alpha subunit of Type II geranylgeranyltransferase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RNR4 |
YGR180C |
Ribonucleotide-diphosphate reductase (RNR) small subunit |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RTN1 |
YDR233C |
Reticulon protein |
genetic |
1 |
1 |
1 |
Dosage Growth Defect |
| EPO1 |
YMR124W |
Protein involved in septin-ER tethering |
genetic |
1 |
1 |
1 |
Positive Genetic |
| ATP18 |
YML081C-A |
Subunit of the mitochondrial F1F0 ATP synthase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ERG2 |
YMR202W |
C-8 sterol isomerase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SRO7 |
YPR032W |
Effector of Rab GTPase Sec4p |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
| YSC84 |
YHR016C |
Actin-binding protein |
physical |
1 |
1 |
1 |
Two-hybrid |
| SSA1 |
YAL005C |
ATPase involved in protein folding and NLS-directed nuclear transport |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| SNC2 |
YOR327C |
Vesicle membrane receptor protein (v-SNARE) |
physical |
1 |
1 |
1 |
Reconstituted Complex |
| SSO2 |
YMR183C |
Plasma membrane t-SNARE |
physical |
1 |
1 |
1 |
Reconstituted Complex |
| SSO2 |
YMR183C |
Plasma membrane t-SNARE |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SEC8 |
YPR055W |
Essential 121 kDa subunit of the exocyst complex |
physical |
1 |
1 |
1 |
Reconstituted Complex |
| YPT1 |
YFL038C |
Rab family GTPase |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| SSS1 |
YDR086C |
Subunit of the Sec61p translocation complex (Sec61p-Sss1p-Sbh1p) |
genetic |
1 |
1 |
1 |
Dosage Rescue |
| SLT2 |
YHR030C |
Serine/threonine MAP kinase |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| TEL2 |
YGR099W |
Subunit of the ASTRA complex, involved in chromatin remodeling |
genetic |
1 |
1 |
1 |
Positive Genetic |
| YCK2 |
YNL154C |
Palmitoylated plasma membrane-bound casein kinase I (CK1) isoform |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| TAF5 |
YBR198C |
Subunit (90 kDa) of TFIID and SAGA complexes |
genetic |
1 |
1 |
1 |
Positive Genetic |
| USE1 |
YGL098W |
Essential SNARE protein localized to the ER |
genetic |
1 |
1 |
1 |
Positive Genetic |
| SMD1 |
YGR074W |
Core Sm protein Sm D1 |
genetic |
1 |
1 |
1 |
Positive Genetic |
| VBA1 |
YMR088C |
Permease of basic amino acids in the vacuolar membrane |
genetic |
1 |
1 |
1 |
Positive Genetic |
| TIF34 |
YMR146C |
eIF3i subunit of the eukaryotic translation initiation factor 3 (eIF3) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SMT3 |
YDR510W |
Ubiquitin-like protein of the SUMO family |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SKI6 |
YGR195W |
Exosome non-catalytic core component |
genetic |
1 |
1 |
1 |
Negative Genetic |
| UTP15 |
YMR093W |
Nucleolar protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SLU7 |
YDR088C |
RNA splicing factor |
genetic |
1 |
1 |
1 |
Negative Genetic |
| TCP1 |
YDR212W |
Alpha subunit of chaperonin-containing T-complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SPT15 |
YER148W |
TATA-binding protein (TBP) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| TAD3 |
YLR316C |
Subunit of tRNA-specific adenosine-34 deaminase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SWF1 |
YDR126W |
Palmitoyltransferase that acts on transmembrane proteins |
genetic |
1 |
1 |
1 |
Negative Genetic |
| YAP3 |
YHL009C |
Basic leucine zipper (bZIP) transcription factor |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SRB2 |
YHR041C |
Subunit of the RNA polymerase II mediator complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SOL3 |
YHR163W |
6-phosphogluconolactonase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| VPS53 |
YJL029C |
Component of the GARP (Golgi-associated retrograde protein) complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| YJL213W |
YJL213W |
Protein of unknown function that may interact with ribosomes |
genetic |
1 |
1 |
1 |
Negative Genetic |
| YJR084W |
YJR084W |
Protein that forms a complex with Thp3p |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SND2 |
YLR065C |
Protein involved in SRP-independent targeting of substrates to the ER |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SST2 |
YLR452C |
GTPase-activating protein for Gpa1p |
genetic |
1 |
1 |
1 |
Negative Genetic |
| UBX2 |
YML013W |
Bridging factor involved in ER-associated protein degradation (ERAD) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SIW14 |
YNL032W |
Inositol phosphatase involved in inositol pyrophosphate metabolism |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SIN3 |
YOL004W |
Component of both the Rpd3S and Rpd3L histone deacetylase complexes |
genetic |
1 |
1 |
1 |
Negative Genetic |
| TLG2 |
YOL018C |
Syntaxin-like t-SNARE |
genetic |
1 |
1 |
1 |
Negative Genetic |
| WHI5 |
YOR083W |
Repressor of G1 transcription |
genetic |
1 |
1 |
1 |
Negative Genetic |
| YAR1 |
YPL239W |
Nucleocytoplasmic shuttling assembly chaperone |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SPO7 |
YAL009W |
Putative regulatory subunit of Nem1p-Spo7p phosphatase holoenzyme |
genetic |
1 |
1 |
1 |
Negative Genetic |
| YBL086C |
YBL086C |
Protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
| YCR007C |
YCR007C |
Putative integral membrane protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SHS1 |
YDL225W |
Component of the septin ring that is required for cytokinesis |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SWA2 |
YDR320C |
Auxilin-like protein involved in vesicular transport |
genetic |
1 |
1 |
1 |
Negative Genetic |
| VAN1 |
YML115C |
Component of the mannan polymerase I |
genetic |
1 |
1 |
1 |
Negative Genetic |
| YKU80 |
YMR106C |
Subunit of telomeric Ku complex (Yku70p-Yku80p) |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| SIR2 |
YDL042C |
Conserved NAD+ dependent histone deacetylase of the Sirtuin family |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| SHR5 |
YOL110W |
Palmitoyltransferase subunit |
genetic |
1 |
1 |
1 |
Negative Genetic |
| VPS17 |
YOR132W |
Subunit of the membrane-associated retromer complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
| SET1 |
YHR119W |
Histone methyltransferase, subunit of the COMPASS (Set1C) complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| KEX1 |
YGL203C |
Cell death protease essential for hypochlorite-induced apoptosis |
genetic |
1 |
1 |
1 |
Negative Genetic |
| HRQ1 |
YDR291W |
3'-5' DNA helicase of the conserved RecQ family |
genetic |
1 |
1 |
1 |
Positive Genetic |
| RPL37A |
YLR185W |
Ribosomal 60S subunit protein L37A |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SAC1 |
YKL212W |
Phosphatidylinositol phosphate phosphatase |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
| RPS10A |
YOR293W |
Protein component of the small (40S) ribosomal subunit |
genetic |
1 |
1 |
1 |
Negative Genetic |
| PIK1 |
YNL267W |
Phosphatidylinositol 4-kinase |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| GAS3 |
YMR215W |
Putative 1,3-beta-glucanosyltransferase |
genetic |
1 |
1 |
1 |
Positive Genetic |
| POT1 |
YIL160C |
3-ketoacyl-CoA thiolase with broad chain length specificity |
genetic |
1 |
1 |
1 |
Positive Genetic |
| RPS27B |
YHR021C |
Protein component of the small (40S) ribosomal subunit |
genetic |
1 |
1 |
1 |
Negative Genetic |
| NCB2 |
YDR397C |
Subunit of a heterodimeric NC2 transcription regulator complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| LDB18 |
YLL049W |
Component of the dynactin complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SCS7 |
YMR272C |
Sphingolipid alpha-hydroxylase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| KRE1 |
YNL322C |
Cell wall glycoprotein involved in beta-glucan assembly |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CDC8 |
YJR057W |
Nucleoside monophosphate and nucleoside diphosphate kinase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| DSC3 |
YOR223W |
Subunit of the DSC ubiquitin ligase complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| GCG1 |
YER163C |
Gamma-glutamyl cyclotransferase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| PTH1 |
YHR189W |
One of two mitochondrially-localized peptidyl-tRNA hydrolases |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SDH5 |
YOL071W |
Protein required for flavinylation of Sdh1p |
genetic |
1 |
1 |
1 |
Negative Genetic |
| LCL3 |
YGL085W |
Putative protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ODC2 |
YOR222W |
Mitochondrial inner membrane transporter |
genetic |
1 |
1 |
1 |
Negative Genetic |
| KCH1 |
YJR054W |
Potassium transporter that mediates K+ influx |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RIT1 |
YMR283C |
Initiator methionine 2'-O-ribosyl phosphate transferase |
genetic |
1 |
1 |
1 |
Positive Genetic |
| MNE1 |
YOR350C |
Protein involved in splicing Group I aI5-beta intron from COX1 mRNA |
genetic |
1 |
1 |
1 |
Negative Genetic |
| NIT1 |
YIL164C |
Nitrilase |
genetic |
1 |
1 |
1 |
Positive Genetic |
