Standard name Systematic name Name description Description
DDI1 YER143W Aspartic-type endopeptidase Aspartic-type endopeptidase; involved in the cleavage of long-chain polyubiquitinated substrates; role in proteasome-independent, ubiquitin (Ub)-dependent proteolysis and DNA-protein crosslink repair; Ub-shuttle receptor for HO and Ufo1p; DNA damage-inducible v-SNARE binding protein and negative regulator of constitutive exocytosis; possible role in the S-phase checkpoint; UBL-UBA family member containing Ub-like (UBL), helical, Ub-associated (UBA) and retroviral-like proteinase (RVP) domains
Visualize the interactome of DDI1
Links to external databases:
  SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)

CYCLoPs localization & abundance

WT1 WT2 WT3
Cytoplasm 0.98 0.956 0.977

GFP localization & abundance

GFP localization GFP abundance
cytoplasm 6510

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
DDI1 3 0 0 0 1

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
UBI4 YLL039C Ubiquitin physical 13 5 10 Two-hybrid, Two-hybrid, Reconstituted Complex, Affinity Capture-Western, Reconstituted Complex, Affinity Capture-Western, Co-crystal Structure, Reconstituted Complex, Reconstituted Complex, Reconstituted Complex, Affinity Capture-Western, Biochemical Activity, Reconstituted Complex
DDI1 YER143W Aspartic-type endopeptidase physical 6 4 4 Co-crystal Structure, Reconstituted Complex, Two-hybrid, Affinity Capture-Western, Co-crystal Structure, Reconstituted Complex
WSS1 YHR134W SUMO-ligase and SUMO-targeted metalloprotease genetic 6 3 4 Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Dosage Rescue
RPN1 YHR027C Non-ATPase base subunit of the 19S RP of the 26S proteasome physical 5 2 4 Affinity Capture-Western, Two-hybrid, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western
RAD23 YEL037C Protein with ubiquitin-like N terminus physical 5 4 3 Two-hybrid, Two-hybrid, Affinity Capture-Western, Co-fractionation, Reconstituted Complex
UFO1 YML088W F-box receptor protein physical 5 3 2 Two-hybrid, Affinity Capture-Western, Reconstituted Complex, Affinity Capture-Western, Affinity Capture-Western
SEC9 YGR009C t-SNARE protein required for secretory vesicle-plasma membrane fusion genetic 4 4 3 Dosage Growth Defect, Synthetic Growth Defect, Phenotypic Enhancement, Dosage Rescue
RAD23 YEL037C Protein with ubiquitin-like N terminus genetic 4 2 3 Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Suppression, Phenotypic Enhancement
RPN11 YFR004W Metalloprotease subunit of 19S regulatory particle physical 3 2 3 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western
HO YDL227C Site-specific endonuclease physical 3 1 3 Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western
SNC2 YOR327C Vesicle membrane receptor protein (v-SNARE) physical 3 2 2 Affinity Capture-Western, Two-hybrid, Affinity Capture-Western
SSO1 YPL232W Plasma membrane t-SNARE physical 3 2 2 Affinity Capture-Western, Reconstituted Complex, Affinity Capture-Western
RPN12 YFR052W Subunit of the 19S regulatory particle of the 26S proteasome lid genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
RPO21 YDL140C RNA polymerase II largest subunit B220 regulation 3 3 1 immunoprecipitation evidence, mutant phenotype evidence, qualitative western immunoblotting evidence
DBR1 YKL149C RNA lariat debranching enzyme genetic 2 2 2 Phenotypic Suppression, Positive Genetic
SNC1 YAL030W Vesicle membrane receptor protein (v-SNARE) physical 2 1 2 Affinity Capture-Western, Affinity Capture-Western
RPN11 YFR004W Metalloprotease subunit of 19S regulatory particle genetic 2 1 2 Negative Genetic, Negative Genetic
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator physical 2 1 2 Affinity Capture-RNA, Affinity Capture-RNA
PDS1 YDR113C Securin genetic 2 1 2 Dosage Rescue, Dosage Rescue
RML2 YEL050C Mitochondrial ribosomal protein of the large subunit (L2) genetic 2 1 2 Negative Genetic, Negative Genetic
DSK2 YMR276W Nuclear-enriched ubiquitin-like polyubiquitin-binding protein genetic 2 1 2 Phenotypic Enhancement, Phenotypic Enhancement
RPT4 YOR259C ATPase of the 19S regulatory particle of the 26S proteasome genetic 2 1 2 Negative Genetic, Negative Genetic
CDC48 YDL126C AAA ATPase with protein-unfoldase activity physical 2 2 1 Affinity Capture-MS, Affinity Capture-Western
NPL4 YBR170C Substrate-recruiting cofactor of the Cdc48p-Npl4p-Ufd1p segregase genetic 2 2 1 Dosage Rescue, Phenotypic Suppression
TDP1 YBR223C Tyrosyl-DNA phosphodiesterase I genetic 2 2 1 Synthetic Growth Defect, Dosage Rescue
CDC53 YDL132W Cullin physical 2 1 1 Affinity Capture-Western, Affinity Capture-Western
IPA1 YJR141W Protein implicated in pre-mRNA processing and proteasomal degradation physical 2 1 1 Two-hybrid, Two-hybrid
CPS1 YJL172W Vacuolar carboxypeptidase S physical 2 1 1 Affinity Capture-Western, Affinity Capture-Western
FKH1 YIL131C Forkhead family transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
FKH2 YNL068C Forkhead family transcription factor regulation 1 1 1 chromatin immunoprecipitation- exonuclease evidence
YAP6 YDR259C Basic leucine zipper (bZIP) transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
TFC7 YOR110W RNA pol III transcription initiation factor complex (TFIIIC) subunit regulation 1 1 1 chromatin immunoprecipitation-chip evidence
SUA7 YPR086W Transcription factor TFIIB regulation 1 1 1 chromatin immunoprecipitation-chip evidence
CDC48 YDL126C AAA ATPase with protein-unfoldase activity genetic 1 1 1 Phenotypic Suppression
ACT1 YFL039C Actin, structural protein in cytoskeleton genetic 1 1 1 Negative Genetic
CCR4 YAL021C Component of the CCR4-NOT transcriptional complex physical 1 1 1 Affinity Capture-RNA
ARP3 YJR065C Essential component of the Arp2/3 complex genetic 1 1 1 Negative Genetic
BOI2 YER114C Protein involved in polar growth genetic 1 1 1 Negative Genetic
ACE2 YLR131C Transcription factor required for septum destruction after cytokinesis genetic 1 1 1 Negative Genetic
BDH2 YAL061W Putative medium-chain alcohol dehydrogenase with similarity to BDH1 genetic 1 1 1 Negative Genetic
BUB2 YMR055C Mitotic exit network regulator physical 1 1 1 Two-hybrid
CMK1 YFR014C Calmodulin-dependent protein kinase physical 1 1 1 Biochemical Activity
ACS2 YLR153C Acetyl-coA synthetase isoform genetic 1 1 1 Negative Genetic
CDC37 YDR168W Essential Hsp90p co-chaperone genetic 1 1 1 Negative Genetic
CRC1 YOR100C Mitochondrial inner membrane carnitine transporter genetic 1 1 1 Negative Genetic
DAD1 YDR016C Essential subunit of the Dam1 complex (aka DASH complex) genetic 1 1 1 Negative Genetic
SSO1 YPL232W Plasma membrane t-SNARE genetic 1 1 1 Synthetic Rescue
TLG1 YDR468C Essential t-SNARE that mediates fusion of vesicles with the late Golgi physical 1 1 1 Affinity Capture-Western
TLG2 YOL018C Syntaxin-like t-SNARE physical 1 1 1 Affinity Capture-Western
TLG2 YOL018C Syntaxin-like t-SNARE genetic 1 1 1 Negative Genetic
RPN12 YFR052W Subunit of the 19S regulatory particle of the 26S proteasome lid physical 1 1 1 Affinity Capture-Western
MPP6 YNR024W Nuclear exosome-associated RNA binding protein physical 1 1 1 Affinity Capture-MS
UFO1 YML088W F-box receptor protein genetic 1 1 1 Dosage Growth Defect
PHO81 YGR233C Cyclin-dependent kinase (CDK) inhibitor physical 1 1 1 Two-hybrid
RPN10 YHR200W Proteasome polyubiquitin receptor physical 1 1 1 Affinity Capture-Western
RPS27A YKL156W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-Western
RPT5 YOR117W ATPase of the 19S regulatory particle of the 26S proteasome physical 1 1 1 Reconstituted Complex
RPT5 YOR117W ATPase of the 19S regulatory particle of the 26S proteasome genetic 1 1 1 Negative Genetic
RPN9 YDR427W Non-ATPase regulatory subunit of the 26S proteasome physical 1 1 1 Affinity Capture-Western
RUB1 YDR139C Ubiquitin-like protein with similarity to mammalian NEDD8 physical 1 1 1 Co-crystal Structure
SSB2 YNL209W Cytoplasmic ATPase that is a ribosome-associated molecular chaperone physical 1 1 1 Co-purification
SCP160 YJL080C Essential RNA-binding G protein effector of mating response pathway physical 1 1 1 Affinity Capture-MS
PSG1 YKL077W Protein that promotes the transport and maturation of Pma1 with Exp1 physical 1 1 1 Affinity Capture-MS
MPT5 YGL178W mRNA-binding protein of the PUF family physical 1 1 1 Affinity Capture-RNA
MCA1 YOR197W Ca2+-dependent cysteine protease physical 1 1 1 Biochemical Activity
NPL4 YBR170C Substrate-recruiting cofactor of the Cdc48p-Npl4p-Ufd1p segregase physical 1 1 1 Affinity Capture-Western
MPS3 YJL019W Nuclear envelope protein physical 1 1 1 Affinity Capture-MS
SEC61 YLR378C Conserved ER protein translocation channel physical 1 1 1 Affinity Capture-MS
POP7 YBR167C Subunit of RNase MRP, nuclear RNase P and telomerase genetic 1 1 1 Negative Genetic
NOP12 YOL041C Nucleolar protein involved in pre-25S rRNA processing genetic 1 1 1 Negative Genetic
KAP120 YPL125W Karyopherin responsible for the nuclear import of Rpf1p genetic 1 1 1 Negative Genetic
YAR029W YAR029W Member of DUP240 gene family but contains no transmembrane domains genetic 1 1 1 Negative Genetic
SSY1 YDR160W Component of the SPS plasma membrane amino acid sensor system genetic 1 1 1 Negative Genetic
EMI1 YDR512C Non-essential protein of unknown function genetic 1 1 1 Negative Genetic
UTR2 YEL040W Chitin transglycosylase genetic 1 1 1 Negative Genetic
GYP6 YJL044C GTPase-activating protein (GAP) for yeast Rab family member Ypt6p genetic 1 1 1 Negative Genetic
RAP1 YNL216W Essential DNA-binding transcription regulator that binds many loci genetic 1 1 1 Positive Genetic
PET20 YPL159C Mitochondrial protein genetic 1 1 1 Negative Genetic
SLT2 YHR030C Serine/threonine MAP kinase genetic 1 1 1 Dosage Growth Defect
MAK16 YAL025C Essential nuclear protein genetic 1 1 1 Negative Genetic
RPN6 YDL097C Essential, non-ATPase regulatory subunit of the 26S proteasome lid genetic 1 1 1 Negative Genetic
RPT6 YGL048C ATPase of the 19S regulatory particle of the 26S proteasome genetic 1 1 1 Negative Genetic
RPP1 YHR062C Subunit of both RNase MRP and nuclear RNase P genetic 1 1 1 Negative Genetic
PAM16 YJL104W Subunit of the import motor (PAM complex) genetic 1 1 1 Negative Genetic
URA6 YKL024C Uridylate kinase genetic 1 1 1 Negative Genetic
RPC25 YKL144C RNA polymerase III subunit C25 genetic 1 1 1 Negative Genetic
RPP0 YLR340W Conserved ribosomal protein P0 of the ribosomal stalk genetic 1 1 1 Negative Genetic
RPN8 YOR261C Essential non-ATPase regulatory subunit of the 26S proteasome genetic 1 1 1 Negative Genetic
RAD53 YPL153C DNA damage response kinase genetic 1 1 1 Negative Genetic
SEC8 YPR055W Essential 121 kDa subunit of the exocyst complex genetic 1 1 1 Negative Genetic
RPN7 YPR108W Essential non-ATPase regulatory subunit of the 26S proteasome genetic 1 1 1 Negative Genetic
SMX3 YPR182W Core Sm protein Sm F genetic 1 1 1 Negative Genetic
PRP9 YDL030W Subunit of the SF3a splicing factor complex genetic 1 1 1 Negative Genetic
NUP57 YGR119C FG-nucleoporin component of central core of the nuclear pore complex genetic 1 1 1 Negative Genetic
MET30 YIL046W F-box protein containing five copies of the WD40 motif genetic 1 1 1 Negative Genetic
MCM1 YMR043W Transcription factor genetic 1 1 1 Negative Genetic
KAP104 YBR017C Transportin or cytosolic karyopherin beta 2 genetic 1 1 1 Negative Genetic
RGD1 YBR260C GTPase-activating protein (RhoGAP) for Rho3p and Rho4p genetic 1 1 1 Negative Genetic
DTD1 YDL219W D-Tyr-tRNA(Tyr) deacylase genetic 1 1 1 Negative Genetic
MRP20 YDR405W Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Negative Genetic
RTC2 YBR147W Putative vacuolar membrane transporter for cationic amino acids genetic 1 1 1 Negative Genetic
LSM7 YNL147W Lsm (Like Sm) protein genetic 1 1 1 Negative Genetic
TYW3 YGL050W tRNA methyltransferase required for synthesis of wybutosine genetic 1 1 1 Negative Genetic
MRF1 YGL143C Mitochondrial translation release factor genetic 1 1 1 Negative Genetic
YGR016W YGR016W Putative protein of unknown function genetic 1 1 1 Negative Genetic
YIL152W YIL152W Putative protein of unknown function genetic 1 1 1 Negative Genetic
RSM26 YJR101W Mitochondrial ribosomal protein of the small subunit genetic 1 1 1 Negative Genetic
TUL1 YKL034W Subunit of the DSC ubiquitin ligase complex genetic 1 1 1 Negative Genetic
YLR159W YLR159W Putative protein of unknown function genetic 1 1 1 Negative Genetic
RSO55 YLR281C Mitochondrial protein of unknown function genetic 1 1 1 Negative Genetic
YML100W-A YML100W-A Putative protein of unknown function genetic 1 1 1 Negative Genetic
TOM7 YNL070W Component of the TOM (translocase of outer membrane) complex genetic 1 1 1 Negative Genetic
YNR061C YNR061C Protein of unknown function genetic 1 1 1 Negative Genetic
ERP4 YOR016C Member of the p24 family involved in ER to Golgi transport genetic 1 1 1 Negative Genetic
WHI2 YOR043W Negative regulator of TORC1 in response to limiting leucine genetic 1 1 1 Negative Genetic
MDM32 YOR147W Mitochondrial inner membrane protein with similarity to Mdm31p genetic 1 1 1 Negative Genetic
VTS1 YOR359W Flap-structured DNA-binding and RNA-binding protein genetic 1 1 1 Negative Genetic
FIT2 YOR382W Mannoprotein that is incorporated into the cell wall genetic 1 1 1 Negative Genetic
TPK2 YPL203W cAMP-dependent protein kinase catalytic subunit genetic 1 1 1 Negative Genetic
YNG2 YHR090C Subunit of NuA4, an essential histone acetyltransferase complex genetic 1 1 1 Negative Genetic
UFD1 YGR048W Substrate-recruiting cofactor of the Cdc48p-Npl4p-Ufd1p segregase genetic 1 1 1 Phenotypic Suppression
CST9 YLR394W SUMO E3 ligase genetic 1 1 1 Negative Genetic
AHK1 YDL073W Scaffold protein in the HKR1 sub-branch of the Hog1p-signaling pathway genetic 1 1 1 Negative Genetic
AIM23 YJL131C Mitochondrial translation initiation factor 3 (IF3, mIF3) genetic 1 1 1 Negative Genetic
COA3 YJL062W-A Mitochondrial protein required for cytochrome c oxidase assembly genetic 1 1 1 Negative Genetic
ABZ2 YMR289W Aminodeoxychorismate lyase (4-amino-4-deoxychorismate lyase) genetic 1 1 1 Negative Genetic
APJ1 YNL077W Hsp40 chaperone with a role in SUMO-mediated protein degradation physical 1 1 1 Affinity Capture-MS
CDC50 YCR094W Endosomal protein that interacts with phospholipid flippase Drs2p genetic 1 1 1 Negative Genetic