RPN10 |
YHR200W |
Proteasome polyubiquitin receptor |
genetic |
7 |
2 |
5 |
Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic |
LAG2 |
YOL025W |
Protein that negatively regulates the SCF E3-ubiquitin ligase |
genetic |
4 |
3 |
2 |
Synthetic Growth Defect, Synthetic Rescue, Dosage Growth Defect, Synthetic Growth Defect |
RPN11 |
YFR004W |
Metalloprotease subunit of 19S regulatory particle |
genetic |
3 |
2 |
3 |
Negative Genetic, Negative Genetic, Synthetic Growth Defect |
CDC34 |
YDR054C |
Ubiquitin-conjugating enzyme (E2) |
genetic |
3 |
2 |
3 |
Synthetic Lethality, Dosage Rescue, Synthetic Lethality |
CDC4 |
YFL009W |
F-box protein required for both the G1/S and G2/M phase transitions |
genetic |
3 |
1 |
3 |
Negative Genetic, Negative Genetic, Negative Genetic |
CDC48 |
YDL126C |
AAA ATPase with protein-unfoldase activity |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
RPN12 |
YFR052W |
Subunit of the 19S regulatory particle of the 26S proteasome lid |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
GTR1 |
YML121W |
Subunit of a TORC1-stimulating GTPase and the EGO/GSE complex |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
SKP1 |
YDR328C |
Evolutionarily conserved kinetochore protein |
physical |
2 |
1 |
2 |
Two-hybrid, Two-hybrid |
YJL163C |
YJL163C |
Putative protein of unknown function |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
RPN10 |
YHR200W |
Proteasome polyubiquitin receptor |
physical |
2 |
2 |
1 |
Co-crystal Structure, Reconstituted Complex |
ATP10 |
YLR393W |
Assembly factor for the F0 sector of mitochondrial F1F0 ATP synthase |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
SFP1 |
YLR403W |
Regulates transcription of ribosomal protein and biogenesis genes |
regulation |
1 |
1 |
1 |
DNA to cDNA expression microarray evidence |
GCN5 |
YGR252W |
Catalytic subunit of ADA and SAGA histone acetyltransferase complexes |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
IXR1 |
YKL032C |
Transcriptional repressor that regulates hypoxic genes during normoxia |
regulation |
1 |
1 |
1 |
DNA to cDNA expression microarray evidence |
RGT2 |
YDL138W |
Plasma membrane high glucose sensor that regulates glucose transport |
genetic |
1 |
1 |
1 |
Negative Genetic |
POP8 |
YBL018C |
Subunit of both RNase MRP and nuclear RNase P |
genetic |
1 |
1 |
1 |
Negative Genetic |
PRP40 |
YKL012W |
U1 snRNP protein involved in splicing |
physical |
1 |
1 |
1 |
Protein-peptide |
RPN1 |
YHR027C |
Non-ATPase base subunit of the 19S RP of the 26S proteasome |
physical |
1 |
1 |
1 |
Reconstituted Complex |
RPN11 |
YFR004W |
Metalloprotease subunit of 19S regulatory particle |
physical |
1 |
1 |
1 |
Biochemical Activity |
RPN7 |
YPR108W |
Essential non-ATPase regulatory subunit of the 26S proteasome |
genetic |
1 |
1 |
1 |
Negative Genetic |
ACT1 |
YFL039C |
Actin, structural protein in cytoskeleton |
genetic |
1 |
1 |
1 |
Negative Genetic |
NAB2 |
YGL122C |
Nuclear polyadenylated RNA-binding protein |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
APC1 |
YNL172W |
Largest subunit of the Anaphase-Promoting Complex/Cyclosome |
genetic |
1 |
1 |
1 |
Positive Genetic |
CDC3 |
YLR314C |
Component of the septin ring that is required for cytokinesis |
genetic |
1 |
1 |
1 |
Negative Genetic |
CSI1 |
YMR025W |
Subunit of the Cop9 signalosome |
genetic |
1 |
1 |
1 |
Positive Genetic |
PTC1 |
YDL006W |
Type 2C protein phosphatase (PP2C) |
genetic |
1 |
1 |
1 |
Positive Genetic |
HYP2 |
YEL034W |
Translation elongation factor eIF-5A |
genetic |
1 |
1 |
1 |
Negative Genetic |
DDC1 |
YPL194W |
DNA damage checkpoint protein |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
MET30 |
YIL046W |
F-box protein containing five copies of the WD40 motif |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
DSK2 |
YMR276W |
Nuclear-enriched ubiquitin-like polyubiquitin-binding protein |
physical |
1 |
1 |
1 |
Reconstituted Complex |
RSP5 |
YER125W |
NEDD4 family E3 ubiquitin ligase |
physical |
1 |
1 |
1 |
Protein-peptide |
RAD24 |
YER173W |
Checkpoint protein |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
KIN28 |
YDL108W |
Ser/Thr protein kinase and subunit of TFIIK, a TFIIH subassembly |
genetic |
1 |
1 |
1 |
Negative Genetic |
PAP2 |
YOL115W |
Non-canonical poly(A) polymerase |
genetic |
1 |
1 |
1 |
Positive Genetic |
MMS22 |
YLR320W |
Subunit of E3 ubiquitin ligase complex involved in replication repair |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
CRC1 |
YOR100C |
Mitochondrial inner membrane carnitine transporter |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
ESS1 |
YJR017C |
Peptidylprolyl-cis/trans-isomerase (PPIase) |
physical |
1 |
1 |
1 |
Protein-peptide |
DDI1 |
YER143W |
Aspartic-type endopeptidase |
physical |
1 |
1 |
1 |
Co-crystal Structure |
YUH1 |
YJR099W |
Ubiquitin C-terminal hydrolase |
physical |
1 |
1 |
1 |
Biochemical Activity |
RUD3 |
YOR216C |
Golgi matrix protein |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
SET2 |
YJL168C |
Histone methyltransferase with a role in transcriptional elongation |
physical |
1 |
1 |
1 |
Protein-peptide |
SLF1 |
YDR515W |
RNA binding protein that associates with polysomes |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
UBA3 |
YPR066W |
Protein that activates Rub1p (NEDD8) before neddylation |
physical |
1 |
1 |
1 |
Reconstituted Complex |
SPT16 |
YGL207W |
Subunit of the heterodimeric FACT complex (Spt16p-Pob3p) |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
SEC66 |
YBR171W |
Non-essential subunit of Sec63 complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
TOP1 |
YOL006C |
Topoisomerase I |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
UBC4 |
YBR082C |
Ubiquitin-conjugating enzyme (E2) |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
TFB3 |
YDR460W |
Subunit of TFIIH and nucleotide excision repair factor 3 complexes |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
USA1 |
YML029W |
Scaffold subunit of the Hrd1p ubiquitin ligase |
genetic |
1 |
1 |
1 |
Positive Genetic |
SLA2 |
YNL243W |
Adaptor protein that links actin to clathrin and endocytosis |
genetic |
1 |
1 |
1 |
Positive Genetic |
USE1 |
YGL098W |
Essential SNARE protein localized to the ER |
genetic |
1 |
1 |
1 |
Negative Genetic |
TAF3 |
YPL011C |
TFIID subunit (47 kDa) |
genetic |
1 |
1 |
1 |
Negative Genetic |
SHP1 |
YBL058W |
UBX domain-containing substrate adaptor for Cdc48p |
genetic |
1 |
1 |
1 |
Negative Genetic |
YJR084W |
YJR084W |
Protein that forms a complex with Thp3p |
genetic |
1 |
1 |
1 |
Negative Genetic |
SIN3 |
YOL004W |
Component of both the Rpd3S and Rpd3L histone deacetylase complexes |
genetic |
1 |
1 |
1 |
Negative Genetic |
ULA1 |
YPL003W |
Protein that activates Rub1p (NEDD8) before neddylation |
genetic |
1 |
1 |
1 |
Negative Genetic |
SRO7 |
YPR032W |
Effector of Rab GTPase Sec4p |
genetic |
1 |
1 |
1 |
Negative Genetic |
SGS1 |
YMR190C |
RecQ family nucleolar DNA helicase |
genetic |
1 |
1 |
1 |
Negative Genetic |
YPC1 |
YBR183W |
Alkaline ceramidase |
genetic |
1 |
1 |
1 |
Negative Genetic |
RLP24 |
YLR009W |
Essential protein required for ribosomal large subunit biogenesis |
genetic |
1 |
1 |
1 |
Positive Genetic |
RTG3 |
YBL103C |
bHLH/Zip transcription factor for retrograde (RTG) and TOR pathways |
genetic |
1 |
1 |
1 |
Negative Genetic |
RAD17 |
YOR368W |
Checkpoint protein |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
GLN3 |
YER040W |
Transcriptional activator in nitrogen catabolite repression system |
genetic |
1 |
1 |
1 |
Negative Genetic |
BUD6 |
YLR319C |
Actin- and formin-interacting protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
HCH1 |
YNL281W |
Heat shock protein regulator |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
DCN1 |
YLR128W |
Scaffold-type E3 ligase |
physical |
1 |
1 |
1 |
Reconstituted Complex |
HRQ1 |
YDR291W |
3'-5' DNA helicase of the conserved RecQ family |
genetic |
1 |
1 |
1 |
Negative Genetic |
KCS1 |
YDR017C |
Inositol hexakisphosphate and inositol heptakisphosphate kinase |
genetic |
1 |
1 |
1 |
Negative Genetic |
PMT5 |
YDL093W |
Protein O-mannosyltransferase |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
GIS2 |
YNL255C |
Translational activator for mRNAs with internal ribosome entry sites |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
ERG3 |
YLR056W |
C-5 sterol desaturase |
genetic |
1 |
1 |
1 |
Negative Genetic |
PHS1 |
YJL097W |
Essential 3-hydroxyacyl-CoA dehydratase of the ER membrane |
genetic |
1 |
1 |
1 |
Negative Genetic |
EDC1 |
YGL222C |
RNA-binding protein that activates mRNA decapping directly |
genetic |
1 |
1 |
1 |
Negative Genetic |
ROF1 |
YHR177W |
Putative transcription factor containing a WOPR domain |
genetic |
1 |
1 |
1 |
Negative Genetic |