Standard name Systematic name Name description Description
OSH2 YDL019C Member of an oxysterol-binding protein family with seven members Member of an oxysterol-binding protein family with seven members; in S. cerevisiae, family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability; contains FFAT motif; interacts with ER anchor Scs2p at patches at the plasma membrane and at the nuclear envelope; regulated by sterol binding; OSH2 has a paralog, SWH1, that arose from the whole genome duplication
Visualize the interactome of OSH2
Links to external databases:
  SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)

CYCLoPs localization & abundance

WT1 WT2 WT3
Bud 0.073 0.110 0.190
Cell Periphery 0.392 0.300 0.204
Cort. Patches 0.395 0.332 0.313
Cytoplasm 0.369 0.445 0.543
ER NaN 0.092 NaN
Mito NaN NaN 0.057

GFP localization & abundance

GFP localization GFP abundance
punctate composite 1070

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
OSH2 1 0 0 0 0

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
MYO5 YMR109W One of two type I myosin motors physical 5 4 4 Affinity Capture-MS, PCA, Two-hybrid, Two-hybrid, Affinity Capture-Western
SCS2 YER120W Integral ER membrane protein, regulates phospholipid metabolism physical 4 2 4 Affinity Capture-MS, Affinity Capture-MS, PCA, PCA
SSO2 YMR183C Plasma membrane t-SNARE genetic 4 1 3 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
SSA1 YAL005C ATPase involved in protein folding and NLS-directed nuclear transport physical 3 1 2 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS
KES1 YPL145C Sterol/phosphatidylinositol-4-phosphate (PI(4)P) exchanger genetic 2 2 2 Negative Genetic, Phenotypic Enhancement
DBF2 YGR092W Ser/Thr kinase involved in transcription and stress response physical 2 1 2 Biochemical Activity, Biochemical Activity
CSG2 YBR036C Endoplasmic reticulum membrane protein genetic 2 1 2 Negative Genetic, Negative Genetic
TSC3 YBR058C-A Protein that stimulates the activity of serine palmitoyltransferase genetic 2 1 1 Negative Genetic, Negative Genetic
SLC1 YDL052C 1-acyl-sn-glycerol-3-phosphate acyltransferase genetic 2 1 1 Negative Genetic, Negative Genetic
PST2 YDR032C FMN-dependent NAD(P)H:quinone oxidoreductase genetic 2 1 1 Negative Genetic, Negative Genetic
FKH1 YIL131C Forkhead family transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
FKH2 YNL068C Forkhead family transcription factor regulation 1 1 1 ChEC-Seq experiments
MED2 YDL005C Subunit of the RNA polymerase II mediator complex regulation 1 1 1 chromatin immunoprecipitation-chip evidence
BUR6 YER159C Subunit of a heterodimeric NC2 transcription regulator complex regulation 1 1 1 chromatin immunoprecipitation-chip evidence
YAP1 YML007W Basic leucine zipper (bZIP) transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
CYC8 YBR112C General transcriptional co-repressor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
SUA7 YPR086W Transcription factor TFIIB regulation 1 1 1 chromatin immunoprecipitation-chip evidence
NCB2 YDR397C Subunit of a heterodimeric NC2 transcription regulator complex regulation 1 1 1 chromatin immunoprecipitation-chip evidence
UGA3 YDL170W Transcriptional activator for GABA-dependent induction of GABA genes regulation 1 1 1 chromatin immunoprecipitation-chip evidence
CDC42 YLR229C Small rho-like GTPase genetic 1 1 1 Dosage Rescue
CCR4 YAL021C Component of the CCR4-NOT transcriptional complex physical 1 1 1 Affinity Capture-RNA
CDC11 YJR076C Component of the septin ring that is required for cytokinesis genetic 1 1 1 Negative Genetic
COX4 YGL187C Subunit IV of cytochrome c oxidase physical 1 1 1 Affinity Capture-MS
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator physical 1 1 1 Affinity Capture-RNA
ISW1 YBR245C ATPase subunit of imitation-switch (ISWI) class chromatin remodelers physical 1 1 1 Affinity Capture-RNA
LAS17 YOR181W Actin assembly factor physical 1 1 1 Affinity Capture-MS
CMR1 YDL156W Nuclear protein with role in transcription, protein quality control genetic 1 1 1 Positive Genetic
MYO2 YOR326W Type V myosin motor involved in actin-based transport of cargos genetic 1 1 1 Dosage Growth Defect
HTA2 YBL003C Histone H2A physical 1 1 1 Affinity Capture-MS
ILV1 YER086W Threonine deaminase, catalyzes first step in isoleucine biosynthesis genetic 1 1 1 Negative Genetic
MRPL6 YHR147C Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Negative Genetic
SCS2 YER120W Integral ER membrane protein, regulates phospholipid metabolism genetic 1 1 1 Dosage Rescue
SWH1 YAR042W Protein similar to mammalian oxysterol-binding protein physical 1 1 1 Affinity Capture-MS
SWH1 YAR042W Protein similar to mammalian oxysterol-binding protein genetic 1 1 1 Synthetic Growth Defect
RPG1 YBR079C eIF3a subunit of the eukaryotic translation initiation factor 3 (eIF3) physical 1 1 1 Affinity Capture-MS
YRA1 YDR381W Nuclear polyadenylated RNA-binding protein physical 1 1 1 Affinity Capture-MS
SEC27 YGL137W Essential beta'-coat protein of the COPI coatomer physical 1 1 1 Affinity Capture-MS
RAD53 YPL153C DNA damage response kinase physical 1 1 1 Biochemical Activity
SKS1 YPL026C Putative serine/threonine protein kinase physical 1 1 1 Biochemical Activity
YCK1 YHR135C Palmitoylated plasma membrane-bound casein kinase I (CK1) isoform physical 1 1 1 Biochemical Activity
YCK2 YNL154C Palmitoylated plasma membrane-bound casein kinase I (CK1) isoform physical 1 1 1 Biochemical Activity
PKP2 YGL059W Mitochondrial protein kinase physical 1 1 1 Biochemical Activity
UME1 YPL139C Component of both the Rpd3S and Rpd3L histone deacetylase complexes physical 1 1 1 PCA
OSH2 YDL019C Member of an oxysterol-binding protein family with seven members physical 1 1 1 Affinity Capture-MS
SCS22 YBL091C-A Protein involved in regulation of phospholipid metabolism physical 1 1 1 PCA
SEC22 YLR268W R-SNARE protein physical 1 1 1 Affinity Capture-Western
SSO1 YPL232W Plasma membrane t-SNARE physical 1 1 1 Affinity Capture-Western
SSC1 YJR045C Hsp70 family ATPase physical 1 1 1 Affinity Capture-MS
PUF4 YGL014W Member of the PUF protein family physical 1 1 1 Affinity Capture-RNA
SEC9 YGR009C t-SNARE protein required for secretory vesicle-plasma membrane fusion physical 1 1 1 PCA
RHO1 YPR165W GTP-binding protein of the rho subfamily of Ras-like proteins genetic 1 1 1 Dosage Lethality
SNN1 YNL086W Subunit of the BLOC-1 complex involved in endosomal maturation genetic 1 1 1 Negative Genetic
OSH3 YHR073W Member of an oxysterol-binding protein family genetic 1 1 1 Synthetic Growth Defect
SEC3 YER008C Subunit of the exocyst complex genetic 1 1 1 Dosage Growth Defect
SEC5 YDR166C Essential 107kDa subunit of the exocyst complex genetic 1 1 1 Dosage Growth Defect
SES1 YDR023W Cytosolic seryl-tRNA synthetase genetic 1 1 1 Negative Genetic
TOR2 YKL203C PIK-related protein kinase and rapamycin target genetic 1 1 1 Negative Genetic
RSM24 YDR175C Mitochondrial ribosomal protein of the small subunit genetic 1 1 1 Positive Genetic
TFB1 YDR311W Subunit of TFIIH and nucleotide excision repair factor 3 complexes genetic 1 1 1 Negative Genetic
UTP9 YHR196W Nucleolar protein genetic 1 1 1 Negative Genetic
SEC23 YPR181C GTPase-activating protein, stimulates the GTPase activity of Sar1p genetic 1 1 1 Negative Genetic
SPF1 YEL031W P-type ATPase, ion transporter of the ER membrane genetic 1 1 1 Synthetic Lethality
BCK1 YJL095W MAPKKK acting in the protein kinase C signaling pathway physical 1 1 1 Biochemical Activity
DRS2 YAL026C Trans-golgi network aminophospholipid translocase (flippase) physical 1 1 1 Affinity Capture-MS
HYP2 YEL034W Translation elongation factor eIF-5A genetic 1 1 1 Positive Genetic
HSP104 YLL026W Disaggregase physical 1 1 1 Affinity Capture-MS
KSP1 YHR082C Serine/threonine protein kinase physical 1 1 1 Biochemical Activity
LAA1 YJL207C AP-1 accessory protein physical 1 1 1 Affinity Capture-MS
MUS81 YDR386W Subunit of structure-specific Mms4p-Mus81p endonuclease physical 1 1 1 Affinity Capture-MS
CDH1 YGL003C Activator of anaphase-promoting complex/cyclosome (APC/C) physical 1 1 1 Affinity Capture-MS
COG2 YGR120C Essential component of the conserved oligomeric Golgi complex genetic 1 1 1 Negative Genetic
GCR1 YPL075W Transcriptional activator of genes involved in glycolysis genetic 1 1 1 Synthetic Lethality
CSE4 YKL049C Centromeric histone H3-like protein physical 1 1 1 Affinity Capture-MS
MYO3 YKL129C One of two type I myosins physical 1 1 1 Two-hybrid
MYO3 YKL129C One of two type I myosins genetic 1 1 1 Phenotypic Suppression
MPT5 YGL178W mRNA-binding protein of the PUF family physical 1 1 1 Affinity Capture-RNA
MSB3 YNL293W Rab GTPase-activating protein genetic 1 1 1 Dosage Growth Defect
MSB4 YOL112W GTPase-activating protein of the Ras superfamily genetic 1 1 1 Dosage Growth Defect
GPI19 YDR437W Subunit of GPI-GlcNAc transferase involved in synthesis of GlcNAc-PI genetic 1 1 1 Negative Genetic
FAA3 YIL009W Long chain fatty acyl-CoA synthetase genetic 1 1 1 Negative Genetic
CDC8 YJR057W Nucleoside monophosphate and nucleoside diphosphate kinase genetic 1 1 1 Negative Genetic
CIT3 YPR001W Dual specificity mitochondrial citrate and methylcitrate synthase genetic 1 1 1 Negative Genetic
ICE2 YIL090W Integral ER membrane protein with type-III transmembrane domains genetic 1 1 1 Dosage Rescue