Standard name Systematic name Name description Description
TUB1 YML085C Alpha-tubulin Alpha-tubulin; associates with beta-tubulin (Tub2p) to form tubulin dimer, which polymerizes to form microtubules; relative distribution to nuclear foci increases upon DNA replication stress; TUB1 has a paralog, TUB3, that arose from the whole genome duplication
Visualize the interactome of TUB1
Links to external databases:
  SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)
S 70

CYCLoPs localization & abundance

WT1 WT2 WT3
Cytoplasm 0.929 0.93 0.768
Endosome NaN NaN 0.147
Nucleolus NaN NaN 0.063

GFP localization & abundance

GFP localization GFP abundance
cytoplasm, punctate composite, spindle pole, microtubule 5590

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
TUB1 0 2 0 0 0

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
TUB2 YFL037W Beta-tubulin physical 9 4 9 Two-hybrid, Two-hybrid, Two-hybrid, Affinity Capture-Western, Co-crystal Structure, Co-purification, Co-crystal Structure, Co-crystal Structure, Two-hybrid
RBL2 YOR265W Protein involved in microtubule morphogenesis genetic 7 3 4 Dosage Lethality, Dosage Rescue, Dosage Rescue, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Dosage Lethality
STU2 YLR045C Microtubule polymerase of the XMAP215/Dis1 family physical 5 3 5 Two-hybrid, Reconstituted Complex, Two-hybrid, Co-crystal Structure, Co-crystal Structure
KIP3 YGL216W Kinesin-related antiparallel sliding motor protein physical 5 2 4 Reconstituted Complex, Co-fractionation, Reconstituted Complex, Reconstituted Complex, Reconstituted Complex
PAC2 YER007W Microtubule effector required for tubulin heterodimer formation physical 5 4 3 Affinity Capture-Western, Two-hybrid, Reconstituted Complex, Co-fractionation, Affinity Capture-Western
DYN1 YKR054C Cytoplasmic heavy chain dynein physical 4 2 4 Co-localization, Reconstituted Complex, Reconstituted Complex, Reconstituted Complex
TUB3 YML124C Alpha-tubulin genetic 4 2 4 Dosage Rescue, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality
STU1 YBL034C Microtubule plus-end-tracking non-motor protein physical 4 4 2 Affinity Capture-Western, Affinity Capture-MS, Reconstituted Complex, Co-crystal Structure
IML3 YBR107C Outer kinetochore protein and component of the Ctf19 complex genetic 4 3 2 Synthetic Lethality, Synthetic Growth Defect, Synthetic Growth Defect, Phenotypic Enhancement
BIM1 YER016W Microtubule plus end-tracking protein physical 3 2 3 Two-hybrid, Two-hybrid, Reconstituted Complex
BIK1 YCL029C Microtubule-associated protein physical 3 2 3 Co-localization, Two-hybrid, Two-hybrid
TUB2 YFL037W Beta-tubulin genetic 3 2 3 Synthetic Rescue, Dosage Rescue, Dosage Rescue
KAR3 YPR141C Minus-end-directed microtubule motor physical 3 2 2 Reconstituted Complex, Reconstituted Complex, Co-crystal Structure
CHL4 YDR254W Outer kinetochore protein required for chromosome stability genetic 3 2 1 Synthetic Growth Defect, Synthetic Growth Defect, Phenotypic Enhancement
PAC2 YER007W Microtubule effector required for tubulin heterodimer formation genetic 2 2 2 Dosage Lethality, Synthetic Lethality
BIM1 YER016W Microtubule plus end-tracking protein genetic 2 2 2 Synthetic Lethality, Phenotypic Enhancement
SPC110 YDR356W Inner plaque spindle pole body (SPB) component physical 2 2 2 Co-purification, Co-localization
CDC40 YDR364C Pre-mRNA splicing factor genetic 2 1 2 Synthetic Rescue, Synthetic Rescue
MCM22 YJR135C Outer kinetochore protein and component of the Ctf3 subcomplex genetic 2 1 2 Synthetic Growth Defect, Synthetic Growth Defect
RVB2 YPL235W ATP-dependent DNA helicase, also known as reptin physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
RPN11 YFR004W Metalloprotease subunit of 19S regulatory particle physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
HSC82 YMR186W Cytoplasmic chaperone of the Hsp90 family genetic 2 1 2 Synthetic Growth Defect, Synthetic Growth Defect
HSP82 YPL240C Hsp90 chaperone genetic 2 1 2 Synthetic Growth Defect, Synthetic Growth Defect
BUB3 YOR026W Kinetochore checkpoint WD40 repeat protein genetic 2 1 2 Dosage Rescue, Dosage Rescue
BUB1 YGR188C Protein kinase involved in the cell cycle checkpoint into anaphase genetic 2 1 2 Dosage Rescue, Dosage Rescue
TUB3 YML124C Alpha-tubulin physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
SHE1 YBL031W Mitotic spindle protein physical 2 1 2 Reconstituted Complex, Reconstituted Complex
SUM1 YDR310C Transcriptional repressor that regulates middle-sporulation genes genetic 2 1 2 Dosage Rescue, Dosage Rescue
CEF1 YMR213W Essential splicing factor genetic 2 2 1 Synthetic Rescue, Dosage Rescue
ELP2 YGR200C Subunit of Elongator complex physical 2 2 1 Affinity Capture-Western, Reconstituted Complex
PAC10 YGR078C Part of the heteromeric co-chaperone GimC/prefoldin complex genetic 2 2 1 Dosage Rescue, Phenotypic Enhancement
SMT3 YDR510W Ubiquitin-like protein of the SUMO family physical 2 2 1 Reconstituted Complex, Two-hybrid
SMC5 YOL034W Subunit of the SMC5-SMC6 complex physical 2 2 1 Reconstituted Complex, Co-localization
ALF1 YNL148C Alpha-tubulin folding protein physical 2 2 1 Affinity Capture-Western, Two-hybrid
ATS1 YAL020C Protein required for modification of wobble nucleosides in tRNA genetic 2 2 1 Dosage Rescue, Synthetic Growth Defect
VIK1 YPL253C Protein that forms a kinesin-14 heterodimeric motor with Kar3p physical 2 2 1 Reconstituted Complex, Co-crystal Structure
YKE2 YLR200W Subunit of the heterohexameric Gim/prefoldin protein complex genetic 2 2 1 Dosage Rescue, Synthetic Lethality
ACT1 YFL039C Actin, structural protein in cytoskeleton genetic 2 1 1 Synthetic Haploinsufficiency, Synthetic Haploinsufficiency
MDY2 YOL111C Protein involved in inserting tail-anchored proteins into ER membranes physical 2 1 1 Affinity Capture-Western, Affinity Capture-Western
MHP1 YJL042W Microtubule-associated protein involved in microtubule organization genetic 2 1 1 Phenotypic Suppression, Phenotypic Suppression
FKH1 YIL131C Forkhead family transcription factor regulation 1 1 1 ChEC-Seq experiments
FKH2 YNL068C Forkhead family transcription factor regulation 1 1 1 ChEC-Seq experiments
GCR1 YPL075W Transcriptional activator of genes involved in glycolysis regulation 1 1 1 DNA to cDNA expression microarray evidence
YAP6 YDR259C Basic leucine zipper (bZIP) transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
CTF19 YPL018W Outer kinetochore protein, needed for accurate chromosome segregation genetic 1 1 1 Synthetic Growth Defect
DSN1 YIR010W Essential component of the outer kinetochore MIND complex physical 1 1 1 Affinity Capture-MS
DED81 YHR019C Cytosolic asparaginyl-tRNA synthetase physical 1 1 1 Affinity Capture-MS
ESA1 YOR244W Catalytic subunit of the histone acetyltransferase complex (NuA4) physical 1 1 1 Affinity Capture-MS
RVB1 YDR190C ATP-dependent DNA helicase, also known as pontin physical 1 1 1 Affinity Capture-MS
MCM21 YDR318W Component of the kinetochore sub-complex COMA genetic 1 1 1 Synthetic Growth Defect
CDC33 YOL139C Translation initiation factor eIF4E physical 1 1 1 Affinity Capture-Western
TIF4631 YGR162W Translation initiation factor eIF4G and scaffold protein physical 1 1 1 Affinity Capture-MS
RET1 YOR207C Second-largest subunit of RNA polymerase III physical 1 1 1 Affinity Capture-MS
RPC82 YPR190C RNA polymerase III subunit C82 physical 1 1 1 Affinity Capture-MS
ARP9 YMR033W Component of both the SWI/SNF and RSC chromatin remodeling complexes genetic 1 1 1 Synthetic Growth Defect
RSC4 YKR008W Component of the RSC chromatin remodeling complex genetic 1 1 1 Synthetic Growth Defect
RSC6 YCR052W Component of the RSC chromatin remodeling complex genetic 1 1 1 Synthetic Growth Defect
RSC8 YFR037C Component of the RSC chromatin remodeling complex genetic 1 1 1 Synthetic Growth Defect
RSC9 YML127W Component of the RSC chromatin remodeling complex genetic 1 1 1 Synthetic Growth Defect
SPT16 YGL207W Subunit of the heterodimeric FACT complex (Spt16p-Pob3p) physical 1 1 1 Affinity Capture-MS
RPG1 YBR079C eIF3a subunit of the eukaryotic translation initiation factor 3 (eIF3) physical 1 1 1 Reconstituted Complex
ECM16 YMR128W Essential DEAH-box ATP-dependent RNA helicase specific to U3 snoRNP physical 1 1 1 Affinity Capture-MS
KAP104 YBR017C Transportin or cytosolic karyopherin beta 2 physical 1 1 1 Affinity Capture-MS
SUP35 YDR172W Translation termination factor eRF3 physical 1 1 1 Affinity Capture-Western
ARO1 YDR127W Pentafunctional arom protein physical 1 1 1 Affinity Capture-MS
CDC11 YJR076C Component of the septin ring that is required for cytokinesis physical 1 1 1 Affinity Capture-Western
CYS4 YGR155W Cystathionine beta-synthase physical 1 1 1 Affinity Capture-MS
GCN1 YGL195W Positive regulator of the Gcn2p kinase activity physical 1 1 1 Affinity Capture-MS
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator physical 1 1 1 Affinity Capture-RNA
CRM1 YGR218W Nuclear export factor, exportin physical 1 1 1 Affinity Capture-MS
LCB1 YMR296C Component of serine palmitoyltransferase physical 1 1 1 Affinity Capture-MS
LCB2 YDR062W Component of serine palmitoyltransferase physical 1 1 1 Affinity Capture-MS
HSC82 YMR186W Cytoplasmic chaperone of the Hsp90 family physical 1 1 1 Affinity Capture-MS
MTR10 YOR160W Nuclear import receptor physical 1 1 1 Affinity Capture-MS
MAM33 YIL070C Acidic protein of the mitochondrial matrix physical 1 1 1 Affinity Capture-MS
LYS12 YIL094C Homo-isocitrate dehydrogenase physical 1 1 1 Affinity Capture-MS
AHA1 YDR214W Co-chaperone that binds Hsp82p and activates its ATPase activity physical 1 1 1 Affinity Capture-MS
PFK1 YGR240C Alpha subunit of heterooctameric phosphofructokinase physical 1 1 1 Affinity Capture-Western
IDH2 YOR136W Subunit of mitochondrial NAD(+)-dependent isocitrate dehydrogenase physical 1 1 1 Affinity Capture-MS
PSE1 YMR308C Karyopherin/importin that interacts with the nuclear pore complex physical 1 1 1 Affinity Capture-MS
PUB1 YNL016W Poly (A)+ RNA-binding protein physical 1 1 1 Affinity Capture-Western
MIR1 YJR077C Mitochondrial phosphate carrier physical 1 1 1 Affinity Capture-MS
MET18 YIL128W Component of cytosolic iron-sulfur protein assembly (CIA) machinery physical 1 1 1 Affinity Capture-MS
RAD3 YER171W 5' to 3' DNA helicase physical 1 1 1 Affinity Capture-MS
ILV1 YER086W Threonine deaminase, catalyzes first step in isoleucine biosynthesis physical 1 1 1 Affinity Capture-MS
NUM1 YDR150W Protein required for nuclear migration genetic 1 1 1 Synthetic Growth Defect
SAM1 YLR180W S-adenosylmethionine synthetase physical 1 1 1 Affinity Capture-MS
SEC7 YDR170C Guanine nucleotide exchange factor (GEF) for ADP ribosylation factors physical 1 1 1 Affinity Capture-MS
SEC7 YDR170C Guanine nucleotide exchange factor (GEF) for ADP ribosylation factors genetic 1 1 1 Synthetic Growth Defect
RPT5 YOR117W ATPase of the 19S regulatory particle of the 26S proteasome physical 1 1 1 Affinity Capture-MS
SPC97 YHR172W Component of the microtubule-nucleating Tub4p (gamma-tubulin) complex physical 1 1 1 Co-localization
SPC98 YNL126W Component of the microtubule-nucleating Tub4p (gamma-tubulin) complex physical 1 1 1 Co-localization
PUF3 YLL013C Protein of the mitochondrial outer surface physical 1 1 1 Affinity Capture-RNA
DNM1 YLL001W Dynamin-related GTPase involved in mitochondrial organization physical 1 1 1 Affinity Capture-MS
CAF20 YOR276W Phosphoprotein of the mRNA cap-binding complex physical 1 1 1 Affinity Capture-MS
CDC5 YMR001C Polo-like kinase required for mitotic exit physical 1 1 1 Affinity Capture-MS
TCP1 YDR212W Alpha subunit of chaperonin-containing T-complex genetic 1 1 1 Synthetic Growth Defect
NMD5 YJR132W Karyopherin physical 1 1 1 Affinity Capture-MS
SEC53 YFL045C Phosphomannomutase physical 1 1 1 Affinity Capture-MS
PRS3 YHL011C 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase physical 1 1 1 Affinity Capture-MS
MAE1 YKL029C Mitochondrial malic enzyme physical 1 1 1 Affinity Capture-MS
ACS2 YLR153C Acetyl-coA synthetase isoform physical 1 1 1 Affinity Capture-MS
RHO1 YPR165W GTP-binding protein of the rho subfamily of Ras-like proteins genetic 1 1 1 Phenotypic Suppression
SMC6 YLR383W Subunit of the SMC5-SMC6 complex physical 1 1 1 Affinity Capture-MS
EST1 YLR233C TLC1 RNA-associated factor involved in telomere length regulation physical 1 1 1 Affinity Capture-MS
ATG4 YNL223W Conserved cysteine protease required for autophagy physical 1 1 1 Two-hybrid
MMS22 YLR320W Subunit of E3 ubiquitin ligase complex involved in replication repair physical 1 1 1 Affinity Capture-MS
CIN4 YMR138W GTP-binding protein involved in beta-tubulin (Tub2p) folding genetic 1 1 1 Synthetic Lethality
MCM16 YPR046W Component of the Ctf19 complex and the COMA subcomplex genetic 1 1 1 Synthetic Growth Defect
MSN5 YDR335W Karyopherin physical 1 1 1 Affinity Capture-MS
CSM3 YMR048W Replication fork associated factor physical 1 1 1 Affinity Capture-MS
SPC72 YAL047C Gamma-tubulin small complex (gamma-TuSC) receptor physical 1 1 1 Co-localization
DOC1 YGL240W Processivity factor genetic 1 1 1 Phenotypic Suppression
RPS13 YDR064W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
NFI1 YOR156C SUMO E3 ligase physical 1 1 1 Two-hybrid
RSC1 YGR056W Component of the RSC chromatin remodeling complex genetic 1 1 1 Synthetic Growth Defect
SMC2 YFR031C Subunit of the condensin complex physical 1 1 1 Reconstituted Complex
PHO4 YFR034C Basic helix-loop-helix (bHLH) transcription factor of the myc-family physical 1 1 1 Affinity Capture-MS
RPS17A YML024W Ribosomal protein 51 (rp51) of the small (40s) subunit physical 1 1 1 Affinity Capture-MS
RPS7A YOR096W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPS22A YJL190C Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
CSE4 YKL049C Centromeric histone H3-like protein physical 1 1 1 Affinity Capture-MS
ALF1 YNL148C Alpha-tubulin folding protein genetic 1 1 1 Synthetic Lethality
BRN1 YBL097W Subunit of the condensin complex physical 1 1 1 Reconstituted Complex
HSP150 YJL159W O-mannosylated heat shock protein physical 1 1 1 Affinity Capture-MS
KAR9 YPL269W Spindle positioning factor physical 1 1 1 Co-localization
MPS1 YDL028C Dual-specificity kinase genetic 1 1 1 Dosage Rescue
BIK1 YCL029C Microtubule-associated protein genetic 1 1 1 Synthetic Lethality
SMC4 YLR086W Subunit of the condensin complex physical 1 1 1 Reconstituted Complex
CIN1 YOR349W Tubulin folding factor D involved in beta-tubulin (Tub2p) folding genetic 1 1 1 Synthetic Lethality
SRM1 YGL097W Nucleotide exchange factor for Gsp1p genetic 1 1 1 Dosage Rescue
SEC2 YNL272C Guanyl-nucleotide exchange factor for the small G-protein Sec4p physical 1 1 1 Affinity Capture-MS
BNR1 YIL159W Formin genetic 1 1 1 Dosage Rescue
PRP22 YER013W DEAH-box RNA-dependent ATPase/ATP-dependent RNA helicase genetic 1 1 1 Synthetic Rescue
SST2 YLR452C GTPase-activating protein for Gpa1p physical 1 1 1 Affinity Capture-MS
MCA1 YOR197W Ca2+-dependent cysteine protease physical 1 1 1 Affinity Capture-MS
RPL25 YOL127W Ribosomal 60S subunit protein L25 physical 1 1 1 Affinity Capture-MS
RPS2 YGL123W Protein component of the small (40S) subunit physical 1 1 1 Affinity Capture-MS
RPS3 YNL178W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
CIN2 YPL241C GTPase-activating protein (GAP) for Cin4p genetic 1 1 1 Synthetic Lethality
URA7 YBL039C Major CTP synthase isozyme (see also URA8) physical 1 1 1 Affinity Capture-MS
YHB1 YGR234W Nitric oxide oxidoreductase physical 1 1 1 Affinity Capture-MS
VPS13 YLL040C Lipid transport protein involved in prospore membrane morphogenesis physical 1 1 1 Affinity Capture-MS
UFD4 YKL010C Ubiquitin-protein ligase (E3) physical 1 1 1 Affinity Capture-MS
TUB4 YLR212C Gamma-tubulin physical 1 1 1 Co-localization
VAM6 YDL077C Guanine nucleotide exchange factor for the GTPase Gtr1p physical 1 1 1 Affinity Capture-MS
YCG1 YDR325W Subunit of the condensin complex physical 1 1 1 Reconstituted Complex
YCS4 YLR272C Subunit of the condensin complex physical 1 1 1 Reconstituted Complex
ULS1 YOR191W Swi2/Snf2-related translocase, SUMO-Targeted Ubiquitin Ligase (STUbL) physical 1 1 1 Two-hybrid
UTP10 YJL109C Nucleolar protein physical 1 1 1 Affinity Capture-MS
UBP15 YMR304W Ubiquitin-specific protease involved in protein deubiquitination physical 1 1 1 Affinity Capture-MS
XRN1 YGL173C Evolutionarily-conserved 5'-3' exonuclease genetic 1 1 1 Synthetic Growth Defect
SSB2 YNL209W Cytoplasmic ATPase that is a ribosome-associated molecular chaperone physical 1 1 1 Co-purification
SSB1 YDL229W Cytoplasmic ATPase that is a ribosome-associated molecular chaperone physical 1 1 1 Affinity Capture-MS
RPL28 YGL103W Ribosomal 60S subunit protein L28 physical 1 1 1 Affinity Capture-Western
RPS20 YHL015W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
MOG1 YJR074W Conserved nuclear protein that interacts with GTP-Gsp1p physical 1 1 1 Affinity Capture-MS
RPS0A YGR214W Ribosomal 40S subunit protein S0A physical 1 1 1 Affinity Capture-MS
PAC1 YOR269W Regulator of dynein, involved in intracellular transport physical 1 1 1 Two-hybrid
KIP2 YPL155C Kinesin-related motor protein involved in mitotic spindle positioning physical 1 1 1 Reconstituted Complex
FUR1 YHR128W Uracil phosphoribosyltransferase physical 1 1 1 Affinity Capture-MS
CNN1 YFR046C Kinetochore protein physical 1 1 1 Affinity Capture-MS
STH1 YIL126W ATPase component of the RSC chromatin remodeling complex genetic 1 1 1 Synthetic Growth Defect
TFC6 YDR362C Subunit of RNA polymerase III transcription initiation factor complex physical 1 1 1 Affinity Capture-MS
RPS6A YPL090C Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPS9A YPL081W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
PTM1 YKL039W Protein of unknown function physical 1 1 1 Affinity Capture-MS
SPB4 YFL002C Putative ATP-dependent RNA helicase physical 1 1 1 Affinity Capture-MS
RPS10A YOR293W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
GPI17 YDR434W Transmembrane protein physical 1 1 1 Affinity Capture-MS
NUP192 YJL039C Essential subunit of inner ring of nuclear pore complex (NPC) physical 1 1 1 Affinity Capture-MS
TSC13 YDL015C Enoyl reductase physical 1 1 1 Affinity Capture-MS
RPL26A YLR344W Ribosomal 60S subunit protein L26A physical 1 1 1 Affinity Capture-MS
RPS12 YOR369C Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPS19A YOL121C Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
APJ1 YNL077W Hsp40 chaperone with a role in SUMO-mediated protein degradation physical 1 1 1 Affinity Capture-MS
GIS1 YDR096W Histone demethylase and transcription factor physical 1 1 1 Affinity Capture-MS
MPS3 YJL019W Nuclear envelope protein physical 1 1 1 Affinity Capture-MS
KIP3 YGL216W Kinesin-related antiparallel sliding motor protein genetic 1 1 1 Phenotypic Suppression
LPX1 YOR084W Peroxisomal matrix-localized lipase physical 1 1 1 Co-purification
PSD1 YNL169C Phosphatidylserine decarboxylase of the mitochondrial inner membrane genetic 1 1 1 Negative Genetic
RPS15 YOL040C Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS