Standard name Systematic name Name description Description
PRS5 YOL061W 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase; synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes; forms cytoplasmic foci upon DNA replication stress
Visualize the interactome of PRS5
Links to external databases:
SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)

CYCLoPs localization & abundance

WT1 WT2 WT3
Cytoplasm 0.995 0.981 0.975

GFP localization & abundance

GFP localization GFP abundance
cytoplasm 3310

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
PRS5 3 0 0 0 0

Enzyme information

Catalyzed reactions in Yeast8
r_0916 (phosphoribosylpyrophosphate synthetase)

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
IPK1 YDR315C Inositol 1,3,4,5,6-pentakisphosphate 2-kinase genetic 6 1 4 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
PRS2 YER099C 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase physical 5 1 4 Two-hybrid, Two-hybrid, Two-hybrid, Two-hybrid, Two-hybrid
PRS4 YBL068W 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP physical 5 1 4 Two-hybrid, Two-hybrid, Two-hybrid, Two-hybrid, Two-hybrid
VIP1 YLR410W Bifunctional inositol pyrophosphate kinase and phosphatase genetic 4 1 3 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
PRS5 YOL061W 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase physical 3 2 3 Two-hybrid, PCA, PCA
PRS3 YHL011C 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase genetic 3 1 2 Synthetic Lethality, Synthetic Lethality, Synthetic Lethality
PKC1 YBL105C Protein serine/threonine kinase genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
OCA4 YCR095C Cytoplasmic protein required for replication of Brome mosaic virus genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
RIM11 YMR139W Protein kinase physical 2 2 2 Affinity Capture-MS, Two-hybrid
SFP1 YLR403W Regulates transcription of ribosomal protein and biogenesis genes regulation 2 1 2 DNA to cDNA expression microarray evidence, DNA to cDNA expression microarray evidence
OCA1 YNL099C Putative protein tyrosine phosphatase genetic 2 1 2 Negative Genetic, Negative Genetic
RPN11 YFR004W Metalloprotease subunit of 19S regulatory particle physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
PUF3 YLL013C Protein of the mitochondrial outer surface physical 2 1 2 Affinity Capture-RNA, Affinity Capture-RNA
SIW14 YNL032W Inositol phosphatase involved in inositol pyrophosphate metabolism genetic 2 1 2 Negative Genetic, Negative Genetic
KKQ8 YKL168C Putative serine/threonine protein kinase with unknown cellular role genetic 2 1 2 Negative Genetic, Negative Genetic
PRS1 YKL181W 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase physical 2 1 2 PCA, PCA
PRS1 YKL181W 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase genetic 2 1 2 Synthetic Lethality, Synthetic Lethality
OCA2 YNL056W Protein of unknown function genetic 2 1 2 Negative Genetic, Negative Genetic
OCA5 YHL029C Cytoplasmic protein required for replication of Brome mosaic virus genetic 2 1 2 Negative Genetic, Negative Genetic
OCA6 YDR067C Cytoplasmic protein required for replication of Brome mosaic virus genetic 2 1 2 Negative Genetic, Negative Genetic
ACT1 YFL039C Actin, structural protein in cytoskeleton genetic 2 2 1 Positive Genetic, Negative Genetic
AFG2 YLR397C ATPase of the CDC48/PAS1/SEC18 (AAA) family, forms a hexameric complex genetic 2 1 1 Negative Genetic, Negative Genetic
SSB1 YDL229W Cytoplasmic ATPase that is a ribosome-associated molecular chaperone physical 2 1 1 Affinity Capture-MS, Affinity Capture-MS
SEC4 YFL005W Rab family GTPase genetic 2 1 1 Negative Genetic, Negative Genetic
TYS1 YGR185C Cytoplasmic tyrosyl-tRNA synthetase genetic 2 1 1 Negative Genetic, Negative Genetic
STT4 YLR305C Phosphatidylinositol-4-kinase genetic 2 1 1 Negative Genetic, Negative Genetic
FKH1 YIL131C Forkhead family transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
GCN5 YGR252W Catalytic subunit of ADA and SAGA histone acetyltransferase complexes regulation 1 1 1 chromatin immunoprecipitation-chip evidence
XBP1 YIL101C Transcriptional repressor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
REB1 YBR049C RNA polymerase I enhancer binding protein regulation 1 1 1 chromatin immunoprecipitation-chip evidence
MED4 YOR174W Subunit of the RNA polymerase II mediator complex regulation 1 1 1 chromatin immunoprecipitation-chip evidence
MMS21 YEL019C Highly conserved SUMO E3 ligase subunit of SMC5-SMC6 complex genetic 1 1 1 Negative Genetic
PRP19 YLL036C Splicing factor associated with the spliceosome genetic 1 1 1 Negative Genetic
POP1 YNL221C Subunit of RNase MRP, nuclear RNase P and telomerase complexes genetic 1 1 1 Negative Genetic
MAK21 YDR060W Constituent of 66S pre-ribosomal particles genetic 1 1 1 Negative Genetic
PAT1 YCR077C Deadenylation-dependent mRNA-decapping factor genetic 1 1 1 Negative Genetic
CDC48 YDL126C AAA ATPase with protein-unfoldase activity genetic 1 1 1 Negative Genetic
NPL3 YDR432W RNA-binding protein genetic 1 1 1 Synthetic Rescue
ARX1 YDR101C Nuclear export factor for the ribosomal pre-60S subunit genetic 1 1 1 Positive Genetic
GCD1 YOR260W Gamma subunit of the translation initiation factor eIF2B genetic 1 1 1 Negative Genetic
ABD1 YBR236C Methyltransferase genetic 1 1 1 Positive Genetic
ARP3 YJR065C Essential component of the Arp2/3 complex genetic 1 1 1 Positive Genetic
BET2 YPR176C Beta subunit of Type II geranylgeranyltransferase genetic 1 1 1 Negative Genetic
CDC12 YHR107C Component of the septin ring that is required for cytokinesis genetic 1 1 1 Negative Genetic
CKS1 YBR135W Cyclin-dependent protein kinase regulatory subunit and adaptor genetic 1 1 1 Positive Genetic
ELP2 YGR200C Subunit of Elongator complex physical 1 1 1 Reconstituted Complex
FIP1 YJR093C Subunit of cleavage polyadenylation factor (CPF) genetic 1 1 1 Negative Genetic
ESP1 YGR098C Separase/separin, a caspase-like cysteine protease genetic 1 1 1 Positive Genetic
HTB2 YBL002W Histone H2B physical 1 1 1 Affinity Capture-MS
KGD2 YDR148C Dihydrolipoyl transsuccinylase genetic 1 1 1 Negative Genetic
KRR1 YCL059C Nucleolar protein required for rRNA synthesis and ribosomal assembly genetic 1 1 1 Negative Genetic
HSC82 YMR186W Cytoplasmic chaperone of the Hsp90 family genetic 1 1 1 Synthetic Growth Defect
CMR1 YDL156W Nuclear protein with role in transcription, protein quality control physical 1 1 1 Affinity Capture-MS
NBP35 YGL091C Essential cytoplasmic iron-sulfur cluster binding protein genetic 1 1 1 Negative Genetic
PAN2 YGL094C Catalytic subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex genetic 1 1 1 Negative Genetic
POP7 YBR167C Subunit of RNase MRP, nuclear RNase P and telomerase genetic 1 1 1 Negative Genetic
HSP82 YPL240C Hsp90 chaperone genetic 1 1 1 Synthetic Growth Defect
BLM10 YFL007W Proteasome activator genetic 1 1 1 Negative Genetic
MIR1 YJR077C Mitochondrial phosphate carrier genetic 1 1 1 Positive Genetic
ILV1 YER086W Threonine deaminase, catalyzes first step in isoleucine biosynthesis genetic 1 1 1 Negative Genetic
MKT1 YNL085W Protein similar to nucleases that forms a complex with Pbp1p genetic 1 1 1 Positive Genetic
CDC6 YJL194W Essential ATP-binding protein required for DNA replication genetic 1 1 1 Negative Genetic
CAB5 YDR196C Subunit of the CoA-Synthesizing Protein Complex (CoA-SPC) genetic 1 1 1 Negative Genetic
GND1 YHR183W 6-phosphogluconate dehydrogenase (decarboxylating) genetic 1 1 1 Negative Genetic
HYP2 YEL034W Translation elongation factor eIF-5A genetic 1 1 1 Positive Genetic
GPP1 YIL053W Constitutively expressed DL-glycerol-3-phosphate phosphatase genetic 1 1 1 Negative Genetic
HTB1 YDR224C Histone H2B physical 1 1 1 Affinity Capture-MS
BFA1 YJR053W Subunit of a two-component GTPase-activating protein, Bfa1p-Bub2p genetic 1 1 1 Positive Genetic
PRS3 YHL011C 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase physical 1 1 1 PCA
HSP104 YLL026W Disaggregase physical 1 1 1 Affinity Capture-MS
CDC20 YGL116W Activator of anaphase-promoting complex/cyclosome (APC/C) genetic 1 1 1 Negative Genetic
ADH4 YGL256W Alcohol dehydrogenase isoenzyme type IV genetic 1 1 1 Negative Genetic
KRI1 YNL308C Essential nucleolar protein required for 40S ribosome biogenesis genetic 1 1 1 Positive Genetic
HHT1 YBR010W Histone H3 physical 1 1 1 Affinity Capture-MS
HOM3 YER052C Aspartate kinase (L-aspartate 4-P-transferase) genetic 1 1 1 Negative Genetic
DUT1 YBR252W Deoxyuridine triphosphate diphosphatase (dUTPase) physical 1 1 1 Reconstituted Complex
YRB2 YIL063C Protein of unknown function physical 1 1 1 Affinity Capture-MS
RBG2 YGR173W Protein with a role in translation physical 1 1 1 Affinity Capture-MS
RPN1 YHR027C Non-ATPase base subunit of the 19S RP of the 26S proteasome physical 1 1 1 Affinity Capture-MS
UBP3 YER151C Ubiquitin-specific protease that cleaves Ub-protein fusions physical 1 1 1 Affinity Capture-MS
RPL4A YBR031W Ribosomal 60S subunit protein L4A physical 1 1 1 Reconstituted Complex
TIF34 YMR146C eIF3i subunit of the eukaryotic translation initiation factor 3 (eIF3) physical 1 1 1 Reconstituted Complex
TRM112 YNR046W Protein involved in methylation of tRNA, rRNA, and translation factors physical 1 1 1 Reconstituted Complex
TRP3 YKL211C Indole-3-glycerol-phosphate synthase physical 1 1 1 Reconstituted Complex
SKA1 YKL023W SKI complex-associated protein physical 1 1 1 Reconstituted Complex
SSB2 YNL209W Cytoplasmic ATPase that is a ribosome-associated molecular chaperone physical 1 1 1 Co-purification
VAM6 YDL077C Guanine nucleotide exchange factor for the GTPase Gtr1p physical 1 1 1 Affinity Capture-MS
RLM1 YPL089C MADS-box transcription factor physical 1 1 1 Two-hybrid
RVB1 YDR190C ATP-dependent DNA helicase, also known as pontin physical 1 1 1 Affinity Capture-MS
TIF4631 YGR162W Translation initiation factor eIF4G and scaffold protein physical 1 1 1 Affinity Capture-MS
SIT4 YDL047W Ceramide-activated, type 2A-related serine-threonine phosphatase genetic 1 1 1 Positive Genetic
ZDS2 YML109W Protein with a role in regulating Swe1p-dependent polarized growth genetic 1 1 1 Positive Genetic
THR4 YCR053W Threonine synthase genetic 1 1 1 Negative Genetic
YKU70 YMR284W Subunit of the telomeric Ku complex (Yku70p-Yku80p) genetic 1 1 1 Negative Genetic
RPL28 YGL103W Ribosomal 60S subunit protein L28 genetic 1 1 1 Positive Genetic
SWC4 YGR002C Component of the Swr1p complex that incorporates Htz1p into chromatin genetic 1 1 1 Positive Genetic
SEC22 YLR268W R-SNARE protein genetic 1 1 1 Positive Genetic
ROF1 YHR177W Putative transcription factor containing a WOPR domain genetic 1 1 1 Positive Genetic
SWC5 YBR231C Component of the SWR1 complex genetic 1 1 1 Positive Genetic
YTA7 YGR270W Chromatin-binding ATPase that regulates histone gene expression genetic 1 1 1 Positive Genetic
SAC1 YKL212W Phosphatidylinositol phosphate phosphatase genetic 1 1 1 Positive Genetic
STB4 YMR019W Putative transcription factor genetic 1 1 1 Positive Genetic
YPL039W YPL039W Putative protein of unknown function genetic 1 1 1 Positive Genetic
RPP1 YHR062C Subunit of both RNase MRP and nuclear RNase P genetic 1 1 1 Negative Genetic
RPT1 YKL145W ATPase of the 19S regulatory particle of the 26S proteasome genetic 1 1 1 Negative Genetic
UTP21 YLR409C Subunit of U3-containing 90S preribosome and SSU processome complexes genetic 1 1 1 Negative Genetic
SEC39 YLR440C Component of the Dsl1p tethering complex genetic 1 1 1 Negative Genetic
RIA1 YNL163C Cytoplasmic GTPase/eEF2-like factor involved in ribosomal biogenesis genetic 1 1 1 Negative Genetic
STU1 YBL034C Microtubule plus-end-tracking non-motor protein genetic 1 1 1 Negative Genetic
SEC17 YBL050W Alpha-SNAP cochaperone genetic 1 1 1 Negative Genetic
TSC13 YDL015C Enoyl reductase genetic 1 1 1 Negative Genetic
RLI1 YDR091C Essential Fe-S protein genetic 1 1 1 Negative Genetic
SUP35 YDR172W Translation termination factor eRF3 genetic 1 1 1 Negative Genetic
TFB1 YDR311W Subunit of TFIIH and nucleotide excision repair factor 3 complexes genetic 1 1 1 Negative Genetic
STT3 YGL022W Catalytic subunit of the oligosaccharyltransferase complex of the ER l genetic 1 1 1 Negative Genetic
RGR1 YLR071C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
SEC61 YLR378C Conserved ER protein translocation channel genetic 1 1 1 Negative Genetic
ROT1 YMR200W Molecular chaperone involved in protein folding in ER genetic 1 1 1 Negative Genetic
SOM1 YEL059C-A Subunit of the mitochondrial inner membrane peptidase (IMP) genetic 1 1 1 Negative Genetic
SAP155 YFR040W Protein required for function of the Sit4p protein phosphatase genetic 1 1 1 Negative Genetic
SEH1 YGL100W Subunit of the Nup84 nuclear pore and SEACAT subcomplexes genetic 1 1 1 Negative Genetic
RSM27 YGR215W Mitochondrial ribosomal protein of the small subunit genetic 1 1 1 Negative Genetic
SFB3 YHR098C Component of the Sec23p-Sfb3p heterodimer of the COPII vesicle coat genetic 1 1 1 Negative Genetic
RPA49 YNL248C RNA polymerase I subunit A49 genetic 1 1 1 Negative Genetic
RPL19B YBL027W Ribosomal 60S subunit protein L19B genetic 1 1 1 Negative Genetic
REI1 YBR267W Cytoplasmic pre-60S factor genetic 1 1 1 Negative Genetic
SNF5 YBR289W Subunit of the SWI/SNF chromatin remodeling complex genetic 1 1 1 Negative Genetic
STE50 YCL032W Adaptor protein for various signaling pathways genetic 1 1 1 Negative Genetic
RPS14A YCR031C Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
SWR1 YDR334W Swi2/Snf2-related ATPase genetic 1 1 1 Negative Genetic
SDC1 YDR469W Subunit of the COMPASS (Set1C) complex genetic 1 1 1 Negative Genetic
URC2 YDR520C Putative Zn(II)2Cys6 motif containing transcription factor genetic 1 1 1 Negative Genetic
UBP6 YFR010W Ubiquitin-specific protease genetic 1 1 1 Negative Genetic
RGD3 YHR182W GTPase activating protein (GAP) for Rho3p, involved in cell polarity g genetic 1 1 1 Negative Genetic
RPE1 YJL121C D-ribulose-5-phosphate 3-epimerase genetic 1 1 1 Negative Genetic
VPS55 YJR044C Late endosomal protein involved in late endosome to vacuole transport genetic 1 1 1 Negative Genetic
VPS24 YKL041W One of four subunits of the ESCRT-III complex genetic 1 1 1 Negative Genetic
YKE2 YLR200W Subunit of the heterohexameric Gim/prefoldin protein complex genetic 1 1 1 Negative Genetic
TOM7 YNL070W Component of the TOM (translocase of outer membrane) complex genetic 1 1 1 Negative Genetic
RPL43A YPR043W Ribosomal 60S subunit protein L43A genetic 1 1 1 Negative Genetic
THP3 YPR045C Protein that may have a role in transcription elongation genetic 1 1 1 Negative Genetic
TKL1 YPR074C Transketolase genetic 1 1 1 Negative Genetic
TUB4 YLR212C Gamma-tubulin genetic 1 1 1 Synthetic Rescue
HOM2 YDR158W Aspartic beta semi-aldehyde dehydrogenase genetic 1 1 1 Negative Genetic
MGT1 YDL200C DNA repair methyltransferase (6-O-methylguanine-DNA methylase) genetic 1 1 1 Negative Genetic
ERG11 YHR007C Lanosterol 14-alpha-demethylase genetic 1 1 1 Negative Genetic
MMS22 YLR320W Subunit of E3 ubiquitin ligase complex involved in replication repair physical 1 1 1 Affinity Capture-MS
INO2 YDR123C Transcription factor genetic 1 1 1 Positive Genetic
NUF2 YOL069W Component of the kinetochore-associated Ndc80 complex physical 1 1 1 Two-hybrid
NUP57 YGR119C FG-nucleoporin component of central core of the nuclear pore complex genetic 1 1 1 Positive Genetic
CDC34 YDR054C Ubiquitin-conjugating enzyme (E2) genetic 1 1 1 Positive Genetic
BAS1 YKR099W Myb-related transcription factor genetic 1 1 1 Positive Genetic
AIM18 YHR198C Protein of unknown function genetic 1 1 1 Positive Genetic
CDC21 YOR074C Thymidylate synthase genetic 1 1 1 Positive Genetic
CST6 YIL036W Basic leucine zipper (bZIP) transcription factor from ATF/CREB family genetic 1 1 1 Negative Genetic
BFR1 YOR198C Component of mRNP complexes associated with polyribosomes physical 1 1 1 Affinity Capture-RNA
MCM3 YEL032W Protein involved in DNA replication genetic 1 1 1 Positive Genetic
ERV41 YML067C Protein localized to COPII-coated vesicles genetic 1 1 1 Positive Genetic
HRB1 YNL004W Poly(A+) RNA-binding protein genetic 1 1 1 Negative Genetic
IMP1 YMR150C Catalytic subunit of mitochondrial inner membrane peptidase complex genetic 1 1 1 Negative Genetic
KAR2 YJL034W ATPase involved in protein import into the ER genetic 1 1 1 Negative Genetic
HAP4 YKL109W Transcription factor genetic 1 1 1 Positive Genetic
MON1 YGL124C Subunit of a heterodimeric guanine nucleotide exchange factor (GEF) genetic 1 1 1 Negative Genetic
HHT2 YNL031C Histone H3 physical 1 1 1 Affinity Capture-MS
HAC1 YFL031W Basic leucine zipper (bZIP) transcription factor (ATF/CREB1 homolog) physical 1 1 1 Affinity Capture-RNA
EAF6 YJR082C Subunit of the NuA4 acetyltransferase complex physical 1 1 1 Reconstituted Complex
PAR32 YDL173W Low complexity protein genetic 1 1 1 Negative Genetic
ATP18 YML081C-A Subunit of the mitochondrial F1F0 ATP synthase genetic 1 1 1 Positive Genetic
BTS1 YPL069C Geranylgeranyl diphosphate synthase (GGPPS) genetic 1 1 1 Positive Genetic
GPI2 YPL076W Protein involved in the synthesis of GlcNAc-PI genetic 1 1 1 Negative Genetic
PDC2 YDR081C Transcription factor for thiamine-regulated genes genetic 1 1 1 Negative Genetic
BRL1 YHR036W Essential nuclear envelope/ER integral membrane protein genetic 1 1 1 Negative Genetic
ATG32 YIL146C Mitochondrial outer membrane protein required to initiate mitophagy genetic 1 1 1 Negative Genetic
KAE1 YKR038C Highly conserved ATPase of HSP70/DnaK family genetic 1 1 1 Negative Genetic
POC4 YPL144W Component of a heterodimeric Poc4p-Irc25p chaperone genetic 1 1 1 Positive Genetic
ADE12 YNL220W Adenylosuccinate synthase genetic 1 1 1 Negative Genetic
GSH1 YJL101C Gamma glutamylcysteine synthetase genetic 1 1 1 Negative Genetic
GPI17 YDR434W Transmembrane protein genetic 1 1 1 Negative Genetic
AIM11 YER093C-A Protein of unknown function genetic 1 1 1 Positive Genetic
ICS2 YBR157C Protein of unknown function genetic 1 1 1 Positive Genetic
HXT1 YHR094C Low-affinity glucose transporter of the major facilitator superfamily genetic 1 1 1 Negative Genetic
CDC8 YJR057W Nucleoside monophosphate and nucleoside diphosphate kinase genetic 1 1 1 Negative Genetic
BUD16 YEL029C Putative pyridoxal kinase physical 1 1 1 Reconstituted Complex
GRS2 YPR081C Glycine-tRNA synthetase, not expressed under normal growth conditions genetic 1 1 1 Positive Genetic
COX8 YLR395C Subunit VIII of cytochrome c oxidase (Complex IV) genetic 1 1 1 Positive Genetic
CYT2 YKL087C Cytochrome c1 heme lyase genetic 1 1 1 Positive Genetic
CDC1 YDR182W Putative mannose-ethanolamine phosphate phosphodiesterase genetic 1 1 1 Negative Genetic
ECM18 YDR125C Protein of unknown function genetic 1 1 1 Negative Genetic
GPI8 YDR331W Catalytic subunit of the ER membrane GPI transamidase complex genetic 1 1 1 Negative Genetic
PET8 YNL003C S-adenosylmethionine transporter of the mitochondrial inner membrane genetic 1 1 1 Positive Genetic
MGR2 YPL098C Subunit of the TIM23 translocase complex genetic 1 1 1 Negative Genetic
AAT1 YKL106W Mitochondrial aspartate aminotransferase genetic 1 1 1 Negative Genetic
KCH1 YJR054W Potassium transporter that mediates K+ influx genetic 1 1 1 Negative Genetic