Standard name Systematic name Name description Description
DNF2 YDR093W Aminophospholipid translocase (flippase) Aminophospholipid translocase (flippase); type 4 P-type ATPase; involved in phospholipid translocation, contributing to endocytosis, protein transport, and cellular polarization; localizes primarily to the plasma membrane; localizes to the shmoo tip where it has a redundant role in the cellular response to mating pheromone; DNF2 has a paralog, DNF1, that arose from the whole genome duplication
Visualize the interactome of DNF2
Links to external databases:
  SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)

CYCLoPs localization & abundance

WT1 WT2 WT3
Bud 0.171 0.178 0.176
Budsite 0.107 0.178 0.115
Cell Periphery 0.174 0.142 0.224
Cort. Patches 0.524 0.571 0.497
Cytoplasm 0.101 0.110 0.170
ER 0.210 0.151 0.145
Mito 0.067 0.187 NaN

GFP localization & abundance

GFP localization GFP abundance
ambiguous, cell periphery, bud low signal

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
DNF2 0 0 0 0 0

Enzyme information

Catalyzed reactions in Yeast8
r_4457 (O-Phosphoryl-Ethanolamine transport in via proton symport)

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
DNF1 YER166W Aminophospholipid translocase (flippase) genetic 9 4 9 Synthetic Lethality, Phenotypic Enhancement, Phenotypic Enhancement, Synthetic Growth Defect, Synthetic Rescue, Phenotypic Enhancement, Synthetic Growth Defect, Phenotypic Enhancement, Phenotypic Enhancement
LEM3 YNL323W Membrane protein of the plasma membrane and ER physical 6 4 5 Affinity Capture-Western, Affinity Capture-Western, PCA, PCA, Co-purification, Co-crystal Structure
ARV1 YLR242C Cortical ER protein genetic 4 1 3 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
ELM1 YKL048C Serine/threonine protein kinase genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
CDC28 YBR160W Cyclin-dependent kinase (CDK) catalytic subunit physical 2 2 2 Affinity Capture-MS, Biochemical Activity
SCS7 YMR272C Sphingolipid alpha-hydroxylase genetic 2 1 2 Positive Genetic, Positive Genetic
ERI1 YPL096C-A Endoplasmic reticulum membrane protein that binds and inhibits Ras2p genetic 2 1 2 Negative Genetic, Negative Genetic
YPK1 YKL126W S/T protein kinase genetic 2 1 2 Phenotypic Suppression, Phenotypic Suppression
DNF3 YMR162C Trans-golgi network aminophospholipid translocase (flippase) genetic 2 1 2 Phenotypic Enhancement, Phenotypic Enhancement
SFP1 YLR403W Regulates transcription of ribosomal protein and biogenesis genes regulation 1 1 1 DNA to cDNA expression microarray evidence
IXR1 YKL032C Transcriptional repressor that regulates hypoxic genes during normoxia regulation 1 1 1 DNA to cDNA expression microarray evidence
PHO2 YDL106C Homeobox transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
MBP1 YDL056W Transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
FPK1 YNR047W Ser/Thr protein kinase regulation 1 1 1 protein kinase assay evidence
CKA1 YIL035C Alpha catalytic subunit of casein kinase 2 (CK2) genetic 1 1 1 Negative Genetic
BMS1 YPL217C GTPase required for ribosomal subunit synthesis and rRNA processing genetic 1 1 1 Positive Genetic
CDC10 YCR002C Component of the septin ring, required for cytokinesis genetic 1 1 1 Negative Genetic
BUD31 YCR063W Component of the SF3b subcomplex of the U2 snRNP genetic 1 1 1 Positive Genetic
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator physical 1 1 1 Affinity Capture-RNA
CMR1 YDL156W Nuclear protein with role in transcription, protein quality control physical 1 1 1 Affinity Capture-MS
ATG9 YDL149W Transmembrane protein involved in forming Cvt and autophagic vesicles physical 1 1 1 Affinity Capture-MS
CHK1 YBR274W Serine/threonine kinase and DNA damage checkpoint effector genetic 1 1 1 Negative Genetic
CLN1 YMR199W G1 cyclin involved in regulation of the cell cycle genetic 1 1 1 Phenotypic Suppression
CDC20 YGL116W Activator of anaphase-promoting complex/cyclosome (APC/C) genetic 1 1 1 Positive Genetic
BIR1 YJR089W Subunit of chromosomal passenger complex (CPC) genetic 1 1 1 Positive Genetic
ATG1 YGL180W Protein serine/threonine kinase genetic 1 1 1 Negative Genetic
CLN3 YAL040C G1 cyclin involved in cell cycle progression genetic 1 1 1 Phenotypic Suppression
CEP3 YMR168C Essential kinetochore protein genetic 1 1 1 Positive Genetic
AMA1 YGR225W Activator of meiotic anaphase promoting complex (APC/C) genetic 1 1 1 Negative Genetic
ATG23 YLR431C Peripheral membrane protein required for autophagy and CVT physical 1 1 1 Affinity Capture-MS
ATG8 YBL078C Ub-like protein physical 1 1 1 Affinity Capture-MS
CSG2 YBR036C Endoplasmic reticulum membrane protein genetic 1 1 1 Positive Genetic
BNR1 YIL159W Formin genetic 1 1 1 Positive Genetic
ALY1 YKR021W Alpha arrestin, substrate of calcineurin genetic 1 1 1 Negative Genetic
CUL3 YGR003W Ubiquitin-protein ligase genetic 1 1 1 Negative Genetic
BYE1 YKL005C Negative regulator of transcription elongation genetic 1 1 1 Negative Genetic
ANY1 YMR010W Protein involved in phospholipid flippase function genetic 1 1 1 Dosage Lethality
DNF1 YER166W Aminophospholipid translocase (flippase) physical 1 1 1 PCA
RCY1 YJL204C F-box protein involved in recycling endocytosed proteins physical 1 1 1 Affinity Capture-Western
TOR1 YJR066W PIK-related protein kinase and rapamycin target physical 1 1 1 Co-fractionation
TOR2 YKL203C PIK-related protein kinase and rapamycin target physical 1 1 1 Co-fractionation
MID2 YLR332W O-glycosylated plasma membrane protein physical 1 1 1 PCA
HEK2 YBL032W RNA binding protein involved in asymmetric localization of ASH1 mRNA physical 1 1 1 Affinity Capture-RNA
STV1 YMR054W Subunit a of the vacuolar-ATPase V0 domain physical 1 1 1 PCA
HTB1 YDR224C Histone H2B physical 1 1 1 Affinity Capture-MS
HTB2 YBL002W Histone H2B physical 1 1 1 Affinity Capture-MS
SBP1 YHL034C Protein that binds eIF4G and has a role in repression of translation physical 1 1 1 Affinity Capture-RNA
PUF3 YLL013C Protein of the mitochondrial outer surface physical 1 1 1 Affinity Capture-RNA
SEC24 YIL109C Component of the Sec23p-Sec24p heterodimer of the COPII vesicle coat physical 1 1 1 Affinity Capture-MS
ISW1 YBR245C ATPase subunit of imitation-switch (ISWI) class chromatin remodelers physical 1 1 1 Affinity Capture-RNA
FPK1 YNR047W Ser/Thr protein kinase physical 1 1 1 Biochemical Activity
FPK1 YNR047W Ser/Thr protein kinase genetic 1 1 1 Synthetic Rescue
MCA1 YOR197W Ca2+-dependent cysteine protease physical 1 1 1 Affinity Capture-MS
PDR10 YOR328W ATP-binding cassette (ABC) transporter genetic 1 1 1 Phenotypic Enhancement
POL5 YEL055C Protein involved in 60S assembly and pre-40S AFs recycling genetic 1 1 1 Negative Genetic
SLA1 YBL007C Cytoskeletal protein binding protein genetic 1 1 1 Negative Genetic
RTG2 YGL252C Sensor of mitochondrial dysfunction genetic 1 1 1 Negative Genetic
XRN1 YGL173C Evolutionarily-conserved 5'-3' exonuclease genetic 1 1 1 Negative Genetic
NSG2 YNL156C Protein involved in regulation of sterol biosynthesis genetic 1 1 1 Negative Genetic
SPT14 YPL175W UDP-glycosyltransferase subunit of the GPI-GnT complex genetic 1 1 1 Negative Genetic
SRO7 YPR032W Effector of Rab GTPase Sec4p genetic 1 1 1 Positive Genetic
PKC1 YBL105C Protein serine/threonine kinase genetic 1 1 1 Positive Genetic
PBR1 YNL181W Putative oxidoreductase genetic 1 1 1 Positive Genetic
YCR090C YCR090C Putative protein of unknown function genetic 1 1 1 Positive Genetic
SRL3 YKR091W Repressor of transcription at Start genetic 1 1 1 Positive Genetic
LHS1 YKL073W Molecular chaperone of the endoplasmic reticulum lumen genetic 1 1 1 Positive Genetic
ROM2 YLR371W Guanine nucleotide exchange factor (GEF) for Rho1p and Rho2p genetic 1 1 1 Positive Genetic
TUS1 YLR425W Guanine nucleotide exchange factor (GEF) that modulates Rho1p activity genetic 1 1 1 Positive Genetic
SLG1 YOR008C Sensor-transducer of the stress-activated PKC1-MPK1 kinase pathway genetic 1 1 1 Positive Genetic
TAF5 YBR198C Subunit (90 kDa) of TFIID and SAGA complexes genetic 1 1 1 Negative Genetic
GPI19 YDR437W Subunit of GPI-GlcNAc transferase involved in synthesis of GlcNAc-PI genetic 1 1 1 Negative Genetic
SPB4 YFL002C Putative ATP-dependent RNA helicase genetic 1 1 1 Negative Genetic
KOG1 YHR186C Subunit of TORC1 genetic 1 1 1 Negative Genetic
TAO3 YIL129C Component of the RAM signaling network genetic 1 1 1 Negative Genetic
DPB11 YJL090C DNA replication initiation protein genetic 1 1 1 Negative Genetic
GPI15 YNL038W Protein involved in the synthesis of GlcNAc-PI genetic 1 1 1 Negative Genetic
GPI2 YPL076W Protein involved in the synthesis of GlcNAc-PI genetic 1 1 1 Negative Genetic
PEX32 YBR168W Peroxisomal integral membrane protein genetic 1 1 1 Negative Genetic
ZTA1 YBR046C NADPH-dependent quinone reductase genetic 1 1 1 Negative Genetic
RDH54 YBR073W DNA-dependent ATPase genetic 1 1 1 Negative Genetic
MSI1 YBR195C Subunit of chromatin assembly factor I (CAF-1) genetic 1 1 1 Negative Genetic
SWC5 YBR231C Component of the SWR1 complex genetic 1 1 1 Negative Genetic
DPB3 YBR278W Third-largest subunit of DNA polymerase II (DNA polymerase epsilon) genetic 1 1 1 Negative Genetic
EXG2 YDR261C Exo-1,3-beta-glucanase genetic 1 1 1 Negative Genetic
RAD34 YDR314C Protein involved in nucleotide excision repair (NER) genetic 1 1 1 Negative Genetic
FLO8 YER109C Transcription factor genetic 1 1 1 Negative Genetic
MIL1 YFL034W Predicted lipase genetic 1 1 1 Negative Genetic
YFR057W YFR057W Putative protein of unknown function genetic 1 1 1 Negative Genetic
RRT6 YGL146C Integral membrane protein, member of the p24 family genetic 1 1 1 Negative Genetic
PEX31 YGR004W Peroxisomal integral membrane protein genetic 1 1 1 Negative Genetic
VMA21 YGR105W Integral membrane protein required for V-ATPase function genetic 1 1 1 Negative Genetic
YTA7 YGR270W Chromatin-binding ATPase that regulates histone gene expression genetic 1 1 1 Negative Genetic
HXT5 YHR096C Hexose transporter with moderate affinity for glucose genetic 1 1 1 Negative Genetic
YHR131C YHR131C Putative protein of unknown function genetic 1 1 1 Negative Genetic
VTH1 YIL173W Putative membrane glycoprotein genetic 1 1 1 Negative Genetic
HAL5 YJL165C Snf1p-related nutrient-responsive protein kinase genetic 1 1 1 Negative Genetic
SAC1 YKL212W Phosphatidylinositol phosphate phosphatase genetic 1 1 1 Negative Genetic
PXL1 YKR090W Protein that localizes to sites of polarized growth genetic 1 1 1 Negative Genetic
RPL8B YLL045C Ribosomal 60S subunit protein L8A genetic 1 1 1 Negative Genetic
YLR036C YLR036C Putative protein predicted to have transmembrane domains genetic 1 1 1 Negative Genetic
PAU23 YLR037C Cell wall mannoprotein genetic 1 1 1 Negative Genetic
LUG1 YLR352W Protein of unknown function with similarity to F-box proteins genetic 1 1 1 Negative Genetic
YML002W YML002W Putative protein of unknown function genetic 1 1 1 Negative Genetic
TRM12 YML005W S-adenosylmethionine-dependent methyltransferase genetic 1 1 1 Negative Genetic
RPS18B YML026C Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
MGR3 YMR115W Subunit of the mitochondrial (mt) i-AAA protease supercomplex genetic 1 1 1 Negative Genetic
MLF3 YNL074C Serine-rich protein of unknown function genetic 1 1 1 Negative Genetic
SYC1 YOR179C Subunit of the APT subcomplex of cleavage and polyadenylation factor genetic 1 1 1 Negative Genetic
REV1 YOR346W Deoxycytidyl transferase genetic 1 1 1 Negative Genetic
RPL21B YPL079W Ribosomal 60S subunit protein L21B genetic 1 1 1 Negative Genetic
FRK1 YPL141C Protein kinase of unknown cellular role genetic 1 1 1 Negative Genetic
RPL43A YPR043W Ribosomal 60S subunit protein L43A genetic 1 1 1 Negative Genetic
SPE3 YPR069C Spermidine synthase genetic 1 1 1 Negative Genetic
VMA8 YEL051W Subunit D of the V1 peripheral membrane domain of V-ATPase genetic 1 1 1 Negative Genetic
YGL188C-A YGL188C-A Putative protein of unknown function genetic 1 1 1 Negative Genetic
HFL1 YKR051W Vacuole membrane protein that interacts with Atg8p genetic 1 1 1 Negative Genetic
MIH1 YMR036C Protein tyrosine phosphatase genetic 1 1 1 Negative Genetic
GAS4 YOL132W 1,3-beta-glucanosyltransferase genetic 1 1 1 Negative Genetic
GUP2 YPL189W Probable membrane protein genetic 1 1 1 Negative Genetic
INN1 YNL152W Essential protein that associates with contractile actomyosin ring genetic 1 1 1 Synthetic Rescue
CDC50 YCR094W Endosomal protein that interacts with phospholipid flippase Drs2p genetic 1 1 1 Negative Genetic
DCR2 YLR361C Protein phosphatase genetic 1 1 1 Negative Genetic
ASI2 YNL159C Subunit of the inner nuclear membrane Asi ubiquitin ligase complex genetic 1 1 1 Negative Genetic
AGA1 YNR044W Anchorage subunit of a-agglutinin of a-cells genetic 1 1 1 Negative Genetic
APS3 YJL024C Small subunit of the clathrin-associated adaptor complex AP-3 genetic 1 1 1 Negative Genetic