Standard name Systematic name Name description Description
UBA2 YDR390C Subunit of heterodimeric nuclear SUMO activating enzyme E1 with Aos1p Subunit of heterodimeric nuclear SUMO activating enzyme E1 with Aos1p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability
Visualize the interactome of UBA2
Links to external databases:
  SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)

CYCLoPs localization & abundance

WT1 WT2 WT3
Nucleus 0.971 0.955 0.968

GFP localization & abundance

GFP localization GFP abundance
nucleus 18800

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
UBA2 2 0 0 0 0

Enzyme information

Catalyzed reactions in Yeast8

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
UBC9 YDL064W SUMO-conjugating enzyme involved in the Smt3p conjugation pathway physical 8 3 6 Co-crystal Structure, Biochemical Activity, Reconstituted Complex, Reconstituted Complex, Reconstituted Complex, Biochemical Activity, Biochemical Activity, Biochemical Activity
AOS1 YPR180W Subunit of heterodimeric nuclear SUMO activating enzyme E1 with Uba2p physical 6 3 5 Affinity Capture-MS, Reconstituted Complex, Affinity Capture-MS, Affinity Capture-MS, Co-fractionation, Reconstituted Complex
ULP2 YIL031W Peptidase that deconjugates Smt3/SUMO-1 peptides from proteins genetic 6 3 3 Synthetic Rescue, Synthetic Rescue, Dosage Growth Defect, Phenotypic Suppression, Synthetic Rescue, Synthetic Rescue
MOT1 YPL082C Essential protein involved in regulation of transcription genetic 3 2 3 Synthetic Rescue, Phenotypic Suppression, Synthetic Rescue
PAP1 YKR002W Poly(A) polymerase physical 2 2 1 Two-hybrid, Reconstituted Complex
SSE1 YPL106C ATPase component of heat shock protein Hsp90 chaperone complex physical 2 1 1 Affinity Capture-MS, Affinity Capture-MS
SSA1 YAL005C ATPase involved in protein folding and NLS-directed nuclear transport physical 2 1 1 Affinity Capture-MS, Affinity Capture-MS
FKH1 YIL131C Forkhead family transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
SFP1 YLR403W Regulates transcription of ribosomal protein and biogenesis genes regulation 1 1 1 DNA to cDNA expression microarray evidence
FKH2 YNL068C Forkhead family transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
XBP1 YIL101C Transcriptional repressor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
YAP1 YML007W Basic leucine zipper (bZIP) transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
CCR4 YAL021C Component of the CCR4-NOT transcriptional complex physical 1 1 1 Affinity Capture-RNA
AOS1 YPR180W Subunit of heterodimeric nuclear SUMO activating enzyme E1 with Uba2p genetic 1 1 1 Dosage Rescue
CDC28 YBR160W Cyclin-dependent kinase (CDK) catalytic subunit genetic 1 1 1 Dosage Lethality
ISW1 YBR245C ATPase subunit of imitation-switch (ISWI) class chromatin remodelers physical 1 1 1 Affinity Capture-RNA
KAP114 YGL241W Karyopherin, responsible for nuclear import of specific proteins physical 1 1 1 Two-hybrid
KAP114 YGL241W Karyopherin, responsible for nuclear import of specific proteins genetic 1 1 1 Phenotypic Suppression
TAF12 YDR145W Subunit (61/68 kDa) of TFIID and SAGA complexes physical 1 1 1 Affinity Capture-MS
PSK1 YAL017W PAS domain-containing serine/threonine protein kinase genetic 1 1 1 Dosage Rescue
ASA1 YPR085C Subunit of the ASTRA complex, involved in chromatin remodeling genetic 1 1 1 Negative Genetic
SLX5 YDL013W Subunit of the Slx5-Slx8 SUMO-targeted Ub ligase (STUbL) complex genetic 1 1 1 Synthetic Lethality
SMC6 YLR383W Subunit of the SMC5-SMC6 complex genetic 1 1 1 Synthetic Growth Defect
PSK2 YOL045W PAS-domain containing serine/threonine protein kinase genetic 1 1 1 Dosage Rescue
SMT3 YDR510W Ubiquitin-like protein of the SUMO family physical 1 1 1 Protein-peptide
SMT3 YDR510W Ubiquitin-like protein of the SUMO family genetic 1 1 1 Synthetic Rescue
SMC5 YOL034W Subunit of the SMC5-SMC6 complex genetic 1 1 1 Synthetic Growth Defect
CHL1 YPL008W Probable DNA helicase genetic 1 1 1 Synthetic Lethality
NFI1 YOR156C SUMO E3 ligase genetic 1 1 1 Synthetic Growth Defect
TAF9 YMR236W Subunit (17 kDa) of TFIID and SAGA complexes physical 1 1 1 Affinity Capture-MS
CBF2 YGR140W Essential kinetochore protein genetic 1 1 1 Dosage Rescue
UBA2 YDR390C Subunit of heterodimeric nuclear SUMO activating enzyme E1 with Aos1p physical 1 1 1 Affinity Capture-Western
UFD1 YGR048W Substrate-recruiting cofactor of the Cdc48p-Npl4p-Ufd1p segregase physical 1 1 1 Two-hybrid
ULP1 YPL020C Protease that specifically cleaves Smt3p protein conjugates physical 1 1 1 PCA
HMT1 YBR034C Nuclear SAM-dependent mono- and asymmetric methyltransferase physical 1 1 1 PCA
SSB2 YNL209W Cytoplasmic ATPase that is a ribosome-associated molecular chaperone physical 1 1 1 Co-purification
SLX8 YER116C Subunit of Slx5-Slx8 SUMO-targeted ubiquitin ligase (STUbL) complex genetic 1 1 1 Synthetic Lethality
SSM4 YIL030C Membrane-embedded ubiquitin-protein ligase and retrotranslocase genetic 1 1 1 Phenotypic Enhancement
MPS3 YJL019W Nuclear envelope protein physical 1 1 1 Affinity Capture-MS