Standard name Systematic name Name description Description
APE1 YKL103C Vacuolar aminopeptidase yscI Vacuolar aminopeptidase yscI; zinc metalloproteinase that belongs to the peptidase family M18; often used as a marker protein in studies of autophagy and cytosol to vacuole targeting (CVT) pathway; protein increases in abundance and relative distribution to cytoplasmic foci increases upon DNA replication stress
Visualize the interactome of APE1
Links to external databases:
  SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)
M 164

CYCLoPs localization & abundance

WT1 WT2 WT3
Bud 0.060 NaN 0.060
Cort. Patches 0.064 0.071 0.057
Cytoplasm 0.648 0.714 0.713
Endosome 0.172 0.102 0.098
Golgi NaN 0.051 NaN
SpindlePole NaN NaN 0.087

GFP localization & abundance

GFP localization GFP abundance
no data no data

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
APE1 0 0 0 0 0

Enzyme information

Catalyzed reactions in Yeast8
r_4204 (Vacuolar aminopeptidase 1 (EC 3.4.11.22) (Aminopeptidase yscI) (Leucine aminopeptidase IV) (LAPIV) (Lysosomal aminopeptidase III) (Polypeptidase) (Vacuolar aminopeptidase I)), r_4203 (Vacuolar aminopeptidase 1 (EC 3.4.11.22) (Aminopeptidase yscI) (Leucine aminopeptidase IV) (LAPIV) (Lysosomal aminopeptidase III) (Polypeptidase) (Vacuolar aminopeptidase I))

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
ATG19 YOL082W Receptor protein for the cytoplasm-to-vacuole targeting (Cvt) pathway physical 21 6 16 Affinity Capture-MS, Two-hybrid, Two-hybrid, Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex, Two-hybrid, Two-hybrid, Affinity Capture-Western, Affinity Capture-Western, Two-hybrid, Two-hybrid, Co-localization, Affinity Capture-Western, Reconstituted Complex, Affinity Capture-MS, Reconstituted Complex, Co-crystal Structure, Reconstituted Complex, Reconstituted Complex, Reconstituted Complex
APE1 YKL103C Vacuolar aminopeptidase yscI physical 11 5 9 Two-hybrid, Two-hybrid, Two-hybrid, Co-purification, Co-crystal Structure, Reconstituted Complex, Reconstituted Complex, Co-crystal Structure, Co-crystal Structure, Reconstituted Complex, Co-fractionation
ATG11 YPR049C Adapter protein for pexophagy and the Cvt targeting pathway physical 4 4 4 Two-hybrid, Co-localization, Affinity Capture-Western, Reconstituted Complex
ATG8 YBL078C Ub-like protein physical 4 4 4 Affinity Capture-Western, Co-localization, Affinity Capture-MS, Reconstituted Complex
ATG9 YDL149W Transmembrane protein involved in forming Cvt and autophagic vesicles physical 3 3 3 Co-fractionation, Affinity Capture-Western, Reconstituted Complex
SWI4 YER111C DNA binding component of the SBF complex (Swi4p-Swi6p) regulation 3 2 3 chromatin immunoprecipitation-chip evidence, chromatin immunoprecipitation-chip evidence, DNA to cDNA expression microarray evidence
ATG1 YGL180W Protein serine/threonine kinase physical 3 3 2 Affinity Capture-Western, Affinity Capture-MS, Reconstituted Complex
FKH1 YIL131C Forkhead family transcription factor regulation 2 2 2 chromatin immunoprecipitation-chip evidence, ChEC-Seq experiments
FKH2 YNL068C Forkhead family transcription factor regulation 2 2 2 chromatin immunoprecipitation-chip evidence, ChEC-Seq experiments
AFT1 YGL071W Transcription factor involved in iron utilization and homeostasis regulation 2 2 2 chromatin immunoprecipitation-chip evidence, DNA to cDNA expression microarray evidence
AMS1 YGL156W Vacuolar alpha mannosidase physical 2 2 2 Affinity Capture-MS, Two-hybrid
TFB1 YDR311W Subunit of TFIIH and nucleotide excision repair factor 3 complexes physical 2 1 2 Two-hybrid, Two-hybrid
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator physical 2 1 2 Affinity Capture-RNA, Affinity Capture-RNA
BCY1 YIL033C Regulatory subunit of the cyclic AMP-dependent protein kinase (PKA) genetic 2 1 2 Negative Genetic, Negative Genetic
YOR1 YGR281W Plasma membrane ATP-binding cassette (ABC) transporter genetic 2 1 2 Negative Genetic, Negative Genetic
LRP1 YHR081W Nuclear exosome-associated nucleic acid binding protein genetic 2 1 2 Negative Genetic, Negative Genetic
VRP1 YLR337C Verprolin, proline-rich actin-associated protein genetic 2 1 2 Negative Genetic, Negative Genetic
ADY3 YDL239C Protein required for spore wall formation physical 2 1 2 Two-hybrid, Two-hybrid
SSB1 YDL229W Cytoplasmic ATPase that is a ribosome-associated molecular chaperone physical 2 1 1 Affinity Capture-MS, Affinity Capture-MS
ATG13 YPR185W Regulatory subunit of the Atg1p signaling complex genetic 2 1 1 Negative Genetic, Negative Genetic
BIM1 YER016W Microtubule plus end-tracking protein genetic 2 1 1 Phenotypic Enhancement, Phenotypic Enhancement
GCN5 YGR252W Catalytic subunit of ADA and SAGA histone acetyltransferase complexes regulation 1 1 1 chromatin immunoprecipitation-chip evidence
SPT10 YJL127C Histone H3 acetylase with a role in transcriptional regulation regulation 1 1 1 DNA to cDNA expression microarray evidence
AFT2 YPL202C Iron-regulated transcriptional activator regulation 1 1 1 chromatin immunoprecipitation-chip evidence
RGR1 YLR071C Subunit of the RNA polymerase II mediator complex regulation 1 1 1 chromatin immunoprecipitation-chip evidence
BUR6 YER159C Subunit of a heterodimeric NC2 transcription regulator complex regulation 1 1 1 chromatin immunoprecipitation-chip evidence
REB1 YBR049C RNA polymerase I enhancer binding protein regulation 1 1 1 chromatin immunoprecipitation-chip evidence
SUA7 YPR086W Transcription factor TFIIB regulation 1 1 1 chromatin immunoprecipitation-chip evidence
GCN4 YEL009C bZIP transcriptional activator of amino acid biosynthetic genes regulation 1 1 1 chromatin immunoprecipitation-chip evidence
CST6 YIL036W Basic leucine zipper (bZIP) transcription factor from ATF/CREB family regulation 1 1 1 DNA to cDNA expression microarray evidence
CDC73 YLR418C Component of the Paf1p complex regulation 1 1 1 DNA to cDNA expression microarray evidence
SIN3 YOL004W Component of both the Rpd3S and Rpd3L histone deacetylase complexes regulation 1 1 1 DNA to cDNA expression microarray evidence
GLN3 YER040W Transcriptional activator in nitrogen catabolite repression system regulation 1 1 1 DNA to cDNA expression microarray evidence
PHO2 YDL106C Homeobox transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
CAD1 YDR423C AP-1-like basic leucine zipper (bZIP) transcriptional activator regulation 1 1 1 chromatin immunoprecipitation-chip evidence
MBP1 YDL056W Transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
RPH1 YER169W JmjC domain-containing histone demethylase regulation 1 1 1 DNA to cDNA expression microarray evidence
MIL1 YFL034W Predicted lipase physical 1 1 1 Affinity Capture-MS
BIK1 YCL029C Microtubule-associated protein physical 1 1 1 Affinity Capture-MS
CPR1 YDR155C Cytoplasmic peptidyl-prolyl cis-trans isomerase (cyclophilin) physical 1 1 1 Affinity Capture-MS
HTB1 YDR224C Histone H2B physical 1 1 1 Affinity Capture-MS
HHT1 YBR010W Histone H3 physical 1 1 1 Affinity Capture-MS
VMA4 YOR332W Subunit E of the V1 domain of the vacuolar H+-ATPase (V-ATPase) physical 1 1 1 Affinity Capture-MS
DLD3 YEL071W 2-hydroxyglutarate transhydrogenase, and minor D-lactate dehydrogenase physical 1 1 1 Affinity Capture-MS
PEX7 YDR142C Peroxisomal signal receptor for peroxisomal matrix proteins physical 1 1 1 Affinity Capture-MS
MTW1 YAL034W-A Essential component of the MIND kinetochore complex physical 1 1 1 Two-hybrid
TEM1 YML064C GTPase involved in initiation of Mitotic Exit Network (MEN) physical 1 1 1 Two-hybrid
SRP1 YNL189W Karyopherin alpha homolog physical 1 1 1 Two-hybrid
APL3 YBL037W Alpha-adaptin physical 1 1 1 Two-hybrid
MXR2 YCL033C Methionine-R-sulfoxide reductase physical 1 1 1 Two-hybrid
APE4 YHR113W Cytoplasmic aspartyl aminopeptidase with possible vacuole function physical 1 1 1 Two-hybrid
SEC24 YIL109C Component of the Sec23p-Sec24p heterodimer of the COPII vesicle coat physical 1 1 1 Two-hybrid
GCD7 YLR291C Beta subunit of translation initiation factor eIF2B physical 1 1 1 Two-hybrid
SWC7 YLR385C Protein of unknown function physical 1 1 1 Two-hybrid
TRS130 YMR218C Component of transport protein particle (TRAPP) complex II physical 1 1 1 Two-hybrid
YAF9 YNL107W Subunit of NuA4 histone H4 acetyltransferase and SWR1 complexes physical 1 1 1 Two-hybrid
CTR9 YOL145C Component of the Paf1p complex involved in transcription elongation physical 1 1 1 Two-hybrid
IDH2 YOR136W Subunit of mitochondrial NAD(+)-dependent isocitrate dehydrogenase physical 1 1 1 Two-hybrid
NAB2 YGL122C Nuclear polyadenylated RNA-binding protein physical 1 1 1 Affinity Capture-RNA
RPN11 YFR004W Metalloprotease subunit of 19S regulatory particle physical 1 1 1 Affinity Capture-MS
CLG1 YGL215W Cyclin-like protein that interacts with Pho85p physical 1 1 1 Affinity Capture-MS
HRR25 YPL204W Conserved casein kinase, monopolin subunit physical 1 1 1 Affinity Capture-MS
MRK1 YDL079C Glycogen synthase kinase 3 (GSK-3) homolog physical 1 1 1 Affinity Capture-MS
PCL6 YER059W Pho85p cyclin of the Pho80p subfamily physical 1 1 1 Affinity Capture-MS
PHO80 YOL001W Cyclin physical 1 1 1 Affinity Capture-MS
PUF3 YLL013C Protein of the mitochondrial outer surface physical 1 1 1 Affinity Capture-MS
YPK2 YMR104C AGC-type S/T protein kinase physical 1 1 1 Affinity Capture-MS
HMG2 YLR450W HMG-CoA reductase physical 1 1 1 Affinity Capture-Western
ATG8 YBL078C Ub-like protein genetic 1 1 1 Negative Genetic
TFS1 YLR178C Inhibitor of carboxypeptidase Y (Prc1p), and Ras GAP (Ira2p) physical 1 1 1 Affinity Capture-MS
SBP1 YHL034C Protein that binds eIF4G and has a role in repression of translation physical 1 1 1 Affinity Capture-RNA
SSB2 YNL209W Cytoplasmic ATPase that is a ribosome-associated molecular chaperone physical 1 1 1 Co-purification
ATG34 YOL083W Receptor protein involved in selective autophagy during starvation physical 1 1 1 Reconstituted Complex
CRM1 YGR218W Nuclear export factor, exportin physical 1 1 1 Affinity Capture-MS
MMS22 YLR320W Subunit of E3 ubiquitin ligase complex involved in replication repair physical 1 1 1 Affinity Capture-MS
SPT16 YGL207W Subunit of the heterodimeric FACT complex (Spt16p-Pob3p) physical 1 1 1 Affinity Capture-MS
PTC7 YHR076W Type 2C serine/threonine protein phosphatase (PP2C) physical 1 1 1 Affinity Capture-MS
COQ9 YLR201C Protein required for ubiquinone biosynthesis and respiratory growth physical 1 1 1 Affinity Capture-MS
CCR4 YAL021C Component of the CCR4-NOT transcriptional complex physical 1 1 1 Affinity Capture-RNA
CDC14 YFR028C Protein phosphatase required for mitotic exit physical 1 1 1 Affinity Capture-MS
MCA1 YOR197W Ca2+-dependent cysteine protease physical 1 1 1 Affinity Capture-MS
ATG13 YPR185W Regulatory subunit of the Atg1p signaling complex physical 1 1 1 Reconstituted Complex
SIS1 YNL007C Type II HSP40 co-chaperone that interacts with the HSP70 protein Ssa1p physical 1 1 1 Affinity Capture-MS
MNN10 YDR245W Subunit of a Golgi mannosyltransferase complex genetic 1 1 1 Negative Genetic
EIS1 YMR031C Component of the eisosome required for proper eisosome assembly genetic 1 1 1 Negative Genetic
ESS1 YJR017C Peptidylprolyl-cis/trans-isomerase (PPIase) genetic 1 1 1 Synthetic Growth Defect
PDX3 YBR035C Pyridoxine (pyridoxamine) phosphate oxidase genetic 1 1 1 Positive Genetic
NSE4 YDL105W Component of the SMC5-SMC6 complex genetic 1 1 1 Negative Genetic
ARP3 YJR065C Essential component of the Arp2/3 complex genetic 1 1 1 Negative Genetic
PBR1 YNL181W Putative oxidoreductase genetic 1 1 1 Negative Genetic
XRN1 YGL173C Evolutionarily-conserved 5'-3' exonuclease genetic 1 1 1 Negative Genetic