Standard name Systematic name Name description Description
MSC2 YDR205W Endoplasmic reticulum zinc transporter Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Zrg17p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; localizes to ER and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids
Visualize the interactome of MSC2
Links to external databases:
  SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)

CYCLoPs localization & abundance

WT1 WT2 WT3
Cort. Patches 0.099 0.060 0.054
Cytoplasm 0.305 0.438 0.296
ER 0.622 0.508 0.542
Vac/Vac Memb 0.056 NaN NaN
Mito NaN 0.063 0.087
Endosome NaN NaN 0.058

GFP localization & abundance

GFP localization GFP abundance
ER 1070

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
MSC2 0 0 0 0 0

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
ZRG17 YNR039C Endoplasmic reticulum zinc transporter physical 5 3 4 Affinity Capture-Western, Affinity Capture-Western, Two-hybrid, Two-hybrid, PCA
SLT2 YHR030C Serine/threonine MAP kinase genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
WHI3 YNL197C RNA binding protein that modulates mRNA stability physical 2 2 2 Protein-RNA, Affinity Capture-RNA
SIN3 YOL004W Component of both the Rpd3S and Rpd3L histone deacetylase complexes genetic 2 2 2 Phenotypic Suppression, Negative Genetic
DEP1 YAL013W Component of the Rpd3L histone deacetylase complex genetic 2 1 2 Negative Genetic, Negative Genetic
KSP1 YHR082C Serine/threonine protein kinase genetic 2 1 2 Negative Genetic, Negative Genetic
ROM1 YGR070W Guanine nucleotide exchange factor (GEF) for Rho1p genetic 2 1 2 Negative Genetic, Negative Genetic
PPT2 YPL148C Phosphopantetheine:protein transferase (PPTase) genetic 2 1 2 Negative Genetic, Negative Genetic
SPO19 YPL130W Meiosis-specific prospore protein genetic 2 1 2 Negative Genetic, Negative Genetic
SEC22 YLR268W R-SNARE protein genetic 2 1 1 Negative Genetic, Negative Genetic
RTN1 YDR233C Reticulon protein genetic 2 1 1 Negative Genetic, Negative Genetic
PMT4 YJR143C Protein O-mannosyltransferase genetic 2 1 1 Negative Genetic, Negative Genetic
SND2 YLR065C Protein involved in SRP-independent targeting of substrates to the ER genetic 2 1 1 Negative Genetic, Negative Genetic
SFP1 YLR403W Regulates transcription of ribosomal protein and biogenesis genes regulation 1 1 1 DNA to cDNA expression microarray evidence
MED2 YDL005C Subunit of the RNA polymerase II mediator complex regulation 1 1 1 chromatin immunoprecipitation-chip evidence
MED4 YOR174W Subunit of the RNA polymerase II mediator complex regulation 1 1 1 chromatin immunoprecipitation-chip evidence
YAP5 YIR018W Basic leucine zipper (bZIP) iron-sensing transcription factor regulation 1 1 1 DNA to cDNA expression microarray evidence
HAP5 YOR358W Subunit of the Hap2p/3p/4p/5p CCAAT-binding complex genetic 1 1 1 Negative Genetic
DIS3 YOL021C Exosome core complex catalytic subunit genetic 1 1 1 Negative Genetic
MPE1 YKL059C Subunit of CPF cleavage and polyadenylation factor and E3 Ub-ligase genetic 1 1 1 Negative Genetic
CCR4 YAL021C Component of the CCR4-NOT transcriptional complex physical 1 1 1 Affinity Capture-RNA
DOA1 YKL213C WD-repeat protein involved in ubiquitin-mediated protein degradation genetic 1 1 1 Negative Genetic
ERV25 YML012W Member of the p24 family involved in ER to Golgi transport genetic 1 1 1 Negative Genetic
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator physical 1 1 1 Affinity Capture-RNA
ISW1 YBR245C ATPase subunit of imitation-switch (ISWI) class chromatin remodelers physical 1 1 1 Affinity Capture-RNA
HSL1 YKL101W Nim1p-related protein kinase genetic 1 1 1 Negative Genetic
GEP3 YOR205C Protein required for mitochondrial ribosome small subunit biogenesis genetic 1 1 1 Negative Genetic
MED8 YBR193C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
FYV10 YIL097W Subunit of GID complex genetic 1 1 1 Negative Genetic
HHT1 YBR010W Histone H3 genetic 1 1 1 Negative Genetic
CTF4 YPR135W Chromatin-associated protein genetic 1 1 1 Negative Genetic
MRE11 YMR224C Nuclease subunit of the MRX complex with Rad50p and Xrs2p genetic 1 1 1 Negative Genetic
ARP1 YHR129C Actin-related protein of the dynactin complex genetic 1 1 1 Negative Genetic
FAR3 YMR052W Protein of unknown function genetic 1 1 1 Negative Genetic
ARP6 YLR085C Actin-related protein that binds nucleosomes genetic 1 1 1 Negative Genetic
BFR1 YOR198C Component of mRNP complexes associated with polyribosomes physical 1 1 1 Affinity Capture-RNA
HSP150 YJL159W O-mannosylated heat shock protein genetic 1 1 1 Dosage Rescue
MCM3 YEL032W Protein involved in DNA replication genetic 1 1 1 Negative Genetic
ERV29 YGR284C Protein localized to COPII-coated vesicles genetic 1 1 1 Negative Genetic
BCS1 YDR375C Protein translocase and chaperone required for Complex III assembly genetic 1 1 1 Negative Genetic
DID2 YKR035W-A Class E protein of the vacuolar protein-sorting (Vps) pathway genetic 1 1 1 Negative Genetic
SSC1 YJR045C Hsp70 family ATPase physical 1 1 1 Affinity Capture-MS
PUF2 YPR042C PUF family mRNA-binding protein physical 1 1 1 Affinity Capture-RNA
SPO13 YHR014W Meiotic regulator genetic 1 1 1 Synthetic Lethality
YKE4 YIL023C Zinc transporter genetic 1 1 1 Synthetic Lethality
PSD1 YNL169C Phosphatidylserine decarboxylase of the mitochondrial inner membrane genetic 1 1 1 Synthetic Growth Defect
RML2 YEL050C Mitochondrial ribosomal protein of the large subunit (L2) genetic 1 1 1 Negative Genetic
VMA3 YEL027W Proteolipid subunit c of the V0 domain of vacuolar H(+)-ATPase genetic 1 1 1 Negative Genetic
YDJ1 YNL064C Type I HSP40 co-chaperone genetic 1 1 1 Negative Genetic
NPL3 YDR432W RNA-binding protein genetic 1 1 1 Synthetic Rescue
PBR1 YNL181W Putative oxidoreductase genetic 1 1 1 Positive Genetic
XYL2 YLR070C Xylitol dehydrogenase genetic 1 1 1 Positive Genetic
YLR287C YLR287C Putative protein of unknown function genetic 1 1 1 Positive Genetic
RSB1 YOR049C Sphingoid long-chain base (LCB) efflux transporter genetic 1 1 1 Positive Genetic
REB1 YBR049C RNA polymerase I enhancer binding protein genetic 1 1 1 Negative Genetic
RAP1 YNL216W Essential DNA-binding transcription regulator that binds many loci genetic 1 1 1 Negative Genetic
RPO31 YOR116C RNA polymerase III largest subunit C160 genetic 1 1 1 Negative Genetic
UBP1 YDL122W Ubiquitin-specific protease genetic 1 1 1 Negative Genetic
RTG3 YBL103C bHLH/Zip transcription factor for retrograde (RTG) and TOR pathways genetic 1 1 1 Negative Genetic
RPP2B YDR382W Ribosomal protein P2 beta genetic 1 1 1 Negative Genetic
RVS167 YDR388W Calmodulin-binding actin-associated protein genetic 1 1 1 Negative Genetic
NPR3 YHL023C Subunit of the Iml1p/SEACIT complex genetic 1 1 1 Negative Genetic
SDS3 YIL084C Component of the Rpd3L histone deacetylase complex genetic 1 1 1 Negative Genetic
SAC1 YKL212W Phosphatidylinositol phosphate phosphatase genetic 1 1 1 Negative Genetic
SHH4 YLR164W Putative alternate subunit of succinate dehydrogenase (SDH) genetic 1 1 1 Negative Genetic
RPS30A YLR287C-A Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
UBC12 YLR306W Enzyme that mediates the conjugation of Rub1p genetic 1 1 1 Negative Genetic
RPL31B YLR406C Ribosomal 60S subunit protein L31B genetic 1 1 1 Negative Genetic
RPS16A YMR143W Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
PFK2 YMR205C Beta subunit of heterooctameric phosphofructokinase genetic 1 1 1 Negative Genetic
SAP30 YMR263W Component of Rpd3L histone deacetylase complex genetic 1 1 1 Negative Genetic
MSN1 YOL116W Transcriptional activator genetic 1 1 1 Negative Genetic
RPL21B YPL079W Ribosomal 60S subunit protein L21B genetic 1 1 1 Negative Genetic
SLX8 YER116C Subunit of Slx5-Slx8 SUMO-targeted ubiquitin ligase (STUbL) complex genetic 1 1 1 Negative Genetic
ZRT1 YGL255W High-affinity zinc transporter of the plasma membrane genetic 1 1 1 Negative Genetic
YJR084W YJR084W Protein that forms a complex with Thp3p genetic 1 1 1 Negative Genetic
YLL053C YLL053C Putative protein genetic 1 1 1 Negative Genetic
YOR186W YOR186W Putative protein of unknown function genetic 1 1 1 Negative Genetic
SEC27 YGL137W Essential beta'-coat protein of the COPI coatomer genetic 1 1 1 Positive Genetic
SET1 YHR119W Histone methyltransferase, subunit of the COMPASS (Set1C) complex genetic 1 1 1 Positive Genetic
PAN1 YIR006C Part of actin cytoskeleton-regulatory complex Pan1p-Sla1p-End3p genetic 1 1 1 Negative Genetic
STT4 YLR305C Phosphatidylinositol-4-kinase genetic 1 1 1 Negative Genetic
YPC1 YBR183W Alkaline ceramidase genetic 1 1 1 Positive Genetic
GLO4 YOR040W Mitochondrial glyoxalase II genetic 1 1 1 Negative Genetic
ILM1 YJR118C Protein of unknown function genetic 1 1 1 Negative Genetic
CEM1 YER061C Mitochondrial beta-keto-acyl synthase genetic 1 1 1 Negative Genetic
HER2 YMR293C Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex genetic 1 1 1 Negative Genetic
GPI13 YLL031C ER membrane localized phosphoryltransferase genetic 1 1 1 Negative Genetic
FEX1 YOR390W Protein involved in fluoride export genetic 1 1 1 Negative Genetic
MET13 YGL125W Major isozyme of methylenetetrahydrofolate reductase genetic 1 1 1 Negative Genetic
IMP2 YMR035W Catalytic subunit of mitochondrial inner membrane peptidase complex genetic 1 1 1 Negative Genetic
MCH2 YKL221W Protein with similarity to mammalian monocarboxylate permeases physical 1 1 1 PCA
DGK1 YOR311C Diacylglycerol kinase genetic 1 1 1 Negative Genetic
HMI1 YOL095C Mitochondrial inner membrane localized ATP-dependent DNA helicase genetic 1 1 1 Negative Genetic
MCH5 YOR306C Plasma membrane riboflavin transporter genetic 1 1 1 Negative Genetic
ECM8 YBR076W Non-essential protein of unknown function genetic 1 1 1 Negative Genetic