Standard name Systematic name Name description Description
TFC3 YAL001C Subunit of RNA polymerase III transcription initiation factor complex Subunit of RNA polymerase III transcription initiation factor complex; part of TauB domain of TFIIIC that binds DNA at BoxB promoter sites of tRNA and similar genes; cooperates with Tfc6p in DNA binding; largest of six subunits of RNA polymerase III transcription initiation factor complex (TFIIIC); colocalizes with condensin at pol III genes and several ETC (extra TFIIIC) sites; may have a role in recruiting or stabilizing Scc2/4 and condensin on chromosomes
Visualize the interactome of TFC3
Links to external databases:
SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)

CYCLoPs localization & abundance

WT1 WT2 WT3
Cytoplasm 0.075 0.052 0.155
Nucleus 0.842 0.639 0.403
Vac/Vac Memb 0.063 0.052 NaN
Mito NaN 0.598 0.723

GFP localization & abundance

GFP localization GFP abundance
cytoplasm, nucleus 125

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
TFC3 5 0 0 0 0

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
TFC1 YBR123C Subunit of RNA polymerase III transcription initiation factor complex physical 7 3 6 Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Co-fractionation, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western
TFC4 YGR047C Subunit of RNA polymerase III transcription initiation factor complex genetic 4 3 3 Dosage Rescue, Synthetic Rescue, Negative Genetic, Negative Genetic
TFC7 YOR110W RNA pol III transcription initiation factor complex (TFIIIC) subunit physical 3 2 3 Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS
TFC6 YDR362C Subunit of RNA polymerase III transcription initiation factor complex physical 3 2 3 Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS
TFC1 YBR123C Subunit of RNA polymerase III transcription initiation factor complex genetic 3 2 2 Dosage Rescue, Negative Genetic, Negative Genetic
TFC6 YDR362C Subunit of RNA polymerase III transcription initiation factor complex genetic 3 2 2 Synthetic Rescue, Negative Genetic, Negative Genetic
CDC60 YPL160W Cytosolic leucyl tRNA synthetase genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
DED1 YOR204W ATP-dependent DEAD-box RNA helicase with strand-annealing activity genetic 2 2 2 Dosage Rescue, Negative Genetic
KAP95 YLR347C Karyopherin beta genetic 2 2 2 Negative Genetic, Positive Genetic
CDC28 YBR160W Cyclin-dependent kinase (CDK) catalytic subunit genetic 2 2 2 Negative Genetic, Dosage Lethality
SPT15 YER148W TATA-binding protein (TBP) genetic 2 2 2 Dosage Rescue, Negative Genetic
BDP1 YNL039W Essential subunit of RNA polymerase III transcription factor (TFIIIB) genetic 2 2 2 Dosage Rescue, Negative Genetic
TFC4 YGR047C Subunit of RNA polymerase III transcription initiation factor complex physical 2 2 2 Affinity Capture-Western, Affinity Capture-MS
PUF3 YLL013C Protein of the mitochondrial outer surface physical 2 1 2 Affinity Capture-RNA, Affinity Capture-RNA
BRF1 YGR246C TFIIIB B-related factor genetic 2 1 2 Dosage Rescue, Dosage Rescue
RPC10 YHR143W-A RNA polymerase subunit ABC10-alpha, found in RNA pol I, II, and III genetic 2 1 2 Dosage Rescue, Dosage Rescue
MUD2 YKL074C Protein involved in early pre-mRNA splicing genetic 2 1 2 Negative Genetic, Negative Genetic
ESC2 YDR363W Sumo-like domain protein genetic 2 1 2 Negative Genetic, Negative Genetic
ACT1 YFL039C Actin, structural protein in cytoskeleton genetic 2 2 1 Positive Genetic, Negative Genetic
RPC34 YNR003C RNA polymerase III subunit C34 genetic 2 1 1 Negative Genetic, Negative Genetic
RPC82 YPR190C RNA polymerase III subunit C82 genetic 2 1 1 Negative Genetic, Negative Genetic
GCD1 YOR260W Gamma subunit of the translation initiation factor eIF2B genetic 2 1 1 Negative Genetic, Negative Genetic
CUS1 YMR240C Protein required for assembly of U2 snRNP into the spliceosome genetic 2 1 1 Negative Genetic, Negative Genetic
POP7 YBR167C Subunit of RNase MRP, nuclear RNase P and telomerase genetic 2 1 1 Negative Genetic, Negative Genetic
PRP4 YPR178W Splicing factor genetic 2 1 1 Negative Genetic, Negative Genetic
RPC11 YDR045C RNA polymerase III subunit C11 genetic 2 1 1 Negative Genetic, Negative Genetic
DPB11 YJL090C DNA replication initiation protein genetic 2 1 1 Negative Genetic, Negative Genetic
BDP1 YNL039W Essential subunit of RNA polymerase III transcription factor (TFIIIB) physical 2 1 1 Affinity Capture-Western, Affinity Capture-Western
GCD10 YNL062C Subunit of tRNA (1-methyladenosine) methyltransferase with Gcd14p genetic 2 1 1 Negative Genetic, Negative Genetic
TFC8 YPL007C Subunit of RNA polymerase III transcription initiation factor complex genetic 2 1 1 Negative Genetic, Negative Genetic
ZPR1 YGR211W Essential protein with two zinc fingers genetic 2 1 1 Negative Genetic, Negative Genetic
PEX32 YBR168W Peroxisomal integral membrane protein genetic 2 1 1 Negative Genetic, Negative Genetic
SAD1 YFR005C Conserved zinc-finger domain protein involved in pre-mRNA splicing genetic 2 1 1 Negative Genetic, Negative Genetic
FKH1 YIL131C Forkhead family transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
SPT10 YJL127C Histone H3 acetylase with a role in transcriptional regulation regulation 1 1 1 DNA to cDNA expression microarray evidence
FKH2 YNL068C Forkhead family transcription factor regulation 1 1 1 chromatin immunoprecipitation- exonuclease evidence
HFI1 YPL254W Adaptor protein required for structural integrity of the SAGA complex regulation 1 1 1 DNA to cDNA expression microarray evidence
RPD3 YNL330C Histone deacetylase, component of both the Rpd3S and Rpd3L complexes regulation 1 1 1 chromatin immunoprecipitation-chip evidence
CLF1 YLR117C Member of the NineTeen Complex (NTC) genetic 1 1 1 Negative Genetic
DSN1 YIR010W Essential component of the outer kinetochore MIND complex physical 1 1 1 Affinity Capture-MS
RPO21 YDL140C RNA polymerase II largest subunit B220 genetic 1 1 1 Negative Genetic
MIA40 YKL195W Import and assembly protein in mitochondrial intermembrane space genetic 1 1 1 Negative Genetic
PRP19 YLL036C Splicing factor associated with the spliceosome genetic 1 1 1 Negative Genetic
POP1 YNL221C Subunit of RNase MRP, nuclear RNase P and telomerase complexes genetic 1 1 1 Negative Genetic
SNT309 YPR101W Member of the NineTeen Complex (NTC) genetic 1 1 1 Negative Genetic
BRE1 YDL074C E3 ubiquitin ligase physical 1 1 1 Affinity Capture-MS
MES1 YGR264C Methionyl-tRNA synthetase genetic 1 1 1 Positive Genetic
LSM6 YDR378C Lsm (Like Sm) protein genetic 1 1 1 Negative Genetic
NOP1 YDL014W Histone glutamine methyltransferase, modifies H2A at Q105 in nucleolus genetic 1 1 1 Dosage Rescue
CDC48 YDL126C AAA ATPase with protein-unfoldase activity genetic 1 1 1 Positive Genetic
RRP45 YDR280W Exosome non-catalytic core component genetic 1 1 1 Positive Genetic
RPC17 YJL011C RNA polymerase III subunit C17 genetic 1 1 1 Negative Genetic
RPC31 YNL151C RNA polymerase III subunit C31 genetic 1 1 1 Negative Genetic
RPC82 YPR190C RNA polymerase III subunit C82 physical 1 1 1 Affinity Capture-MS
RPN5 YDL147W Subunit of the CSN and 26S proteasome lid complexes physical 1 1 1 Affinity Capture-MS
RPN6 YDL097C Essential, non-ATPase regulatory subunit of the 26S proteasome lid physical 1 1 1 Affinity Capture-MS
RPN12 YFR052W Subunit of the 19S regulatory particle of the 26S proteasome lid physical 1 1 1 Affinity Capture-MS
SSD1 YDR293C Translational repressor genetic 1 1 1 Positive Genetic
CCR4 YAL021C Component of the CCR4-NOT transcriptional complex physical 1 1 1 Affinity Capture-RNA
ADE4 YMR300C Phosphoribosylpyrophosphate amidotransferase (PRPPAT) genetic 1 1 1 Negative Genetic
CKS1 YBR135W Cyclin-dependent protein kinase regulatory subunit and adaptor genetic 1 1 1 Negative Genetic
CLP1 YOR250C Component of the cleavage and polyadenylation factor I (CF I) genetic 1 1 1 Negative Genetic
COP1 YDL145C Alpha subunit of COPI vesicle coatomer complex genetic 1 1 1 Positive Genetic
GCD7 YLR291C Beta subunit of translation initiation factor eIF2B genetic 1 1 1 Negative Genetic
HHF1 YBR009C Histone H4 physical 1 1 1 Affinity Capture-MS
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator physical 1 1 1 Affinity Capture-RNA
HHF2 YNL030W Histone H4 physical 1 1 1 Affinity Capture-MS
ISW1 YBR245C ATPase subunit of imitation-switch (ISWI) class chromatin remodelers physical 1 1 1 Affinity Capture-RNA
HSL1 YKL101W Nim1p-related protein kinase genetic 1 1 1 Positive Genetic
LSM2 YBL026W Lsm (Like Sm) protein genetic 1 1 1 Negative Genetic
HRR25 YPL204W Conserved casein kinase, monopolin subunit genetic 1 1 1 Negative Genetic
IMG2 YCR071C Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Negative Genetic
MRP7 YNL005C Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Negative Genetic
MRM1 YOR201C Ribose methyltransferase genetic 1 1 1 Negative Genetic
PRP31 YGR091W Splicing factor genetic 1 1 1 Negative Genetic
PUB1 YNL016W Poly (A)+ RNA-binding protein genetic 1 1 1 Positive Genetic
RAD51 YER095W Strand exchange protein genetic 1 1 1 Synthetic Lethality
RET2 YFR051C Delta subunit of the coatomer complex (COPI) genetic 1 1 1 Positive Genetic
RFC4 YOL094C Subunit of heteropentameric Replication factor C (RF-C) genetic 1 1 1 Negative Genetic
CSI1 YMR025W Subunit of the Cop9 signalosome genetic 1 1 1 Negative Genetic
SEC26 YDR238C Essential beta-coat protein of the COPI coatomer genetic 1 1 1 Positive Genetic
SEC63 YOR254C Essential subunit of Sec63 complex genetic 1 1 1 Negative Genetic
PRP18 YGR006W Splicing factor and component of snRNP U5 genetic 1 1 1 Negative Genetic
PRP11 YDL043C Subunit of the SF3a splicing factor complex genetic 1 1 1 Negative Genetic
MLP1 YKR095W Myosin-like protein associated with the nuclear envelope physical 1 1 1 Affinity Capture-MS
SYF1 YDR416W Member of the NineTeen Complex (NTC) genetic 1 1 1 Negative Genetic
SPS1 YDR523C STE20-family GCKIII protein kinase physical 1 1 1 Affinity Capture-MS
GET1 YGL020C Subunit of the GET complex genetic 1 1 1 Negative Genetic
RGP1 YDR137W Subunit of a Golgi membrane exchange factor (Ric1p-Rgp1p) genetic 1 1 1 Negative Genetic
SLX5 YDL013W Subunit of the Slx5-Slx8 SUMO-targeted Ub ligase (STUbL) complex genetic 1 1 1 Negative Genetic
COF1 YLL050C Cofilin, involved in pH-dependent actin filament depolarization genetic 1 1 1 Positive Genetic
SUI2 YJR007W Alpha subunit of the translation initiation factor eIF2 genetic 1 1 1 Negative Genetic
DOP1 YDR141C Protein involved in vesicular transport at trans-Golgi network (TGN) genetic 1 1 1 Negative Genetic
GID8 YMR135C Subunit of GID Complex, binds strongly to central component Vid30p genetic 1 1 1 Negative Genetic
SGS1 YMR190C RecQ family nucleolar DNA helicase genetic 1 1 1 Positive Genetic
FHL1 YPR104C Regulator of ribosomal protein (RP) transcription genetic 1 1 1 Dosage Rescue
RNA1 YMR235C GTPase activating protein (GAP) for Gsp1p genetic 1 1 1 Positive Genetic
GPN3 YLR243W Putative GTPase with a role in biogenesis of RNA pol II and polIII genetic 1 1 1 Negative Genetic
FRS2 YFL022C Alpha subunit of cytoplasmic phenylalanyl-tRNA synthetase genetic 1 1 1 Negative Genetic
KIN28 YDL108W Ser/Thr protein kinase and subunit of TFIIK, a TFIIH subassembly genetic 1 1 1 Negative Genetic
ELC1 YPL046C Elongin C, conserved among eukaryotes genetic 1 1 1 Negative Genetic
LSM8 YJR022W Lsm (Like Sm) protein genetic 1 1 1 Negative Genetic
FAL1 YDR021W Nucleolar protein required for maturation of 18S rRNA genetic 1 1 1 Negative Genetic
IST3 YIR005W Component of the U2 snRNP genetic 1 1 1 Negative Genetic
MDH3 YDL078C Peroxisomal malate dehydrogenase physical 1 1 1 Affinity Capture-MS
CDC7 YDL017W S/T kinase and catalytic subunit of DDK (Dbf4-dependent kinase) genetic 1 1 1 Negative Genetic
MLP2 YIL149C Myosin-like protein associated with the nuclear envelope physical 1 1 1 Affinity Capture-MS
SRV2 YNL138W CAP (cyclase-associated protein) genetic 1 1 1 Negative Genetic
SPC24 YMR117C Component of the kinetochore-associated Ndc80 complex genetic 1 1 1 Negative Genetic
BUD27 YFL023W Unconventional prefoldin protein involved in translation initiation genetic 1 1 1 Negative Genetic
MOB2 YFL034C-B Activator of Cbk1p kinase genetic 1 1 1 Negative Genetic
PRP5 YBR237W RNA helicase in the DEAD-box family genetic 1 1 1 Negative Genetic
ASK1 YKL052C Essential subunit of the Dam1 complex (aka DASH complex) genetic 1 1 1 Negative Genetic
BOS1 YLR078C v-SNARE (vesicle specific SNAP receptor) genetic 1 1 1 Negative Genetic
CWC15 YDR163W Non-essential protein involved in pre-mRNA splicing genetic 1 1 1 Negative Genetic
BRF1 YGR246C TFIIIB B-related factor physical 1 1 1 Affinity Capture-Western
ARP6 YLR085C Actin-related protein that binds nucleosomes genetic 1 1 1 Negative Genetic
RPP1 YHR062C Subunit of both RNase MRP and nuclear RNase P genetic 1 1 1 Negative Genetic
DAL81 YIR023W Positive regulator of genes in multiple nitrogen degradation pathways genetic 1 1 1 Negative Genetic
FRQ1 YDR373W N-myristoylated calcium-binding protein genetic 1 1 1 Positive Genetic
SEC22 YLR268W R-SNARE protein genetic 1 1 1 Negative Genetic
RAP1 YNL216W Essential DNA-binding transcription regulator that binds many loci genetic 1 1 1 Negative Genetic
STU1 YBL034C Microtubule plus-end-tracking non-motor protein genetic 1 1 1 Negative Genetic
MPT5 YGL178W mRNA-binding protein of the PUF family physical 1 1 1 Affinity Capture-RNA
MON1 YGL124C Subunit of a heterodimeric guanine nucleotide exchange factor (GEF) genetic 1 1 1 Positive Genetic
PET494 YNR045W Mitochondrial translational activator specific for the COX3 mRNA genetic 1 1 1 Negative Genetic
MSL5 YLR116W Component of commitment complex genetic 1 1 1 Negative Genetic
MDL1 YLR188W Mitochondrial inner membrane half-type ABC transporter genetic 1 1 1 Negative Genetic
BET4 YJL031C Alpha subunit of Type II geranylgeranyltransferase genetic 1 1 1 Negative Genetic
TFC7 YOR110W RNA pol III transcription initiation factor complex (TFIIIC) subunit genetic 1 1 1 Dosage Rescue
YRA1 YDR381W Nuclear polyadenylated RNA-binding protein physical 1 1 1 Affinity Capture-MS
UTP6 YDR449C Nucleolar protein physical 1 1 1 Affinity Capture-MS
UTP6 YDR449C Nucleolar protein genetic 1 1 1 Negative Genetic
UTP15 YMR093W Nucleolar protein physical 1 1 1 Affinity Capture-MS
TFC8 YPL007C Subunit of RNA polymerase III transcription initiation factor complex physical 1 1 1 Affinity Capture-MS
YIP1 YGR172C Integral membrane protein genetic 1 1 1 Positive Genetic
TPI1 YDR050C Triose phosphate isomerase, abundant glycolytic enzyme genetic 1 1 1 Negative Genetic
TSC11 YER093C Subunit of TORC2 (Tor2p-Lst8p-Avo1-Avo2-Tsc11p-Bit61p) genetic 1 1 1 Negative Genetic
YJU2 YKL095W Essential protein required for pre-mRNA splicing genetic 1 1 1 Negative Genetic
UTP13 YLR222C Nucleolar protein genetic 1 1 1 Negative Genetic
YHC1 YLR298C Component of the U1 snRNP complex required for pre-mRNA splicing genetic 1 1 1 Negative Genetic
YDR341C YDR341C Arginyl-tRNA synthetase genetic 1 1 1 Negative Genetic
UGA4 YDL210W GABA (gamma-aminobutyrate) permease genetic 1 1 1 Negative Genetic
YER137C YER137C Protein of unknown function genetic 1 1 1 Negative Genetic
YMR187C YMR187C Putative protein of unknown function genetic 1 1 1 Negative Genetic
TOP1 YOL006C Topoisomerase I genetic 1 1 1 Negative Genetic
VSB1 YGR125W Vacuolar membrane protein required for uptake and storage of arginine genetic 1 1 1 Negative Genetic
VPS71 YML041C Nucleosome-binding component of the SWR1 complex genetic 1 1 1 Negative Genetic
YMR315W-A YMR315W-A Putative protein of unknown function genetic 1 1 1 Negative Genetic
SRP101 YDR292C Signal recognition particle (SRP) receptor alpha subunit genetic 1 1 1 Positive Genetic
SSB2 YNL209W Cytoplasmic ATPase that is a ribosome-associated molecular chaperone physical 1 1 1 Co-purification
TEF1 YPR080W Translational elongation factor EF-1 alpha genetic 1 1 1 Negative Genetic
PET127 YOR017W Protein with a role in 5'-end processing of mitochondrial RNAs genetic 1 1 1 Positive Genetic
PRP24 YMR268C Splicing factor that reanneals snRNPs during spliceosome recycling genetic 1 1 1 Negative Genetic
PBN1 YCL052C Component of glycosylphosphatidylinositol-mannosyltransferase I genetic 1 1 1 Negative Genetic
SPC105 YGL093W Subunit of a kinetochore-microtubule binding complex genetic 1 1 1 Negative Genetic
HRQ1 YDR291W 3'-5' DNA helicase of the conserved RecQ family genetic 1 1 1 Positive Genetic
SRP40 YKR092C Nucleolar serine-rich protein genetic 1 1 1 Dosage Rescue
STP1 YDR463W Transcription factor genetic 1 1 1 Negative Genetic
MTC1 YJL123C Protein of unknown function that may interact with ribosomes genetic 1 1 1 Negative Genetic
GRX4 YER174C Glutathione-dependent oxidoreductase and glutathione S-transferase genetic 1 1 1 Negative Genetic
CAB4 YGR277C Subunit of the CoA-Synthesizing Protein Complex (CoA-SPC) genetic 1 1 1 Negative Genetic
GCD14 YJL125C Subunit of tRNA (1-methyladenosine) methyltransferase genetic 1 1 1 Negative Genetic
RPL6A YML073C Ribosomal 60S subunit protein L6A genetic 1 1 1 Dosage Rescue
RPL26A YLR344W Ribosomal 60S subunit protein L26A genetic 1 1 1 Dosage Rescue
APJ1 YNL077W Hsp40 chaperone with a role in SUMO-mediated protein degradation physical 1 1 1 Affinity Capture-MS
DEG1 YFL001W tRNA:pseudouridine synthase genetic 1 1 1 Negative Genetic
RNH70 YGR276C 3'-5' exoribonuclease genetic 1 1 1 Negative Genetic
SUB1 YMR039C Transcriptional regulator physical 1 1 1 Far Western
SUB1 YMR039C Transcriptional regulator genetic 1 1 1 Negative Genetic
RPL14A YKL006W Ribosomal 60S subunit protein L14A genetic 1 1 1 Dosage Rescue
ERG3 YLR056W C-5 sterol desaturase genetic 1 1 1 Positive Genetic
PXP1 YEL020C Peroxisomal matrix protein genetic 1 1 1 Negative Genetic
ATG41 YPL250C Protein of unknown function genetic 1 1 1 Negative Genetic
NCE103 YNL036W Carbonic anhydrase genetic 1 1 1 Negative Genetic
SRP102 YKL154W Signal recognition particle (SRP) receptor beta subunit genetic 1 1 1 Negative Genetic
ALG11 YNL048W Alpha-1,2-mannosyltransferase genetic 1 1 1 Negative Genetic
GPI1 YGR216C Membrane protein involved in the synthesis of GlcNAc-PI genetic 1 1 1 Negative Genetic
PET20 YPL159C Mitochondrial protein genetic 1 1 1 Negative Genetic
RIT1 YMR283C Initiator methionine 2'-O-ribosyl phosphate transferase genetic 1 1 1 Negative Genetic
PEX9 YMR018W Peroxisomal membrane signal receptor for peroxisomal matrix proteins genetic 1 1 1 Negative Genetic
SPO23 YBR250W Protein of unknown function genetic 1 1 1 Negative Genetic
PAU1 YJL223C Member of the seripauperin multigene family genetic 1 1 1 Negative Genetic
PAU3 YCR104W Member of the seripauperin multigene family genetic 1 1 1 Negative Genetic