Standard name Systematic name Name description Description
HEM15 YOR176W Ferrochelatase Ferrochelatase; a mitochondrial inner membrane protein, catalyzes insertion of ferrous iron into protoporphyrin IX, the eighth and final step in the heme biosynthetic pathway; human homolog FECH can complement yeast mutant and allow growth of haploid null after sporulation of a heterozygous diploid
Visualize the interactome of HEM15
Links to external databases:
  SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)
M 174

CYCLoPs localization & abundance

WT1 WT2 WT3
Endosome 0.050 0.056 NaN
Mito 0.863 0.874 0.918
Nuc Periphery 0.050 NaN NaN
Vac/Vac Memb 0.180 0.167 0.056
Peroxisome NaN NaN 0.082

GFP localization & abundance

GFP localization GFP abundance
mitochondrion 22700

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
HEM15 1 0 0 0 0

Enzyme information

Catalyzed reactions in Yeast8
r_0436 (ferrochelatase)

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
CDC31 YOR257W Calcium-binding component of the spindle pole body (SPB) half-bridge physical 5 2 2 Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western
YFH1 YDL120W Mitochondrial matrix iron chaperone physical 4 2 3 Reconstituted Complex, Co-crystal Structure, Reconstituted Complex, Co-crystal Structure
FKH1 YIL131C Forkhead family transcription factor regulation 3 2 3 chromatin immunoprecipitation-chip evidence, chromatin immunoprecipitation-chip evidence, ChEC-Seq experiments
HEM15 YOR176W Ferrochelatase physical 3 3 1 Reconstituted Complex, Two-hybrid, Affinity Capture-Western
MED2 YDL005C Subunit of the RNA polymerase II mediator complex regulation 1 1 1 chromatin immunoprecipitation-chip evidence
YAP6 YDR259C Basic leucine zipper (bZIP) transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
YAP1 YML007W Basic leucine zipper (bZIP) transcription factor regulation 1 1 1 DNA to cDNA expression microarray evidence
TFC7 YOR110W RNA pol III transcription initiation factor complex (TFIIIC) subunit regulation 1 1 1 chromatin immunoprecipitation-chip evidence
BMH1 YER177W 14-3-3 protein, major isoform physical 1 1 1 Affinity Capture-MS
BMH2 YDR099W 14-3-3 protein, minor isoform physical 1 1 1 Affinity Capture-MS
BNI1 YNL271C Formin physical 1 1 1 Reconstituted Complex
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator physical 1 1 1 Affinity Capture-RNA
PWP1 YLR196W Protein with WD-40 repeats involved in rRNA processing physical 1 1 1 Affinity Capture-MS
NUP85 YJR042W Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC) physical 1 1 1 Affinity Capture-MS
KAP104 YBR017C Transportin or cytosolic karyopherin beta 2 physical 1 1 1 Affinity Capture-MS
PPH21 YDL134C Catalytic subunit of protein phosphatase 2A, PP2A physical 1 1 1 Affinity Capture-MS
LCD1 YDR499W Essential protein required for the DNA integrity checkpoint pathways physical 1 1 1 Affinity Capture-MS
RPN10 YHR200W Proteasome polyubiquitin receptor physical 1 1 1 Affinity Capture-MS
PET9 YBL030C Major ADP/ATP carrier of the mitochondrial inner membrane physical 1 1 1 Affinity Capture-MS
NAB2 YGL122C Nuclear polyadenylated RNA-binding protein physical 1 1 1 Affinity Capture-RNA
RLI1 YDR091C Essential Fe-S protein physical 1 1 1 Affinity Capture-Western
SUP45 YBR143C Polypeptide release factor (eRF1) in translation termination physical 1 1 1 Affinity Capture-Western
SUP35 YDR172W Translation termination factor eRF3 physical 1 1 1 Affinity Capture-Western
MIC60 YKR016W Component of the MICOS complex physical 1 1 1 Affinity Capture-MS
PUF3 YLL013C Protein of the mitochondrial outer surface physical 1 1 1 Affinity Capture-RNA
SSB2 YNL209W Cytoplasmic ATPase that is a ribosome-associated molecular chaperone physical 1 1 1 Co-purification
SSC1 YJR045C Hsp70 family ATPase physical 1 1 1 Affinity Capture-MS
HSP104 YLL026W Disaggregase physical 1 1 1 Affinity Capture-MS
HSP82 YPL240C Hsp90 chaperone physical 1 1 1 Affinity Capture-MS
HSC82 YMR186W Cytoplasmic chaperone of the Hsp90 family physical 1 1 1 Affinity Capture-MS
TOM22 YNL131W Component of the TOM (Translocase of Outer Membrane) complex physical 1 1 1 Affinity Capture-MS
RPS13 YDR064W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPS18A YDR450W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPS19A YOL121C Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPS22A YJL190C Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPL26A YLR344W Ribosomal 60S subunit protein L26A physical 1 1 1 Affinity Capture-MS
RPS27A YKL156W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPS3 YNL178W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
TIM23 YNR017W Essential component of the TIM23 complex physical 1 1 1 Affinity Capture-MS
SGS1 YMR190C RecQ family nucleolar DNA helicase genetic 1 1 1 Synthetic Lethality
NCE102 YPR149W Protein of unknown function genetic 1 1 1 Synthetic Rescue
CHL1 YPL008W Probable DNA helicase genetic 1 1 1 Synthetic Lethality
GIS1 YDR096W Histone demethylase and transcription factor physical 1 1 1 Affinity Capture-MS
COX20 YDR231C Mitochondrial inner membrane protein physical 1 1 1 Affinity Capture-MS