| Standard name | Systematic name | Name description | Description |
|---|---|---|---|
| HEM3 | YDL205C | Porphobilinogen deaminase | Porphobilinogen deaminase; catalyzes the conversion of 4-porphobilinogen to hydroxymethylbilane, the third step in heme biosynthesis; localizes to the cytoplasm and nucleus; expression is regulated by Hap2p-Hap3p, but not by levels of heme; human homolog HMBS can complement yeast mutant and allow growth of haploid null after sporulation of a heterozygous diploid |
Cell cycle phase and timing of transcription peak
| Cell cycle phase | Time (min) |
|---|---|
CYCLoPs localization & abundance
| WT1 | WT2 | WT3 | |
|---|---|---|---|
| Cytoplasm | 0.997 | 1.000 | NaN |
| Mito | NaN | 0.053 | NaN |
GFP localization & abundance
| GFP localization | GFP abundance |
|---|---|
| cytoplasm, nucleus | 8480 |
GO term count
| Metabolism | Cell cycle | Cell division | Signal transduction | DNA replication | |
|---|---|---|---|---|---|
| HEM3 | 2 | 0 | 0 | 0 | 0 |
Enzyme information
| Catalyzed reactions in Yeast8 |
|---|
| r_0557 (hydroxymethylbilane synthase) |
List of interactors
Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.| Standard name | Systematic name | Name description | Type | #Experiments | #Methods | #Publications | Evidence |
|---|---|---|---|---|---|---|---|
| PUF3 | YLL013C | Protein of the mitochondrial outer surface | physical | 2 | 1 | 2 | Affinity Capture-RNA, Affinity Capture-RNA |
| IXR1 | YKL032C | Transcriptional repressor that regulates hypoxic genes during normoxia | regulation | 1 | 1 | 1 | DNA to cDNA expression microarray evidence |
| GND1 | YHR183W | 6-phosphogluconate dehydrogenase (decarboxylating) | genetic | 1 | 1 | 1 | Positive Genetic |
| FUM1 | YPL262W | Fumarase | genetic | 1 | 1 | 1 | Negative Genetic |
| ELO3 | YLR372W | Elongase | genetic | 1 | 1 | 1 | Negative Genetic |
| CSG2 | YBR036C | Endoplasmic reticulum membrane protein | genetic | 1 | 1 | 1 | Positive Genetic |
| HEM12 | YDR047W | Uroporphyrinogen decarboxylase | genetic | 1 | 1 | 1 | Phenotypic Suppression |
| GUP1 | YGL084C | Plasma membrane protein involved in remodeling GPI anchors | genetic | 1 | 1 | 1 | Positive Genetic |
| HEM2 | YGL040C | Aminolevulinate dehydratase | genetic | 1 | 1 | 1 | Phenotypic Suppression |
| NAB2 | YGL122C | Nuclear polyadenylated RNA-binding protein | physical | 1 | 1 | 1 | Affinity Capture-RNA |
| SRO9 | YCL037C | Cytoplasmic RNA-binding protein | physical | 1 | 1 | 1 | Affinity Capture-RNA |
| SBP1 | YHL034C | Protein that binds eIF4G and has a role in repression of translation | physical | 1 | 1 | 1 | Affinity Capture-RNA |
| SSB2 | YNL209W | Cytoplasmic ATPase that is a ribosome-associated molecular chaperone | physical | 1 | 1 | 1 | Co-purification |
| PUF2 | YPR042C | PUF family mRNA-binding protein | physical | 1 | 1 | 1 | Affinity Capture-RNA |
| PFK1 | YGR240C | Alpha subunit of heterooctameric phosphofructokinase | genetic | 1 | 1 | 1 | Negative Genetic |
| INP53 | YOR109W | Polyphosphatidylinositol phosphatase | genetic | 1 | 1 | 1 | Negative Genetic |
| HEM4 | YOR278W | Uroporphyrinogen III synthase | genetic | 1 | 1 | 1 | Phenotypic Enhancement |
| TTI1 | YKL033W | Subunit of the ASTRA complex, involved in chromatin remodeling | genetic | 1 | 1 | 1 | Positive Genetic |
| POL2 | YNL262W | Catalytic subunit of DNA polymerase (II) epsilon | genetic | 1 | 1 | 1 | Synthetic Rescue |
| ARG7 | YMR062C | Mitochondrial ornithine acetyltransferase | genetic | 1 | 1 | 1 | Negative Genetic |