Standard name Systematic name Name description Description
COX1 Q0045 Subunit I of cytochrome c oxidase (Complex IV) Subunit I of cytochrome c oxidase (Complex IV); Complex IV is the terminal member of the mitochondrial inner membrane electron transport chain; one of three mitochondrially-encoded subunits; number of introns in different strains varies from 2 to 8, with most strains having 4-6 introns
Visualize the interactome of COX1
Links to external databases:
  SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)

CYCLoPs localization & abundance

WT1 WT2 WT3
no data no data no data

GFP localization & abundance

GFP localization GFP abundance
no data no data

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
COX1 2 0 0 0 0

Enzyme information

Catalyzed reactions in Yeast8
r_0438 (ferrocytochrome-c:oxygen oxidoreductase)

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
MSS51 YLR203C Specific translational activator for the mitochondrial COX1 mRNA physical 11 2 10 Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-Western
COX2 Q0250 Subunit II of cytochrome c oxidase (Complex IV) physical 9 5 9 Co-fractionation, Affinity Capture-Western, Affinity Capture-Western, Co-purification, Affinity Capture-Western, Reconstituted Complex, Affinity Capture-Western, Affinity Capture-MS, Co-purification
COX4 YGL187C Subunit IV of cytochrome c oxidase physical 8 4 7 Co-fractionation, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-Western, Reconstituted Complex, Affinity Capture-MS, Affinity Capture-Western
COX3 Q0275 Subunit III of cytochrome c oxidase (Complex IV) physical 7 5 7 Co-fractionation, Affinity Capture-Western, Affinity Capture-Western, Co-purification, Affinity Capture-Western, Reconstituted Complex, Affinity Capture-MS
RCF1 YML030W Cytochrome c oxidase subunit physical 7 3 7 Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex, Affinity Capture-Western, Co-purification
COA3 YJL062W-A Mitochondrial protein required for cytochrome c oxidase assembly physical 6 1 6 Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western
COR1 YBL045C Core subunit of the ubiquinol-cytochrome c reductase complex physical 5 2 4 Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western
SHY1 YGR112W Mitochondrial inner membrane protein required for complex IV assembly physical 5 2 3 Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western
COX8 YLR395C Subunit VIII of cytochrome c oxidase (Complex IV) physical 4 4 4 Co-fractionation, Co-purification, Affinity Capture-MS, Affinity Capture-Western
COX6 YHR051W Subunit VI of cytochrome c oxidase (Complex IV) physical 4 3 4 Co-fractionation, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-MS
COX14 YML129C Mitochondrial cytochrome c oxidase (complex IV) assembly factor physical 4 1 4 Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western
COA1 YIL157C Mitochondrial inner membrane protein physical 4 1 4 Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western
COX7 YMR256C Subunit VII of cytochrome c oxidase (Complex IV) physical 3 3 3 Co-fractionation, Reconstituted Complex, Affinity Capture-MS
RCF2 YNR018W Cytochrome c oxidase subunit physical 3 1 3 Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western
COX16 YJL003W Mitochondrial inner membrane protein physical 3 2 1 Co-purification, Affinity Capture-MS, Affinity Capture-MS
COX5A YNL052W Subunit Va of cytochrome c oxidase physical 2 2 2 Co-fractionation, Affinity Capture-MS
PET54 YGR222W Mitochondrial inner membrane protein physical 2 2 2 Protein-RNA, Affinity Capture-RNA
TIM23 YNR017W Essential component of the TIM23 complex physical 2 2 2 Affinity Capture-Western, Affinity Capture-MS
COX20 YDR231C Mitochondrial inner membrane protein physical 2 2 2 Affinity Capture-Western, Affinity Capture-MS
VAR1 Q0140 Mitochondrial ribosomal protein of the small subunit physical 2 1 2 Affinity Capture-Western, Affinity Capture-Western
PUT1 YLR142W Proline oxidase genetic 2 1 1 Synthetic Lethality, Synthetic Lethality
URA1 YKL216W Dihydroorotate dehydrogenase genetic 2 1 1 Synthetic Lethality, Synthetic Lethality
CBP6 YBR120C Mitochondrial protein required for translation of the COB mRNA genetic 1 1 1 Phenotypic Enhancement
CDC31 YOR257W Calcium-binding component of the spindle pole body (SPB) half-bridge physical 1 1 1 Affinity Capture-MS
MSS51 YLR203C Specific translational activator for the mitochondrial COX1 mRNA genetic 1 1 1 Synthetic Rescue
OXA1 YER154W Mitochondrial inner membrane insertase physical 1 1 1 Affinity Capture-Western
COX5B YIL111W Subunit Vb of cytochrome c oxidase physical 1 1 1 Co-fractionation
MDM38 YOL027C Membrane-associated mitochondrial ribosome receptor physical 1 1 1 Co-fractionation
COX10 YPL172C Heme A:farnesyltransferase physical 1 1 1 Affinity Capture-Western
MIC60 YKR016W Component of the MICOS complex physical 1 1 1 Affinity Capture-MS
COX13 YGL191W Subunit VIa of cytochrome c oxidase physical 1 1 1 Affinity Capture-Western
TIM21 YGR033C Nonessential component of the TIM23 complex physical 1 1 1 Affinity Capture-Western
QCR2 YPR191W Subunit 2 of ubiquinol cytochrome-c reductase (Complex III) physical 1 1 1 Co-purification
SSC1 YJR045C Hsp70 family ATPase physical 1 1 1 Affinity Capture-MS
PUF2 YPR042C PUF family mRNA-binding protein physical 1 1 1 Affinity Capture-RNA
RCF3 YBR255C-A Mitochondrial inner membrane protein physical 1 1 1 Affinity Capture-Western
COX26 YDR119W-A Subunit of cytochrome C oxidase complex physical 1 1 1 Affinity Capture-Western
PET309 YLR067C Specific translational activator for the COX1 mRNA physical 1 1 1 Affinity Capture-RNA
HSP10 YOR020C Mitochondrial matrix co-chaperonin physical 1 1 1 Affinity Capture-MS
COX9 YDL067C Subunit VIIa of cytochrome c oxidase (Complex IV) physical 1 1 1 Affinity Capture-MS
NFS1 YCL017C Cysteine desulfurase involved in iron-sulfur cluster biogenesis physical 1 1 1 Affinity Capture-Western
INA22 YIR024C F1F0 ATP synthase peripheral stalk assembly factor physical 1 1 1 Affinity Capture-Western
QCR10 YHR001W-A Subunit of the ubiqunol-cytochrome c oxidoreductase complex physical 1 1 1 Affinity Capture-Western
PUB1 YNL016W Poly (A)+ RNA-binding protein physical 1 1 1 Affinity Capture-MS
MTF2 YDL044C Mitochondrial protein that interacts with mitochondrial RNA polymerase genetic 1 1 1 Dosage Rescue
NAM7 YMR080C ATP-dependent RNA helicase of the SFI superfamily genetic 1 1 1 Dosage Rescue
NAM8 YHR086W RNA binding protein, component of the U1 snRNP protein genetic 1 1 1 Dosage Rescue
MRF1 YGL143C Mitochondrial translation release factor genetic 1 1 1 Synthetic Rescue
SDH3 YKL141W Subunit of succinate dehydrogenase and of TIM22 translocase genetic 1 1 1 Synthetic Lethality
DIC1 YLR348C Mitochondrial dicarboxylate carrier genetic 1 1 1 Synthetic Lethality
FRD1 YEL047C Soluble fumarate reductase genetic 1 1 1 Synthetic Lethality
FUM1 YPL262W Fumarase genetic 1 1 1 Synthetic Lethality
PRO1 YDR300C Gamma-glutamyl kinase genetic 1 1 1 Synthetic Lethality
PRO2 YOR323C Gamma-glutamyl phosphate reductase genetic 1 1 1 Synthetic Lethality
MRH4 YGL064C Mitochondrial ATP-dependent RNA helicase of the DEAD-box family genetic 1 1 1 Dosage Rescue
BAT2 YJR148W Cytosolic branched-chain amino acid (BCAA) aminotransferase genetic 1 1 1 Synthetic Lethality
COB Q0105 Cytochrome b physical 1 1 1 Affinity Capture-Western
ATP6 Q0085 Subunit a of the F0 sector of mitochondrial F1F0 ATP synthase physical 1 1 1 Affinity Capture-Western
ACP1 YKL192C Mitochondrial matrix acyl carrier protein physical 1 1 1 Affinity Capture-Western
COA2 YPL189C-A Cytochrome oxidase assembly factor genetic 1 1 1 Synthetic Rescue
ATP23 YNR020C Putative metalloprotease of the mitochondrial inner membrane physical 1 1 1 Affinity Capture-Western