Standard name Systematic name Name description Description
ISU2 YOR226C Mitochondrial protein required for iron-sulfur protein synthesis Mitochondrial protein required for iron-sulfur protein synthesis; performs scaffolding function during Fe/S cluster assembly; involved in Fe-S cluster assembly for both mitochondrial and cytosolic proteins; protein abundance increases under DNA replication stress; ISU2 has a paralog, ISU1, that arose from the whole genome duplication; isu1 isu2 double mutant is inviable; human homolog ISCU implicated in mitochondrial myopathy, can complement isu1 isu2 double mutant
Visualize the interactome of ISU2
Links to external databases:
  SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)

CYCLoPs localization & abundance

WT1 WT2 WT3
Mito 0.916 0.862 0.963
Nucleolus 0.155 0.110 0.143
Vac/Vac Memb 0.101 0.103 NaN

GFP localization & abundance

GFP localization GFP abundance
mitochondrion 3420

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
ISU2 3 0 0 0 0

Enzyme information

Catalyzed reactions in Yeast8
r_4325 (Iron sulfur cluster assembly protein 2, mitochondrial (Iron sulfur cluster scaffold protein 2))

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
ISU1 YPL135W Conserved protein of the mitochondrial matrix genetic 6 2 4 Negative Genetic, Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
OCA2 YNL056W Protein of unknown function genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
FKH1 YIL131C Forkhead family transcription factor regulation 2 2 2 chromatin immunoprecipitation-chip evidence, ChEC-Seq experiments
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator physical 2 1 2 Affinity Capture-RNA, Affinity Capture-RNA
CTK3 YML112W Gamma subunit of C-terminal domain kinase I genetic 2 1 2 Negative Genetic, Negative Genetic
CUB1 YPL260W Conserved fungal gene linked to DNA repair and proteasome function genetic 2 1 2 Negative Genetic, Negative Genetic
UBX2 YML013W Bridging factor involved in ER-associated protein degradation (ERAD) genetic 2 1 1 Negative Genetic, Negative Genetic
TIM18 YOR297C Component of the mitochondrial TIM22 complex genetic 2 1 1 Negative Genetic, Negative Genetic
SFP1 YLR403W Regulates transcription of ribosomal protein and biogenesis genes regulation 1 1 1 DNA to cDNA expression microarray evidence
GCN5 YGR252W Catalytic subunit of ADA and SAGA histone acetyltransferase complexes regulation 1 1 1 chromatin immunoprecipitation-chip evidence
AFT2 YPL202C Iron-regulated transcriptional activator regulation 1 1 1 chromatin immunoprecipitation-chip evidence
FKH2 YNL068C Forkhead family transcription factor regulation 1 1 1 ChEC-Seq experiments
HFI1 YPL254W Adaptor protein required for structural integrity of the SAGA complex regulation 1 1 1 DNA to cDNA expression microarray evidence
MSN2 YMR037C Stress-responsive transcriptional activator regulation 1 1 1 chromatin immunoprecipitation-chip evidence
CYC8 YBR112C General transcriptional co-repressor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
MED4 YOR174W Subunit of the RNA polymerase II mediator complex regulation 1 1 1 chromatin immunoprecipitation-chip evidence
MSN4 YKL062W Stress-responsive transcriptional activator regulation 1 1 1 chromatin immunoprecipitation-chip evidence
NRG1 YDR043C Transcriptional repressor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
MED6 YHR058C Subunit of the RNA polymerase II mediator complex regulation 1 1 1 chromatin immunoprecipitation-chip evidence
SPT3 YDR392W Subunit of the SAGA and SAGA-like transcriptional regulatory complexes regulation 1 1 1 chromatin immunoprecipitation-chip evidence
SKN7 YHR206W Nuclear response regulator and transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
LEU3 YLR451W Zinc-knuckle transcription factor, repressor and activator regulation 1 1 1 DNA to cDNA expression microarray evidence
HCM1 YCR065W Forkhead transcription factor regulation 1 1 1 DNA to cDNA expression microarray evidence
SSN2 YDR443C Subunit of the RNA polymerase II mediator complex regulation 1 1 1 DNA to cDNA expression microarray evidence
AFT1 YGL071W Transcription factor involved in iron utilization and homeostasis regulation 1 1 1 DNA to cDNA expression microarray evidence
DIS3 YOL021C Exosome core complex catalytic subunit genetic 1 1 1 Negative Genetic
CCR4 YAL021C Component of the CCR4-NOT transcriptional complex physical 1 1 1 Affinity Capture-RNA
ASC1 YMR116C G-protein beta subunit and guanine dissociation inhibitor for Gpa2p genetic 1 1 1 Negative Genetic
ATG17 YLR423C Scaffold protein responsible for phagophore assembly site organization physical 1 1 1 Two-hybrid
BNI4 YNL233W Targeting subunit for Glc7p protein phosphatase genetic 1 1 1 Negative Genetic
YPL088W YPL088W Putative aryl alcohol dehydrogenase physical 1 1 1 Two-hybrid
WHI3 YNL197C RNA binding protein that modulates mRNA stability physical 1 1 1 Protein-RNA
SRO9 YCL037C Cytoplasmic RNA-binding protein physical 1 1 1 Affinity Capture-RNA
SSC1 YJR045C Hsp70 family ATPase physical 1 1 1 Affinity Capture-MS
PUF2 YPR042C PUF family mRNA-binding protein physical 1 1 1 Affinity Capture-RNA
MPT5 YGL178W mRNA-binding protein of the PUF family physical 1 1 1 Affinity Capture-RNA
UBP6 YFR010W Ubiquitin-specific protease genetic 1 1 1 Negative Genetic
UGA1 YGR019W Gamma-aminobutyrate (GABA) transaminase genetic 1 1 1 Negative Genetic
SNX4 YJL036W Sorting nexin genetic 1 1 1 Negative Genetic
PUT3 YKL015W Transcriptional activator genetic 1 1 1 Negative Genetic
SEC59 YMR013C Dolichol kinase genetic 1 1 1 Negative Genetic
MDM12 YOL009C Mitochondrial outer membrane protein, ERMES complex subunit genetic 1 1 1 Negative Genetic
YFH1 YDL120W Mitochondrial matrix iron chaperone genetic 1 1 1 Synthetic Rescue
MCM3 YEL032W Protein involved in DNA replication genetic 1 1 1 Positive Genetic
RPS8A YBL072C Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Positive Genetic
MRM2 YGL136C Mitochondrial 2' O-ribose methyltransferase genetic 1 1 1 Positive Genetic
PET117 YER058W Assembly factor that couples heme a synthesis to complex IV assembly genetic 1 1 1 Negative Genetic
LPD1 YFL018C Dihydrolipoamide dehydrogenase genetic 1 1 1 Negative Genetic
ZWF1 YNL241C Glucose-6-phosphate dehydrogenase (G6PD) genetic 1 1 1 Negative Genetic
YOR034C-A YOR034C-A Putative protein of unknown function genetic 1 1 1 Negative Genetic
URA7 YBL039C Major CTP synthase isozyme (see also URA8) genetic 1 1 1 Negative Genetic
POT1 YIL160C 3-ketoacyl-CoA thiolase with broad chain length specificity genetic 1 1 1 Negative Genetic
REE1 YJL217W Cytoplasmic protein involved in the regulation of enolase (ENO1) genetic 1 1 1 Negative Genetic
TUB4 YLR212C Gamma-tubulin genetic 1 1 1 Synthetic Growth Defect
ASK10 YGR097W Regulator of the Fps1p glycerol channel genetic 1 1 1 Negative Genetic
IES2 YNL215W Protein that associates with the INO80 chromatin remodeling complex genetic 1 1 1 Negative Genetic
ELO2 YCR034W Fatty acid elongase, involved in sphingolipid biosynthesis genetic 1 1 1 Negative Genetic
GPR1 YDL035C Plasma membrane G protein coupled receptor (GPCR) genetic 1 1 1 Negative Genetic
AZR1 YGR224W Plasma membrane transporter of the major facilitator superfamily genetic 1 1 1 Negative Genetic