| CUR1 |
YPR158W |
Sorting factor, central regulator of spatial protein quality control |
genetic |
4 |
2 |
4 |
Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Suppression, Phenotypic Enhancement |
| TDA3 |
YHR009C |
Putative oxidoreductase involved in late endosome to Golgi transport |
physical |
4 |
3 |
2 |
Two-hybrid, Affinity Capture-Western, Co-localization, Affinity Capture-Western |
| HSP42 |
YDR171W |
Small heat shock protein (sHSP) with chaperone activity |
genetic |
3 |
2 |
3 |
Phenotypic Suppression, Phenotypic Enhancement, Phenotypic Enhancement |
| SNC1 |
YAL030W |
Vesicle membrane receptor protein (v-SNARE) |
physical |
3 |
2 |
2 |
Affinity Capture-Western, Two-hybrid, Affinity Capture-Western |
| SIS1 |
YNL007C |
Type II HSP40 co-chaperone that interacts with the HSP70 protein Ssa1p |
physical |
3 |
2 |
1 |
Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex |
| HSF1 |
YGL073W |
Trimeric heat shock transcription factor |
regulation |
2 |
2 |
2 |
chromatin immunoprecipitation-chip evidence, DNA to cDNA expression microarray evidence |
| YIF1 |
YNL263C |
Integral membrane protein |
physical |
2 |
2 |
2 |
Two-hybrid, Affinity Capture-Western |
| IST2 |
YBR086C |
Cortical ER protein involved in ER-plasma membrane (PM) tethering |
genetic |
2 |
2 |
2 |
Synthetic Lethality, Synthetic Rescue |
| YHC3 |
YJL059W |
Protein required for the ATP-dependent transport of arginine |
genetic |
2 |
2 |
2 |
Synthetic Growth Defect, Synthetic Lethality |
| SEC11 |
YIR022W |
18kDa catalytic subunit of the Signal Peptidase Complex (SPC) |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| MGM1 |
YOR211C |
Mitochondrial GTPase, present in complex with Ugo1p and Fzo1p |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| ERR1 |
YOR393W |
Putative phosphopyruvate hydratase |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| IST2 |
YBR086C |
Cortical ER protein involved in ER-plasma membrane (PM) tethering |
physical |
2 |
2 |
1 |
Affinity Capture-Western, Co-localization |
| TDA3 |
YHR009C |
Putative oxidoreductase involved in late endosome to Golgi transport |
genetic |
2 |
1 |
1 |
Phenotypic Suppression, Phenotypic Suppression |
| DPB3 |
YBR278W |
Third-largest subunit of DNA polymerase II (DNA polymerase epsilon) |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| UBP1 |
YDL122W |
Ubiquitin-specific protease |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| RPD3 |
YNL330C |
Histone deacetylase, component of both the Rpd3S and Rpd3L complexes |
genetic |
2 |
1 |
1 |
Dosage Lethality, Dosage Lethality |
| FKH1 |
YIL131C |
Forkhead family transcription factor |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
| GCN5 |
YGR252W |
Catalytic subunit of ADA and SAGA histone acetyltransferase complexes |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
| AFT2 |
YPL202C |
Iron-regulated transcriptional activator |
regulation |
1 |
1 |
1 |
DNA to cDNA expression microarray evidence |
| FKH2 |
YNL068C |
Forkhead family transcription factor |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
| MED2 |
YDL005C |
Subunit of the RNA polymerase II mediator complex |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
| RGR1 |
YLR071C |
Subunit of the RNA polymerase II mediator complex |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
| RPN4 |
YDL020C |
Transcription factor that stimulates expression of proteasome genes |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
| XBP1 |
YIL101C |
Transcriptional repressor |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
| YAP1 |
YML007W |
Basic leucine zipper (bZIP) transcription factor |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
| REB1 |
YBR049C |
RNA polymerase I enhancer binding protein |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
| MIG1 |
YGL035C |
Transcription factor involved in glucose repression |
regulation |
1 |
1 |
1 |
DNA to cDNA expression microarray evidence |
| SUA7 |
YPR086W |
Transcription factor TFIIB |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
| SPT3 |
YDR392W |
Subunit of the SAGA and SAGA-like transcriptional regulatory complexes |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
| SPT7 |
YBR081C |
Subunit of the SAGA transcriptional regulatory complex |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
| SPT6 |
YGR116W |
Nucleosome remodeling protein |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
| UME6 |
YDR207C |
Rpd3L histone deacetylase complex subunit |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
| ADA2 |
YDR448W |
Transcription coactivator |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
| NCB2 |
YDR397C |
Subunit of a heterodimeric NC2 transcription regulator complex |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
| SRB5 |
YGR104C |
Subunit of the RNA polymerase II mediator complex |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
| UGA3 |
YDL170W |
Transcriptional activator for GABA-dependent induction of GABA genes |
regulation |
1 |
1 |
1 |
DNA to cDNA expression microarray evidence |
| RTG3 |
YBL103C |
bHLH/Zip transcription factor for retrograde (RTG) and TOR pathways |
regulation |
1 |
1 |
1 |
DNA to cDNA expression microarray evidence |
| CRZ1 |
YNL027W |
Transcription factor, activates transcription of stress response genes |
regulation |
1 |
1 |
1 |
DNA to cDNA expression microarray evidence |
| MOT3 |
YMR070W |
Transcriptional repressor, activator |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
| MSS11 |
YMR164C |
Transcription factor |
regulation |
1 |
1 |
1 |
DNA to cDNA expression microarray evidence |
| RPH1 |
YER169W |
JmjC domain-containing histone demethylase |
regulation |
1 |
1 |
1 |
DNA to cDNA expression microarray evidence |
| NHP6A |
YPR052C |
High-mobility group (HMG) protein |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
| UME1 |
YPL139C |
Component of both the Rpd3S and Rpd3L histone deacetylase complexes |
regulation |
1 |
1 |
1 |
DNA to cDNA expression microarray evidence |
| ADA2 |
YDR448W |
Transcription coactivator |
physical |
1 |
1 |
1 |
Two-hybrid |
| SEC27 |
YGL137W |
Essential beta'-coat protein of the COPI coatomer |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| FDO1 |
YMR144W |
Protein involved in directionality of mating type switching |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| TLG2 |
YOL018C |
Syntaxin-like t-SNARE |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
| TLG1 |
YDR468C |
Essential t-SNARE that mediates fusion of vesicles with the late Golgi |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
| VTI1 |
YMR197C |
Protein involved in cis-Golgi membrane traffic |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
| SNC1 |
YAL030W |
Vesicle membrane receptor protein (v-SNARE) |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| SNC2 |
YOR327C |
Vesicle membrane receptor protein (v-SNARE) |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
| VPS35 |
YJL154C |
Endosomal subunit of membrane-associated retromer complex |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
| PEP8 |
YJL053W |
Vacuolar protein component of the retromer |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
| SNX4 |
YJL036W |
Sorting nexin |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
| RNQ1 |
YCL028W |
[PIN(+)] prion |
physical |
1 |
1 |
1 |
Two-hybrid |
| SPP382 |
YLR424W |
Essential protein that forms a dimer with Ntr2p |
physical |
1 |
1 |
1 |
Two-hybrid |
| MAC1 |
YMR021C |
Copper-sensing transcription factor |
physical |
1 |
1 |
1 |
Two-hybrid |
| SSK22 |
YCR073C |
MAP kinase kinase kinase of HOG1 mitogen-activated signaling pathway |
physical |
1 |
1 |
1 |
Two-hybrid |
| RSF2 |
YJR127C |
Zinc-finger protein |
physical |
1 |
1 |
1 |
Two-hybrid |
| MAP2 |
YBL091C |
Methionine aminopeptidase |
physical |
1 |
1 |
1 |
Two-hybrid |
| NAB2 |
YGL122C |
Nuclear polyadenylated RNA-binding protein |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
| PPH21 |
YDL134C |
Catalytic subunit of protein phosphatase 2A, PP2A |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| CSE4 |
YKL049C |
Centromeric histone H3-like protein |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| GIS2 |
YNL255C |
Translational activator for mRNAs with internal ribosome entry sites |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
| HSP104 |
YLL026W |
Disaggregase |
physical |
1 |
1 |
1 |
Co-localization |
| SIS1 |
YNL007C |
Type II HSP40 co-chaperone that interacts with the HSP70 protein Ssa1p |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| HSP42 |
YDR171W |
Small heat shock protein (sHSP) with chaperone activity |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
| MGE1 |
YOR232W |
Mitochondrial matrix cochaperone |
physical |
1 |
1 |
1 |
Two-hybrid |
| PUF3 |
YLL013C |
Protein of the mitochondrial outer surface |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
| ISW1 |
YBR245C |
ATPase subunit of imitation-switch (ISWI) class chromatin remodelers |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
| CAF20 |
YOR276W |
Phosphoprotein of the mRNA cap-binding complex |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
| PUB1 |
YNL016W |
Poly (A)+ RNA-binding protein |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| RSC2 |
YLR357W |
Component of the RSC chromatin remodeling complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
| YML108W |
YML108W |
Protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
| YHR020W |
YHR020W |
Prolyl-tRNA synthetase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| YDJ1 |
YNL064C |
Type I HSP40 co-chaperone |
genetic |
1 |
1 |
1 |
Dosage Growth Defect |
| PRE1 |
YER012W |
Beta 4 subunit of the 20S proteasome |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
| DIA2 |
YOR080W |
Origin-binding F-box protein |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
| PPH3 |
YDR075W |
Catalytic subunit of protein phosphatase PP4 complex |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
| POL2 |
YNL262W |
Catalytic subunit of DNA polymerase (II) epsilon |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
| CMD1 |
YBR109C |
Calmodulin |
genetic |
1 |
1 |
1 |
Positive Genetic |
| MIC12 |
YBR262C |
Component of the MICOS complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
| RFT1 |
YBL020W |
Membrane protein required for translocation of Man5GlcNac2-PP-Dol |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SEC5 |
YDR166C |
Essential 107kDa subunit of the exocyst complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CCT8 |
YJL008C |
Subunit of the cytosolic chaperonin Cct ring complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SSC1 |
YJR045C |
Hsp70 family ATPase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| HSP10 |
YOR020C |
Mitochondrial matrix co-chaperonin |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RPT4 |
YOR259C |
ATPase of the 19S regulatory particle of the 26S proteasome |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ISC10 |
YER180C |
Meiosis-specific MAPK inhibitor |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MPC1 |
YGL080W |
Highly conserved subunit of mitochondrial pyruvate carrier (MPC) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RPS8A |
YBL072C |
Protein component of the small (40S) ribosomal subunit |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MAF1 |
YDR005C |
Highly conserved negative regulator of RNA polymerase III |
genetic |
1 |
1 |
1 |
Negative Genetic |
| LEA1 |
YPL213W |
Component of U2 snRNP complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| YHR050W-A |
YHR050W-A |
Protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
| FLO10 |
YKR102W |
Member of the FLO family of cell wall flocculation proteins |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ECM5 |
YMR176W |
Subunit of the Snt2C complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| YOR034C-A |
YOR034C-A |
Putative protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CSR2 |
YPR030W |
Nuclear ubiquitin protein ligase binding protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SIP5 |
YMR140W |
Protein of unknown function |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| RPL21B |
YPL079W |
Ribosomal 60S subunit protein L21B |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| RPL4A |
YBR031W |
Ribosomal 60S subunit protein L4A |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| UBR2 |
YLR024C |
Cytoplasmic ubiquitin-protein ligase (E3) |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| RPL21A |
YBR191W |
Ribosomal 60S subunit protein L21A |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| RPL11B |
YGR085C |
Ribosomal 60S subunit protein L11B |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| RPL16B |
YNL069C |
Ribosomal 60S subunit protein L16B |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| APJ1 |
YNL077W |
Hsp40 chaperone with a role in SUMO-mediated protein degradation |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| APJ1 |
YNL077W |
Hsp40 chaperone with a role in SUMO-mediated protein degradation |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| APQ12 |
YIL040W |
Nuclear envelope/ER integral membrane protein |
genetic |
1 |
1 |
1 |
Negative Genetic |