Standard name Systematic name Name description Description
COA6 YMR244C-A Protein involved in cytochrome c oxidase (Complex IV) assembly Protein involved in cytochrome c oxidase (Complex IV) assembly; involved in delivery of copper to Complex IV; also required for efficient formation of respiratory supercomplexes comprised of Complexes III and IV; localizes to the mitochondrial intermembrane space; ortholog implicated in cardiac defects in zebrafish and human; transcription is induced in response to the DNA-damaging agent MMS; protein abundance increases in response to DNA replication stress
Visualize the interactome of COA6
Links to external databases:
  SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)

CYCLoPs localization & abundance

WT1 WT2 WT3
Cytoplasm 0.973 0.976 0.985

GFP localization & abundance

GFP localization GFP abundance
no data no data

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
COA6 0 0 0 0 0

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
SCO2 YBR024W Protein anchored to mitochondrial inner membrane genetic 5 4 3 Negative Genetic, Synthetic Growth Defect, Phenotypic Enhancement, Dosage Rescue, Negative Genetic
COX2 Q0250 Subunit II of cytochrome c oxidase (Complex IV) physical 4 2 3 Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Co-purification
COX12 YLR038C Subunit VIb of cytochrome c oxidase genetic 4 4 1 Synthetic Growth Defect, Phenotypic Enhancement, Dosage Rescue, Dosage Growth Defect
PUF3 YLL013C Protein of the mitochondrial outer surface physical 3 1 3 Affinity Capture-RNA, Affinity Capture-RNA, Affinity Capture-RNA
KIN4 YOR233W Serine/threonine protein kinase genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
IRA2 YOL081W GTPase-activating protein genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
FKH1 YIL131C Forkhead family transcription factor regulation 2 2 2 chromatin immunoprecipitation-chip evidence, ChEC-Seq experiments
GSH1 YJL101C Gamma glutamylcysteine synthetase genetic 2 1 2 Negative Genetic, Negative Genetic
MSS1 YMR023C Mitochondrial protein genetic 2 1 2 Negative Genetic, Negative Genetic
RPS19B YNL302C Protein component of the small (40S) ribosomal subunit genetic 2 1 2 Positive Genetic, Positive Genetic
PHO23 YNL097C Component of the Rpd3L histone deacetylase complex genetic 2 1 2 Negative Genetic, Negative Genetic
PNT1 YOR266W Mitochondrial integral inner membrane protein genetic 2 1 2 Negative Genetic, Negative Genetic
IRC15 YPL017C Microtubule associated protein genetic 2 1 2 Negative Genetic, Negative Genetic
JID1 YPR061C Probable Hsp40p co-chaperone genetic 2 1 2 Negative Genetic, Negative Genetic
FKH2 YNL068C Forkhead family transcription factor regulation 1 1 1 ChEC-Seq experiments
MED2 YDL005C Subunit of the RNA polymerase II mediator complex regulation 1 1 1 chromatin immunoprecipitation-chip evidence
XBP1 YIL101C Transcriptional repressor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
YAP6 YDR259C Basic leucine zipper (bZIP) transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
CIN5 YOR028C Basic leucine zipper (bZIP) transcription factor of the yAP-1 family regulation 1 1 1 chromatin immunoprecipitation-chip evidence
UME6 YDR207C Rpd3L histone deacetylase complex subunit regulation 1 1 1 chromatin immunoprecipitation-chip evidence
CCR4 YAL021C Component of the CCR4-NOT transcriptional complex physical 1 1 1 Affinity Capture-RNA
CDC14 YFR028C Protein phosphatase required for mitotic exit genetic 1 1 1 Positive Genetic
BUD31 YCR063W Component of the SF3b subcomplex of the U2 snRNP genetic 1 1 1 Positive Genetic
CDC9 YDL164C DNA ligase I found in nucleus and mitochondria genetic 1 1 1 Negative Genetic
CMC1 YKL137W Copper-binding protein of the mitochondrial intermembrane space genetic 1 1 1 Synthetic Rescue
CAB2 YIL083C Phosphopantothenoylcysteine synthetase (PPCS) genetic 1 1 1 Negative Genetic
ALE1 YOR175C Broad-specificity lysophospholipid acyltransferase genetic 1 1 1 Negative Genetic
GIS2 YNL255C Translational activator for mRNAs with internal ribosome entry sites physical 1 1 1 Affinity Capture-RNA
SRO9 YCL037C Cytoplasmic RNA-binding protein physical 1 1 1 Affinity Capture-RNA
PUF2 YPR042C PUF family mRNA-binding protein physical 1 1 1 Affinity Capture-RNA
MPT5 YGL178W mRNA-binding protein of the PUF family physical 1 1 1 Affinity Capture-RNA
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator physical 1 1 1 Affinity Capture-RNA
SCO1 YBR037C Copper-binding protein of mitochondrial inner membrane physical 1 1 1 Affinity Capture-Western
SCO1 YBR037C Copper-binding protein of mitochondrial inner membrane genetic 1 1 1 Dosage Rescue
SCO2 YBR024W Protein anchored to mitochondrial inner membrane physical 1 1 1 Affinity Capture-Western
TIM23 YNR017W Essential component of the TIM23 complex physical 1 1 1 Affinity Capture-MS
GIS1 YDR096W Histone demethylase and transcription factor physical 1 1 1 Affinity Capture-MS
UBP1 YDL122W Ubiquitin-specific protease genetic 1 1 1 Negative Genetic
RAP1 YNL216W Essential DNA-binding transcription regulator that binds many loci genetic 1 1 1 Negative Genetic
SPR2 YOR214C Putative spore wall protein genetic 1 1 1 Negative Genetic
ERR1 YOR393W Putative phosphopyruvate hydratase genetic 1 1 1 Negative Genetic
SVL3 YPL032C Protein of unknown function genetic 1 1 1 Negative Genetic
YOR1 YGR281W Plasma membrane ATP-binding cassette (ABC) transporter genetic 1 1 1 Positive Genetic
COX20 YDR231C Mitochondrial inner membrane protein genetic 1 1 1 Dosage Rescue
PIC2 YER053C Mitochondrial copper and phosphate carrier genetic 1 1 1 Synthetic Growth Defect
HYP2 YEL034W Translation elongation factor eIF-5A genetic 1 1 1 Positive Genetic
TIM54 YJL054W Component of the mitochondrial TIM22 complex genetic 1 1 1 Positive Genetic
IRC25 YLR021W Component of a heterodimeric Poc4p-Irc25p chaperone genetic 1 1 1 Positive Genetic
DBP10 YDL031W Putative ATP-dependent RNA helicase of the DEAD-box protein family genetic 1 1 1 Negative Genetic
SSC1 YJR045C Hsp70 family ATPase genetic 1 1 1 Negative Genetic
MAK11 YKL021C Protein involved in an early step of 60S ribosomal subunit biogenesis genetic 1 1 1 Negative Genetic
SMD2 YLR275W Core Sm protein Sm D2 genetic 1 1 1 Negative Genetic
NAR1 YNL240C Subunit of the cytosolic iron-sulfur (FeS) protein assembly machinery genetic 1 1 1 Negative Genetic
RPB10 YOR210W RNA polymerase subunit ABC10-beta genetic 1 1 1 Negative Genetic
YBR285W YBR285W Putative protein of unknown function genetic 1 1 1 Negative Genetic
OST4 YDL232W Subunit of the oligosaccharyltransferase complex of the ER lumen genetic 1 1 1 Negative Genetic
YER188C-A YER188C-A Putative protein of unknown function genetic 1 1 1 Negative Genetic
EDC1 YGL222C RNA-binding protein that activates mRNA decapping directly genetic 1 1 1 Negative Genetic
YGL235W YGL235W Putative protein of unknown function genetic 1 1 1 Negative Genetic
RPL40B YKR094C Ubiquitin-ribosomal 60S subunit protein L40B fusion protein genetic 1 1 1 Negative Genetic
RCF1 YML030W Cytochrome c oxidase subunit genetic 1 1 1 Negative Genetic
PML39 YML107C Protein required for nuclear retention of unspliced pre-mRNAs genetic 1 1 1 Negative Genetic
RPS8A YBL072C Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
MGR1 YCL044C Subunit of the mitochondrial (mt) i-AAA protease supercomplex genetic 1 1 1 Negative Genetic
RVS161 YCR009C Amphiphysin-like lipid raft protein genetic 1 1 1 Negative Genetic
GPR1 YDL035C Plasma membrane G protein coupled receptor (GPCR) genetic 1 1 1 Negative Genetic
RVS167 YDR388W Calmodulin-binding actin-associated protein genetic 1 1 1 Negative Genetic
SPG1 YGR236C Protein required for high temperature survival during stationary phase genetic 1 1 1 Negative Genetic
YTA7 YGR270W Chromatin-binding ATPase that regulates histone gene expression genetic 1 1 1 Negative Genetic
SNF6 YHL025W Subunit of the SWI/SNF chromatin remodeling complex genetic 1 1 1 Negative Genetic
SRB2 YHR041C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
ICE2 YIL090W Integral ER membrane protein with type-III transmembrane domains genetic 1 1 1 Negative Genetic
SRY1 YKL218C 3-hydroxyaspartate dehydratase genetic 1 1 1 Negative Genetic
VPS27 YNR006W Endosomal protein that forms a complex with Hse1p genetic 1 1 1 Negative Genetic
MPC54 YOR177C Component of the meiotic outer plaque genetic 1 1 1 Negative Genetic
HSP82 YPL240C Hsp90 chaperone genetic 1 1 1 Negative Genetic
SKI3 YPR189W Ski complex component and TPR protein genetic 1 1 1 Negative Genetic
MRPL17 YNL252C Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Negative Genetic
RGS2 YOR107W Negative regulator of glucose-induced cAMP signaling genetic 1 1 1 Negative Genetic
REV1 YOR346W Deoxycytidyl transferase genetic 1 1 1 Negative Genetic
CSE4 YKL049C Centromeric histone H3-like protein genetic 1 1 1 Positive Genetic
HRQ1 YDR291W 3'-5' DNA helicase of the conserved RecQ family genetic 1 1 1 Negative Genetic
SGS1 YMR190C RecQ family nucleolar DNA helicase genetic 1 1 1 Negative Genetic