Standard name Systematic name Name description Description
PCH2 YBR186W Hexameric ring ATPase that remodels chromosome axis protein Hop1p Hexameric ring ATPase that remodels chromosome axis protein Hop1p; nucleolar component of the pachytene checkpoint, which prevents chromosome segregation when recombination and chromosome synapsis are defective; also represses meiotic interhomolog recombination in rDNA; required for meiotic double-stranded break formation
Visualize the interactome of PCH2
Links to external databases:
  SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)

CYCLoPs localization & abundance

WT1 WT2 WT3
no data no data no data

GFP localization & abundance

GFP localization GFP abundance
no data no data

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
PCH2 0 3 0 1 0

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
DMC1 YER179W Meiosis-specific recombinase required for double-strand break repair genetic 9 4 6 Synthetic Rescue, Phenotypic Suppression, Phenotypic Suppression, Synthetic Growth Defect, Synthetic Rescue, Phenotypic Enhancement, Phenotypic Suppression, Phenotypic Suppression, Phenotypic Suppression
ZIP1 YDR285W Transverse filament protein of the synaptonemal complex genetic 8 4 7 Synthetic Rescue, Synthetic Growth Defect, Phenotypic Suppression, Synthetic Rescue, Phenotypic Suppression, Phenotypic Enhancement, Phenotypic Suppression, Phenotypic Enhancement
RAD17 YOR368W Checkpoint protein genetic 7 4 5 Synthetic Lethality, Synthetic Growth Defect, Phenotypic Suppression, Phenotypic Enhancement, Synthetic Growth Defect, Phenotypic Enhancement, Synthetic Growth Defect
MEK1 YOR351C Meiosis-specific serine/threonine protein kinase genetic 5 3 4 Negative Genetic, Dosage Rescue, Synthetic Growth Defect, Dosage Rescue, Negative Genetic
ORC1 YML065W Largest subunit of the origin recognition complex physical 5 3 3 Two-hybrid, Affinity Capture-Western, Co-localization, Affinity Capture-Western, Co-localization
SPO11 YHL022C Meiosis-specific protein required for meiotic recombination genetic 4 2 2 Synthetic Growth Defect, Phenotypic Suppression, Phenotypic Suppression, Synthetic Growth Defect
UME6 YDR207C Rpd3L histone deacetylase complex subunit regulation 2 2 2 chromatin immunoprecipitation-chip evidence, DNA to cDNA expression microarray evidence
MEC1 YBR136W Genome integrity checkpoint protein and PI kinase superfamily member genetic 2 2 2 Synthetic Growth Defect, Phenotypic Enhancement
MMS4 YBR098W Subunit of structure-specific Mms4p-Mus81p endonuclease genetic 2 2 2 Phenotypic Suppression, Phenotypic Enhancement
NDT80 YHR124W Meiosis-specific transcription factor genetic 2 2 2 Phenotypic Enhancement, Phenotypic Suppression
RAD54 YGL163C DNA-dependent ATPase that stimulates strand exchange genetic 2 2 2 Synthetic Growth Defect, Phenotypic Enhancement
MLH3 YPL164C Protein involved in DNA mismatch repair and meiotic recombination genetic 2 1 2 Phenotypic Suppression, Phenotypic Suppression
FIT1 YDR534C Mannoprotein that is incorporated into the cell wall genetic 2 1 2 Negative Genetic, Negative Genetic
FKH1 YIL131C Forkhead family transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
IXR1 YKL032C Transcriptional repressor that regulates hypoxic genes during normoxia regulation 1 1 1 DNA to cDNA expression microarray evidence
SPT10 YJL127C Histone H3 acetylase with a role in transcriptional regulation regulation 1 1 1 DNA to cDNA expression microarray evidence
YAP5 YIR018W Basic leucine zipper (bZIP) iron-sensing transcription factor regulation 1 1 1 DNA to cDNA expression microarray evidence
CKB1 YGL019W Beta regulatory subunit of casein kinase 2 (CK2) genetic 1 1 1 Negative Genetic
NOP56 YLR197W Essential evolutionarily-conserved nucleolar protein genetic 1 1 1 Negative Genetic
BUD14 YAR014C Protein involved in bud-site selection physical 1 1 1 Two-hybrid
CDC3 YLR314C Component of the septin ring that is required for cytokinesis genetic 1 1 1 Negative Genetic
MOT1 YPL082C Essential protein involved in regulation of transcription genetic 1 1 1 Phenotypic Suppression
MRPL24 YMR193W Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Negative Genetic
NAM8 YHR086W RNA binding protein, component of the U1 snRNP protein genetic 1 1 1 Synthetic Growth Defect
MSH4 YFL003C Protein involved in meiotic recombination genetic 1 1 1 Synthetic Growth Defect
HYP2 YEL034W Translation elongation factor eIF-5A genetic 1 1 1 Negative Genetic
CDC53 YDL132W Cullin genetic 1 1 1 Phenotypic Suppression
MTC5 YDR128W Subunit of SEACAT, a subcomplex of the SEA complex genetic 1 1 1 Negative Genetic
CDC60 YPL160W Cytosolic leucyl tRNA synthetase genetic 1 1 1 Negative Genetic
CDC4 YFL009W F-box protein required for both the G1/S and G2/M phase transitions genetic 1 1 1 Phenotypic Suppression
ECM11 YDR446W Meiosis-specific protein genetic 1 1 1 Phenotypic Enhancement
INO2 YDR123C Transcription factor genetic 1 1 1 Negative Genetic
MSH5 YDL154W Protein of the MutS family genetic 1 1 1 Phenotypic Suppression
MSN5 YDR335W Karyopherin genetic 1 1 1 Negative Genetic
HOP1 YIL072W Meiosis-specific protein required for chromosome synapsis physical 1 1 1 Reconstituted Complex
HOP1 YIL072W Meiosis-specific protein required for chromosome synapsis genetic 1 1 1 Phenotypic Suppression
CST9 YLR394W SUMO E3 ligase genetic 1 1 1 Phenotypic Enhancement
OST4 YDL232W Subunit of the oligosaccharyltransferase complex of the ER lumen genetic 1 1 1 Negative Genetic
DOT1 YDR440W Nucleosomal histone H3-Lys79 methylase genetic 1 1 1 Phenotypic Suppression
ALG5 YPL227C UDP-glucose:dolichyl-phosphate glucosyltransferase genetic 1 1 1 Positive Genetic
HBT1 YDL223C Shmoo tip protein, substrate of Hub1p ubiquitin-like protein genetic 1 1 1 Negative Genetic
NDJ1 YOL104C Protein that regulates meiotic SPB cohesion and telomere clustering genetic 1 1 1 Synthetic Growth Defect
GRE3 YHR104W Aldose reductase physical 1 1 1 Affinity Capture-MS
AQY3 YFL054C Putative channel-like protein genetic 1 1 1 Negative Genetic
GCS1 YDL226C ADP-ribosylation factor GTPase activating protein (ARF GAP) genetic 1 1 1 Negative Genetic
GIS1 YDR096W Histone demethylase and transcription factor genetic 1 1 1 Negative Genetic
MPS3 YJL019W Nuclear envelope protein physical 1 1 1 Affinity Capture-MS
SRP14 YDL092W Signal recognition particle (SRP) subunit physical 1 1 1 PCA
TAE1 YBR261C AdoMet-dependent proline methyltransferase physical 1 1 1 Two-hybrid
RAD5 YLR032W DNA helicase/Ubiquitin ligase physical 1 1 1 Two-hybrid
XRS2 YDR369C FHA domain-containing component of the Mre11 complex physical 1 1 1 Two-hybrid
PCH2 YBR186W Hexameric ring ATPase that remodels chromosome axis protein Hop1p physical 1 1 1 Reconstituted Complex
SPO16 YHR153C Meiosis-specific protein involved in synaptonemal complex assembly physical 1 1 1 Affinity Capture-MS
SLT2 YHR030C Serine/threonine MAP kinase physical 1 1 1 PCA
ZIP2 YGL249W Meiosis-specific protein genetic 1 1 1 Synthetic Rescue
PDS1 YDR113C Securin genetic 1 1 1 Phenotypic Suppression
YIR016W YIR016W Putative protein of unknown function genetic 1 1 1 Negative Genetic
YKE2 YLR200W Subunit of the heterohexameric Gim/prefoldin protein complex genetic 1 1 1 Synthetic Growth Defect
SPO13 YHR014W Meiotic regulator genetic 1 1 1 Synthetic Rescue
SAE2 YGL175C Endonuclease required for telomere elongation genetic 1 1 1 Phenotypic Suppression
RAD51 YER095W Strand exchange protein genetic 1 1 1 Phenotypic Suppression
REC114 YMR133W Protein involved in early stages of meiotic recombination genetic 1 1 1 Synthetic Growth Defect
RED1 YLR263W Protein component of the synaptonemal complex axial elements genetic 1 1 1 Phenotypic Suppression
YAR029W YAR029W Member of DUP240 gene family but contains no transmembrane domains genetic 1 1 1 Negative Genetic
RVS161 YCR009C Amphiphysin-like lipid raft protein genetic 1 1 1 Negative Genetic
RPS16B YDL083C Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
RVS167 YDR388W Calmodulin-binding actin-associated protein genetic 1 1 1 Negative Genetic
RAD4 YER162C Damaged-DNA binding subunit of Nuclear Excision Repair Factor 2 genetic 1 1 1 Negative Genetic
YHR022C YHR022C Putative protein of unknown function genetic 1 1 1 Negative Genetic
SSF1 YHR066W Constituent of 66S pre-ribosomal particles genetic 1 1 1 Negative Genetic
VPS53 YJL029C Component of the GARP (Golgi-associated retrograde protein) complex genetic 1 1 1 Negative Genetic
UFO1 YML088W F-box receptor protein genetic 1 1 1 Negative Genetic
SUT2 YPR009W Zn2Cys6 family transcription factor genetic 1 1 1 Negative Genetic
PPH3 YDR075W Catalytic subunit of protein phosphatase PP4 complex genetic 1 1 1 Phenotypic Suppression
SLX4 YLR135W Endonuclease involved in processing DNA genetic 1 1 1 Phenotypic Enhancement
MCP1 YOR228C Mitochondrial protein of unknown function involved in lipid homeostas genetic 1 1 1 Negative Genetic