Standard name Systematic name Name description Description
TRR1 YDR353W Cytoplasmic thioredoxin reductase Cytoplasmic thioredoxin reductase; key regulatory enzyme that determines the redox state of the thioredoxin system, which acts as a disulfide reductase system and protects cells against both oxidative and reductive stress; protein abundance increases in response to DNA replication stress; TRR1 has a paralog, TRR2, that arose from the whole genome duplication
Visualize the interactome of TRR1
Links to external databases:
  SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)
G1(P) 20

CYCLoPs localization & abundance

WT1 WT2 WT3
Cytoplasm 1.0 1.0 0.981

GFP localization & abundance

GFP localization GFP abundance
cytoplasm, nucleus 292000

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
TRR1 0 0 0 0 0

Enzyme information

Catalyzed reactions in Yeast8
r_1038 (thioredoxin reductase (NADPH))

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
TRX2 YGR209C Cytoplasmic thioredoxin isoenzyme genetic 8 3 5 Synthetic Rescue, Phenotypic Enhancement, Phenotypic Suppression, Synthetic Rescue, Phenotypic Suppression, Phenotypic Suppression, Synthetic Rescue, Synthetic Rescue
TSA1 YML028W Thioredoxin peroxidase genetic 7 3 5 Synthetic Rescue, Phenotypic Suppression, Synthetic Rescue, Synthetic Lethality, Synthetic Rescue, Phenotypic Suppression, Phenotypic Suppression
TRX1 YLR043C Cytoplasmic thioredoxin isoenzyme genetic 6 3 4 Synthetic Rescue, Phenotypic Enhancement, Phenotypic Suppression, Synthetic Rescue, Phenotypic Suppression, Phenotypic Suppression
TRR2 YHR106W Mitochondrial thioredoxin reductase physical 4 3 4 Affinity Capture-MS, Two-hybrid, Affinity Capture-Western, Affinity Capture-MS
TRR2 YHR106W Mitochondrial thioredoxin reductase genetic 3 2 3 Synthetic Growth Defect, Synthetic Growth Defect, Phenotypic Enhancement
TRX2 YGR209C Cytoplasmic thioredoxin isoenzyme physical 2 2 2 Two-hybrid, Affinity Capture-MS
GLR1 YPL091W Cytosolic and mitochondrial glutathione oxidoreductase genetic 2 2 2 Dosage Rescue, Phenotypic Enhancement
HAC1 YFL031W Basic leucine zipper (bZIP) transcription factor (ATF/CREB1 homolog) genetic 2 2 1 Phenotypic Suppression, Synthetic Rescue
GSH1 YJL101C Gamma glutamylcysteine synthetase genetic 2 2 1 Synthetic Growth Defect, Phenotypic Enhancement
SFP1 YLR403W Regulates transcription of ribosomal protein and biogenesis genes regulation 1 1 1 DNA to cDNA expression microarray evidence
GCN5 YGR252W Catalytic subunit of ADA and SAGA histone acetyltransferase complexes regulation 1 1 1 chromatin immunoprecipitation-chip evidence
RFX1 YLR176C Major transcriptional repressor of DNA-damage-regulated genes regulation 1 1 1 chromatin immunoprecipitation-chip evidence
SPT10 YJL127C Histone H3 acetylase with a role in transcriptional regulation regulation 1 1 1 DNA to cDNA expression microarray evidence
GCR1 YPL075W Transcriptional activator of genes involved in glycolysis regulation 1 1 1 DNA to cDNA expression microarray evidence
XBP1 YIL101C Transcriptional repressor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
RAP1 YNL216W Essential DNA-binding transcription regulator that binds many loci regulation 1 1 1 DNA to cDNA expression microarray evidence
SUA7 YPR086W Transcription factor TFIIB regulation 1 1 1 chromatin immunoprecipitation-chip evidence
MED6 YHR058C Subunit of the RNA polymerase II mediator complex regulation 1 1 1 chromatin immunoprecipitation-chip evidence
UGA3 YDL170W Transcriptional activator for GABA-dependent induction of GABA genes regulation 1 1 1 chromatin immunoprecipitation-chip evidence
RRP6 YOR001W Nuclear exosome exonuclease component physical 1 1 1 Affinity Capture-MS
RPC82 YPR190C RNA polymerase III subunit C82 physical 1 1 1 Affinity Capture-MS
RPN10 YHR200W Proteasome polyubiquitin receptor physical 1 1 1 Affinity Capture-MS
RPN11 YFR004W Metalloprotease subunit of 19S regulatory particle physical 1 1 1 Affinity Capture-MS
AAH1 YNL141W Adenine deaminase (adenine aminohydrolase) genetic 1 1 1 Positive Genetic
NAB2 YGL122C Nuclear polyadenylated RNA-binding protein physical 1 1 1 Affinity Capture-RNA
ESP1 YGR098C Separase/separin, a caspase-like cysteine protease physical 1 1 1 Affinity Capture-MS
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator physical 1 1 1 Affinity Capture-RNA
PRP6 YBR055C Splicing factor physical 1 1 1 Affinity Capture-MS
RAD51 YER095W Strand exchange protein genetic 1 1 1 Synthetic Rescue
SER3 YER081W 3-phosphoglycerate dehydrogenase and alpha-ketoglutarate reductase genetic 1 1 1 Negative Genetic
SBP1 YHL034C Protein that binds eIF4G and has a role in repression of translation physical 1 1 1 Affinity Capture-RNA
ADO1 YJR105W Adenosine kinase genetic 1 1 1 Positive Genetic
CPR6 YLR216C Peptidyl-prolyl cis-trans isomerase (cyclophilin) physical 1 1 1 Affinity Capture-MS
SAC6 YDR129C Fimbrin, actin-bundling protein physical 1 1 1 Affinity Capture-MS
RHO5 YNL180C Non-essential small GTPase of the Rho/Rac family of Ras-like proteins physical 1 1 1 Affinity Capture-MS
AAT2 YLR027C Cytosolic aspartate aminotransferase involved in nitrogen metabolism genetic 1 1 1 Negative Genetic
PTC5 YOR090C Mitochondrial type 2C protein phosphatase (PP2C) physical 1 1 1 Affinity Capture-MS
TPS2 YDR074W Phosphatase subunit of the trehalose-6-P synthase/phosphatase complex genetic 1 1 1 Negative Genetic
ADH3 YMR083W Mitochondrial alcohol dehydrogenase isozyme III genetic 1 1 1 Positive Genetic
SUI1 YNL244C Translation initiation factor eIF1 physical 1 1 1 Affinity Capture-MS
YGK3 YOL128C Protein kinase related to mammalian GSK-3 glycogen synthase kinases physical 1 1 1 Affinity Capture-MS
TRR1 YDR353W Cytoplasmic thioredoxin reductase physical 1 1 1 Co-crystal Structure
TRX3 YCR083W Mitochondrial thioredoxin physical 1 1 1 Biochemical Activity
YAP1 YML007W Basic leucine zipper (bZIP) transcription factor physical 1 1 1 Biochemical Activity
ULP1 YPL020C Protease that specifically cleaves Smt3p protein conjugates physical 1 1 1 PCA
UBC9 YDL064W SUMO-conjugating enzyme involved in the Smt3p conjugation pathway physical 1 1 1 Affinity Capture-MS
TSA2 YDR453C Stress inducible cytoplasmic thioredoxin peroxidase genetic 1 1 1 Phenotypic Suppression
CYS3 YAL012W Cystathionine gamma-lyase genetic 1 1 1 Negative Genetic
GTR1 YML121W Subunit of a TORC1-stimulating GTPase and the EGO/GSE complex physical 1 1 1 Affinity Capture-MS
ACO2 YJL200C Putative mitochondrial aconitase isozyme genetic 1 1 1 Positive Genetic
IRE1 YHR079C Serine-threonine kinase and endoribonuclease genetic 1 1 1 Phenotypic Suppression
SWI6 YLR182W Transcription cofactor genetic 1 1 1 Synthetic Rescue
BFR1 YOR198C Component of mRNP complexes associated with polyribosomes physical 1 1 1 Affinity Capture-RNA
MPT5 YGL178W mRNA-binding protein of the PUF family physical 1 1 1 Affinity Capture-RNA
TOM1 YDR457W E3 ubiquitin ligase of the hect-domain class physical 1 1 1 Affinity Capture-MS
SSB2 YNL209W Cytoplasmic ATPase that is a ribosome-associated molecular chaperone physical 1 1 1 Co-purification
SSB1 YDL229W Cytoplasmic ATPase that is a ribosome-associated molecular chaperone physical 1 1 1 Affinity Capture-MS
MEU1 YLR017W Methylthioadenosine phosphorylase (MTAP) genetic 1 1 1 Negative Genetic
ATP15 YPL271W Epsilon subunit of the F1 sector of mitochondrial F1F0 ATP synthase genetic 1 1 1 Positive Genetic
PUF4 YGL014W Member of the PUF protein family physical 1 1 1 Affinity Capture-RNA
GUP1 YGL084C Plasma membrane protein involved in remodeling GPI anchors genetic 1 1 1 Positive Genetic
CEM1 YER061C Mitochondrial beta-keto-acyl synthase genetic 1 1 1 Negative Genetic
TEL2 YGR099W Subunit of the ASTRA complex, involved in chromatin remodeling physical 1 1 1 Two-hybrid
SAM50 YNL026W Component of the Sorting and Assembly Machinery (SAM) complex physical 1 1 1 Affinity Capture-MS
SPE1 YKL184W Ornithine decarboxylase genetic 1 1 1 Positive Genetic
SCS3 YGL126W Protein required for normal ER membrane biosynthesis in response to ER physical 1 1 1 PCA
IAH1 YOR126C Isoamyl acetate-hydrolyzing esterase genetic 1 1 1 Positive Genetic
AAT1 YKL106W Mitochondrial aspartate aminotransferase genetic 1 1 1 Negative Genetic