Standard name Systematic name Name description Description
HSP31 YDR533C Methylglyoxalase that converts methylglyoxal to D-lactate Methylglyoxalase that converts methylglyoxal to D-lactate; involved in oxidative stress resistance, diauxic shift, and stationary phase survival; has similarity to E. coli Hsp31 and C. albicans Glx3p; member of the DJ-1/ThiJ/PfpI superfamily, which includes human DJ-1 involved in Parkinson's disease and cancer; exists as a dimer and contains a putative metal-binding site; protein abundance increases in response to DNA replication stress
Visualize the interactome of HSP31
Links to external databases:
  SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)

CYCLoPs localization & abundance

WT1 WT2 WT3
Cytoplasm 0.885 0.987 0.99
Vac/Vac Memb 0.058 NaN NaN

GFP localization & abundance

GFP localization GFP abundance
no data no data

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
HSP31 1 0 0 0 0

Enzyme information

Catalyzed reactions in Yeast8
r_4236 ((R)-lactate hydro-lyase)

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
FKH1 YIL131C Forkhead family transcription factor regulation 3 2 3 chromatin immunoprecipitation-chip evidence, chromatin immunoprecipitation-chip evidence, ChEC-Seq experiments
SNO4 YMR322C Possible chaperone and cysteine protease genetic 3 3 2 Dosage Rescue, Synthetic Growth Defect, Phenotypic Enhancement
UBR1 YGR184C E3 ubiquitin ligase (N-recognin) genetic 3 2 1 Phenotypic Enhancement, Phenotypic Suppression, Phenotypic Suppression
HSP104 YLL026W Disaggregase genetic 2 2 1 Phenotypic Suppression, Phenotypic Enhancement
HSP82 YPL240C Hsp90 chaperone physical 2 2 1 Two-hybrid, Affinity Capture-MS
HSP31 YDR533C Methylglyoxalase that converts methylglyoxal to D-lactate physical 2 2 1 Co-crystal Structure, Reconstituted Complex
HSP104 YLL026W Disaggregase physical 2 1 1 Affinity Capture-Western, Affinity Capture-Western
PSY4 YBL046W Regulatory subunit of protein phosphatase PP4 physical 2 1 1 Affinity Capture-MS, Affinity Capture-MS
SFP1 YLR403W Regulates transcription of ribosomal protein and biogenesis genes regulation 1 1 1 DNA to cDNA expression microarray evidence
RFX1 YLR176C Major transcriptional repressor of DNA-damage-regulated genes regulation 1 1 1 chromatin immunoprecipitation-chip evidence
SPT10 YJL127C Histone H3 acetylase with a role in transcriptional regulation regulation 1 1 1 DNA to cDNA expression microarray evidence
XBP1 YIL101C Transcriptional repressor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
BUR6 YER159C Subunit of a heterodimeric NC2 transcription regulator complex regulation 1 1 1 chromatin immunoprecipitation-chip evidence
SUA7 YPR086W Transcription factor TFIIB regulation 1 1 1 chromatin immunoprecipitation-chip evidence
SPT3 YDR392W Subunit of the SAGA and SAGA-like transcriptional regulatory complexes regulation 1 1 1 chromatin immunoprecipitation-chip evidence
UME6 YDR207C Rpd3L histone deacetylase complex subunit regulation 1 1 1 chromatin immunoprecipitation-chip evidence
TUP1 YCR084C General repressor of transcription in complex with Cyc8p regulation 1 1 1 DNA to cDNA expression microarray evidence
SIR2 YDL042C Conserved NAD+ dependent histone deacetylase of the Sirtuin family regulation 1 1 1 RNA-sequencing evidence
SIR3 YLR442C Silencing protein regulation 1 1 1 RNA-sequencing evidence
SIR4 YDR227W SIR protein involved in assembly of silent chromatin domains regulation 1 1 1 RNA-sequencing evidence
CCR4 YAL021C Component of the CCR4-NOT transcriptional complex physical 1 1 1 Affinity Capture-RNA
BUD14 YAR014C Protein involved in bud-site selection genetic 1 1 1 Negative Genetic
CDC3 YLR314C Component of the septin ring that is required for cytokinesis physical 1 1 1 Affinity Capture-MS
ESP1 YGR098C Separase/separin, a caspase-like cysteine protease genetic 1 1 1 Negative Genetic
AEP2 YMR282C Mitochondrial protein genetic 1 1 1 Negative Genetic
BBC1 YJL020C Protein possibly involved in assembly of actin patches genetic 1 1 1 Negative Genetic
EST1 YLR233C TLC1 RNA-associated factor involved in telomere length regulation genetic 1 1 1 Negative Genetic
BEM4 YPL161C Protein involved in establishment of cell polarity and bud emergence genetic 1 1 1 Negative Genetic
ATG20 YDL113C Sorting nexin family member genetic 1 1 1 Negative Genetic
CTF8 YHR191C Subunit of a complex with Ctf18p genetic 1 1 1 Negative Genetic
HAP4 YKL109W Transcription factor genetic 1 1 1 Negative Genetic
GPR1 YDL035C Plasma membrane G protein coupled receptor (GPCR) genetic 1 1 1 Negative Genetic
CPR7 YJR032W Peptidyl-prolyl cis-trans isomerase (cyclophilin) genetic 1 1 1 Negative Genetic
BCS1 YDR375C Protein translocase and chaperone required for Complex III assembly genetic 1 1 1 Negative Genetic
SNO4 YMR322C Possible chaperone and cysteine protease physical 1 1 1 Affinity Capture-MS
IRE1 YHR079C Serine-threonine kinase and endoribonuclease physical 1 1 1 Biochemical Activity
SRP1 YNL189W Karyopherin alpha homolog physical 1 1 1 Two-hybrid
NAB2 YGL122C Nuclear polyadenylated RNA-binding protein physical 1 1 1 Affinity Capture-RNA
ULP2 YIL031W Peptidase that deconjugates Smt3/SUMO-1 peptides from proteins physical 1 1 1 PCA
SSB2 YNL209W Cytoplasmic ATPase that is a ribosome-associated molecular chaperone physical 1 1 1 Co-purification
MPT5 YGL178W mRNA-binding protein of the PUF family physical 1 1 1 Affinity Capture-RNA
MFG1 YDL233W Regulator of filamentous growth genetic 1 1 1 Negative Genetic
RIA1 YNL163C Cytoplasmic GTPase/eEF2-like factor involved in ribosomal biogenesis genetic 1 1 1 Negative Genetic
TOP1 YOL006C Topoisomerase I genetic 1 1 1 Synthetic Growth Defect
SRS2 YJL092W DNA helicase and DNA-dependent ATPase genetic 1 1 1 Dosage Lethality
TEL2 YGR099W Subunit of the ASTRA complex, involved in chromatin remodeling genetic 1 1 1 Positive Genetic
HSP32 YPL280W Possible chaperone and cysteine protease genetic 1 1 1 Dosage Rescue
HSP33 YOR391C Possible chaperone and cysteine protease genetic 1 1 1 Dosage Rescue
VAM6 YDL077C Guanine nucleotide exchange factor for the GTPase Gtr1p genetic 1 1 1 Positive Genetic
IML1 YJR138W GTPase-activating protein (GAP) subunit of the Iml1p/SEACIT complex genetic 1 1 1 Positive Genetic
UBC1 YDR177W Ubiquitin-conjugating enzyme genetic 1 1 1 Negative Genetic
MED6 YHR058C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
KOG1 YHR186C Subunit of TORC1 genetic 1 1 1 Negative Genetic
RSC4 YKR008W Component of the RSC chromatin remodeling complex genetic 1 1 1 Negative Genetic
RLP24 YLR009W Essential protein required for ribosomal large subunit biogenesis genetic 1 1 1 Negative Genetic
RRB1 YMR131C Specific assembly chaperone for ribosomal protein Rpl3p genetic 1 1 1 Negative Genetic
SRV2 YNL138W CAP (cyclase-associated protein) genetic 1 1 1 Negative Genetic
MTR10 YOR160W Nuclear import receptor genetic 1 1 1 Negative Genetic
YAL064W YAL064W Protein of unknown function genetic 1 1 1 Negative Genetic
IMG1 YCR046C Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Negative Genetic
SHG1 YBR258C Subunit of the COMPASS (Set1C) complex genetic 1 1 1 Negative Genetic
STE50 YCL032W Adaptor protein for various signaling pathways genetic 1 1 1 Negative Genetic
RVS161 YCR009C Amphiphysin-like lipid raft protein genetic 1 1 1 Negative Genetic
IMG2 YCR071C Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Negative Genetic
RPP1A YDL081C Ribosomal stalk protein P1 alpha genetic 1 1 1 Negative Genetic
MAF1 YDR005C Highly conserved negative regulator of RNA polymerase III genetic 1 1 1 Negative Genetic
VPS41 YDR080W Subunit of the HOPS endocytic tethering complex genetic 1 1 1 Negative Genetic
RVS167 YDR388W Calmodulin-binding actin-associated protein genetic 1 1 1 Negative Genetic
YGL235W YGL235W Putative protein of unknown function genetic 1 1 1 Negative Genetic
VMA21 YGR105W Integral membrane protein required for V-ATPase function genetic 1 1 1 Negative Genetic
YGR111W YGR111W Putative protein of unknown function genetic 1 1 1 Negative Genetic
PTK2 YJR059W Serine/threonine protein kinase genetic 1 1 1 Negative Genetic
SAC1 YKL212W Phosphatidylinositol phosphate phosphatase genetic 1 1 1 Negative Genetic
VRP1 YLR337C Verprolin, proline-rich actin-associated protein genetic 1 1 1 Negative Genetic
VID22 YLR373C G-quadruplex (G4) DNA binding protein genetic 1 1 1 Negative Genetic
LDO16 YMR148W Protein of unknown function with possible role in spore wall assembly genetic 1 1 1 Negative Genetic
SSO2 YMR183C Plasma membrane t-SNARE genetic 1 1 1 Negative Genetic
YME1 YPR024W Catalytic subunit of i-AAA protease complex genetic 1 1 1 Negative Genetic
PET191 YJR034W Protein required for assembly of cytochrome c oxidase genetic 1 1 1 Negative Genetic
KTI12 YKL110C Protein that plays a role in modification of tRNA wobble nucleosides genetic 1 1 1 Negative Genetic
RCF1 YML030W Cytochrome c oxidase subunit genetic 1 1 1 Negative Genetic
RPS10B YMR230W Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
MEP2 YNL142W Ammonium permease involved in regulation of pseudohyphal growth genetic 1 1 1 Negative Genetic
YVC1 YOR087W Vacuolar cation channel genetic 1 1 1 Negative Genetic
SSA1 YAL005C ATPase involved in protein folding and NLS-directed nuclear transport genetic 1 1 1 Phenotypic Suppression
SGS1 YMR190C RecQ family nucleolar DNA helicase genetic 1 1 1 Positive Genetic
HRQ1 YDR291W 3'-5' DNA helicase of the conserved RecQ family genetic 1 1 1 Positive Genetic
ALD6 YPL061W Cytosolic aldehyde dehydrogenase genetic 1 1 1 Dosage Rescue
COA4 YLR218C Twin Cx(9)C protein involved in cytochrome c oxidase organization genetic 1 1 1 Negative Genetic
GAA1 YLR088W Subunit of the GPI:protein transamidase complex genetic 1 1 1 Negative Genetic
DOT5 YIL010W Nuclear thiol peroxidase genetic 1 1 1 Negative Genetic
COX10 YPL172C Heme A:farnesyltransferase genetic 1 1 1 Negative Genetic
GPM2 YDL021W Nonfunctional homolog of Gpm1p phosphoglycerate mutase genetic 1 1 1 Negative Genetic
GLO1 YML004C Monomeric glyoxalase I genetic 1 1 1 Dosage Rescue
EMC2 YJR088C Member of conserved ER transmembrane complex genetic 1 1 1 Negative Genetic