Standard name Systematic name Name description Description
OSM1 YJR051W Fumarate reductase, catalyzes the reduction of fumarate to succinate Fumarate reductase, catalyzes the reduction of fumarate to succinate; required for the reoxidation of intracellular NADH under anaerobic conditions; acts as electron acceptor in mitochondrial intermembrane space; has two translation start sites, one at the annotated start codon which produces an ER-targeted form required for anaerobic growth, and one at codon 32 which produces a mitochondrially-targeted form; OSM1 has a paralog, FRD1, that arose from the whole genome duplication
Visualize the interactome of OSM1
Links to external databases:
  SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)

CYCLoPs localization & abundance

WT1 WT2 WT3
Cytoplasm 0.526 0.568 0.847
Mito 0.548 0.411 0.131
Vac/Vac Memb 0.067 0.127 NaN

GFP localization & abundance

GFP localization GFP abundance
ambiguous, mitochondrion 432

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
OSM1 1 0 0 0 0

Enzyme information

Catalyzed reactions in Yeast8
r_4264 (succinate:NAD+ oxidoreductase)

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
TPS2 YDR074W Phosphatase subunit of the trehalose-6-P synthase/phosphatase complex genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
GCS1 YDL226C ADP-ribosylation factor GTPase activating protein (ARF GAP) genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
ERO1 YML130C Thiol oxidase required for oxidative protein folding in the ER physical 3 2 1 Affinity Capture-Western, Reconstituted Complex, Reconstituted Complex
ISW2 YOR304W ATP-dependent DNA translocase involved in chromatin remodeling genetic 2 1 2 Negative Genetic, Negative Genetic
GLT1 YDL171C NAD(+)-dependent glutamate synthase (GOGAT) genetic 2 1 2 Negative Genetic, Negative Genetic
MPH1 YIR002C 3'-5' DNA helicase involved in error-free bypass of DNA lesions genetic 2 1 2 Negative Genetic, Negative Genetic
ATG18 YFR021W Phosphoinositide binding protein genetic 2 1 2 Negative Genetic, Negative Genetic
MSH4 YFL003C Protein involved in meiotic recombination genetic 2 1 2 Negative Genetic, Negative Genetic
BUD7 YOR299W Member of the ChAPs family (Chs5p-Arf1p-binding proteins) genetic 2 1 2 Negative Genetic, Negative Genetic
ATG5 YPL149W Conserved protein involved in autophagy and the Cvt pathway genetic 2 1 2 Negative Genetic, Negative Genetic
FRD1 YEL047C Soluble fumarate reductase genetic 2 1 2 Synthetic Growth Defect, Synthetic Growth Defect
RPS8A YBL072C Protein component of the small (40S) ribosomal subunit genetic 2 1 2 Negative Genetic, Negative Genetic
TPS1 YBR126C Synthase subunit of trehalose-6-P synthase/phosphatase complex genetic 2 1 2 Negative Genetic, Negative Genetic
VMS1 YDR049W Peptidyl-tRNA hydrolase that releases stalled peptides from ribosomes, genetic 2 1 2 Negative Genetic, Negative Genetic
YER134C YER134C Magnesium-dependent acid phosphatase genetic 2 1 2 Negative Genetic, Negative Genetic
YLR179C YLR179C Protein of unknown function with similarity to Tfs1p genetic 2 1 2 Negative Genetic, Negative Genetic
SPH1 YLR313C Protein involved in shmoo formation and bipolar bud site selection genetic 2 1 2 Negative Genetic, Negative Genetic
PRM6 YML047C Potassium transporter that mediates K+ influx genetic 2 1 2 Negative Genetic, Negative Genetic
PDA1 YER178W E1 alpha subunit of the pyruvate dehydrogenase (PDH) complex genetic 2 1 2 Negative Genetic, Negative Genetic
GVP36 YIL041W BAR domain protein that localizes to early and late Golgi vesicles genetic 2 1 2 Negative Genetic, Negative Genetic
CYT2 YKL087C Cytochrome c1 heme lyase genetic 2 1 2 Negative Genetic, Negative Genetic
LEA1 YPL213W Component of U2 snRNP complex genetic 2 1 1 Negative Genetic, Negative Genetic
BIM1 YER016W Microtubule plus end-tracking protein genetic 2 1 1 Phenotypic Enhancement, Phenotypic Enhancement
MNN11 YJL183W Subunit of a Golgi mannosyltransferase complex genetic 2 1 1 Negative Genetic, Negative Genetic
RHB1 YCR027C Putative Rheb-related GTPase genetic 2 1 1 Negative Genetic, Negative Genetic
TRM1 YDR120C tRNA methyltransferase genetic 2 1 1 Negative Genetic, Negative Genetic
RPS30A YLR287C-A Protein component of the small (40S) ribosomal subunit genetic 2 1 1 Negative Genetic, Negative Genetic
FKH1 YIL131C Forkhead family transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
CWC25 YNL245C Splicing factor required for the first step of pre-mRNA splicing genetic 1 1 1 Positive Genetic
LSM6 YDR378C Lsm (Like Sm) protein genetic 1 1 1 Negative Genetic
CBC2 YPL178W Small subunit of the heterodimeric cap binding complex with Sto1p genetic 1 1 1 Positive Genetic
CDC14 YFR028C Protein phosphatase required for mitotic exit physical 1 1 1 Affinity Capture-MS
ERO1 YML130C Thiol oxidase required for oxidative protein folding in the ER genetic 1 1 1 Negative Genetic
CMR1 YDL156W Nuclear protein with role in transcription, protein quality control genetic 1 1 1 Negative Genetic
LIN1 YHR156C Non-essential component of U5 snRNP genetic 1 1 1 Negative Genetic
LTE1 YAL024C Protein similar to GDP/GTP exchange factors genetic 1 1 1 Negative Genetic
BDH2 YAL061W Putative medium-chain alcohol dehydrogenase with similarity to BDH1 genetic 1 1 1 Negative Genetic
CAF20 YOR276W Phosphoprotein of the mRNA cap-binding complex physical 1 1 1 Affinity Capture-MS
OM45 YIL136W Mitochondrial outer membrane protein of unknown function genetic 1 1 1 Negative Genetic
ACA1 YER045C ATF/CREB family basic leucine zipper (bZIP) transcription factor genetic 1 1 1 Negative Genetic
FIS1 YIL065C Protein involved in mitochondrial fission and peroxisome abundance genetic 1 1 1 Negative Genetic
ESL1 YIL151C hEST1A/B (SMG5/6)-like protein genetic 1 1 1 Negative Genetic
BFR1 YOR198C Component of mRNP complexes associated with polyribosomes physical 1 1 1 Affinity Capture-RNA
GPR1 YDL035C Plasma membrane G protein coupled receptor (GPCR) genetic 1 1 1 Negative Genetic
ERG2 YMR202W C-8 sterol isomerase genetic 1 1 1 Negative Genetic
KEX1 YGL203C Cell death protease essential for hypochlorite-induced apoptosis genetic 1 1 1 Negative Genetic
LAM1 YHR155W Putative sterol transfer protein genetic 1 1 1 Negative Genetic
DIN7 YDR263C Mitochondrial nuclease functioning in DNA repair and replication genetic 1 1 1 Negative Genetic
RRP40 YOL142W Exosome non-catalytic core component physical 1 1 1 Affinity Capture-MS
RSP5 YER125W NEDD4 family E3 ubiquitin ligase physical 1 1 1 Reconstituted Complex
TOM22 YNL131W Component of the TOM (Translocase of Outer Membrane) complex physical 1 1 1 Affinity Capture-MS
SEC61 YLR378C Conserved ER protein translocation channel physical 1 1 1 Affinity Capture-MS
TAH1 YCR060W Component of conserved R2TP complex (Rvb1-Rvb2-Tah1-Pih1) genetic 1 1 1 Negative Genetic
PUS2 YGL063W Mitochondrial tRNA:pseudouridine synthase genetic 1 1 1 Negative Genetic
PPT2 YPL148C Phosphopantetheine:protein transferase (PPTase) genetic 1 1 1 Negative Genetic
PFK1 YGR240C Alpha subunit of heterooctameric phosphofructokinase genetic 1 1 1 Positive Genetic
TSC11 YER093C Subunit of TORC2 (Tor2p-Lst8p-Avo1-Avo2-Tsc11p-Bit61p) genetic 1 1 1 Positive Genetic
YNK1 YKL067W Nucleoside diphosphate kinase genetic 1 1 1 Positive Genetic
SLA2 YNL243W Adaptor protein that links actin to clathrin and endocytosis genetic 1 1 1 Positive Genetic
TIM21 YGR033C Nonessential component of the TIM23 complex genetic 1 1 1 Negative Genetic
SWA2 YDR320C Auxilin-like protein involved in vesicular transport genetic 1 1 1 Negative Genetic
RPP2B YDR382W Ribosomal protein P2 beta genetic 1 1 1 Negative Genetic
RVS167 YDR388W Calmodulin-binding actin-associated protein genetic 1 1 1 Negative Genetic
RAD51 YER095W Strand exchange protein genetic 1 1 1 Negative Genetic
PTH1 YHR189W One of two mitochondrially-localized peptidyl-tRNA hydrolases genetic 1 1 1 Negative Genetic
YIL054W YIL054W Protein of unknown function genetic 1 1 1 Negative Genetic
VPS51 YKR020W Component of the GARP (Golgi-associated retrograde protein) complex genetic 1 1 1 Negative Genetic
RNP1 YLL046C Ribonucleoprotein that contains two RNA recognition motifs (RRM) genetic 1 1 1 Negative Genetic
PLB3 YOL011W Phospholipase B (lysophospholipase) involved in lipid metabolism genetic 1 1 1 Negative Genetic
YPQ1 YOL092W Putative vacuolar membrane transporter for cationic amino acids genetic 1 1 1 Negative Genetic
TGL5 YOR081C Bifunctional triacylglycerol lipase and LPA acyltransferase genetic 1 1 1 Negative Genetic
REV3 YPL167C Catalytic subunit of DNA polymerase zeta genetic 1 1 1 Negative Genetic
PBI2 YNL015W Cytosolic inhibitor of vacuolar proteinase B (PRB1) genetic 1 1 1 Negative Genetic
CYC3 YAL039C Cytochrome c heme lyase (holocytochrome c synthase) genetic 1 1 1 Phenotypic Enhancement
GIS1 YDR096W Histone demethylase and transcription factor physical 1 1 1 Affinity Capture-MS
ERV1 YGR029W Flavin-linked sulfhydryl oxidase of the mitochondrial IMS physical 1 1 1 Reconstituted Complex
ERV1 YGR029W Flavin-linked sulfhydryl oxidase of the mitochondrial IMS genetic 1 1 1 Synthetic Lethality
EDC1 YGL222C RNA-binding protein that activates mRNA decapping directly genetic 1 1 1 Positive Genetic
COX8 YLR395C Subunit VIII of cytochrome c oxidase (Complex IV) genetic 1 1 1 Negative Genetic
MRM2 YGL136C Mitochondrial 2' O-ribose methyltransferase genetic 1 1 1 Negative Genetic
GMC1 YDR506C Protein involved in meiotic progression genetic 1 1 1 Negative Genetic
MGR2 YPL098C Subunit of the TIM23 translocase complex genetic 1 1 1 Negative Genetic
HMI1 YOL095C Mitochondrial inner membrane localized ATP-dependent DNA helicase genetic 1 1 1 Negative Genetic