Standard name Systematic name Name description Description
PRS4 YBL068W 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP; which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes; PRS4 has a paralog, PRS2, that arose from the whole genome duplication; a missense mutation in the conserved residue R196 of its human homolog PRPS1 is pathogenic
Visualize the interactome of PRS4
Links to external databases:
  SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)

CYCLoPs localization & abundance

WT1 WT2 WT3
Cytoplasm 0.978 0.972 0.951

GFP localization & abundance

GFP localization GFP abundance
cytoplasm 5280

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
PRS4 3 0 0 0 0

Enzyme information

Catalyzed reactions in Yeast8
r_0916 (phosphoribosylpyrophosphate synthetase)

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
IPK1 YDR315C Inositol 1,3,4,5,6-pentakisphosphate 2-kinase genetic 6 1 4 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
PRS5 YOL061W 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase physical 5 1 4 Two-hybrid, Two-hybrid, Two-hybrid, Two-hybrid, Two-hybrid
VIP1 YLR410W Bifunctional inositol pyrophosphate kinase and phosphatase genetic 4 1 3 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
MEK1 YOR351C Meiosis-specific serine/threonine protein kinase genetic 3 1 3 Positive Genetic, Positive Genetic, Positive Genetic
PRS2 YER099C 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase genetic 2 2 2 Synthetic Lethality, Synthetic Growth Defect
GPP1 YIL053W Constitutively expressed DL-glycerol-3-phosphate phosphatase genetic 2 1 2 Negative Genetic, Negative Genetic
PRS1 YKL181W 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase physical 2 1 2 PCA, PCA
DGK1 YOR311C Diacylglycerol kinase genetic 2 1 2 Negative Genetic, Negative Genetic
XBP1 YIL101C Transcriptional repressor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
HAP5 YOR358W Subunit of the Hap2p/3p/4p/5p CCAAT-binding complex genetic 1 1 1 Negative Genetic
NAF1 YNL124W RNA-binding protein required for the assembly of box H/ACA snoRNPs physical 1 1 1 Affinity Capture-MS
NUT1 YGL151W Component of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
ACT1 YFL039C Actin, structural protein in cytoskeleton genetic 1 1 1 Positive Genetic
PRE8 YML092C Alpha 2 subunit of the 20S proteasome genetic 1 1 1 Negative Genetic
NAB2 YGL122C Nuclear polyadenylated RNA-binding protein physical 1 1 1 Affinity Capture-RNA
ADE13 YLR359W Adenylosuccinate lyase genetic 1 1 1 Negative Genetic
COP1 YDL145C Alpha subunit of COPI vesicle coatomer complex genetic 1 1 1 Negative Genetic
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator physical 1 1 1 Affinity Capture-RNA
KRR1 YCL059C Nucleolar protein required for rRNA synthesis and ribosomal assembly physical 1 1 1 Affinity Capture-MS
MSH2 YOL090W Protein that binds to DNA mismatches genetic 1 1 1 Negative Genetic
ILV1 YER086W Threonine deaminase, catalyzes first step in isoleucine biosynthesis genetic 1 1 1 Negative Genetic
PRP18 YGR006W Splicing factor and component of snRNP U5 genetic 1 1 1 Negative Genetic
KTR5 YNL029C Putative mannosyltransferase involved in protein glycosylation genetic 1 1 1 Negative Genetic
GET3 YDL100C Guanine nucleotide exchange factor for Gpa1p genetic 1 1 1 Negative Genetic
CDC13 YDL220C Single stranded DNA-binding protein found at TG1-3 telomere G-tails genetic 1 1 1 Synthetic Rescue
PHO84 YML123C High-affinity inorganic phosphate (Pi) transporter genetic 1 1 1 Negative Genetic
GND1 YHR183W 6-phosphogluconate dehydrogenase (decarboxylating) genetic 1 1 1 Negative Genetic
GSP1 YLR293C Ran GTPase genetic 1 1 1 Negative Genetic
PBR1 YNL181W Putative oxidoreductase genetic 1 1 1 Negative Genetic
FAA1 YOR317W Long chain fatty acyl-CoA synthetase genetic 1 1 1 Negative Genetic
PRS2 YER099C 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase physical 1 1 1 PCA
ERG11 YHR007C Lanosterol 14-alpha-demethylase genetic 1 1 1 Negative Genetic
DCK1 YLR422W Dock family protein (Dedicator Of CytoKinesis), homolog of human DOCK1 genetic 1 1 1 Positive Genetic
CUP2 YGL166W Copper-binding transcription factor genetic 1 1 1 Negative Genetic
NUF2 YOL069W Component of the kinetochore-associated Ndc80 complex physical 1 1 1 Two-hybrid
CTL1 YMR180C RNA 5'-triphosphatase, localizes to both the nucleus and cytoplasm genetic 1 1 1 Negative Genetic
PEF1 YGR058W Penta-EF-hand protein genetic 1 1 1 Negative Genetic
JIP5 YPR169W Protein required for biogenesis of the large ribosomal subunit genetic 1 1 1 Negative Genetic
PAN1 YIR006C Part of actin cytoskeleton-regulatory complex Pan1p-Sla1p-End3p genetic 1 1 1 Negative Genetic
OST4 YDL232W Subunit of the oligosaccharyltransferase complex of the ER lumen genetic 1 1 1 Negative Genetic
FBP1 YLR377C Fructose-1,6-bisphosphatase genetic 1 1 1 Negative Genetic
SLT2 YHR030C Serine/threonine MAP kinase physical 1 1 1 Two-hybrid
SLF1 YDR515W RNA binding protein that associates with polysomes physical 1 1 1 Affinity Capture-RNA
SRO9 YCL037C Cytoplasmic RNA-binding protein physical 1 1 1 Affinity Capture-RNA
PUF3 YLL013C Protein of the mitochondrial outer surface physical 1 1 1 Affinity Capture-RNA
SSB2 YNL209W Cytoplasmic ATPase that is a ribosome-associated molecular chaperone physical 1 1 1 Co-purification
SEC28 YIL076W Epsilon-COP subunit of the coatomer genetic 1 1 1 Synthetic Rescue
SNF1 YDR477W AMP-activated S/T protein kinase genetic 1 1 1 Negative Genetic
RML2 YEL050C Mitochondrial ribosomal protein of the large subunit (L2) genetic 1 1 1 Negative Genetic
YML082W YML082W Putative protein predicted to have carbon-sulfur lyase activity genetic 1 1 1 Negative Genetic
RTG1 YOL067C Transcription factor (bHLH) involved in interorganelle communication genetic 1 1 1 Positive Genetic
STU2 YLR045C Microtubule polymerase of the XMAP215/Dis1 family genetic 1 1 1 Negative Genetic
UTP21 YLR409C Subunit of U3-containing 90S preribosome and SSU processome complexes genetic 1 1 1 Negative Genetic
RKI1 YOR095C Ribose-5-phosphate ketol-isomerase genetic 1 1 1 Negative Genetic
RAD9 YDR217C DNA damage-dependent checkpoint protein genetic 1 1 1 Negative Genetic
VPS53 YJL029C Component of the GARP (Golgi-associated retrograde protein) complex genetic 1 1 1 Negative Genetic
VPS5 YOR069W Nexin-1 homolog genetic 1 1 1 Negative Genetic
YDL012C YDL012C Tail-anchored plasma membrane protein with a conserved CYSTM module genetic 1 1 1 Negative Genetic
YGL235W YGL235W Putative protein of unknown function genetic 1 1 1 Negative Genetic
YOL019W-A YOL019W-A Protein of unknown function genetic 1 1 1 Negative Genetic
RPS11B YBR048W Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
UBP12 YJL197W Ubiquitin-specific protease genetic 1 1 1 Negative Genetic
RNR3 YIL066C Minor isoform of large subunit of ribonucleotide-diphosphate reductase genetic 1 1 1 Positive Genetic
XRN1 YGL173C Evolutionarily-conserved 5'-3' exonuclease genetic 1 1 1 Negative Genetic
ADE12 YNL220W Adenylosuccinate synthase genetic 1 1 1 Negative Genetic
ABZ2 YMR289W Aminodeoxychorismate lyase (4-amino-4-deoxychorismate lyase) genetic 1 1 1 Negative Genetic
ILM1 YJR118C Protein of unknown function genetic 1 1 1 Negative Genetic
CHO2 YGR157W Phosphatidylethanolamine methyltransferase (PEMT) genetic 1 1 1 Positive Genetic
DAL2 YIR029W Allantoicase genetic 1 1 1 Negative Genetic
ALG2 YGL065C Mannosyltransferase in the N-linked glycosylation pathway genetic 1 1 1 Negative Genetic
OPT1 YJL212C Proton-coupled oligopeptide transporter of the plasma membrane genetic 1 1 1 Positive Genetic
IFM1 YOL023W Mitochondrial translation initiation factor 2 genetic 1 1 1 Negative Genetic
GPM3 YOL056W Nonfunctional homolog of Gpm1p phosphoglycerate mutase genetic 1 1 1 Positive Genetic
COX8 YLR395C Subunit VIII of cytochrome c oxidase (Complex IV) genetic 1 1 1 Negative Genetic
MPH3 YJR160C Alpha-glucoside permease genetic 1 1 1 Positive Genetic
PMP1 YCR024C-A Regulatory subunit for the plasma membrane H(+)-ATPase Pma1p genetic 1 1 1 Negative Genetic