| Standard name | Systematic name | Name description | Description |
|---|---|---|---|
| TGL3 | YMR313C | Bifunctional triacylglycerol lipase and LPE acyltransferase | Bifunctional triacylglycerol lipase and LPE acyltransferase; major lipid particle-localized triacylglycerol (TAG) lipase; catalyzes acylation of lysophosphatidylethanolamine (LPE), a function which is essential for sporulation; protein level and stability of Tgl3p are markedly reduced in the absence of lipid droplets; required with Tgl4p for timely bud formation |
Cell cycle phase and timing of transcription peak
| Cell cycle phase | Time (min) |
|---|---|
CYCLoPs localization & abundance
| WT1 | WT2 | WT3 | |
|---|---|---|---|
| Endosome | 0.165 | 0.188 | 0.268 |
| Mito | 0.377 | 0.392 | 0.109 |
| Nucleolus | 0.217 | 0.174 | 0.132 |
| Peroxisome | 0.453 | 0.420 | 0.355 |
| SpindlePole | 0.349 | 0.205 | 0.445 |
GFP localization & abundance
| GFP localization | GFP abundance |
|---|---|
| punctate composite, lipid particle | 3210 |
GO term count
| Metabolism | Cell cycle | Cell division | Signal transduction | DNA replication | |
|---|---|---|---|---|---|
| TGL3 | 3 | 0 | 2 | 0 | 0 |
Enzyme information
| Catalyzed reactions in Yeast8 |
|---|
| r_3302 (DAG lipase (1-18:0, 2-18:1), lipid particle), r_3282 (TAG lipase (1-16:0, 2-18:1, 3-18:0), lipid particle), r_3287 (TAG lipase (1-16:1, 2-18:1, 3-18:1), lipid particle), r_3315 (lysoPE (1-18:1) oleoyl-CoA acyltransferase, lipid particle), r_3268 (TAG lipase (1-16:1, 2-16:1, 3-16:0), lipid particle), r_3292 (TAG lipase (1-18:1, 2-18:1, 3-16:0), lipid particle), r_3297 (DAG lipase (1-16:1, 2-16:1), lipid particle), r_3303 (DAG lipase (1-18:1, 2-18:1), lipid particle), r_3273 (TAG lipase (1-18:0, 2-16:1, 3-16:1), lipid particle), r_3296 (DAG lipase (1-16:0, 2-16:1), lipid particle), r_3278 (TAG lipase (1-18:1, 2-16:1, 3-18:0), lipid particle), r_3283 (TAG lipase (1-16:0, 2-18:1, 3-18:1), lipid particle), r_3264 (TAG lipase (1-16:0, 2-16:1, 3-16:0), lipid particle), r_3288 (TAG lipase (1-18:0, 2-18:1, 3-16:0), lipid particle), r_3298 (DAG lipase (1-18:0, 2-16:1), lipid particle), r_3269 (TAG lipase (1-16:1, 2-16:1, 3-16:1), lipid particle), r_3293 (TAG lipase (1-18:1, 2-18:1, 3-16:1), lipid particle), r_3274 (TAG lipase (1-18:0, 2-16:1, 3-18:0), lipid particle), r_3279 (TAG lipase (1-18:1, 2-16:1, 3-18:1), lipid particle), r_3284 (TAG lipase (1-16:1, 2-18:1, 3-16:0), lipid particle), r_3299 (DAG lipase (1-18:1, 2-16:1), lipid particle), r_3265 (TAG lipase (1-16:0, 2-16:1, 3-16:1), lipid particle), r_3289 (TAG lipase (1-18:0, 2-18:1, 3-16:1), lipid particle), r_3270 (TAG lipase (1-16:1, 2-16:1, 3-18:0), lipid particle), r_3294 (TAG lipase (1-18:1, 2-18:1, 3-18:0), lipid particle), r_3277 (TAG lipase (1-18:1, 2-16:1, 3-16:1), lipid particle), r_3275 (TAG lipase (1-18:0, 2-16:1, 3-18:1), lipid particle), r_3280 (TAG lipase (1-16:0, 2-18:1, 3-16:0), lipid particle), r_3312 (lysoPE (1-16:0) oleoyl-CoA acyltransferase, lipid particle), r_3300 (DAG lipase (1-16:0, 2-18:1), lipid particle), r_3285 (TAG lipase (1-16:1, 2-18:1, 3-16:1), lipid particle), r_3266 (TAG lipase (1-16:0, 2-16:1, 3-18:0), lipid particle), r_3290 (TAG lipase (1-18:0, 2-18:1, 3-18:0), lipid particle), r_3271 (TAG lipase (1-16:1, 2-16:1, 3-18:1), lipid particle), r_3295 (TAG lipase (1-18:1, 2-18:1, 3-18:1), lipid particle), r_3313 (lysoPE (1-16:1) oleoyl-CoA acyltransferase, lipid particle), r_3276 (TAG lipase (1-18:1, 2-16:1, 3-16:0), lipid particle), r_3301 (DAG lipase (1-16:1, 2-18:1), lipid particle), r_3281 (TAG lipase (1-16:0, 2-18:1, 3-16:1), lipid particle), r_3286 (TAG lipase (1-16:1, 2-18:1, 3-18:0), lipid particle), r_3291 (TAG lipase (1-18:0, 2-18:1, 3-18:1), lipid particle), r_3267 (TAG lipase (1-16:0, 2-16:1, 3-18:1), lipid particle), r_3314 (lysoPE (1-18:0) oleoyl-CoA acyltransferase, lipid particle), r_3272 (TAG lipase (1-18:0, 2-16:1, 3-16:0), lipid particle) |
List of interactors
Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.| Standard name | Systematic name | Name description | Type | #Experiments | #Methods | #Publications | Evidence |
|---|---|---|---|---|---|---|---|
| MGA2 | YIR033W | ER membrane protein involved in regulation of OLE1 transcription | genetic | 4 | 1 | 2 | Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
| TGL4 | YKR089C | Multifunctional lipase/hydrolase/phospholipase | genetic | 3 | 2 | 2 | Phenotypic Enhancement, Synthetic Growth Defect, Phenotypic Enhancement |
| RIC1 | YLR039C | Protein involved in retrograde transport to the cis-Golgi network | genetic | 3 | 1 | 2 | Positive Genetic, Positive Genetic, Positive Genetic |
| OPI3 | YJR073C | Methylene-fatty-acyl-phospholipid synthase | genetic | 3 | 1 | 2 | Positive Genetic, Positive Genetic, Positive Genetic |
| GAS1 | YMR307W | Beta-1,3-glucanosyltransferase required for cell wall assembly | genetic | 2 | 1 | 2 | Synthetic Lethality, Synthetic Lethality |
| FAR10 | YLR238W | Protein involved in recovery from arrest in response to pheromone | genetic | 2 | 1 | 2 | Negative Genetic, Negative Genetic |
| PEX5 | YDR244W | Peroxisomal membrane signal receptor for peroxisomal matrix proteins | genetic | 2 | 1 | 2 | Positive Genetic, Positive Genetic |
| MNE1 | YOR350C | Protein involved in splicing Group I aI5-beta intron from COX1 mRNA | genetic | 2 | 1 | 2 | Negative Genetic, Negative Genetic |
| ATG15 | YCR068W | Phospholipase | genetic | 2 | 2 | 1 | Phenotypic Suppression, Synthetic Rescue |
| RGP1 | YDR137W | Subunit of a Golgi membrane exchange factor (Ric1p-Rgp1p) | genetic | 2 | 1 | 1 | Positive Genetic, Positive Genetic |
| LPP1 | YDR503C | Lipid phosphate phosphatase | genetic | 2 | 1 | 1 | Positive Genetic, Positive Genetic |
| ALD6 | YPL061W | Cytosolic aldehyde dehydrogenase | genetic | 2 | 1 | 1 | Negative Genetic, Negative Genetic |
| TSC3 | YBR058C-A | Protein that stimulates the activity of serine palmitoyltransferase | genetic | 2 | 1 | 1 | Positive Genetic, Positive Genetic |
| SPF1 | YEL031W | P-type ATPase, ion transporter of the ER membrane | genetic | 2 | 1 | 1 | Positive Genetic, Positive Genetic |
| SPT10 | YJL127C | Histone H3 acetylase with a role in transcriptional regulation | regulation | 1 | 1 | 1 | quantitative reverse transcription polymerase chain reaction evidence |
| BUR6 | YER159C | Subunit of a heterodimeric NC2 transcription regulator complex | regulation | 1 | 1 | 1 | chromatin immunoprecipitation-chip evidence |
| PEX19 | YDL065C | Chaperone and import receptor for newly-synthesized class I PMPs | physical | 1 | 1 | 1 | PCA |
| RAT1 | YOR048C | Nuclear 5' to 3' single-stranded RNA exonuclease | genetic | 1 | 1 | 1 | Negative Genetic |
| PRP40 | YKL012W | U1 snRNP protein involved in splicing | physical | 1 | 1 | 1 | Protein-peptide |
| RPN1 | YHR027C | Non-ATPase base subunit of the 19S RP of the 26S proteasome | genetic | 1 | 1 | 1 | Negative Genetic |
| RPN8 | YOR261C | Essential non-ATPase regulatory subunit of the 26S proteasome | genetic | 1 | 1 | 1 | Negative Genetic |
| CCR4 | YAL021C | Component of the CCR4-NOT transcriptional complex | physical | 1 | 1 | 1 | Affinity Capture-RNA |
| REB1 | YBR049C | RNA polymerase I enhancer binding protein | genetic | 1 | 1 | 1 | Positive Genetic |
| ARC15 | YIL062C | Subunit of the ARP2/3 complex | physical | 1 | 1 | 1 | PCA |
| CDC28 | YBR160W | Cyclin-dependent kinase (CDK) catalytic subunit | genetic | 1 | 1 | 1 | Phenotypic Suppression |
| CDC55 | YGL190C | Regulatory subunit B of protein phosphatase 2A (PP2A) | genetic | 1 | 1 | 1 | Phenotypic Enhancement |
| COX5A | YNL052W | Subunit Va of cytochrome c oxidase | genetic | 1 | 1 | 1 | Negative Genetic |
| DHH1 | YDL160C | Cytoplasmic DEAD-box helicase and mRNA decapping activator | physical | 1 | 1 | 1 | Affinity Capture-RNA |
| ISW1 | YBR245C | ATPase subunit of imitation-switch (ISWI) class chromatin remodelers | physical | 1 | 1 | 1 | Affinity Capture-RNA |
| IMG2 | YCR071C | Mitochondrial ribosomal protein of the large subunit | genetic | 1 | 1 | 1 | Negative Genetic |
| MRPL24 | YMR193W | Mitochondrial ribosomal protein of the large subunit | genetic | 1 | 1 | 1 | Negative Genetic |
| PRP4 | YPR178W | Splicing factor | genetic | 1 | 1 | 1 | Negative Genetic |
| MRPL6 | YHR147C | Mitochondrial ribosomal protein of the large subunit | genetic | 1 | 1 | 1 | Negative Genetic |
| SIN3 | YOL004W | Component of both the Rpd3S and Rpd3L histone deacetylase complexes | genetic | 1 | 1 | 1 | Phenotypic Enhancement |
| BZZ1 | YHR114W | SH3 domain protein implicated in regulating actin polymerization | physical | 1 | 1 | 1 | Two-hybrid |
| SLA1 | YBL007C | Cytoskeletal protein binding protein | physical | 1 | 1 | 1 | Two-hybrid |
| PHO85 | YPL031C | Cyclin-dependent kinase | physical | 1 | 1 | 1 | Biochemical Activity |
| AYR1 | YIL124W | Bifunctional triacylglycerol lipase and 1-acyl DHAP reductase | physical | 1 | 1 | 1 | PCA |
| ILV3 | YJR016C | Dihydroxyacid dehydratase | genetic | 1 | 1 | 1 | Negative Genetic |
| GPP2 | YER062C | DL-glycerol-3-phosphate phosphatase involved in glycerol biosynthesis | genetic | 1 | 1 | 1 | Negative Genetic |
| SGS1 | YMR190C | RecQ family nucleolar DNA helicase | genetic | 1 | 1 | 1 | Negative Genetic |
| SWE1 | YJL187C | Protein kinase that regulates the G2/M transition | genetic | 1 | 1 | 1 | Phenotypic Suppression |
| HOF1 | YMR032W | F-BAR protein that regulates actin cytoskeleton organization | genetic | 1 | 1 | 1 | Positive Genetic |
| PKC1 | YBL105C | Protein serine/threonine kinase | genetic | 1 | 1 | 1 | Negative Genetic |
| NBA1 | YOL070C | Protein involved in axial bud site selection | genetic | 1 | 1 | 1 | Negative Genetic |
| MET14 | YKL001C | Adenylylsulfate kinase | genetic | 1 | 1 | 1 | Negative Genetic |
| BRE5 | YNR051C | Ubiquitin protease cofactor | genetic | 1 | 1 | 1 | Negative Genetic |
| RPL20B | YOR312C | Ribosomal 60S subunit protein L20B | genetic | 1 | 1 | 1 | Negative Genetic |
| PUP1 | YOR157C | Beta 2 subunit of the 20S proteasome | genetic | 1 | 1 | 1 | Negative Genetic |
| RSM19 | YNR037C | Mitochondrial ribosomal protein of the small subunit | genetic | 1 | 1 | 1 | Negative Genetic |
| OST4 | YDL232W | Subunit of the oligosaccharyltransferase complex of the ER lumen | genetic | 1 | 1 | 1 | Negative Genetic |
| MPT5 | YGL178W | mRNA-binding protein of the PUF family | physical | 1 | 1 | 1 | Affinity Capture-RNA |
| CSG2 | YBR036C | Endoplasmic reticulum membrane protein | genetic | 1 | 1 | 1 | Positive Genetic |
| RBL2 | YOR265W | Protein involved in microtubule morphogenesis | genetic | 1 | 1 | 1 | Negative Genetic |
| SMI1 | YGR229C | Protein involved in the regulation of cell wall synthesis | genetic | 1 | 1 | 1 | Positive Genetic |
| MRF1 | YGL143C | Mitochondrial translation release factor | genetic | 1 | 1 | 1 | Negative Genetic |
| SNM1 | YDR478W | Ribonuclease MRP complex subunit | genetic | 1 | 1 | 1 | Negative Genetic |
| FAT1 | YBR041W | Very long chain fatty acyl-CoA synthetase and fatty acid transporter | physical | 1 | 1 | 1 | Co-fractionation |
| HRQ1 | YDR291W | 3'-5' DNA helicase of the conserved RecQ family | genetic | 1 | 1 | 1 | Negative Genetic |
| KCS1 | YDR017C | Inositol hexakisphosphate and inositol heptakisphosphate kinase | genetic | 1 | 1 | 1 | Positive Genetic |
| MRPL22 | YNL177C | Mitochondrial ribosomal protein of the large subunit | genetic | 1 | 1 | 1 | Negative Genetic |
| JID1 | YPR061C | Probable Hsp40p co-chaperone | genetic | 1 | 1 | 1 | Negative Genetic |
| DGA1 | YOR245C | Diacylglycerol acyltransferase | genetic | 1 | 1 | 1 | Phenotypic Enhancement |
| COQ8 | YGL119W | ATPase required for ubiquinone biosynthesis and respiratory growth | genetic | 1 | 1 | 1 | Negative Genetic |
| EOS1 | YNL080C | Protein involved in N-glycosylation | genetic | 1 | 1 | 1 | Negative Genetic |
| COX10 | YPL172C | Heme A:farnesyltransferase | genetic | 1 | 1 | 1 | Negative Genetic |
| CYT1 | YOR065W | Cytochrome c1 | genetic | 1 | 1 | 1 | Negative Genetic |
| OM14 | YBR230C | Mitochondrial outer membrane receptor for cytosolic ribosomes | physical | 1 | 1 | 1 | PCA |
| AST2 | YER101C | Lipid raft associated protein | genetic | 1 | 1 | 1 | Negative Genetic |
| ERG9 | YHR190W | Farnesyl-diphosphate farnesyl transferase (squalene synthase) | genetic | 1 | 1 | 1 | Negative Genetic |
| YSC84 | YHR016C | Actin-binding protein | physical | 1 | 1 | 1 | Two-hybrid |
| TGL3 | YMR313C | Bifunctional triacylglycerol lipase and LPE acyltransferase | physical | 1 | 1 | 1 | Affinity Capture-MS |
| VAM6 | YDL077C | Guanine nucleotide exchange factor for the GTPase Gtr1p | physical | 1 | 1 | 1 | Affinity Capture-MS |
| TOP1 | YOL006C | Topoisomerase I | genetic | 1 | 1 | 1 | Synthetic Growth Defect |
| TSC13 | YDL015C | Enoyl reductase | genetic | 1 | 1 | 1 | Negative Genetic |
| URB2 | YJR041C | Protein required for normal metabolism of the rRNA primary transcript | genetic | 1 | 1 | 1 | Negative Genetic |
| VPS64 | YDR200C | Protein required for cytoplasm to vacuole targeting of proteins | genetic | 1 | 1 | 1 | Negative Genetic |
| YJL070C | YJL070C | Putative metallo-dependent hydrolase superfamily protein | genetic | 1 | 1 | 1 | Negative Genetic |
| TOK1 | YJL093C | Outward-rectifier potassium channel of the plasma membrane | genetic | 1 | 1 | 1 | Negative Genetic |
| TOR1 | YJR066W | PIK-related protein kinase and rapamycin target | genetic | 1 | 1 | 1 | Phenotypic Enhancement |
| TSR3 | YOR006C | Protein required for 20S pre-rRNA processing | genetic | 1 | 1 | 1 | Negative Genetic |
| VPS5 | YOR069W | Nexin-1 homolog | genetic | 1 | 1 | 1 | Negative Genetic |
| VPS30 | YPL120W | Subunit of phosphatidylinositol (PtdIns) 3-kinase complexes I and II | genetic | 1 | 1 | 1 | Negative Genetic |
| VPS4 | YPR173C | AAA-ATPase involved in multivesicular body (MVB) protein sorting | genetic | 1 | 1 | 1 | Phenotypic Suppression |
| ALG8 | YOR067C | Glucosyl transferase | genetic | 1 | 1 | 1 | Negative Genetic |
| PGA3 | YML125C | Putative cytochrome b5 reductase, localized to the plasma membrane | genetic | 1 | 1 | 1 | Negative Genetic |
| NCE101 | YJL205C | Protein of unknown function | genetic | 1 | 1 | 1 | Negative Genetic |
| MRX11 | YPL041C | Protein that associates with mitochondrial ribosome | genetic | 1 | 1 | 1 | Negative Genetic |
| SRF1 | YDL133W | Regulator of phospholipase D (Spo14p) | genetic | 1 | 1 | 1 | Negative Genetic |