Standard name Systematic name Name description Description
EDC3 YEL015W Non-essential conserved protein with a role in mRNA decapping Non-essential conserved protein with a role in mRNA decapping; specifically affects the function of the decapping enzyme Dcp1p; mediates decay of the RPS28B mRNA via binding to both Rps28Bp (or Rps28Ap) and the RPS28B mRNA; mediates decay of the YRA1 mRNA by a different, translation-independent mechanism; localizes to cytoplasmic mRNA processing bodies; forms cytoplasmic foci upon DNA replication stress
Visualize the interactome of EDC3
Links to external databases:
  SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)

CYCLoPs localization & abundance

WT1 WT2 WT3
Cort. Patches 0.149 0.240 0.268
Cytoplasm 0.403 0.384 0.157
ER 0.130 0.369 0.297
Endosome 0.123 NaN 0.054
Golgi 0.136 0.225 0.355
Mito 0.276 NaN 0.281
Bud NaN NaN 0.061

GFP localization & abundance

GFP localization GFP abundance
punctate composite 2340

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
EDC3 3 0 0 0 0

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
DCP2 YNL118C Catalytic subunit of Dcp1p-Dcp2p decapping enzyme complex physical 18 5 13 Affinity Capture-MS, Two-hybrid, Two-hybrid, Two-hybrid, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Two-hybrid, Reconstituted Complex, Affinity Capture-Western, PCA, Affinity Capture-MS, Affinity Capture-Western, Reconstituted Complex, Reconstituted Complex, Two-hybrid, Affinity Capture-MS, Two-hybrid
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator physical 12 6 10 Two-hybrid, Two-hybrid, Two-hybrid, Reconstituted Complex, PCA, Affinity Capture-MS, Two-hybrid, Reconstituted Complex, Co-crystal Structure, Affinity Capture-MS, Affinity Capture-RNA, Affinity Capture-RNA
DCP1 YOL149W Subunit of the Dcp1p-Dcp2p decapping enzyme complex physical 8 2 6 Two-hybrid, Two-hybrid, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Two-hybrid, Affinity Capture-MS, Affinity Capture-MS
PBY1 YBR094W Putative tubulin tyrosine ligase associated with P-bodies physical 6 4 4 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Two-hybrid, Reconstituted Complex, Co-localization
EDC3 YEL015W Non-essential conserved protein with a role in mRNA decapping physical 5 3 5 Two-hybrid, Protein-peptide, Two-hybrid, Two-hybrid, Affinity Capture-MS
FKH1 YIL131C Forkhead family transcription factor regulation 5 2 5 chromatin immunoprecipitation-chip evidence, chromatin immunoprecipitation-chip evidence, chromatin immunoprecipitation- exonuclease evidence, chromatin immunoprecipitation-chip evidence, chromatin immunoprecipitation- exonuclease evidence
SCD6 YPR129W Repressor of translation initiation genetic 5 3 3 Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic, Phenotypic Enhancement, Negative Genetic
LSM4 YER112W Lsm (Like Sm) protein genetic 4 2 4 Negative Genetic, Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement
RPS28A YOR167C Protein component of the small (40S) ribosomal subunit physical 4 3 2 Two-hybrid, Co-purification, Two-hybrid, Reconstituted Complex
XRN1 YGL173C Evolutionarily-conserved 5'-3' exonuclease physical 3 3 3 Two-hybrid, Affinity Capture-MS, Affinity Capture-Western
RPS28B YLR264W Protein component of the small (40S) ribosomal subunit physical 3 2 3 Two-hybrid, Two-hybrid, Affinity Capture-Western
LSM8 YJR022W Lsm (Like Sm) protein physical 3 1 3 Two-hybrid, Two-hybrid, Two-hybrid
NAM7 YMR080C ATP-dependent RNA helicase of the SFI superfamily physical 3 3 2 Two-hybrid, Affinity Capture-MS, Affinity Capture-Western
CCR4 YAL021C Component of the CCR4-NOT transcriptional complex genetic 2 2 2 Synthetic Rescue, Phenotypic Suppression
DCP1 YOL149W Subunit of the Dcp1p-Dcp2p decapping enzyme complex genetic 2 2 2 Synthetic Growth Defect, Phenotypic Suppression
HRR25 YPL204W Conserved casein kinase, monopolin subunit physical 2 2 2 Affinity Capture-MS, Affinity Capture-Western
XRN1 YGL173C Evolutionarily-conserved 5'-3' exonuclease genetic 2 2 2 Phenotypic Suppression, Synthetic Growth Defect
PBY1 YBR094W Putative tubulin tyrosine ligase associated with P-bodies genetic 2 2 2 Phenotypic Suppression, Dosage Rescue
PAT1 YCR077C Deadenylation-dependent mRNA-decapping factor physical 2 1 2 Two-hybrid, Two-hybrid
PAT1 YCR077C Deadenylation-dependent mRNA-decapping factor genetic 2 1 2 Synthetic Growth Defect, Synthetic Growth Defect
SCD6 YPR129W Repressor of translation initiation physical 2 2 1 Affinity Capture-MS, Two-hybrid
LSM12 YHR121W Protein of unknown function that may function in RNA processing genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
PBP4 YDL053C Pbp1p binding protein genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
PBP1 YGR178C Component of glucose deprivation induced stress granules genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
EDC1 YGL222C RNA-binding protein that activates mRNA decapping directly genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
STP1 YDR463W Transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
REB1 YBR049C RNA polymerase I enhancer binding protein regulation 1 1 1 chromatin immunoprecipitation-chip evidence
ADF1 YCL058W-A Transcriptional repressor encoded by the FYV5 antisense strand regulation 1 1 1 chromatin immunoprecipitation evidence
CHD1 YER164W Chromatin remodeler that regulates various aspects of transcription genetic 1 1 1 Negative Genetic
DSN1 YIR010W Essential component of the outer kinetochore MIND complex physical 1 1 1 Affinity Capture-MS
DED81 YHR019C Cytosolic asparaginyl-tRNA synthetase genetic 1 1 1 Negative Genetic
DCP2 YNL118C Catalytic subunit of Dcp1p-Dcp2p decapping enzyme complex genetic 1 1 1 Synthetic Growth Defect
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator genetic 1 1 1 Phenotypic Suppression
CRM1 YGR218W Nuclear export factor, exportin physical 1 1 1 Affinity Capture-MS
BRR1 YPR057W snRNP protein component of spliceosomal snRNPs genetic 1 1 1 Negative Genetic
MET30 YIL046W F-box protein containing five copies of the WD40 motif physical 1 1 1 Two-hybrid
NUP157 YER105C Subunit of the inner ring of the nuclear pore complex (NPC) physical 1 1 1 Two-hybrid
TEM1 YML064C GTPase involved in initiation of Mitotic Exit Network (MEN) physical 1 1 1 Two-hybrid
LSM2 YBL026W Lsm (Like Sm) protein physical 1 1 1 Two-hybrid
FIR1 YER032W Protein involved in 3' mRNA processing physical 1 1 1 Two-hybrid
HIR3 YJR140C Subunit of the HIR complex physical 1 1 1 Two-hybrid
SEF1 YBL066C Putative transcription factor physical 1 1 1 Two-hybrid
SKT5 YBL061C Activator of Chs3p (chitin synthase III) during vegetative growth physical 1 1 1 Two-hybrid
SPT6 YGR116W Nucleosome remodeling protein physical 1 1 1 Two-hybrid
SRL2 YLR082C Protein of unknown function physical 1 1 1 Two-hybrid
LSM1 YJL124C Lsm (Like Sm) protein physical 1 1 1 Affinity Capture-MS
LSM3 YLR438C-A Lsm (Like Sm) protein physical 1 1 1 Affinity Capture-MS
MCK1 YNL307C Dual-specificity ser/thr and tyrosine protein kinase physical 1 1 1 Biochemical Activity
TPK1 YJL164C cAMP-dependent protein kinase catalytic subunit physical 1 1 1 Biochemical Activity
RPS28A YOR167C Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Synthetic Rescue
LSM4 YER112W Lsm (Like Sm) protein physical 1 1 1 PCA
TEF1 YPR080W Translational elongation factor EF-1 alpha physical 1 1 1 Affinity Capture-MS
TEF2 YBR118W Translational elongation factor EF-1 alpha physical 1 1 1 Affinity Capture-MS
RPL4A YBR031W Ribosomal 60S subunit protein L4A physical 1 1 1 Affinity Capture-MS
RPP0 YLR340W Conserved ribosomal protein P0 of the ribosomal stalk physical 1 1 1 Affinity Capture-MS
MYO5 YMR109W One of two type I myosin motors physical 1 1 1 Two-hybrid
PHO85 YPL031C Cyclin-dependent kinase physical 1 1 1 Biochemical Activity
URN1 YPR152C Protein of unknown function containing WW and FF domains physical 1 1 1 Affinity Capture-MS
SSD1 YDR293C Translational repressor physical 1 1 1 Co-localization
HHT1 YBR010W Histone H3 physical 1 1 1 Affinity Capture-MS
HHT2 YNL031C Histone H3 physical 1 1 1 Affinity Capture-MS
SBP1 YHL034C Protein that binds eIF4G and has a role in repression of translation physical 1 1 1 Affinity Capture-RNA
SCP160 YJL080C Essential RNA-binding G protein effector of mating response pathway physical 1 1 1 Affinity Capture-Western
SSB2 YNL209W Cytoplasmic ATPase that is a ribosome-associated molecular chaperone physical 1 1 1 Co-purification
PUF3 YLL013C Protein of the mitochondrial outer surface physical 1 1 1 Affinity Capture-RNA
MMS22 YLR320W Subunit of E3 ubiquitin ligase complex involved in replication repair physical 1 1 1 Affinity Capture-MS
TMA108 YIL137C Ribosome-associated, nascent chain binding factor physical 1 1 1 Affinity Capture-MS
NMD4 YLR363C Protein that may be involved in nonsense-mediated mRNA decay physical 1 1 1 Affinity Capture-MS
STL1 YDR536W Glycerol proton symporter of the plasma membrane physical 1 1 1 Affinity Capture-RNA
GPD1 YDL022W NAD-dependent glycerol-3-phosphate dehydrogenase physical 1 1 1 Affinity Capture-RNA
RPS12 YOR369C Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPS13 YDR064W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPS3 YNL178W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
MTQ2 YDR140W S-adenosylmethionine-dependent methyltransferase physical 1 1 1 Affinity Capture-MS
SKI3 YPR189W Ski complex component and TPR protein genetic 1 1 1 Synthetic Lethality
SKI8 YGL213C Ski complex component and WD-repeat protein genetic 1 1 1 Synthetic Lethality
MEF1 YLR069C Mitochondrial elongation factor involved in translational elongation genetic 1 1 1 Negative Genetic
HCR1 YLR192C eIF3j component of translation initiation factor 3 (eIF3) genetic 1 1 1 Negative Genetic
GCD14 YJL125C Subunit of tRNA (1-methyladenosine) methyltransferase genetic 1 1 1 Negative Genetic
PRP22 YER013W DEAH-box RNA-dependent ATPase/ATP-dependent RNA helicase genetic 1 1 1 Negative Genetic
GCD11 YER025W Gamma subunit of the translation initiation factor eIF2 genetic 1 1 1 Negative Genetic
LCP5 YER127W Essential protein involved in maturation of 18S rRNA genetic 1 1 1 Negative Genetic
PAB1 YER165W Poly(A) binding protein genetic 1 1 1 Negative Genetic
LSM7 YNL147W Lsm (Like Sm) protein genetic 1 1 1 Positive Genetic
TOP1 YOL006C Topoisomerase I genetic 1 1 1 Synthetic Growth Defect
TEL2 YGR099W Subunit of the ASTRA complex, involved in chromatin remodeling genetic 1 1 1 Negative Genetic
SNF5 YBR289W Subunit of the SWI/SNF chromatin remodeling complex genetic 1 1 1 Negative Genetic
SAC1 YKL212W Phosphatidylinositol phosphate phosphatase genetic 1 1 1 Negative Genetic
RPL22A YLR061W Ribosomal 60S subunit protein L22A genetic 1 1 1 Negative Genetic
PET9 YBL030C Major ADP/ATP carrier of the mitochondrial inner membrane genetic 1 1 1 Dosage Rescue
YME1 YPR024W Catalytic subunit of i-AAA protease complex genetic 1 1 1 Dosage Rescue
TOM70 YNL121C Component of the TOM (translocase of outer membrane) complex genetic 1 1 1 Dosage Rescue
MGR2 YPL098C Subunit of the TIM23 translocase complex genetic 1 1 1 Dosage Rescue
PSP2 YML017W Asn rich cytoplasmic protein that contains RGG motifs genetic 1 1 1 Phenotypic Suppression
PMA1 YGL008C Plasma membrane P2-type H+-ATPase genetic 1 1 1 Negative Genetic
CCT3 YJL014W Subunit of the cytosolic chaperonin Cct ring complex physical 1 1 1 Affinity Capture-MS
DIA2 YOR080W Origin-binding F-box protein genetic 1 1 1 Negative Genetic
EBS1 YDR206W Protein involved in translation inhibition and nonsense-mediated decay physical 1 1 1 Affinity Capture-MS
CAK1 YFL029C Cyclin-dependent kinase-activating kinase genetic 1 1 1 Positive Genetic
AIM4 YBR194W Protein proposed to be associated with the nuclear pore complex physical 1 1 1 Affinity Capture-MS
DAL81 YIR023W Positive regulator of genes in multiple nitrogen degradation pathways genetic 1 1 1 Negative Genetic
CSE4 YKL049C Centromeric histone H3-like protein physical 1 1 1 Affinity Capture-MS
DSE1 YER124C Daughter cell-specific protein physical 1 1 1 Two-hybrid
ATP1 YBL099W Alpha subunit of the F1 sector of mitochondrial F1F0 ATP synthase genetic 1 1 1 Dosage Rescue
EDC2 YER035W RNA-binding protein that directly activates mRNA decapping physical 1 1 1 Affinity Capture-MS
CHO2 YGR157W Phosphatidylethanolamine methyltransferase (PEMT) genetic 1 1 1 Negative Genetic