Standard name Systematic name Name description Description
ERG12 YMR208W Mevalonate kinase Mevalonate kinase; acts in the biosynthesis of isoprenoids and sterols, including ergosterol, from mevalonate; human MVK functionally complements the lethality of the erg12 null mutation
Visualize the interactome of ERG12
Links to external databases:
  SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)
S 76

CYCLoPs localization & abundance

WT1 WT2 WT3
Cytoplasm 0.979 0.976 0.915

GFP localization & abundance

GFP localization GFP abundance
cytoplasm, nucleus 3300

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
ERG12 4 0 0 0 0

Enzyme information

Catalyzed reactions in Yeast8
r_0738 (mevalonate kinase (UTP)), r_0737 (mevalonate kinase (gtp)), r_0736 (mevalonate kinase (ctp)), r_0735 (mevalonate kinase (atp))

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
BTS1 YPL069C Geranylgeranyl diphosphate synthase (GGPPS) genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
YDJ1 YNL064C Type I HSP40 co-chaperone genetic 2 1 2 Negative Genetic, Negative Genetic
SFP1 YLR403W Regulates transcription of ribosomal protein and biogenesis genes regulation 1 1 1 DNA to cDNA expression microarray evidence
GCN5 YGR252W Catalytic subunit of ADA and SAGA histone acetyltransferase complexes regulation 1 1 1 chromatin immunoprecipitation-chip evidence
MED2 YDL005C Subunit of the RNA polymerase II mediator complex regulation 1 1 1 chromatin immunoprecipitation-chip evidence
YAP6 YDR259C Basic leucine zipper (bZIP) transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
REB1 YBR049C RNA polymerase I enhancer binding protein regulation 1 1 1 chromatin immunoprecipitation-chip evidence
BRE1 YDL074C E3 ubiquitin ligase genetic 1 1 1 Negative Genetic
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator physical 1 1 1 Affinity Capture-RNA
COG3 YER157W Essential component of the conserved oligomeric Golgi complex genetic 1 1 1 Negative Genetic
CMD1 YBR109C Calmodulin genetic 1 1 1 Negative Genetic
DEP1 YAL013W Component of the Rpd3L histone deacetylase complex genetic 1 1 1 Negative Genetic
BCK1 YJL095W MAPKKK acting in the protein kinase C signaling pathway genetic 1 1 1 Negative Genetic
ALT2 YDR111C Catalytically inactive alanine transaminase genetic 1 1 1 Positive Genetic
DIA4 YHR011W Probable mitochondrial seryl-tRNA synthetase genetic 1 1 1 Negative Genetic
ACO1 YLR304C Aconitase genetic 1 1 1 Negative Genetic
CNB1 YKL190W Calcineurin B genetic 1 1 1 Negative Genetic
ARE2 YNR019W Acyl-CoA:sterol acyltransferase genetic 1 1 1 Negative Genetic
DBF2 YGR092W Ser/Thr kinase involved in transcription and stress response genetic 1 1 1 Negative Genetic
ATG13 YPR185W Regulatory subunit of the Atg1p signaling complex genetic 1 1 1 Negative Genetic
CDC43 YGL155W Beta subunit of geranylgeranyltransferase type I genetic 1 1 1 Negative Genetic
ELP4 YPL101W Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex genetic 1 1 1 Negative Genetic
DPM1 YPR183W Dolichol phosphate mannose (Dol-P-Man) synthase of ER membrane genetic 1 1 1 Negative Genetic
DAL5 YJR152W Allantoate permease genetic 1 1 1 Positive Genetic
ARV1 YLR242C Cortical ER protein genetic 1 1 1 Negative Genetic
ALG14 YBR070C Component of UDP-GlcNAc transferase genetic 1 1 1 Negative Genetic
COX12 YLR038C Subunit VIb of cytochrome c oxidase genetic 1 1 1 Negative Genetic
ERD1 YDR414C Predicted membrane protein required for lumenal ER protein retention genetic 1 1 1 Negative Genetic
NAB2 YGL122C Nuclear polyadenylated RNA-binding protein physical 1 1 1 Affinity Capture-RNA
SRO9 YCL037C Cytoplasmic RNA-binding protein physical 1 1 1 Affinity Capture-RNA
LSB3 YFR024C-A Protein containing a C-terminal SH3 domain physical 1 1 1 Affinity Capture-MS
ERG12 YMR208W Mevalonate kinase physical 1 1 1 Affinity Capture-MS
SSB1 YDL229W Cytoplasmic ATPase that is a ribosome-associated molecular chaperone physical 1 1 1 Affinity Capture-MS
SSB2 YNL209W Cytoplasmic ATPase that is a ribosome-associated molecular chaperone physical 1 1 1 Co-purification
SGT1 YOR057W Cochaperone protein physical 1 1 1 Reconstituted Complex
HSC82 YMR186W Cytoplasmic chaperone of the Hsp90 family physical 1 1 1 Reconstituted Complex
MAF1 YDR005C Highly conserved negative regulator of RNA polymerase III genetic 1 1 1 Synthetic Growth Defect
RIM1 YCR028C-A ssDNA-binding protein essential for mitochondrial genome maintenance genetic 1 1 1 Negative Genetic
XRS2 YDR369C FHA domain-containing component of the Mre11 complex genetic 1 1 1 Negative Genetic
PET122 YER153C Mitochondrial translational activator specific for the COX3 mRNA genetic 1 1 1 Negative Genetic
NUT1 YGL151W Component of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
ICE2 YIL090W Integral ER membrane protein with type-III transmembrane domains genetic 1 1 1 Negative Genetic
OPI3 YJR073C Methylene-fatty-acyl-phospholipid synthase genetic 1 1 1 Negative Genetic
SAC1 YKL212W Phosphatidylinositol phosphate phosphatase genetic 1 1 1 Negative Genetic
NST1 YNL091W Translational inhibitor and suppressor of proteasome-assembly defects genetic 1 1 1 Negative Genetic
SWS2 YNL081C Putative mitochondrial ribosomal protein of the small subunit genetic 1 1 1 Negative Genetic
YIG1 YPL201C Protein that interacts with glycerol 3-phosphatase genetic 1 1 1 Negative Genetic
SPE1 YKL184W Ornithine decarboxylase genetic 1 1 1 Negative Genetic
PFK1 YGR240C Alpha subunit of heterooctameric phosphofructokinase genetic 1 1 1 Positive Genetic
HYR1 YIR037W Glutathione peroxidase genetic 1 1 1 Negative Genetic
GSH1 YJL101C Gamma glutamylcysteine synthetase genetic 1 1 1 Negative Genetic
SPE3 YPR069C Spermidine synthase genetic 1 1 1 Negative Genetic
TRP4 YDR354W Anthranilate phosphoribosyl transferase genetic 1 1 1 Positive Genetic
TNA1 YGR260W High affinity nicotinic acid plasma membrane permease genetic 1 1 1 Negative Genetic
MET8 YBR213W Bifunctional dehydrogenase and ferrochelatase genetic 1 1 1 Negative Genetic
HOM6 YJR139C Homoserine dehydrogenase (L-homoserine:NADP oxidoreductase) genetic 1 1 1 Negative Genetic
IDP2 YLR174W Cytosolic NADP-specific isocitrate dehydrogenase genetic 1 1 1 Negative Genetic
ILV1 YER086W Threonine deaminase, catalyzes first step in isoleucine biosynthesis genetic 1 1 1 Positive Genetic
TPS2 YDR074W Phosphatase subunit of the trehalose-6-P synthase/phosphatase complex genetic 1 1 1 Negative Genetic
MMM1 YLL006W ER integral membrane protein, ERMES complex subunit genetic 1 1 1 Negative Genetic
GEP5 YLR091W Protein of unknown function genetic 1 1 1 Negative Genetic
HER2 YMR293C Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex genetic 1 1 1 Negative Genetic
YME1 YPR024W Catalytic subunit of i-AAA protease complex genetic 1 1 1 Positive Genetic
SMC3 YJL074C Subunit of the multiprotein cohesin complex genetic 1 1 1 Synthetic Lethality
FAA3 YIL009W Long chain fatty acyl-CoA synthetase genetic 1 1 1 Negative Genetic
SLG1 YOR008C Sensor-transducer of the stress-activated PKC1-MPK1 kinase pathway genetic 1 1 1 Negative Genetic
IWR1 YDL115C RNA polymerase II transport factor, conserved from yeast to humans genetic 1 1 1 Negative Genetic
ERG26 YGL001C C-3 sterol dehydrogenase genetic 1 1 1 Positive Genetic
PKC1 YBL105C Protein serine/threonine kinase genetic 1 1 1 Negative Genetic
MED8 YBR193C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
SLU7 YDR088C RNA splicing factor genetic 1 1 1 Negative Genetic
GPI19 YDR437W Subunit of GPI-GlcNAc transferase involved in synthesis of GlcNAc-PI genetic 1 1 1 Negative Genetic
HSF1 YGL073W Trimeric heat shock transcription factor genetic 1 1 1 Negative Genetic
TAF6 YGL112C Subunit (60 kDa) of TFIID and SAGA complexes genetic 1 1 1 Negative Genetic
MED6 YHR058C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
PAN1 YIR006C Part of actin cytoskeleton-regulatory complex Pan1p-Sla1p-End3p genetic 1 1 1 Negative Genetic
ERG27 YLR100W 3-keto sterol reductase genetic 1 1 1 Negative Genetic
SEC59 YMR013C Dolichol kinase genetic 1 1 1 Negative Genetic
MGE1 YOR232W Mitochondrial matrix cochaperone genetic 1 1 1 Negative Genetic
GPI2 YPL076W Protein involved in the synthesis of GlcNAc-PI genetic 1 1 1 Negative Genetic
HEM25 YDL119C Mitochondrial glycine transporter genetic 1 1 1 Negative Genetic
TRP1 YDR007W Phosphoribosylanthranilate isomerase genetic 1 1 1 Negative Genetic
UPC2 YDR213W Sterol regulatory element binding protein genetic 1 1 1 Negative Genetic
MNN10 YDR245W Subunit of a Golgi mannosyltransferase complex genetic 1 1 1 Negative Genetic
MSN5 YDR335W Karyopherin genetic 1 1 1 Negative Genetic
SLT2 YHR030C Serine/threonine MAP kinase genetic 1 1 1 Negative Genetic
SRB2 YHR041C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
SDS3 YIL084C Component of the Rpd3L histone deacetylase complex genetic 1 1 1 Negative Genetic
SND2 YLR065C Protein involved in SRP-independent targeting of substrates to the ER genetic 1 1 1 Negative Genetic
MID2 YLR332W O-glycosylated plasma membrane protein genetic 1 1 1 Negative Genetic
ORM2 YLR350W Protein that mediates sphingolipid homeostasis genetic 1 1 1 Negative Genetic
STI1 YOR027W Evolutionarily-conserved Hsp90 cochaperone genetic 1 1 1 Negative Genetic
LGE1 YPL055C Protein involved in histone H2B ubiquitination genetic 1 1 1 Negative Genetic
SUR1 YPL057C Mannosylinositol phosphorylceramide (MIPC) synthase catalytic subunit genetic 1 1 1 Negative Genetic
RLM1 YPL089C MADS-box transcription factor genetic 1 1 1 Negative Genetic
RPS6A YPL090C Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
SSN8 YNL025C Cyclin-like component of RNA polymerase II holoenzyme genetic 1 1 1 Negative Genetic
SIC1 YLR079W Cyclin-dependent kinase inhibitor (CKI) genetic 1 1 1 Negative Genetic
TPM1 YNL079C Major isoform of tropomyosin genetic 1 1 1 Negative Genetic
FUS3 YBL016W Mitogen-activated serine/threonine protein kinase involved in mating genetic 1 1 1 Negative Genetic
POL4 YCR014C DNA polymerase IV genetic 1 1 1 Positive Genetic
DAL1 YIR027C Allantoinase genetic 1 1 1 Negative Genetic