Standard name Systematic name Name description Description
TPA1 YER049W Prolyl hydroxylase Prolyl hydroxylase; catalyzes oxygen-dependent dihydroxylation of Rps23a/b, a 40S ribosomal decoding center subunit; influences translational termination and regulates translational accuracy; interacts with Sup45p (eRF1), Sup35p (eRF3) and Pab1p; disputed role as a oxidative dealkylase repairing DNA methyl-base lesions; poly(rA)-binding protein affecting poly(A) tail length and mRNA stability; Fe(II)/2-oxoglutarate-dependent dioxygenase family member similar to human prolyl 4-hydroxylase OGFOD1
Visualize the interactome of TPA1
Links to external databases:
  SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)

CYCLoPs localization & abundance

WT1 WT2 WT3
Nucleus 0.963 0.804 0.93
Cytoplasm NaN 0.115 NaN
Vac/Vac Memb NaN 0.076 NaN

GFP localization & abundance

GFP localization GFP abundance
no data no data

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
TPA1 6 0 0 0 0

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
RBD2 YPL246C Possible rhomboid protease genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
RPS6A YPL090C Protein component of the small (40S) ribosomal subunit genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
RPL35B YDL136W Ribosomal 60S subunit protein L35B genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
MCT1 YOR221C Predicted malonyl-CoA:ACP transferase genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
YEF3 YLR249W Translation elongation factor 3 physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
YDR249C YDR249C Putative protein of unknown function genetic 2 1 2 Negative Genetic, Negative Genetic
YPL247C YPL247C Putative protein of unknown function genetic 2 1 2 Negative Genetic, Negative Genetic
YPL088W YPL088W Putative aryl alcohol dehydrogenase genetic 2 1 2 Negative Genetic, Negative Genetic
PHO85 YPL031C Cyclin-dependent kinase genetic 2 1 2 Synthetic Lethality, Synthetic Lethality
MAG1 YER142C 3-methyl-adenine DNA glycosylase genetic 2 1 2 Synthetic Growth Defect, Synthetic Growth Defect
SHS1 YDL225W Component of the septin ring that is required for cytokinesis genetic 2 1 2 Negative Genetic, Negative Genetic
MGT1 YDL200C DNA repair methyltransferase (6-O-methylguanine-DNA methylase) genetic 2 1 2 Negative Genetic, Negative Genetic
PEX10 YDR265W Peroxisomal membrane E3 ubiquitin ligase genetic 2 1 2 Negative Genetic, Negative Genetic
CMR2 YOR093C Putative protein of unknown function genetic 2 1 2 Negative Genetic, Negative Genetic
GYP7 YDL234C GTPase-activating protein for yeast Rab family members genetic 2 1 2 Positive Genetic, Positive Genetic
RPL35A YDL191W Ribosomal 60S subunit protein L35A genetic 2 1 2 Negative Genetic, Negative Genetic
CSA1 YPR174C Protein of unknown function genetic 2 1 2 Negative Genetic, Negative Genetic
CGR1 YGL029W Protein involved in nucleolar integrity and processing of pre-rRNA genetic 2 1 2 Negative Genetic, Negative Genetic
DPC25 YPL107W Putative mitochondrial protein of unknown function genetic 2 1 2 Negative Genetic, Negative Genetic
AQY1 YPR192W Spore-specific water channel genetic 2 1 2 Negative Genetic, Negative Genetic
MTC4 YBR255W Protein of unknown function genetic 2 1 2 Negative Genetic, Negative Genetic
SRL4 YPL033C Protein of unknown function genetic 2 1 2 Negative Genetic, Negative Genetic
RTF1 YGL244W Subunit of RNAPII-associated chromatin remodeling Paf1 complex genetic 2 1 1 Negative Genetic, Negative Genetic
TPO4 YOR273C Polyamine transporter of the major facilitator superfamily genetic 2 1 1 Negative Genetic, Negative Genetic
ARF2 YDL137W ADP-ribosylation factor genetic 2 1 1 Negative Genetic, Negative Genetic
PRM3 YPL192C Protein required for nuclear envelope fusion during karyogamy genetic 2 1 1 Positive Genetic, Positive Genetic
FKH1 YIL131C Forkhead family transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
FKH2 YNL068C Forkhead family transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
STP1 YDR463W Transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
TFC7 YOR110W RNA pol III transcription initiation factor complex (TFIIIC) subunit regulation 1 1 1 chromatin immunoprecipitation-chip evidence
RPL16A YIL133C Ribosomal 60S subunit protein L16A genetic 1 1 1 Negative Genetic
TPA1 YER049W Prolyl hydroxylase physical 1 1 1 Affinity Capture-MS
YML131W YML131W Protein of unknown function physical 1 1 1 Affinity Capture-MS
TRM1 YDR120C tRNA methyltransferase physical 1 1 1 Affinity Capture-MS
UMP1 YBR173C Chaperone required for correct maturation of the 20S proteasome genetic 1 1 1 Positive Genetic
YGR122W YGR122W Protein that may be involved in pH regulation genetic 1 1 1 Negative Genetic
YPT7 YML001W Rab family GTPase genetic 1 1 1 Negative Genetic
YPT11 YNL304W Rab GTPase genetic 1 1 1 Negative Genetic
YVC1 YOR087W Vacuolar cation channel genetic 1 1 1 Negative Genetic
YPL039W YPL039W Putative protein of unknown function genetic 1 1 1 Negative Genetic
PAB1 YER165W Poly(A) binding protein physical 1 1 1 Affinity Capture-Western
RPC82 YPR190C RNA polymerase III subunit C82 physical 1 1 1 Affinity Capture-MS
CBC2 YPL178W Small subunit of the heterodimeric cap binding complex with Sto1p genetic 1 1 1 Positive Genetic
RPN11 YFR004W Metalloprotease subunit of 19S regulatory particle physical 1 1 1 Affinity Capture-MS
BMS1 YPL217C GTPase required for ribosomal subunit synthesis and rRNA processing genetic 1 1 1 Negative Genetic
ASC1 YMR116C G-protein beta subunit and guanine dissociation inhibitor for Gpa2p genetic 1 1 1 Negative Genetic
CDC28 YBR160W Cyclin-dependent kinase (CDK) catalytic subunit genetic 1 1 1 Dosage Lethality
CDC11 YJR076C Component of the septin ring that is required for cytokinesis genetic 1 1 1 Negative Genetic
CDC3 YLR314C Component of the septin ring that is required for cytokinesis genetic 1 1 1 Negative Genetic
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator physical 1 1 1 Affinity Capture-RNA
LAS17 YOR181W Actin assembly factor genetic 1 1 1 Positive Genetic
MED6 YHR058C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
NUP116 YMR047C FG-nucleoporin component of central core of the nuclear pore complex physical 1 1 1 Co-purification
BLM10 YFL007W Proteasome activator genetic 1 1 1 Negative Genetic
PUB1 YNL016W Poly (A)+ RNA-binding protein genetic 1 1 1 Negative Genetic
PTI1 YGR156W Essential component of CPF (cleavage and polyadenylation factor) genetic 1 1 1 Negative Genetic
SEC27 YGL137W Essential beta'-coat protein of the COPI coatomer physical 1 1 1 Affinity Capture-MS
SNU66 YOR308C Component of the U4/U6.U5 snRNP complex genetic 1 1 1 Negative Genetic
SGV1 YPR161C Cyclin (Bur2p)-dependent protein kinase genetic 1 1 1 Negative Genetic
CRN1 YLR429W Coronin physical 1 1 1 Affinity Capture-MS
MKS1 YNL076W Pleiotropic negative transcriptional regulator genetic 1 1 1 Positive Genetic
SAW1 YAL027W 5'- and 3'-flap DNA binding protein physical 1 1 1 Affinity Capture-MS
PUF3 YLL013C Protein of the mitochondrial outer surface genetic 1 1 1 Negative Genetic
CAF20 YOR276W Phosphoprotein of the mRNA cap-binding complex physical 1 1 1 Affinity Capture-MS
RVS161 YCR009C Amphiphysin-like lipid raft protein genetic 1 1 1 Negative Genetic
ATG11 YPR049C Adapter protein for pexophagy and the Cvt targeting pathway genetic 1 1 1 Negative Genetic
RVS167 YDR388W Calmodulin-binding actin-associated protein physical 1 1 1 Affinity Capture-MS
ERG6 YML008C Delta(24)-sterol C-methyltransferase genetic 1 1 1 Synthetic Rescue
LHS1 YKL073W Molecular chaperone of the endoplasmic reticulum lumen genetic 1 1 1 Negative Genetic
OMS1 YDR316W Protein integral to the mitochondrial membrane genetic 1 1 1 Negative Genetic
TEF4 YKL081W Gamma subunit of translational elongation factor eEF1B genetic 1 1 1 Negative Genetic
PEX15 YOL044W Tail-anchored type II integral peroxisomal membrane protein genetic 1 1 1 Negative Genetic
GTR1 YML121W Subunit of a TORC1-stimulating GTPase and the EGO/GSE complex genetic 1 1 1 Negative Genetic
CWC24 YLR323C General splicing factor genetic 1 1 1 Negative Genetic
ASK10 YGR097W Regulator of the Fps1p glycerol channel genetic 1 1 1 Negative Genetic
SIW14 YNL032W Inositol phosphatase involved in inositol pyrophosphate metabolism genetic 1 1 1 Negative Genetic
CHL1 YPL008W Probable DNA helicase genetic 1 1 1 Negative Genetic
BRE5 YNR051C Ubiquitin protease cofactor genetic 1 1 1 Negative Genetic
DAL81 YIR023W Positive regulator of genes in multiple nitrogen degradation pathways genetic 1 1 1 Negative Genetic
BUB1 YGR188C Protein kinase involved in the cell cycle checkpoint into anaphase genetic 1 1 1 Positive Genetic
IOC4 YMR044W Member of a complex (Isw1b) with Isw1p and Ioc2p genetic 1 1 1 Negative Genetic
TIM23 YNR017W Essential component of the TIM23 complex genetic 1 1 1 Negative Genetic
HAP1 YLR256W Zinc finger transcription factor genetic 1 1 1 Synthetic Rescue
MPT5 YGL178W mRNA-binding protein of the PUF family physical 1 1 1 Affinity Capture-RNA
SLA2 YNL243W Adaptor protein that links actin to clathrin and endocytosis genetic 1 1 1 Negative Genetic
RLM1 YPL089C MADS-box transcription factor physical 1 1 1 Affinity Capture-MS
ARK1 YNL020C Ser/Thr protein kinase genetic 1 1 1 Negative Genetic
REV3 YPL167C Catalytic subunit of DNA polymerase zeta genetic 1 1 1 Synthetic Growth Defect
PRI1 YIR008C Subunit of DNA primase genetic 1 1 1 Negative Genetic
ETT1 YOR051C Nuclear protein that inhibits replication of Brome mosaic virus physical 1 1 1 Affinity Capture-MS
MON2 YNL297C Protein with a role in endocytosis and vacuole integrity genetic 1 1 1 Negative Genetic
SSB2 YNL209W Cytoplasmic ATPase that is a ribosome-associated molecular chaperone physical 1 1 1 Co-purification
FRK1 YPL141C Protein kinase of unknown cellular role physical 1 1 1 Affinity Capture-MS
ERG2 YMR202W C-8 sterol isomerase genetic 1 1 1 Synthetic Rescue
FCF2 YLR051C Nucleolar protein involved in the early steps of 35S rRNA processing genetic 1 1 1 Negative Genetic
PUF4 YGL014W Member of the PUF protein family physical 1 1 1 Affinity Capture-RNA
SLX8 YER116C Subunit of Slx5-Slx8 SUMO-targeted ubiquitin ligase (STUbL) complex genetic 1 1 1 Negative Genetic
ECM3 YOR092W Non-essential protein of unknown function genetic 1 1 1 Negative Genetic
APJ1 YNL077W Hsp40 chaperone with a role in SUMO-mediated protein degradation physical 1 1 1 Affinity Capture-MS
PUF2 YPR042C PUF family mRNA-binding protein physical 1 1 1 Affinity Capture-RNA
SUM1 YDR310C Transcriptional repressor that regulates middle-sporulation genes genetic 1 1 1 Negative Genetic
SCS7 YMR272C Sphingolipid alpha-hydroxylase genetic 1 1 1 Negative Genetic
SFB3 YHR098C Component of the Sec23p-Sfb3p heterodimer of the COPII vesicle coat genetic 1 1 1 Negative Genetic
SWS2 YNL081C Putative mitochondrial ribosomal protein of the small subunit genetic 1 1 1 Negative Genetic
SAM37 YMR060C Component of the Sorting and Assembly Machinery (SAM) complex genetic 1 1 1 Negative Genetic
SND2 YLR065C Protein involved in SRP-independent targeting of substrates to the ER genetic 1 1 1 Negative Genetic
LST4 YKL176C Subunit of the Lst4p-Lst7p GTPase activating protein complex for Gtr2p genetic 1 1 1 Negative Genetic
SPO71 YDR104C Meiosis-specific protein required for prospore membrane morphogenesis genetic 1 1 1 Negative Genetic
RDL2 YOR286W Protein with rhodanese activity genetic 1 1 1 Negative Genetic
FAT3 YKL187C Protein required for fatty acid uptake genetic 1 1 1 Negative Genetic