Standard name Systematic name Name description Description
PDC6 YGR087C Minor isoform of pyruvate decarboxylase Minor isoform of pyruvate decarboxylase; decarboxylates pyruvate to acetaldehyde, involved in amino acid catabolism; transcription is glucose- and ethanol-dependent, and is strongly induced during sulfur limitation
Visualize the interactome of PDC6
Links to external databases:
  SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)

CYCLoPs localization & abundance

WT1 WT2 WT3
Cytoplasm 0.769 0.899 0.96
Mito 0.183 NaN NaN
Vac/Vac Memb 0.125 0.118 NaN

GFP localization & abundance

GFP localization GFP abundance
cytoplasm 1520

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
PDC6 9 0 0 0 0

Enzyme information

Catalyzed reactions in Yeast8
r_0959 (pyruvate decarboxylase), r_0567 (indole-3-pyruvate decarboxylase), r_0095 (acetaldehyde condensation), r_4669 (pyruvate decarboxylase (hydroxy-phenyl)), r_0062 (3-methyl-2-oxobutanoate decarboxylase), r_4651 (pyruvate decarboxylase (aldedyde-forming)), r_0960 (pyruvate decarboxylase (acetoin-forming)), r_0064 (3-methyl-2-oxopentanoate decarboxylase)

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
PDC1 YLR044C Major of three pyruvate decarboxylase isozymes genetic 2 2 2 Phenotypic Enhancement, Synthetic Lethality
PDC5 YLR134W Minor isoform of pyruvate decarboxylase genetic 2 2 2 Phenotypic Enhancement, Synthetic Lethality
ERG3 YLR056W C-5 sterol desaturase genetic 2 1 2 Negative Genetic, Negative Genetic
SFP1 YLR403W Regulates transcription of ribosomal protein and biogenesis genes regulation 1 1 1 DNA to cDNA expression microarray evidence
RFX1 YLR176C Major transcriptional repressor of DNA-damage-regulated genes regulation 1 1 1 chromatin immunoprecipitation-chip evidence
SPT10 YJL127C Histone H3 acetylase with a role in transcriptional regulation regulation 1 1 1 DNA to cDNA expression microarray evidence
GCR1 YPL075W Transcriptional activator of genes involved in glycolysis regulation 1 1 1 DNA to cDNA expression microarray evidence
MET32 YDR253C Zinc-finger DNA-binding transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
MET4 YNL103W Leucine-zipper transcriptional activator regulation 1 1 1 chromatin immunoprecipitation-chip evidence
MSN2 YMR037C Stress-responsive transcriptional activator regulation 1 1 1 chromatin immunoprecipitation-chip evidence
SPT20 YOL148C Subunit of the SAGA transcriptional regulatory complex regulation 1 1 1 DNA to cDNA expression microarray evidence
RAP1 YNL216W Essential DNA-binding transcription regulator that binds many loci regulation 1 1 1 DNA to cDNA expression microarray evidence
SIN4 YNL236W Subunit of the RNA polymerase II mediator complex regulation 1 1 1 DNA to cDNA expression microarray evidence
MSN4 YKL062W Stress-responsive transcriptional activator regulation 1 1 1 chromatin immunoprecipitation-chip evidence
YAP5 YIR018W Basic leucine zipper (bZIP) iron-sensing transcription factor regulation 1 1 1 DNA to cDNA expression microarray evidence
CST6 YIL036W Basic leucine zipper (bZIP) transcription factor from ATF/CREB family regulation 1 1 1 DNA to cDNA expression microarray evidence
TUP1 YCR084C General repressor of transcription in complex with Cyc8p regulation 1 1 1 DNA to cDNA expression microarray evidence
INO2 YDR123C Transcription factor regulation 1 1 1 chromatin immunoprecipitation- exonuclease evidence
NOP16 YER002W Constituent of 66S pre-ribosomal particles genetic 1 1 1 Negative Genetic
LRP1 YHR081W Nuclear exosome-associated nucleic acid binding protein genetic 1 1 1 Negative Genetic
HDA1 YNL021W Catalytic subunit of class II HDA1 histone deacetylase complex genetic 1 1 1 Negative Genetic
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator physical 1 1 1 Affinity Capture-RNA
MRPL1 YDR116C Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Negative Genetic
LPD1 YFL018C Dihydrolipoamide dehydrogenase genetic 1 1 1 Negative Genetic
PDA1 YER178W E1 alpha subunit of the pyruvate dehydrogenase (PDH) complex genetic 1 1 1 Negative Genetic
PDB1 YBR221C E1 beta subunit of the pyruvate dehydrogenase (PDH) complex genetic 1 1 1 Negative Genetic
ILV1 YER086W Threonine deaminase, catalyzes first step in isoleucine biosynthesis genetic 1 1 1 Positive Genetic
HEM13 YDR044W Coproporphyrinogen III oxidase physical 1 1 1 Affinity Capture-MS
FAR11 YNL127W Protein involved in recovery from cell cycle arrest genetic 1 1 1 Negative Genetic
CDC53 YDL132W Cullin physical 1 1 1 Affinity Capture-MS
GRR1 YJR090C F-box protein component of an SCF ubiquitin-ligase complex physical 1 1 1 Affinity Capture-MS
GID7 YCL039W Subunit of GID Complex that binds directly to central component Vid30p physical 1 1 1 Affinity Capture-MS
RAD1 YPL022W Single-stranded DNA endonuclease (with Rad10p) physical 1 1 1 Affinity Capture-MS
YBL036C YBL036C Putative non-specific single-domain racemase physical 1 1 1 Affinity Capture-MS
SLT2 YHR030C Serine/threonine MAP kinase physical 1 1 1 Affinity Capture-MS
UGP1 YKL035W UDP-glucose pyrophosphorylase (UGPase) genetic 1 1 1 Negative Genetic
STR3 YGL184C Peroxisomal cystathionine beta-lyase genetic 1 1 1 Negative Genetic
POS5 YPL188W Mitochondrial NADH kinase genetic 1 1 1 Positive Genetic
SLX5 YDL013W Subunit of the Slx5-Slx8 SUMO-targeted Ub ligase (STUbL) complex genetic 1 1 1 Positive Genetic
RFT1 YBL020W Membrane protein required for translocation of Man5GlcNac2-PP-Dol genetic 1 1 1 Negative Genetic
SSC1 YJR045C Hsp70 family ATPase genetic 1 1 1 Negative Genetic
PST2 YDR032C FMN-dependent NAD(P)H:quinone oxidoreductase genetic 1 1 1 Negative Genetic
PET122 YER153C Mitochondrial translational activator specific for the COX3 mRNA genetic 1 1 1 Negative Genetic
PMR1 YGL167C High affinity Ca2+/Mn2+ P-type ATPase genetic 1 1 1 Negative Genetic
VAM7 YGL212W Vacuolar SNARE protein genetic 1 1 1 Negative Genetic
YTA7 YGR270W Chromatin-binding ATPase that regulates histone gene expression genetic 1 1 1 Negative Genetic
YOR1 YGR281W Plasma membrane ATP-binding cassette (ABC) transporter genetic 1 1 1 Negative Genetic
PIH1 YHR034C Component of the conserved R2TP complex (Rvb1-Rvb2-Tah1-Pih1) genetic 1 1 1 Negative Genetic
RPS4B YHR203C Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
SOA1 YIL166C Sulfonate and inorganic sulfur transporter genetic 1 1 1 Negative Genetic
RPL8B YLL045C Ribosomal 60S subunit protein L8A genetic 1 1 1 Negative Genetic
VPS9 YML097C Guanine nucleotide exchange factor (GEF) and ubiquitin receptor genetic 1 1 1 Negative Genetic
RPS16A YMR143W Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
SIW14 YNL032W Inositol phosphatase involved in inositol pyrophosphate metabolism genetic 1 1 1 Negative Genetic
SGT2 YOR007C Glutamine-rich cytoplasmic cochaperone genetic 1 1 1 Negative Genetic
TCB1 YOR086C Lipid-binding ER protein involved in ER-plasma membrane tethering genetic 1 1 1 Negative Genetic
YOR131C YOR131C Putative haloacid dehalogenase-like hydrolase genetic 1 1 1 Negative Genetic
SUV3 YPL029W ATP-dependent RNA helicase genetic 1 1 1 Negative Genetic
YPC1 YBR183W Alkaline ceramidase genetic 1 1 1 Positive Genetic
PBA1 YLR199C Protein involved in 20S proteasome assembly physical 1 1 1 Affinity Capture-MS
MAG2 YLR427W Cytoplasmic protein of unknown function physical 1 1 1 Affinity Capture-MS
HOM2 YDR158W Aspartic beta semi-aldehyde dehydrogenase genetic 1 1 1 Negative Genetic
CDC7 YDL017W S/T kinase and catalytic subunit of DDK (Dbf4-dependent kinase) physical 1 1 1 Affinity Capture-MS
ACO2 YJL200C Putative mitochondrial aconitase isozyme genetic 1 1 1 Negative Genetic
HPC2 YBR215W Subunit of the HIR complex genetic 1 1 1 Negative Genetic
MDM12 YOL009C Mitochondrial outer membrane protein, ERMES complex subunit genetic 1 1 1 Negative Genetic
MTH1 YDR277C Negative regulator of the glucose-sensing signal transduction pathway genetic 1 1 1 Synthetic Rescue
JEM1 YJL073W DnaJ-like chaperone required for nuclear membrane fusion during mating genetic 1 1 1 Negative Genetic
MRF1 YGL143C Mitochondrial translation release factor genetic 1 1 1 Negative Genetic
FRA1 YLL029W Protein involved in negative regulation of iron regulon transcription genetic 1 1 1 Negative Genetic
ANT1 YPR128C Peroxisomal adenine nucleotide transporter genetic 1 1 1 Negative Genetic
HTD2 YHR067W Mitochondrial 3-hydroxyacyl-thioester dehydratase genetic 1 1 1 Negative Genetic
GRE3 YHR104W Aldose reductase genetic 1 1 1 Negative Genetic
GCD14 YJL125C Subunit of tRNA (1-methyladenosine) methyltransferase genetic 1 1 1 Negative Genetic
LIP5 YOR196C Protein involved in biosynthesis of the coenzyme lipoic acid genetic 1 1 1 Negative Genetic
GSH1 YJL101C Gamma glutamylcysteine synthetase genetic 1 1 1 Negative Genetic
NHA1 YLR138W Na+/H+ antiporter genetic 1 1 1 Positive Genetic
HEM1 YDR232W 5-aminolevulinate synthase genetic 1 1 1 Negative Genetic
CAB1 YDR531W Pantothenate kinase, ATP:D-pantothenate 4'-phosphotransferase genetic 1 1 1 Negative Genetic
MRX3 YBL095W Protein that associates with mitochondrial ribosome genetic 1 1 1 Negative Genetic
CYT1 YOR065W Cytochrome c1 genetic 1 1 1 Negative Genetic
MPS3 YJL019W Nuclear envelope protein physical 1 1 1 Affinity Capture-MS
ASP3-4 YLR160C Cell-wall L-asparaginase II involved in asparagine catabolism genetic 1 1 1 Negative Genetic
ALG9 YNL219C Mannosyltransferase, involved in N-linked glycosylation genetic 1 1 1 Negative Genetic
DSE2 YHR143W Daughter cell-specific secreted protein with similarity to glucanases genetic 1 1 1 Negative Genetic
MET5 YJR137C Sulfite reductase beta subunit genetic 1 1 1 Negative Genetic
COX8 YLR395C Subunit VIII of cytochrome c oxidase (Complex IV) genetic 1 1 1 Negative Genetic
IZH2 YOL002C Plasma membrane receptor for plant antifungal osmotin genetic 1 1 1 Negative Genetic
LIP2 YLR239C Lipoyl ligase genetic 1 1 1 Negative Genetic
MPH3 YJR160C Alpha-glucoside permease genetic 1 1 1 Negative Genetic
GUP2 YPL189W Probable membrane protein genetic 1 1 1 Negative Genetic
MET22 YOL064C Bisphosphate-3'-nucleotidase genetic 1 1 1 Negative Genetic