| CDC60 |
YPL160W |
Cytosolic leucyl tRNA synthetase |
genetic |
4 |
1 |
3 |
Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
| SMM1 |
YNR015W |
Dihydrouridine synthase |
genetic |
4 |
1 |
3 |
Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
| TRM1 |
YDR120C |
tRNA methyltransferase |
genetic |
4 |
1 |
3 |
Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
| LOS1 |
YKL205W |
Nuclear pore protein |
genetic |
3 |
2 |
3 |
Negative Genetic, Synthetic Growth Defect, Negative Genetic |
| PUS4 |
YNL292W |
Pseudouridine synthase |
genetic |
3 |
1 |
3 |
Negative Genetic, Negative Genetic, Negative Genetic |
| MET22 |
YOL064C |
Bisphosphate-3'-nucleotidase |
genetic |
3 |
2 |
2 |
Synthetic Rescue, Phenotypic Suppression, Synthetic Rescue |
| NCL1 |
YBL024W |
S-adenosyl-L-methionine-dependent tRNA: m5C-methyltransferase |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
| MAF1 |
YDR005C |
Highly conserved negative regulator of RNA polymerase III |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
| TRM2 |
YKR056W |
tRNA methyltransferase |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
| TEF1 |
YPR080W |
Translational elongation factor EF-1 alpha |
genetic |
3 |
3 |
1 |
Phenotypic Suppression, Dosage Rescue, Synthetic Growth Defect |
| GCD7 |
YLR291C |
Beta subunit of translation initiation factor eIF2B |
genetic |
2 |
2 |
2 |
Negative Genetic, Dosage Rescue |
| TRM44 |
YPL030W |
tRNA(Ser) Um(44) 2'-O-methyltransferase |
genetic |
2 |
2 |
2 |
Synthetic Growth Defect, Synthetic Lethality |
| ANP1 |
YEL036C |
Subunit of the alpha-1,6 mannosyltransferase complex |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| UBP1 |
YDL122W |
Ubiquitin-specific protease |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| MRPL32 |
YCR003W |
Mitochondrial ribosomal protein of the large subunit |
genetic |
2 |
2 |
1 |
Positive Genetic, Negative Genetic |
| TEF2 |
YBR118W |
Translational elongation factor EF-1 alpha |
genetic |
2 |
2 |
1 |
Dosage Rescue, Phenotypic Suppression |
| SSB1 |
YDL229W |
Cytoplasmic ATPase that is a ribosome-associated molecular chaperone |
physical |
2 |
1 |
1 |
Affinity Capture-MS, Affinity Capture-MS |
| SFP1 |
YLR403W |
Regulates transcription of ribosomal protein and biogenesis genes |
regulation |
1 |
1 |
1 |
DNA to cDNA expression microarray evidence |
| XBP1 |
YIL101C |
Transcriptional repressor |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
| YAP6 |
YDR259C |
Basic leucine zipper (bZIP) transcription factor |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
| CDC73 |
YLR418C |
Component of the Paf1p complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ARP4 |
YJL081C |
Nuclear actin-related protein involved in chromatin remodeling |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SMX3 |
YPR182W |
Core Sm protein Sm F |
genetic |
1 |
1 |
1 |
Positive Genetic |
| PUS7 |
YOR243C |
Pseudouridine synthase |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| RAT1 |
YOR048C |
Nuclear 5' to 3' single-stranded RNA exonuclease |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
| NPL3 |
YDR432W |
RNA-binding protein |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
| RRP6 |
YOR001W |
Nuclear exosome exonuclease component |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
| RPC25 |
YKL144C |
RNA polymerase III subunit C25 |
genetic |
1 |
1 |
1 |
Positive Genetic |
| SIN4 |
YNL236W |
Subunit of the RNA polymerase II mediator complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| GCD1 |
YOR260W |
Gamma subunit of the translation initiation factor eIF2B |
genetic |
1 |
1 |
1 |
Dosage Rescue |
| KAP95 |
YLR347C |
Karyopherin beta |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| SRP1 |
YNL189W |
Karyopherin alpha homolog |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| NAB2 |
YGL122C |
Nuclear polyadenylated RNA-binding protein |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
| PUS1 |
YPL212C |
tRNA:pseudouridine synthase |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| GCN2 |
YDR283C |
Protein kinase |
genetic |
1 |
1 |
1 |
Dosage Rescue |
| DPB4 |
YDR121W |
Subunit of DNA pol epsilon and of ISW2 chromatin accessibility complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| HTZ1 |
YOL012C |
Histone variant H2AZ |
genetic |
1 |
1 |
1 |
Positive Genetic |
| GIM5 |
YML094W |
Subunit of the heterohexameric cochaperone prefoldin complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| PRE9 |
YGR135W |
Alpha 3 subunit of the 20S proteasome |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ILV1 |
YER086W |
Threonine deaminase, catalyzes first step in isoleucine biosynthesis |
genetic |
1 |
1 |
1 |
Negative Genetic |
| DEP1 |
YAL013W |
Component of the Rpd3L histone deacetylase complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| TAF1 |
YGR274C |
TFIID subunit, involved in RNA pol II transcription initiation |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| ATG9 |
YDL149W |
Transmembrane protein involved in forming Cvt and autophagic vesicles |
genetic |
1 |
1 |
1 |
Negative Genetic |
| IRA2 |
YOL081W |
GTPase-activating protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RVS161 |
YCR009C |
Amphiphysin-like lipid raft protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| PBR1 |
YNL181W |
Putative oxidoreductase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| HIR2 |
YOR038C |
Subunit of HIR nucleosome assembly complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
| BUD7 |
YOR299W |
Member of the ChAPs family (Chs5p-Arf1p-binding proteins) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| PAP2 |
YOL115W |
Non-canonical poly(A) polymerase |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
| DBF2 |
YGR092W |
Ser/Thr kinase involved in transcription and stress response |
physical |
1 |
1 |
1 |
Proximity Label-MS |
| MGT1 |
YDL200C |
DNA repair methyltransferase (6-O-methylguanine-DNA methylase) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| BIR1 |
YJR089W |
Subunit of chromosomal passenger complex (CPC) |
genetic |
1 |
1 |
1 |
Positive Genetic |
| PKH1 |
YDR490C |
Serine/threonine protein kinase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| IPK1 |
YDR315C |
Inositol 1,3,4,5,6-pentakisphosphate 2-kinase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RAD4 |
YER162C |
Damaged-DNA binding subunit of Nuclear Excision Repair Factor 2 |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MDY2 |
YOL111C |
Protein involved in inserting tail-anchored proteins into ER membranes |
genetic |
1 |
1 |
1 |
Negative Genetic |
| PEX2 |
YJL210W |
RING-finger peroxin and E3 ubiquitin ligase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| HPC2 |
YBR215W |
Subunit of the HIR complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| BFR1 |
YOR198C |
Component of mRNP complexes associated with polyribosomes |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
| RPA14 |
YDR156W |
RNA polymerase I subunit A14 |
genetic |
1 |
1 |
1 |
Positive Genetic |
| HAP4 |
YKL109W |
Transcription factor |
genetic |
1 |
1 |
1 |
Negative Genetic |
| NUP170 |
YBL079W |
Subunit of inner ring of nuclear pore complex (NPC) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| GAL10 |
YBR019C |
UDP-glucose-4-epimerase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MPT5 |
YGL178W |
mRNA-binding protein of the PUF family |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
| ORC5 |
YNL261W |
Subunit of the origin recognition complex (ORC) |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
| SHE9 |
YDR393W |
Protein required for normal mitochondrial morphology |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MBA1 |
YBR185C |
Membrane-associated mitochondrial ribosome receptor |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SOK1 |
YDR006C |
Protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SLF1 |
YDR515W |
RNA binding protein that associates with polysomes |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
| MTC1 |
YJL123C |
Protein of unknown function that may interact with ribosomes |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RAD27 |
YKL113C |
5' to 3' exonuclease, 5' flap endonuclease |
genetic |
1 |
1 |
1 |
Negative Genetic |
| AQY3 |
YFL054C |
Putative channel-like protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| BIL1 |
YOR304C-A |
Protein that binds Bud6p and has a role in actin cable assembly |
genetic |
1 |
1 |
1 |
Positive Genetic |
| MRPL22 |
YNL177C |
Mitochondrial ribosomal protein of the large subunit |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| GIS2 |
YNL255C |
Translational activator for mRNAs with internal ribosome entry sites |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| RPL6B |
YLR448W |
Ribosomal 60S subunit protein L6B |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RPL36A |
YMR194W |
Ribosomal 60S subunit protein L36A |
genetic |
1 |
1 |
1 |
Negative Genetic |
| APJ1 |
YNL077W |
Hsp40 chaperone with a role in SUMO-mediated protein degradation |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| CMR3 |
YPR013C |
Putative zinc finger protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SOK2 |
YMR016C |
Nuclear protein that negatively regulates pseudohyphal differentiation |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SPO16 |
YHR153C |
Meiosis-specific protein involved in synaptonemal complex assembly |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| COS7 |
YDL248W |
Endosomal protein involved in turnover of plasma membrane proteins |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SRP102 |
YKL154W |
Signal recognition particle (SRP) receptor beta subunit |
genetic |
1 |
1 |
1 |
Positive Genetic |
| RPL41A |
YDL184C |
Ribosomal 60S subunit protein L41A |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ICE2 |
YIL090W |
Integral ER membrane protein with type-III transmembrane domains |
genetic |
1 |
1 |
1 |
Negative Genetic |
| PCP1 |
YGR101W |
Mitochondrial serine protease |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ZIP2 |
YGL249W |
Meiosis-specific protein |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| TTI1 |
YKL033W |
Subunit of the ASTRA complex, involved in chromatin remodeling |
genetic |
1 |
1 |
1 |
Positive Genetic |
| THS1 |
YIL078W |
Threonyl-tRNA synthetase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| TPT1 |
YOL102C |
tRNA 2'-phosphotransferase that catalyzes final step in tRNA splicing |
genetic |
1 |
1 |
1 |
Negative Genetic |
| UTP5 |
YDR398W |
Subunit of U3-containing Small Subunit (SSU) processome complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| UTP15 |
YMR093W |
Nucleolar protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| TYR1 |
YBR166C |
Prephenate dehydrogenase involved in tyrosine biosynthesis |
genetic |
1 |
1 |
1 |
Negative Genetic |
| THI4 |
YGR144W |
Thiazole synthase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| YJR084W |
YJR084W |
Protein that forms a complex with Thp3p |
genetic |
1 |
1 |
1 |
Negative Genetic |
| TRK2 |
YKR050W |
Component of the Trk1p-Trk2p potassium transport system |
genetic |
1 |
1 |
1 |
Negative Genetic |
| TMA23 |
YMR269W |
Nucleolar protein implicated in ribosome biogenesis |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ULS1 |
YOR191W |
Swi2/Snf2-related translocase, SUMO-Targeted Ubiquitin Ligase (STUbL) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RKM3 |
YBR030W |
Ribosomal lysine methyltransferase |
genetic |
1 |
1 |
1 |
Negative Genetic |