Standard name Systematic name Name description Description
TSL1 YML100W Large subunit of trehalose 6-phosphate synthase/phosphatase complex Large subunit of trehalose 6-phosphate synthase/phosphatase complex; Tps1p-Tps2p complex converts uridine-5'-diphosphoglucose and glucose 6-phosphate to trehalose; contributes to survival to acute lethal heat stress; mutant has aneuploidy tolerance; protein abundance increases in response to DNA replication stress; TSL1 has a paralog, TPS3, that arose from the whole genome duplication
Visualize the interactome of TSL1
Links to external databases:
  SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)
M 160

CYCLoPs localization & abundance

WT1 WT2 WT3
Cell Periphery 0.060 NaN NaN
Cytoplasm 0.985 0.955 0.969

GFP localization & abundance

GFP localization GFP abundance
cytoplasm 1960

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
TSL1 1 0 0 0 0

Enzyme information

Catalyzed reactions in Yeast8
r_0195 (alpha,alpha-trehalose-phosphate synthase (UDP-forming)), r_1051 (trehalose-phosphatase)

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
TPS1 YBR126C Synthase subunit of trehalose-6-P synthase/phosphatase complex physical 6 2 5 Affinity Capture-MS, Two-hybrid, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Two-hybrid
TPS2 YDR074W Phosphatase subunit of the trehalose-6-P synthase/phosphatase complex physical 4 2 3 Two-hybrid, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS
TPS3 YMR261C Regulatory subunit of trehalose-6-phosphate synthase/phosphatase genetic 3 3 3 Phenotypic Enhancement, Synthetic Growth Defect, Synthetic Lethality
FKH1 YIL131C Forkhead family transcription factor regulation 3 2 3 chromatin immunoprecipitation-chip evidence, chromatin immunoprecipitation-chip evidence, ChEC-Seq experiments
FKH2 YNL068C Forkhead family transcription factor regulation 2 2 2 chromatin immunoprecipitation-chip evidence, ChEC-Seq experiments
MSN2 YMR037C Stress-responsive transcriptional activator regulation 2 2 2 chromatin immunoprecipitation-chip evidence, RNA-sequencing evidence
MSN4 YKL062W Stress-responsive transcriptional activator regulation 2 2 2 chromatin immunoprecipitation-chip evidence, RNA-sequencing evidence
SWI4 YER111C DNA binding component of the SBF complex (Swi4p-Swi6p) regulation 2 2 2 chromatin immunoprecipitation-chip evidence, DNA to cDNA expression microarray evidence
UME6 YDR207C Rpd3L histone deacetylase complex subunit regulation 2 2 2 chromatin immunoprecipitation-chip evidence, DNA to cDNA expression microarray evidence
RPD3 YNL330C Histone deacetylase, component of both the Rpd3S and Rpd3L complexes regulation 2 2 2 chromatin immunoprecipitation-chip evidence, DNA to cDNA expression microarray evidence
RPN11 YFR004W Metalloprotease subunit of 19S regulatory particle physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator physical 2 1 2 Affinity Capture-RNA, Affinity Capture-RNA
MDL1 YLR188W Mitochondrial inner membrane half-type ABC transporter genetic 2 1 2 Negative Genetic, Negative Genetic
PMT6 YGR199W Protein O-mannosyltransferase genetic 2 1 2 Negative Genetic, Negative Genetic
SPS2 YDR522C Protein expressed during sporulation genetic 2 1 2 Negative Genetic, Negative Genetic
TPS2 YDR074W Phosphatase subunit of the trehalose-6-P synthase/phosphatase complex genetic 2 1 1 Positive Genetic, Positive Genetic
STE12 YHR084W Transcription factor that is activated by a MAPK signaling cascade regulation 1 1 1 DNA to cDNA expression microarray evidence
GCN5 YGR252W Catalytic subunit of ADA and SAGA histone acetyltransferase complexes regulation 1 1 1 chromatin immunoprecipitation-chip evidence
IXR1 YKL032C Transcriptional repressor that regulates hypoxic genes during normoxia regulation 1 1 1 DNA to cDNA expression microarray evidence
TEC1 YBR083W Transcription factor targeting filamentation genes and Ty1 expression regulation 1 1 1 DNA to cDNA expression microarray evidence
ACE2 YLR131C Transcription factor required for septum destruction after cytokinesis regulation 1 1 1 chromatin immunoprecipitation-chip evidence
CBF1 YJR060W Basic helix-loop-helix (bHLH) protein regulation 1 1 1 DNA to cDNA expression microarray evidence
MED2 YDL005C Subunit of the RNA polymerase II mediator complex regulation 1 1 1 chromatin immunoprecipitation-chip evidence
MET32 YDR253C Zinc-finger DNA-binding transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
MET4 YNL103W Leucine-zipper transcriptional activator regulation 1 1 1 chromatin immunoprecipitation-chip evidence
RGR1 YLR071C Subunit of the RNA polymerase II mediator complex regulation 1 1 1 chromatin immunoprecipitation-chip evidence
BUR6 YER159C Subunit of a heterodimeric NC2 transcription regulator complex regulation 1 1 1 chromatin immunoprecipitation-chip evidence
YAP6 YDR259C Basic leucine zipper (bZIP) transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
MSN1 YOL116W Transcriptional activator regulation 1 1 1 DNA to cDNA expression microarray evidence
HSF1 YGL073W Trimeric heat shock transcription factor regulation 1 1 1 DNA to cDNA expression microarray evidence
REB1 YBR049C RNA polymerase I enhancer binding protein regulation 1 1 1 chromatin immunoprecipitation-chip evidence
CDC28 YBR160W Cyclin-dependent kinase (CDK) catalytic subunit regulation 1 1 1 quantitative mass spectrometry evidence
CYC8 YBR112C General transcriptional co-repressor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
SUA7 YPR086W Transcription factor TFIIB regulation 1 1 1 chromatin immunoprecipitation-chip evidence
ZAP1 YJL056C Zinc-regulated transcription factor regulation 1 1 1 DNA to cDNA expression microarray evidence
SPT3 YDR392W Subunit of the SAGA and SAGA-like transcriptional regulatory complexes regulation 1 1 1 chromatin immunoprecipitation-chip evidence
SKN7 YHR206W Nuclear response regulator and transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
CIN5 YOR028C Basic leucine zipper (bZIP) transcription factor of the yAP-1 family regulation 1 1 1 DNA to cDNA expression microarray evidence
SPT6 YGR116W Nucleosome remodeling protein regulation 1 1 1 chromatin immunoprecipitation-chip evidence
CST6 YIL036W Basic leucine zipper (bZIP) transcription factor from ATF/CREB family regulation 1 1 1 DNA to cDNA expression microarray evidence
TUP1 YCR084C General repressor of transcription in complex with Cyc8p regulation 1 1 1 chromatin immunoprecipitation-chip evidence
SPT2 YER161C Protein involved in negative regulation of transcription regulation 1 1 1 DNA to cDNA expression microarray evidence
NCB2 YDR397C Subunit of a heterodimeric NC2 transcription regulator complex regulation 1 1 1 chromatin immunoprecipitation-chip evidence
SSN2 YDR443C Subunit of the RNA polymerase II mediator complex regulation 1 1 1 DNA to cDNA expression microarray evidence
ARG80 YMR042W Transcription factor involved in regulating arginine-responsive genes regulation 1 1 1 DNA to cDNA expression microarray evidence
GAT3 YLR013W Protein containing GATA family zinc finger motifs regulation 1 1 1 DNA to cDNA expression microarray evidence
MAC1 YMR021C Copper-sensing transcription factor regulation 1 1 1 DNA to cDNA expression microarray evidence
RGM1 YMR182C Putative zinc finger DNA binding transcription factor regulation 1 1 1 DNA to cDNA expression microarray evidence
WTM2 YOR229W Transcriptional modulator regulation 1 1 1 DNA to cDNA expression microarray evidence
ASH1 YKL185W Component of the Rpd3L histone deacetylase complex regulation 1 1 1 DNA to cDNA expression microarray evidence
SWI6 YLR182W Transcription cofactor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
AFT1 YGL071W Transcription factor involved in iron utilization and homeostasis regulation 1 1 1 DNA to cDNA expression microarray evidence
HMS1 YOR032C bHLH protein with similarity to myc-family transcription factors regulation 1 1 1 DNA to cDNA expression microarray evidence
SPN1 YPR133C Protein involved in RNA polymerase II transcription regulation 1 1 1 chromatin immunoprecipitation-chip evidence
YHP1 YDR451C Homeobox transcriptional repressor regulation 1 1 1 DNA to cDNA expression microarray evidence
SSN3 YPL042C Component of the RNA polymerase II mediator complex regulation 1 1 1 DNA to cDNA expression microarray evidence
CAT8 YMR280C Zinc cluster transcriptional activator regulation 1 1 1 DNA to cDNA expression microarray evidence
CUP2 YGL166W Copper-binding transcription factor regulation 1 1 1 DNA to cDNA expression microarray evidence
FLO8 YER109C Transcription factor regulation 1 1 1 DNA to cDNA expression microarray evidence
HAA1 YPR008W Transcriptional activator involved in adaptation to weak acid stress regulation 1 1 1 DNA to cDNA expression microarray evidence
SRB8 YCR081W Subunit of the RNA polymerase II mediator complex regulation 1 1 1 DNA to cDNA expression microarray evidence
MBF1 YOR298C-A Transcriptional coactivator regulation 1 1 1 DNA to cDNA expression microarray evidence
GAL4 YPL248C DNA-binding transcription factor required for activating GAL genes regulation 1 1 1 DNA to cDNA expression microarray evidence
PIP2 YOR363C Autoregulatory, oleate-activated transcription factor regulation 1 1 1 DNA to cDNA expression microarray evidence
NOC2 YOR206W Protein involved in ribosome biogenesis physical 1 1 1 Affinity Capture-MS
HAP5 YOR358W Subunit of the Hap2p/3p/4p/5p CCAAT-binding complex genetic 1 1 1 Negative Genetic
RSC6 YCR052W Component of the RSC chromatin remodeling complex genetic 1 1 1 Positive Genetic
RPN1 YHR027C Non-ATPase base subunit of the 19S RP of the 26S proteasome physical 1 1 1 Affinity Capture-MS
RPT2 YDL007W ATPase of the 19S regulatory particle of the 26S proteasome genetic 1 1 1 Negative Genetic
CCR4 YAL021C Component of the CCR4-NOT transcriptional complex physical 1 1 1 Affinity Capture-RNA
APL3 YBL037W Alpha-adaptin genetic 1 1 1 Negative Genetic
CDC55 YGL190C Regulatory subunit B of protein phosphatase 2A (PP2A) genetic 1 1 1 Positive Genetic
ISW1 YBR245C ATPase subunit of imitation-switch (ISWI) class chromatin remodelers physical 1 1 1 Affinity Capture-RNA
HSP42 YDR171W Small heat shock protein (sHSP) with chaperone activity physical 1 1 1 Biochemical Activity
PFK1 YGR240C Alpha subunit of heterooctameric phosphofructokinase genetic 1 1 1 Negative Genetic
HSP82 YPL240C Hsp90 chaperone physical 1 1 1 Affinity Capture-MS
BLM10 YFL007W Proteasome activator genetic 1 1 1 Negative Genetic
PTC1 YDL006W Type 2C protein phosphatase (PP2C) physical 1 1 1 Affinity Capture-MS
SBP1 YHL034C Protein that binds eIF4G and has a role in repression of translation physical 1 1 1 Affinity Capture-MS
TPS1 YBR126C Synthase subunit of trehalose-6-P synthase/phosphatase complex genetic 1 1 1 Synthetic Lethality
PUF3 YLL013C Protein of the mitochondrial outer surface physical 1 1 1 Affinity Capture-RNA
RIM15 YFL033C Protein kinase involved in cell proliferation in response to nutrients genetic 1 1 1 Phenotypic Suppression
POR1 YNL055C Mitochondrial porin (voltage-dependent anion channel) genetic 1 1 1 Negative Genetic
OYE3 YPL171C Conserved NADPH oxidoreductase containing flavin mononucleotide (FMN) genetic 1 1 1 Negative Genetic
HSP104 YLL026W Disaggregase physical 1 1 1 Affinity Capture-MS
AXL1 YPR122W Haploid specific endoprotease of a-factor mating pheromone genetic 1 1 1 Negative Genetic
SGS1 YMR190C RecQ family nucleolar DNA helicase genetic 1 1 1 Negative Genetic
UFD2 YDL190C Ubiquitin (Ub) chain assembly factor (E4) physical 1 1 1 Affinity Capture-MS
TSL1 YML100W Large subunit of trehalose 6-phosphate synthase/phosphatase complex physical 1 1 1 Two-hybrid
UBC9 YDL064W SUMO-conjugating enzyme involved in the Smt3p conjugation pathway physical 1 1 1 Affinity Capture-MS
YHC1 YLR298C Component of the U1 snRNP complex required for pre-mRNA splicing genetic 1 1 1 Positive Genetic
YEA4 YEL004W Uridine diphosphate-N-acetylglucosamine (UDP-GlcNAc) transporter genetic 1 1 1 Negative Genetic
YHR050W-A YHR050W-A Protein of unknown function genetic 1 1 1 Negative Genetic
YNK1 YKL067W Nucleoside diphosphate kinase genetic 1 1 1 Negative Genetic
YAK1 YJL141C Serine-threonine protein kinase genetic 1 1 1 Phenotypic Suppression
MET6 YER091C Cobalamin-independent methionine synthase genetic 1 1 1 Negative Genetic
PTC7 YHR076W Type 2C serine/threonine protein phosphatase (PP2C) physical 1 1 1 Affinity Capture-MS
LAS1 YKR063C Endonuclease involved in pre-rRNA processing at both ends of ITS2 physical 1 1 1 Affinity Capture-MS
HOG1 YLR113W Mitogen-activated protein kinase involved in osmoregulation physical 1 1 1 Co-localization
MMS4 YBR098W Subunit of structure-specific Mms4p-Mus81p endonuclease genetic 1 1 1 Negative Genetic
RIM11 YMR139W Protein kinase physical 1 1 1 Affinity Capture-MS
CAK1 YFL029C Cyclin-dependent kinase-activating kinase genetic 1 1 1 Positive Genetic
NST1 YNL091W Translational inhibitor and suppressor of proteasome-assembly defects genetic 1 1 1 Negative Genetic
IOC4 YMR044W Member of a complex (Isw1b) with Isw1p and Ioc2p genetic 1 1 1 Negative Genetic
SAS4 YDR181C Subunit of the SAS complex (Sas2p, Sas4p, Sas5p) genetic 1 1 1 Negative Genetic
SIZ1 YDR409W SUMO E3 ligase physical 1 1 1 Affinity Capture-MS
CSG2 YBR036C Endoplasmic reticulum membrane protein genetic 1 1 1 Negative Genetic
BPT1 YLL015W ABC type transmembrane transporter of MRP/CFTR family genetic 1 1 1 Negative Genetic
RPL1B YGL135W Ribosomal 60S subunit protein L1B genetic 1 1 1 Negative Genetic
SSB1 YDL229W Cytoplasmic ATPase that is a ribosome-associated molecular chaperone physical 1 1 1 Affinity Capture-MS
RPL28 YGL103W Ribosomal 60S subunit protein L28 genetic 1 1 1 Negative Genetic
MOG1 YJR074W Conserved nuclear protein that interacts with GTP-Gsp1p physical 1 1 1 Affinity Capture-MS
RPL19B YBL027W Ribosomal 60S subunit protein L19B genetic 1 1 1 Negative Genetic
AUS1 YOR011W Plasma membrane sterol transporter of the ATP-binding cassette family genetic 1 1 1 Positive Genetic
COQ9 YLR201C Protein required for ubiquinone biosynthesis and respiratory growth physical 1 1 1 Affinity Capture-MS
ERG2 YMR202W C-8 sterol isomerase genetic 1 1 1 Positive Genetic
HRQ1 YDR291W 3'-5' DNA helicase of the conserved RecQ family genetic 1 1 1 Negative Genetic
NDE2 YDL085W Mitochondrial external NADH dehydrogenase genetic 1 1 1 Negative Genetic
TPS3 YMR261C Regulatory subunit of trehalose-6-phosphate synthase/phosphatase physical 1 1 1 Affinity Capture-MS
FAS1 YKL182W Beta subunit of fatty acid synthetase physical 1 1 1 Affinity Capture-MS
SDD3 YOL098C Putative metalloprotease genetic 1 1 1 Negative Genetic
RPL8B YLL045C Ribosomal 60S subunit protein L8A genetic 1 1 1 Negative Genetic
SLM3 YDL033C tRNA-specific 2-thiouridylase genetic 1 1 1 Negative Genetic
MRX18 YBR056W Putative glycoside hydrolase of the mitochondrial intermembrane space genetic 1 1 1 Negative Genetic
ILM1 YJR118C Protein of unknown function genetic 1 1 1 Negative Genetic
SIC1 YLR079W Cyclin-dependent kinase inhibitor (CKI) genetic 1 1 1 Negative Genetic
COX9 YDL067C Subunit VIIa of cytochrome c oxidase (Complex IV) genetic 1 1 1 Negative Genetic
POS5 YPL188W Mitochondrial NADH kinase genetic 1 1 1 Positive Genetic
APA2 YDR530C Diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase II genetic 1 1 1 Negative Genetic
DPC25 YPL107W Putative mitochondrial protein of unknown function genetic 1 1 1 Negative Genetic
IRC20 YLR247C E3 ubiquitin ligase and putative helicase physical 1 1 1 Affinity Capture-MS
AGP1 YCL025C Broad-specificity, low-affinity amino acid permease genetic 1 1 1 Negative Genetic
MRX20 YFR045W Putative mitochondrial transport protein genetic 1 1 1 Negative Genetic
KCH1 YJR054W Potassium transporter that mediates K+ influx genetic 1 1 1 Positive Genetic