Standard name Systematic name Name description Description
PIN3 YPR154W Negative regulator of actin nucleation-promoting factor activity Negative regulator of actin nucleation-promoting factor activity; interacts with Las17p, a homolog of human Wiskott-Aldrich Syndrome protein (WASP), via an N-terminal SH3 domain, and along with LSB1 cooperatively inhibits the nucleation of actin filaments; short-lived protein whose levels increase in response to thermal stress; induces the formation of the [PIN+] and [RNQ+] prions when overproduced; PIN3 has a paralog, LSB1, that arose from the whole genome duplication
Visualize the interactome of PIN3
Links to external databases:
  SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)

CYCLoPs localization & abundance

WT1 WT2 WT3
Cytoplasm 0.953 0.976 0.969

GFP localization & abundance

GFP localization GFP abundance
cytoplasm, nucleus 2190

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
PIN3 0 0 0 0 0

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
LAS17 YOR181W Actin assembly factor physical 9 5 6 Two-hybrid, Affinity Capture-Western, Protein-peptide, Two-hybrid, Two-hybrid, Two-hybrid, Affinity Capture-Luminescence, Affinity Capture-Western, PCA
LSB1 YGR136W Negative regulator of actin nucleation-promoting factor activity physical 5 3 2 Affinity Capture-Western, Affinity Capture-Western, Two-hybrid, Affinity Capture-Western, Co-localization
UBI4 YLL039C Ubiquitin physical 4 3 2 Two-hybrid, Affinity Capture-Western, Two-hybrid, Reconstituted Complex
MCA1 YOR197W Ca2+-dependent cysteine protease physical 3 2 3 Two-hybrid, Two-hybrid, Affinity Capture-MS
SUP35 YDR172W Translation termination factor eRF3 physical 3 2 2 Two-hybrid, Two-hybrid, Co-localization
RSP5 YER125W NEDD4 family E3 ubiquitin ligase physical 2 2 2 Reconstituted Complex, Affinity Capture-MS
APP1 YNL094W Phosphatidate phosphatase, converts phosphatidate to diacylglycerol physical 2 1 2 Two-hybrid, Two-hybrid
GYP5 YPL249C GTPase-activating protein (GAP) for yeast Rab family members physical 2 1 2 Two-hybrid, Two-hybrid
GYL1 YMR192W Putative GTPase activating protein (GAP) with a role in exocytosis physical 2 1 2 Two-hybrid, Two-hybrid
YIL108W YIL108W Putative metalloendopeptidase physical 2 1 2 Two-hybrid, Two-hybrid
NOP6 YDL213C rRNA-binding protein required for 40S ribosomal subunit biogenesis genetic 2 1 1 Negative Genetic, Negative Genetic
FKH1 YIL131C Forkhead family transcription factor regulation 1 1 1 ChEC-Seq experiments
GCN5 YGR252W Catalytic subunit of ADA and SAGA histone acetyltransferase complexes regulation 1 1 1 chromatin immunoprecipitation-chip evidence
FKH2 YNL068C Forkhead family transcription factor regulation 1 1 1 ChEC-Seq experiments
MED2 YDL005C Subunit of the RNA polymerase II mediator complex regulation 1 1 1 chromatin immunoprecipitation-chip evidence
RGR1 YLR071C Subunit of the RNA polymerase II mediator complex regulation 1 1 1 chromatin immunoprecipitation-chip evidence
XBP1 YIL101C Transcriptional repressor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
BUR6 YER159C Subunit of a heterodimeric NC2 transcription regulator complex regulation 1 1 1 chromatin immunoprecipitation-chip evidence
YAP6 YDR259C Basic leucine zipper (bZIP) transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
SUA7 YPR086W Transcription factor TFIIB regulation 1 1 1 chromatin immunoprecipitation-chip evidence
SPT3 YDR392W Subunit of the SAGA and SAGA-like transcriptional regulatory complexes regulation 1 1 1 chromatin immunoprecipitation-chip evidence
SPT7 YBR081C Subunit of the SAGA transcriptional regulatory complex regulation 1 1 1 chromatin immunoprecipitation-chip evidence
SPT6 YGR116W Nucleosome remodeling protein regulation 1 1 1 chromatin immunoprecipitation-chip evidence
UGA3 YDL170W Transcriptional activator for GABA-dependent induction of GABA genes regulation 1 1 1 chromatin immunoprecipitation-chip evidence
INO4 YOL108C Transcription factor involved in phospholipid synthesis regulation 1 1 1 chromatin immunoprecipitation-chip evidence
CBF5 YLR175W Pseudouridine synthase catalytic subunit of box H/ACA snoRNPs genetic 1 1 1 Positive Genetic
MMP1 YLL061W High-affinity S-methylmethionine permease genetic 1 1 1 Negative Genetic
DBP3 YGL078C RNA-Dependent ATPase, member of DExD/H-box family genetic 1 1 1 Negative Genetic
ACT1 YFL039C Actin, structural protein in cytoskeleton physical 1 1 1 Co-localization
NAB2 YGL122C Nuclear polyadenylated RNA-binding protein physical 1 1 1 Affinity Capture-RNA
ARC15 YIL062C Subunit of the ARP2/3 complex physical 1 1 1 PCA
ARC18 YLR370C Subunit of the ARP2/3 complex physical 1 1 1 PCA
CDC55 YGL190C Regulatory subunit B of protein phosphatase 2A (PP2A) physical 1 1 1 Two-hybrid
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator physical 1 1 1 Affinity Capture-RNA
ISW2 YOR304W ATP-dependent DNA translocase involved in chromatin remodeling genetic 1 1 1 Negative Genetic
MRD1 YPR112C Essential conserved small ribosomal subunit (40s) synthesis factor physical 1 1 1 Two-hybrid
MCM6 YGL201C Protein involved in DNA replication physical 1 1 1 Two-hybrid
MYO4 YAL029C Type V myosin motor involved in actin-based transport of cargos genetic 1 1 1 Negative Genetic
NAM8 YHR086W RNA binding protein, component of the U1 snRNP protein genetic 1 1 1 Negative Genetic
GIM3 YNL153C Subunit of the heterohexameric cochaperone prefoldin complex genetic 1 1 1 Negative Genetic
INO4 YOL108C Transcription factor involved in phospholipid synthesis genetic 1 1 1 Negative Genetic
MDS3 YGL197W Putative component of the TOR regulatory pathway genetic 1 1 1 Negative Genetic
ADE57 YGL234W Bifunctional enzyme of 'de novo' purine nucleotide pathway physical 1 1 1 Two-hybrid
BSP1 YPR171W Adapter that links synaptojanins to the cortical actin cytoskeleton physical 1 1 1 Two-hybrid
HEK2 YBL032W RNA binding protein involved in asymmetric localization of ASH1 mRNA physical 1 1 1 Affinity Capture-RNA
FES1 YBR101C Hsp70 (Ssa1p) nucleotide exchange factor physical 1 1 1 Two-hybrid
LSB1 YGR136W Negative regulator of actin nucleation-promoting factor activity genetic 1 1 1 Phenotypic Enhancement
DNL4 YOR005C DNA ligase required for nonhomologous end-joining (NHEJ) genetic 1 1 1 Negative Genetic
GPG1 YGL121C Proposed gamma subunit of the heterotrimeric G protein genetic 1 1 1 Negative Genetic
MNN9 YPL050C Subunit of Golgi mannosyltransferase complex physical 1 1 1 Two-hybrid
FZO1 YBR179C Mitofusin, protein involved in mitochondrial outer membrane fusion genetic 1 1 1 Negative Genetic
HMG2 YLR450W HMG-CoA reductase physical 1 1 1 Two-hybrid
NUP133 YKR082W Subunit of Nup84p subcomplex of nuclear pore complex (NPC) genetic 1 1 1 Negative Genetic
CTK3 YML112W Gamma subunit of C-terminal domain kinase I genetic 1 1 1 Negative Genetic
IME2 YJL106W Serine/threonine protein kinase involved in activation of meiosis genetic 1 1 1 Negative Genetic
MSN5 YDR335W Karyopherin genetic 1 1 1 Negative Genetic
AIM3 YBR108W Protein that inhibits barbed-end actin filament elongation physical 1 1 1 Two-hybrid
AIM4 YBR194W Protein proposed to be associated with the nuclear pore complex genetic 1 1 1 Negative Genetic
ARP6 YLR085C Actin-related protein that binds nucleosomes genetic 1 1 1 Positive Genetic
HOS3 YPL116W Trichostatin A-insensitive homodimeric histone deacetylase (HDAC) genetic 1 1 1 Negative Genetic
ATS1 YAL020C Protein required for modification of wobble nucleosides in tRNA genetic 1 1 1 Negative Genetic
MET31 YPL038W Zinc-finger DNA-binding transcription factor physical 1 1 1 Two-hybrid
PEX25 YPL112C Peripheral peroxisomal membrane peroxin physical 1 1 1 Two-hybrid
GPR1 YDL035C Plasma membrane G protein coupled receptor (GPCR) genetic 1 1 1 Negative Genetic
ACF2 YLR144C Intracellular beta-1,3-endoglucanase physical 1 1 1 Two-hybrid
CPR7 YJR032W Peptidyl-prolyl cis-trans isomerase (cyclophilin) genetic 1 1 1 Negative Genetic
KAP120 YPL125W Karyopherin responsible for the nuclear import of Rpf1p genetic 1 1 1 Negative Genetic
ENT1 YDL161W Epsin-like protein involved in endocytosis and actin patch assembly genetic 1 1 1 Negative Genetic
PKC1 YBL105C Protein serine/threonine kinase physical 1 1 1 Two-hybrid
UFD1 YGR048W Substrate-recruiting cofactor of the Cdc48p-Npl4p-Ufd1p segregase physical 1 1 1 Two-hybrid
RPL3 YOR063W Ribosomal 60S subunit protein L3 physical 1 1 1 Two-hybrid
PRE6 YOL038W Alpha 4 subunit of the 20S proteasome physical 1 1 1 Two-hybrid
PIN3 YPR154W Negative regulator of actin nucleation-promoting factor activity physical 1 1 1 Reconstituted Complex
PSP1 YDR505C Asn and gln rich protein of unknown function physical 1 1 1 Two-hybrid
ULS1 YOR191W Swi2/Snf2-related translocase, SUMO-Targeted Ubiquitin Ligase (STUbL) physical 1 1 1 Two-hybrid
RRP7 YCL031C Essential protein involved in rRNA processing and ribosome biogenesis physical 1 1 1 Two-hybrid
SCM3 YDL139C Nonhistone component of centromeric chromatin physical 1 1 1 Two-hybrid
SWC4 YGR002C Component of the Swr1p complex that incorporates Htz1p into chromatin physical 1 1 1 Two-hybrid
THI21 YPL258C Hydroxymethylpyrimidine (HMP) and HMP-phosphate kinase physical 1 1 1 Two-hybrid
UBP7 YIL156W Ubiquitin-specific protease that cleaves ubiquitin-protein fusions physical 1 1 1 Two-hybrid
VAS1 YGR094W Mitochondrial and cytoplasmic valyl-tRNA synthetase physical 1 1 1 Two-hybrid
VTC4 YJL012C Vacuolar membrane polyphosphate polymerase physical 1 1 1 Two-hybrid
YAL063C-A YAL063C-A Putative protein of unknown function physical 1 1 1 Two-hybrid
YDL159W-A YDL159W-A Putative protein of unknown function physical 1 1 1 Two-hybrid
ZAP1 YJL056C Zinc-regulated transcription factor physical 1 1 1 Two-hybrid
SUP35 YDR172W Translation termination factor eRF3 genetic 1 1 1 Phenotypic Enhancement
PUF2 YPR042C PUF family mRNA-binding protein physical 1 1 1 Affinity Capture-RNA
TOM1 YDR457W E3 ubiquitin ligase of the hect-domain class physical 1 1 1 Affinity Capture-MS
THS1 YIL078W Threonyl-tRNA synthetase physical 1 1 1 PCA
SGF73 YGL066W Subunit of DUBm module of SAGA and SLIK genetic 1 1 1 Synthetic Growth Defect
SLX5 YDL013W Subunit of the Slx5-Slx8 SUMO-targeted Ub ligase (STUbL) complex genetic 1 1 1 Synthetic Growth Defect
TTI1 YKL033W Subunit of the ASTRA complex, involved in chromatin remodeling genetic 1 1 1 Positive Genetic
URE2 YNL229C Nitrogen catabolite repression transcriptional regulator genetic 1 1 1 Phenotypic Suppression
TSC11 YER093C Subunit of TORC2 (Tor2p-Lst8p-Avo1-Avo2-Tsc11p-Bit61p) genetic 1 1 1 Positive Genetic
SET1 YHR119W Histone methyltransferase, subunit of the COMPASS (Set1C) complex genetic 1 1 1 Positive Genetic
YGL039W YGL039W Aldehyde reductase genetic 1 1 1 Positive Genetic
RTF1 YGL244W Subunit of RNAPII-associated chromatin remodeling Paf1 complex genetic 1 1 1 Positive Genetic
RIM21 YNL294C pH sensor molecule, component of the RIM101 pathway genetic 1 1 1 Negative Genetic
TBS1 YBR150C Protein of unknown function genetic 1 1 1 Negative Genetic
PLP1 YDR183W Protein that interacts with CCT (chaperonin containing TCP-1) complex genetic 1 1 1 Negative Genetic
RAD30 YDR419W DNA polymerase eta genetic 1 1 1 Negative Genetic
RPS24A YER074W Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
YER137C YER137C Protein of unknown function genetic 1 1 1 Negative Genetic
RAD24 YER173W Checkpoint protein genetic 1 1 1 Negative Genetic
YIP5 YGL161C Protein that interacts with Rab GTPases genetic 1 1 1 Negative Genetic
TNA1 YGR260W High affinity nicotinic acid plasma membrane permease genetic 1 1 1 Negative Genetic
SDH9 YJL045W Minor succinate dehydrogenase isozyme genetic 1 1 1 Negative Genetic
YJR084W YJR084W Protein that forms a complex with Thp3p genetic 1 1 1 Negative Genetic
RPS27A YKL156W Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
SWI6 YLR182W Transcription cofactor genetic 1 1 1 Negative Genetic
ROM2 YLR371W Guanine nucleotide exchange factor (GEF) for Rho1p and Rho2p genetic 1 1 1 Negative Genetic
SST2 YLR452C GTPase-activating protein for Gpa1p genetic 1 1 1 Negative Genetic
YML003W YML003W Putative protein of unknown function genetic 1 1 1 Negative Genetic
RSF1 YMR030W Protein required for respiratory growth genetic 1 1 1 Negative Genetic
SIW14 YNL032W Inositol phosphatase involved in inositol pyrophosphate metabolism genetic 1 1 1 Negative Genetic
RNH201 YNL072W Ribonuclease H2 catalytic subunit genetic 1 1 1 Negative Genetic
SPO19 YPL130W Meiosis-specific prospore protein genetic 1 1 1 Negative Genetic
YPC1 YBR183W Alkaline ceramidase genetic 1 1 1 Negative Genetic
MCR1 YKL150W Mitochondrial NADH-cytochrome b5 reductase physical 1 1 1 Two-hybrid
ABZ1 YNR033W Para-aminobenzoate (PABA) synthase physical 1 1 1 Two-hybrid
MCH1 YDL054C Protein with similarity to mammalian monocarboxylate permeases genetic 1 1 1 Negative Genetic
CTP1 YBR291C Mitochondrial inner membrane citrate transporter genetic 1 1 1 Negative Genetic
ALD4 YOR374W Mitochondrial aldehyde dehydrogenase genetic 1 1 1 Negative Genetic
CUP9 YPL177C Homeodomain-containing transcriptional repressor genetic 1 1 1 Negative Genetic
CDA1 YLR307W Chitin deacetylase genetic 1 1 1 Negative Genetic
AIM29 YKR074W Protein of unknown function genetic 1 1 1 Negative Genetic
GIS1 YDR096W Histone demethylase and transcription factor physical 1 1 1 Two-hybrid
MRX18 YBR056W Putative glycoside hydrolase of the mitochondrial intermembrane space genetic 1 1 1 Negative Genetic
BRE4 YDL231C Zinc finger protein containing five transmembrane domains genetic 1 1 1 Negative Genetic
CRS5 YOR031W Copper-binding metallothionein genetic 1 1 1 Negative Genetic
DNF3 YMR162C Trans-golgi network aminophospholipid translocase (flippase) physical 1 1 1 Two-hybrid
GRS2 YPR081C Glycine-tRNA synthetase, not expressed under normal growth conditions physical 1 1 1 Two-hybrid
DIT2 YDR402C N-formyltyrosine oxidase genetic 1 1 1 Negative Genetic
KCH1 YJR054W Potassium transporter that mediates K+ influx genetic 1 1 1 Positive Genetic