Standard name Systematic name Name description Description
PKH2 YOL100W Serine/threonine protein kinase Serine/threonine protein kinase; involved in sphingolipid-mediated signaling pathway that controls endocytosis; activates Ypk1p and Ykr2p, components of signaling cascade required for maintenance of cell wall integrity; contains a PH-like domain; redundant with Pkh1p; PKH2 has a paralog, PKH1, that arose from the whole genome duplication
Visualize the interactome of PKH2
Links to external databases:
  SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)

CYCLoPs localization & abundance

WT1 WT2 WT3
Cytoplasm 0.941 0.980 0.973
Cell Periphery NaN 0.073 0.062

GFP localization & abundance

GFP localization GFP abundance
cytoplasm low signal

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
PKH2 4 0 0 2 0

Enzyme information

Catalyzed reactions in Yeast8

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
PKH1 YDR490C Serine/threonine protein kinase genetic 12 5 12 Synthetic Growth Defect, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Synthetic Lethality, Negative Genetic, Negative Genetic, Synthetic Lethality, Phenotypic Enhancement, Negative Genetic, Synthetic Rescue, Phenotypic Enhancement
PIL1 YGR086C Eisosome core component physical 3 3 3 Affinity Capture-MS, Biochemical Activity, PCA
LSP1 YPL004C Eisosome core component physical 3 3 3 Affinity Capture-MS, Biochemical Activity, Reconstituted Complex
GET2 YER083C Subunit of the GET complex genetic 2 1 2 Negative Genetic, Negative Genetic
CSG2 YBR036C Endoplasmic reticulum membrane protein genetic 2 1 2 Negative Genetic, Negative Genetic
YPK1 YKL126W S/T protein kinase genetic 2 2 1 Synthetic Growth Defect, Synthetic Rescue
IXR1 YKL032C Transcriptional repressor that regulates hypoxic genes during normoxia regulation 1 1 1 DNA to cDNA expression microarray evidence
CBF1 YJR060W Basic helix-loop-helix (bHLH) protein regulation 1 1 1 chromatin immunoprecipitation-chip evidence
TFC7 YOR110W RNA pol III transcription initiation factor complex (TFIIIC) subunit regulation 1 1 1 chromatin immunoprecipitation-chip evidence
FHL1 YPR104C Regulator of ribosomal protein (RP) transcription regulation 1 1 1 chromatin immunoprecipitation-chip evidence
UME6 YDR207C Rpd3L histone deacetylase complex subunit regulation 1 1 1 chromatin immunoprecipitation-chip evidence
DSN1 YIR010W Essential component of the outer kinetochore MIND complex physical 1 1 1 Affinity Capture-MS
NKP1 YDR383C Central kinetochore protein and subunit of the Ctf19 complex physical 1 1 1 Biochemical Activity
BRX1 YOL077C Nucleolar protein physical 1 1 1 Biochemical Activity
DRS1 YLL008W Nucleolar DEAD-box protein required for ribosome assembly and function physical 1 1 1 Reconstituted Complex
PFK27 YOL136C 6-phosphofructo-2-kinase genetic 1 1 1 Negative Genetic
NOP12 YOL041C Nucleolar protein involved in pre-25S rRNA processing physical 1 1 1 Affinity Capture-MS
GCD1 YOR260W Gamma subunit of the translation initiation factor eIF2B physical 1 1 1 Reconstituted Complex
CCR4 YAL021C Component of the CCR4-NOT transcriptional complex physical 1 1 1 Affinity Capture-RNA
CDC28 YBR160W Cyclin-dependent kinase (CDK) catalytic subunit physical 1 1 1 Biochemical Activity
FRS1 YLR060W Beta subunit of cytoplasmic phenylalanyl-tRNA synthetase physical 1 1 1 Reconstituted Complex
FKS1 YLR342W Catalytic subunit of 1,3-beta-D-glucan synthase genetic 1 1 1 Synthetic Growth Defect
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator genetic 1 1 1 Synthetic Growth Defect
ISW1 YBR245C ATPase subunit of imitation-switch (ISWI) class chromatin remodelers physical 1 1 1 Affinity Capture-RNA
PAC10 YGR078C Part of the heteromeric co-chaperone GimC/prefoldin complex physical 1 1 1 Reconstituted Complex
CCT6 YDR188W Subunit of the cytosolic chaperonin Cct ring complex physical 1 1 1 Reconstituted Complex
BCK1 YJL095W MAPKKK acting in the protein kinase C signaling pathway genetic 1 1 1 Synthetic Growth Defect
HEK2 YBL032W RNA binding protein involved in asymmetric localization of ASH1 mRNA physical 1 1 1 Affinity Capture-RNA
CRZ1 YNL027W Transcription factor, activates transcription of stress response genes physical 1 1 1 Reconstituted Complex
GAS1 YMR307W Beta-1,3-glucanosyltransferase required for cell wall assembly genetic 1 1 1 Synthetic Growth Defect
HXT6 YDR343C High-affinity glucose transporter physical 1 1 1 Affinity Capture-MS
TIM21 YGR033C Nonessential component of the TIM23 complex physical 1 1 1 Affinity Capture-MS
TOR1 YJR066W PIK-related protein kinase and rapamycin target physical 1 1 1 Affinity Capture-Western
PKH2 YOL100W Serine/threonine protein kinase physical 1 1 1 PCA
RVS161 YCR009C Amphiphysin-like lipid raft protein physical 1 1 1 PCA
POL31 YJR006W Subunit of DNA polymerase delta (polymerase III) physical 1 1 1 Reconstituted Complex
PRS1 YKL181W 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase physical 1 1 1 Reconstituted Complex
RDS2 YPL133C Transcription factor involved in regulating gluconeogenesis physical 1 1 1 Reconstituted Complex
RIM4 YHL024W Putative RNA-binding protein physical 1 1 1 Reconstituted Complex
RPP2B YDR382W Ribosomal protein P2 beta physical 1 1 1 Reconstituted Complex
RPT5 YOR117W ATPase of the 19S regulatory particle of the 26S proteasome physical 1 1 1 Reconstituted Complex
RSC6 YCR052W Component of the RSC chromatin remodeling complex physical 1 1 1 Reconstituted Complex
RTR1 YER139C Dual specificity protein phosphatase physical 1 1 1 Reconstituted Complex
SCH9 YHR205W AGC family protein kinase physical 1 1 1 Reconstituted Complex
SCH9 YHR205W AGC family protein kinase genetic 1 1 1 Negative Genetic
SHP1 YBL058W UBX domain-containing substrate adaptor for Cdc48p physical 1 1 1 Reconstituted Complex
SHQ1 YIL104C Chaperone protein physical 1 1 1 Reconstituted Complex
SRC1 YML034W Inner nuclear membrane protein physical 1 1 1 Reconstituted Complex
TIF2 YJL138C Translation initiation factor eIF4A physical 1 1 1 Reconstituted Complex
YAP3 YHL009C Basic leucine zipper (bZIP) transcription factor physical 1 1 1 Reconstituted Complex
YPL077C YPL077C Putative protein of unknown function physical 1 1 1 Reconstituted Complex
YPT7 YML001W Rab family GTPase physical 1 1 1 Reconstituted Complex
VPS27 YNR006W Endosomal protein that forms a complex with Hse1p physical 1 1 1 Biochemical Activity
VAM6 YDL077C Guanine nucleotide exchange factor for the GTPase Gtr1p physical 1 1 1 Affinity Capture-MS
SPT16 YGL207W Subunit of the heterodimeric FACT complex (Spt16p-Pob3p) physical 1 1 1 Affinity Capture-MS
SLM1 YIL105C Phosphoinositide PI4,5P(2) binding protein, forms a complex with Slm2p genetic 1 1 1 Dosage Rescue
SIT4 YDL047W Ceramide-activated, type 2A-related serine-threonine phosphatase genetic 1 1 1 Negative Genetic
ROM2 YLR371W Guanine nucleotide exchange factor (GEF) for Rho1p and Rho2p genetic 1 1 1 Synthetic Growth Defect
SLT2 YHR030C Serine/threonine MAP kinase genetic 1 1 1 Synthetic Growth Defect
SMI1 YGR229C Protein involved in the regulation of cell wall synthesis genetic 1 1 1 Synthetic Growth Defect
YUR1 YJL139C Mannosyltransferase involved in protein N-glycosylation genetic 1 1 1 Synthetic Growth Defect
RIM21 YNL294C pH sensor molecule, component of the RIM101 pathway genetic 1 1 1 Synthetic Growth Defect
XRN1 YGL173C Evolutionarily-conserved 5'-3' exonuclease genetic 1 1 1 Synthetic Growth Defect
RTG3 YBL103C bHLH/Zip transcription factor for retrograde (RTG) and TOR pathways genetic 1 1 1 Negative Genetic
PLM2 YDR501W Putative transcription factor, contains Forkhead Associated domain genetic 1 1 1 Negative Genetic
SUM1 YDR310C Transcriptional repressor that regulates middle-sporulation genes genetic 1 1 1 Negative Genetic
VMS1 YDR049W Peptidyl-tRNA hydrolase that releases stalled peptides from ribosomes, genetic 1 1 1 Negative Genetic
TAF1 YGR274C TFIID subunit, involved in RNA pol II transcription initiation genetic 1 1 1 Synthetic Lethality
HXT7 YDR342C High-affinity glucose transporter physical 1 1 1 Affinity Capture-MS
LIA1 YJR070C Deoxyhypusine hydroxylase physical 1 1 1 Reconstituted Complex
CDH1 YGL003C Activator of anaphase-promoting complex/cyclosome (APC/C) genetic 1 1 1 Positive Genetic
PKH1 YDR490C Serine/threonine protein kinase physical 1 1 1 PCA
BUD27 YFL023W Unconventional prefoldin protein involved in translation initiation physical 1 1 1 Reconstituted Complex
DID4 YKL002W Class E Vps protein of the ESCRT-III complex physical 1 1 1 Reconstituted Complex
ATG19 YOL082W Receptor protein for the cytoplasm-to-vacuole targeting (Cvt) pathway physical 1 1 1 Reconstituted Complex
PKC1 YBL105C Protein serine/threonine kinase physical 1 1 1 Biochemical Activity
CSM3 YMR048W Replication fork associated factor physical 1 1 1 Reconstituted Complex
NNF1 YJR112W Essential component of the outer kinetochore MIND complex physical 1 1 1 Reconstituted Complex
BUD4 YJR092W Anillin-like protein involved in bud-site selection physical 1 1 1 Reconstituted Complex
CLC1 YGR167W Clathrin light chain physical 1 1 1 Reconstituted Complex
MYO5 YMR109W One of two type I myosin motors physical 1 1 1 Two-hybrid
MYO5 YMR109W One of two type I myosin motors genetic 1 1 1 Synthetic Growth Defect
OST6 YML019W Subunit of the oligosaccharyltransferase complex of the ER lumen genetic 1 1 1 Synthetic Growth Defect
MPT5 YGL178W mRNA-binding protein of the PUF family physical 1 1 1 Affinity Capture-RNA
GSY2 YLR258W Glycogen synthase physical 1 1 1 Reconstituted Complex
HMT1 YBR034C Nuclear SAM-dependent mono- and asymmetric methyltransferase physical 1 1 1 PCA
DPC29 YGR021W Putative mitochondrial protein of unknown function physical 1 1 1 Reconstituted Complex
BUG1 YDL099W Cis-golgi localized protein involved in ER to Golgi transport physical 1 1 1 Reconstituted Complex
ORC6 YHR118C Subunit of the origin recognition complex (ORC) physical 1 1 1 PCA
GAS5 YOL030W 1,3-beta-glucanosyltransferase genetic 1 1 1 Synthetic Growth Defect
KCS1 YDR017C Inositol hexakisphosphate and inositol heptakisphosphate kinase genetic 1 1 1 Negative Genetic
ARA2 YMR041C NAD-dependent arabinose dehydrogenase physical 1 1 1 Reconstituted Complex
MDM36 YPR083W Mitochondrial protein physical 1 1 1 Reconstituted Complex
CMK2 YOL016C Calmodulin-dependent protein kinase physical 1 1 1 Biochemical Activity
FMP45 YDL222C Integral membrane protein localized to mitochondria physical 1 1 1 PCA
JJJ3 YJR097W Iron-binding protein physical 1 1 1 Reconstituted Complex
LAS21 YJL062W Mannose-ethanolamine phosphotransferase genetic 1 1 1 Synthetic Growth Defect
GAS4 YOL132W 1,3-beta-glucanosyltransferase genetic 1 1 1 Synthetic Growth Defect
ALP1 YNL270C Arginine transporter genetic 1 1 1 Negative Genetic