Standard name Systematic name Name description Description
SPS1 YDR523C STE20-family GCKIII protein kinase STE20-family GCKIII protein kinase; required for prospore membrane closure, efficient spore packaging, and localization of enzymes involved in spore wall synthesis; component of a non-canonical Hippo pathway with Cdc15p involved in spindle disassembly and sustained release of Cdc14p during anaphase II; forms a complex with Cdc15p; phosphorylation requires Cdc15p; required for Ssp1p phosphorylation and turnover; interacts with 14-3-3 proteins; expressed in late meiosis; nuclear and cytoplasmic
Visualize the interactome of SPS1
Links to external databases:
  SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)
G1 242

CYCLoPs localization & abundance

WT1 WT2 WT3
Cytoplasm 0.860 0.961 NaN
Mito 0.355 0.050 NaN

GFP localization & abundance

GFP localization GFP abundance
cytoplasm, nucleus no data

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
SPS1 1 5 0 0 0

Enzyme information

Catalyzed reactions in Yeast8

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
RRP8 YDR083W Nucleolar S-adenosylmethionine-dependent rRNA methyltransferase genetic 2 1 2 Negative Genetic, Negative Genetic
AAH1 YNL141W Adenine deaminase (adenine aminohydrolase) genetic 2 1 2 Negative Genetic, Negative Genetic
SST2 YLR452C GTPase-activating protein for Gpa1p genetic 2 1 2 Negative Genetic, Negative Genetic
STB5 YHR178W Transcription factor genetic 2 1 2 Negative Genetic, Negative Genetic
FAA1 YOR317W Long chain fatty acyl-CoA synthetase genetic 2 1 2 Negative Genetic, Negative Genetic
BTS1 YPL069C Geranylgeranyl diphosphate synthase (GGPPS) genetic 2 1 2 Negative Genetic, Negative Genetic
RPS10A YOR293W Protein component of the small (40S) ribosomal subunit genetic 2 1 2 Negative Genetic, Negative Genetic
ESA1 YOR244W Catalytic subunit of the histone acetyltransferase complex (NuA4) genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
SSP1 YHR184W Protein involved in the control of meiotic nuclear division physical 2 1 1 Affinity Capture-Western, Affinity Capture-Western
YAF9 YNL107W Subunit of NuA4 histone H4 acetyltransferase and SWR1 complexes genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
SFP1 YLR403W Regulates transcription of ribosomal protein and biogenesis genes regulation 1 1 1 DNA to cDNA expression microarray evidence
NDT80 YHR124W Meiosis-specific transcription factor regulation 1 1 1 northern blot evidence
CDC15 YAR019C Hippo-like kinase of the Mitotic Exit Network regulation 1 1 1 protein kinase assay evidence
CDC40 YDR364C Pre-mRNA splicing factor physical 1 1 1 Reconstituted Complex
DSN1 YIR010W Essential component of the outer kinetochore MIND complex physical 1 1 1 Affinity Capture-MS
RPO21 YDL140C RNA polymerase II largest subunit B220 genetic 1 1 1 Negative Genetic
CKB1 YGL019W Beta regulatory subunit of casein kinase 2 (CK2) physical 1 1 1 Reconstituted Complex
SDS22 YKL193C Regulatory subunit of the type 1 protein phosphatase (PP1) Glc7p physical 1 1 1 Reconstituted Complex
GUS1 YGL245W Glutamyl-tRNA synthetase (GluRS) physical 1 1 1 Reconstituted Complex
BMH1 YER177W 14-3-3 protein, major isoform physical 1 1 1 Affinity Capture-Western
BMH1 YER177W 14-3-3 protein, major isoform genetic 1 1 1 Phenotypic Enhancement
RPN8 YOR261C Essential non-ATPase regulatory subunit of the 26S proteasome physical 1 1 1 Affinity Capture-MS
RPT6 YGL048C ATPase of the 19S regulatory particle of the 26S proteasome genetic 1 1 1 Negative Genetic
NAM7 YMR080C ATP-dependent RNA helicase of the SFI superfamily physical 1 1 1 Affinity Capture-RNA
ARP2 YDL029W Essential component of the Arp2/3 complex physical 1 1 1 Affinity Capture-MS
BMH2 YDR099W 14-3-3 protein, minor isoform physical 1 1 1 Affinity Capture-Western
BMH2 YDR099W 14-3-3 protein, minor isoform genetic 1 1 1 Phenotypic Enhancement
CDC28 YBR160W Cyclin-dependent kinase (CDK) catalytic subunit genetic 1 1 1 Dosage Lethality
CDC23 YHR166C Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) genetic 1 1 1 Negative Genetic
ISW1 YBR245C ATPase subunit of imitation-switch (ISWI) class chromatin remodelers physical 1 1 1 Affinity Capture-RNA
DIB1 YPR082C 17-kDa component of the U4/U6aU5 tri-snRNP physical 1 1 1 Reconstituted Complex
AHA1 YDR214W Co-chaperone that binds Hsp82p and activates its ATPase activity physical 1 1 1 Affinity Capture-MS
HMO1 YDR174W Chromatin associated high mobility group (HMG) family member genetic 1 1 1 Negative Genetic
PPH22 YDL188C Catalytic subunit of protein phosphatase 2A, PP2A physical 1 1 1 Affinity Capture-MS
DAM1 YGR113W Essential subunit of the Dam1 complex (aka DASH complex) genetic 1 1 1 Negative Genetic
CTI6 YPL181W Component of the Rpd3L histone deacetylase complex genetic 1 1 1 Positive Genetic
PPH21 YDL134C Catalytic subunit of protein phosphatase 2A, PP2A physical 1 1 1 Affinity Capture-MS
SIR2 YDL042C Conserved NAD+ dependent histone deacetylase of the Sirtuin family genetic 1 1 1 Phenotypic Suppression
HFI1 YPL254W Adaptor protein required for structural integrity of the SAGA complex physical 1 1 1 Affinity Capture-MS
SGF73 YGL066W Subunit of DUBm module of SAGA and SLIK physical 1 1 1 Biochemical Activity
SGV1 YPR161C Cyclin (Bur2p)-dependent protein kinase genetic 1 1 1 Negative Genetic
CCT6 YDR188W Subunit of the cytosolic chaperonin Cct ring complex physical 1 1 1 Reconstituted Complex
CCT6 YDR188W Subunit of the cytosolic chaperonin Cct ring complex genetic 1 1 1 Negative Genetic
NEW1 YPL226W Translation termination and ribosome biogenesis factor genetic 1 1 1 Negative Genetic
HEK2 YBL032W RNA binding protein involved in asymmetric localization of ASH1 mRNA physical 1 1 1 Affinity Capture-RNA
ABP1 YCR088W Actin-binding protein of the cortical actin cytoskeleton physical 1 1 1 Affinity Capture-MS
PHO84 YML123C High-affinity inorganic phosphate (Pi) transporter physical 1 1 1 Affinity Capture-MS
ATP3 YBR039W Gamma subunit of the F1 sector of mitochondrial F1F0 ATP synthase physical 1 1 1 Affinity Capture-MS
PYC1 YGL062W Pyruvate carboxylase isoform physical 1 1 1 Affinity Capture-MS
IDH1 YNL037C Subunit of mitochondrial NAD(+)-dependent isocitrate dehydrogenase physical 1 1 1 Affinity Capture-MS
PLN1 YKR046C Perilipin, involved in formation and stability of lipid droplets physical 1 1 1 Affinity Capture-MS
YHR033W YHR033W Putative protein of unknown function physical 1 1 1 Affinity Capture-MS
VMA8 YEL051W Subunit D of the V1 peripheral membrane domain of V-ATPase physical 1 1 1 Affinity Capture-MS
VPS74 YDR372C Golgi PI4K effector, PtdIns4P sensor, and retention receptor physical 1 1 1 Affinity Capture-MS
TFC3 YAL001C Subunit of RNA polymerase III transcription initiation factor complex physical 1 1 1 Affinity Capture-MS
TMA16 YOR252W Protein of unknown function that associates with ribosomes physical 1 1 1 Biochemical Activity
SSE1 YPL106C ATPase component of heat shock protein Hsp90 chaperone complex physical 1 1 1 Reconstituted Complex
UBC6 YER100W Ubiquitin-conjugating enzyme involved in ERAD physical 1 1 1 Reconstituted Complex
UBP10 YNL186W Ubiquitin-specific protease, deubiquitinates Ub-protein moieties physical 1 1 1 Reconstituted Complex
YBL036C YBL036C Putative non-specific single-domain racemase physical 1 1 1 Reconstituted Complex
YMR196W YMR196W Putative protein of unknown function physical 1 1 1 Reconstituted Complex
YAK1 YJL141C Serine-threonine protein kinase physical 1 1 1 Reconstituted Complex
YPK1 YKL126W S/T protein kinase physical 1 1 1 Reconstituted Complex
SUS1 YBR111W-A Global transcriptional regulator, component of SAGA, TREX-2 complexes physical 1 1 1 Affinity Capture-MS
TAF5 YBR198C Subunit (90 kDa) of TFIID and SAGA complexes physical 1 1 1 Affinity Capture-MS
STE20 YHL007C Cdc42p-activated signal transducing kinase genetic 1 1 1 Negative Genetic
YOR289W YOR289W Putative protein of unknown function genetic 1 1 1 Dosage Growth Defect
TIM22 YDL217C Essential core component of mitochondrial TIM22 complex genetic 1 1 1 Negative Genetic
TAF12 YDR145W Subunit (61/68 kDa) of TFIID and SAGA complexes genetic 1 1 1 Negative Genetic
TEL2 YGR099W Subunit of the ASTRA complex, involved in chromatin remodeling genetic 1 1 1 Negative Genetic
STP2 YHR006W Transcription factor genetic 1 1 1 Phenotypic Suppression
CPR6 YLR216C Peptidyl-prolyl cis-trans isomerase (cyclophilin) physical 1 1 1 Affinity Capture-MS
PRB1 YEL060C Vacuolar proteinase B (yscB) with H3 N-terminal endopeptidase activity physical 1 1 1 Affinity Capture-MS
SDH2 YLL041C Iron-sulfur protein subunit of succinate dehydrogenase physical 1 1 1 Affinity Capture-MS
NMD5 YJR132W Karyopherin physical 1 1 1 Affinity Capture-MS
DPS1 YLL018C Aspartyl-tRNA synthetase, primarily cytoplasmic physical 1 1 1 Reconstituted Complex
MPC54 YOR177C Component of the meiotic outer plaque physical 1 1 1 Reconstituted Complex
PMA1 YGL008C Plasma membrane P2-type H+-ATPase genetic 1 1 1 Negative Genetic
DUN1 YDL101C Cell-cycle checkpoint S/T protein kinase physical 1 1 1 Biochemical Activity
RNA1 YMR235C GTPase activating protein (GAP) for Gsp1p physical 1 1 1 Reconstituted Complex
RVS167 YDR388W Calmodulin-binding actin-associated protein physical 1 1 1 Affinity Capture-MS
CDC15 YAR019C Hippo-like kinase of the Mitotic Exit Network physical 1 1 1 Affinity Capture-Western
CDC15 YAR019C Hippo-like kinase of the Mitotic Exit Network genetic 1 1 1 Negative Genetic
HHO1 YPL127C Histone H1, linker histone with roles in meiosis and sporulation genetic 1 1 1 Synthetic Rescue
SKA1 YKL023W SKI complex-associated protein physical 1 1 1 Reconstituted Complex
ATG1 YGL180W Protein serine/threonine kinase genetic 1 1 1 Dosage Growth Defect
MOB2 YFL034C-B Activator of Cbk1p kinase genetic 1 1 1 Negative Genetic
IME1 YJR094C Master regulator of meiosis that is active only during meiotic events genetic 1 1 1 Positive Genetic
RBD2 YPL246C Possible rhomboid protease physical 1 1 1 Biochemical Activity
SMC5 YOL034W Subunit of the SMC5-SMC6 complex genetic 1 1 1 Negative Genetic
CDC27 YBL084C Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) physical 1 1 1 Two-hybrid
RPL22A YLR061W Ribosomal 60S subunit protein L22A genetic 1 1 1 Negative Genetic
CSE4 YKL049C Centromeric histone H3-like protein physical 1 1 1 Two-hybrid
APN1 YKL114C Major apurinic/apyrimidinic endonuclease physical 1 1 1 Reconstituted Complex
AMA1 YGR225W Activator of meiotic anaphase promoting complex (APC/C) genetic 1 1 1 Phenotypic Enhancement
PUP1 YOR157C Beta 2 subunit of the 20S proteasome physical 1 1 1 Two-hybrid
DPH1 YIL103W Protein required for synthesis of diphthamide physical 1 1 1 Biochemical Activity
COQ1 YBR003W Hexaprenyl pyrophosphate synthetase genetic 1 1 1 Dosage Growth Defect
GPR1 YDL035C Plasma membrane G protein coupled receptor (GPCR) genetic 1 1 1 Positive Genetic
CQD1 YPL109C UbiB family mitochondrial protein genetic 1 1 1 Dosage Growth Defect
DOM34 YNL001W Protein that facilitates ribosomal subunit dissociation physical 1 1 1 Reconstituted Complex
ARO8 YGL202W Aromatic aminotransferase I physical 1 1 1 Affinity Capture-MS
BCH2 YKR027W Member of the ChAPs (Chs5p-Arf1p-binding proteins) family genetic 1 1 1 Dosage Growth Defect
PHR1 YOR386W DNA photolyase involved in photoreactivation genetic 1 1 1 Dosage Growth Defect
SPO75 YLL005C Meiosis-specific protein of unknown function physical 1 1 1 Affinity Capture-MS
CYK3 YDL117W SH3-domain protein located in the bud neck and cytokinetic actin ring genetic 1 1 1 Dosage Growth Defect
RDS2 YPL133C Transcription factor involved in regulating gluconeogenesis physical 1 1 1 Reconstituted Complex
CYC7 YEL039C Cytochrome c isoform 2, expressed under hypoxic conditions physical 1 1 1 Reconstituted Complex
BNA2 YJR078W Tryptophan 2,3-dioxygenase or indoleamine 2,3-dioxygenase physical 1 1 1 Biochemical Activity
LIP1 YMR298W Ceramide synthase subunit genetic 1 1 1 Negative Genetic
ARF3 YOR094W Glucose-repressible ADP-ribosylation factor physical 1 1 1 Reconstituted Complex
KNH1 YDL049C Protein with similarity to Kre9p genetic 1 1 1 Dosage Growth Defect
MET22 YOL064C Bisphosphate-3'-nucleotidase genetic 1 1 1 Negative Genetic
SPO77 YLR341W Meiosis-specific protein of unknown function genetic 1 1 1 Phenotypic Suppression