Standard name Systematic name Name description Description
DUG1 YFR044C Cys-Gly metallo-di-peptidase Cys-Gly metallo-di-peptidase; forms a complex with Dug2p and Dug3p to degrade glutathione (GSH) and other peptides containing a gamma-glu-X bond in an alternative pathway to GSH degradation by gamma-glutamyl transpeptidase (Ecm38p); human homolog CNDP2 can complement yeast dug1 mutant
Visualize the interactome of DUG1
Links to external databases:
  SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)

CYCLoPs localization & abundance

WT1 WT2 WT3
Cell Periphery 0.053 NaN NaN
Cytoplasm 0.967 0.972 0.97

GFP localization & abundance

GFP localization GFP abundance
no data no data

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
DUG1 1 0 0 0 0

Enzyme information

Catalyzed reactions in Yeast8
r_4214 (L-cysteinylglycine dipeptidase), r_4215 (Cys-Gly metallodipeptidase DUG1 (EC 3.4.13.-) (Deficient in utilization of glutathione protein 1) (GSH degradosomal complex subunit DUG1))

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
DUG1 YFR044C Cys-Gly metallo-di-peptidase physical 7 4 5 Two-hybrid, Affinity Capture-Western, Reconstituted Complex, Reconstituted Complex, Reconstituted Complex, Co-crystal Structure, Reconstituted Complex
FKH1 YIL131C Forkhead family transcription factor regulation 2 1 2 chromatin immunoprecipitation-chip evidence, chromatin immunoprecipitation-chip evidence
SEC7 YDR170C Guanine nucleotide exchange factor (GEF) for ADP ribosylation factors physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
SEH1 YGL100W Subunit of the Nup84 nuclear pore and SEACAT subcomplexes genetic 2 1 2 Negative Genetic, Negative Genetic
PDR1 YGL013C Transcription factor that regulates the pleiotropic drug response genetic 2 1 2 Negative Genetic, Negative Genetic
ERG6 YML008C Delta(24)-sterol C-methyltransferase genetic 2 1 2 Negative Genetic, Negative Genetic
PHO23 YNL097C Component of the Rpd3L histone deacetylase complex genetic 2 1 2 Negative Genetic, Negative Genetic
ERG3 YLR056W C-5 sterol desaturase genetic 2 1 2 Negative Genetic, Negative Genetic
DUG2 YBR281C Component of glutamine amidotransferase (GATase II) physical 2 2 1 Two-hybrid, Affinity Capture-Western
DUG3 YNL191W Component of glutamine amidotransferase (GATase II) physical 2 1 1 Affinity Capture-Western, Affinity Capture-Western
GCN5 YGR252W Catalytic subunit of ADA and SAGA histone acetyltransferase complexes regulation 1 1 1 chromatin immunoprecipitation-chip evidence
GCR1 YPL075W Transcriptional activator of genes involved in glycolysis regulation 1 1 1 DNA to cDNA expression microarray evidence
RGR1 YLR071C Subunit of the RNA polymerase II mediator complex regulation 1 1 1 chromatin immunoprecipitation-chip evidence
XBP1 YIL101C Transcriptional repressor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
BUR6 YER159C Subunit of a heterodimeric NC2 transcription regulator complex regulation 1 1 1 chromatin immunoprecipitation-chip evidence
RAP1 YNL216W Essential DNA-binding transcription regulator that binds many loci regulation 1 1 1 DNA to cDNA expression microarray evidence
ABF1 YKL112W DNA binding protein with possible chromatin-reorganizing activity regulation 1 1 1 DNA to cDNA expression microarray evidence
REB1 YBR049C RNA polymerase I enhancer binding protein regulation 1 1 1 DNA to cDNA expression microarray evidence
SUA7 YPR086W Transcription factor TFIIB regulation 1 1 1 chromatin immunoprecipitation-chip evidence
TUP1 YCR084C General repressor of transcription in complex with Cyc8p regulation 1 1 1 DNA to cDNA expression microarray evidence
ROX1 YPR065W Heme-dependent repressor of hypoxic genes regulation 1 1 1 DNA to cDNA expression microarray evidence
RLM1 YPL089C MADS-box transcription factor regulation 1 1 1 DNA to cDNA expression microarray evidence
UPC2 YDR213W Sterol regulatory element binding protein regulation 1 1 1 DNA to cDNA expression microarray evidence
BRE1 YDL074C E3 ubiquitin ligase genetic 1 1 1 Negative Genetic
CDC11 YJR076C Component of the septin ring that is required for cytokinesis genetic 1 1 1 Negative Genetic
BNI1 YNL271C Formin physical 1 1 1 Reconstituted Complex
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator physical 1 1 1 Affinity Capture-RNA
RHO1 YPR165W GTP-binding protein of the rho subfamily of Ras-like proteins physical 1 1 1 Affinity Capture-MS
HRD1 YOL013C Ubiquitin-protein ligase involved in ER-associated degradation (ERAD) physical 1 1 1 Affinity Capture-MS
RPN11 YFR004W Metalloprotease subunit of 19S regulatory particle physical 1 1 1 Affinity Capture-MS
SRO9 YCL037C Cytoplasmic RNA-binding protein physical 1 1 1 Affinity Capture-RNA
SSB2 YNL209W Cytoplasmic ATPase that is a ribosome-associated molecular chaperone physical 1 1 1 Co-purification
SSC1 YJR045C Hsp70 family ATPase physical 1 1 1 Affinity Capture-MS
RPC82 YPR190C RNA polymerase III subunit C82 physical 1 1 1 Affinity Capture-MS
HSP82 YPL240C Hsp90 chaperone physical 1 1 1 Affinity Capture-MS
HSP82 YPL240C Hsp90 chaperone genetic 1 1 1 Synthetic Growth Defect
HSC82 YMR186W Cytoplasmic chaperone of the Hsp90 family physical 1 1 1 Affinity Capture-MS
HSC82 YMR186W Cytoplasmic chaperone of the Hsp90 family genetic 1 1 1 Synthetic Growth Defect
MET17 YLR303W O-acetyl homoserine-O-acetyl serine sulfhydrylase genetic 1 1 1 Synthetic Growth Defect
OPT1 YJL212C Proton-coupled oligopeptide transporter of the plasma membrane genetic 1 1 1 Phenotypic Enhancement
RAD9 YDR217C DNA damage-dependent checkpoint protein genetic 1 1 1 Phenotypic Enhancement
STU1 YBL034C Microtubule plus-end-tracking non-motor protein genetic 1 1 1 Negative Genetic
HSP60 YLR259C Tetradecameric mitochondrial chaperonin genetic 1 1 1 Negative Genetic
SNN1 YNL086W Subunit of the BLOC-1 complex involved in endosomal maturation genetic 1 1 1 Negative Genetic
PPA2 YMR267W Mitochondrial inorganic pyrophosphatase genetic 1 1 1 Positive Genetic
STE50 YCL032W Adaptor protein for various signaling pathways genetic 1 1 1 Positive Genetic
RPP1A YDL081C Ribosomal stalk protein P1 alpha genetic 1 1 1 Positive Genetic
VPS41 YDR080W Subunit of the HOPS endocytic tethering complex genetic 1 1 1 Positive Genetic
STN1 YDR082W Telomere end-binding and capping protein genetic 1 1 1 Negative Genetic
VID24 YBR105C GID Complex regulatory subunit genetic 1 1 1 Negative Genetic
MRPS5 YBR251W Mitochondrial ribosomal protein of the small subunit genetic 1 1 1 Negative Genetic
IMG2 YCR071C Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Negative Genetic
TPS2 YDR074W Phosphatase subunit of the trehalose-6-P synthase/phosphatase complex genetic 1 1 1 Negative Genetic
SRB2 YHR041C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
RPL14A YKL006W Ribosomal 60S subunit protein L14A genetic 1 1 1 Negative Genetic
SIC1 YLR079W Cyclin-dependent kinase inhibitor (CKI) genetic 1 1 1 Negative Genetic
ELO3 YLR372W Elongase genetic 1 1 1 Negative Genetic
SST2 YLR452C GTPase-activating protein for Gpa1p genetic 1 1 1 Negative Genetic
RIM20 YOR275C Protein involved in proteolytic activation of Rim101p genetic 1 1 1 Negative Genetic
ROX1 YPR065W Heme-dependent repressor of hypoxic genes genetic 1 1 1 Negative Genetic
HCS1 YKL017C Hexameric DNA polymerase alpha-associated DNA helicase A genetic 1 1 1 Negative Genetic
KIN2 YLR096W S/T protein kinase genetic 1 1 1 Negative Genetic
RIM21 YNL294C pH sensor molecule, component of the RIM101 pathway genetic 1 1 1 Negative Genetic
BFR1 YOR198C Component of mRNP complexes associated with polyribosomes physical 1 1 1 Affinity Capture-RNA
CYB5 YNL111C Cytochrome b5 genetic 1 1 1 Negative Genetic