Standard name Systematic name Name description Description
HOT1 YMR172W Transcription factor for glycerol biosynthetic genes Transcription factor for glycerol biosynthetic genes; required for the transient induction of glycerol biosynthetic genes GPD1 and GPP2 in response to high osmolarity; targets Hog1p to osmostress responsive promoters; has similarity to Msn1p and Gcr1p
Visualize the interactome of HOT1
Links to external databases:
  SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)

CYCLoPs localization & abundance

WT1 WT2 WT3
Mito 0.294 0.475 0.065
Nucleolus 0.119 0.054 NaN
Nucleus 0.588 0.446 0.588
SpindlePole 0.094 0.083 0.333
Cytoplasm NaN 0.062 NaN
Vac/Vac Memb NaN 0.058 NaN
Budneck NaN NaN 0.082

GFP localization & abundance

GFP localization GFP abundance
nucleus 149

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
HOT1 9 0 0 0 0

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
HOG1 YLR113W Mitogen-activated protein kinase involved in osmoregulation physical 10 5 7 Two-hybrid, Two-hybrid, Biochemical Activity, Affinity Capture-MS, Co-localization, Affinity Capture-Western, Affinity Capture-Western, Two-hybrid, Co-localization, Affinity Capture-MS
CKA1 YIL035C Alpha catalytic subunit of casein kinase 2 (CK2) physical 6 3 4 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Biochemical Activity
CKB2 YOR039W Beta' regulatory subunit of casein kinase 2 (CK2) physical 4 1 4 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS
CKA2 YOR061W Alpha' catalytic subunit of casein kinase 2 (CK2) physical 3 2 3 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western
CKB1 YGL019W Beta regulatory subunit of casein kinase 2 (CK2) physical 3 1 3 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS
SUB1 YMR039C Transcriptional regulator physical 3 3 1 Affinity Capture-MS, Affinity Capture-Western, Co-localization
SKO1 YNL167C Basic leucine zipper transcription factor of the ATF/CREB family genetic 2 1 2 Phenotypic Enhancement, Phenotypic Enhancement
COX23 YHR116W Protein that functions in mitochondrial copper homeostasis genetic 2 1 2 Negative Genetic, Negative Genetic
STL1 YDR536W Glycerol proton symporter of the plasma membrane regulation 2 2 1 beta-galactosidase reporter gene assay evidence, electrophoretic mobility shift assay evidence
PAB1 YER165W Poly(A) binding protein physical 2 2 1 Affinity Capture-MS, Affinity Capture-Western
RPO26 YPR187W RNA polymerase subunit ABC23 physical 2 2 1 Affinity Capture-MS, Affinity Capture-Western
FKH1 YIL131C Forkhead family transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
TFC7 YOR110W RNA pol III transcription initiation factor complex (TFIIIC) subunit regulation 1 1 1 chromatin immunoprecipitation-chip evidence
ALD3 YMR169C Cytoplasmic aldehyde dehydrogenase regulation 1 1 1 quantitative reverse transcription polymerase chain reaction evidence
GRE1 YPL223C Hydrophilin essential in desiccation-rehydration process regulation 1 1 1 northern blot evidence
HSP12 YFL014W Plasma membrane protein involved in maintaining membrane organization regulation 1 1 1 quantitative reverse transcription polymerase chain reaction evidence
RTC3 YHR087W Protein of unknown function involved in RNA metabolism regulation 1 1 1 quantitative reverse transcription polymerase chain reaction evidence
SPS100 YHR139C Protein required for spore wall maturation regulation 1 1 1 northern blot evidence
CBC2 YPL178W Small subunit of the heterodimeric cap binding complex with Sto1p genetic 1 1 1 Positive Genetic
HCR1 YLR192C eIF3j component of translation initiation factor 3 (eIF3) genetic 1 1 1 Positive Genetic
CCR4 YAL021C Component of the CCR4-NOT transcriptional complex physical 1 1 1 Affinity Capture-RNA
BDF1 YLR399C BET family transcriptional regulator physical 1 1 1 Two-hybrid
CLP1 YOR250C Component of the cleavage and polyadenylation factor I (CF I) genetic 1 1 1 Negative Genetic
COX6 YHR051W Subunit VI of cytochrome c oxidase (Complex IV) genetic 1 1 1 Negative Genetic
DPB3 YBR278W Third-largest subunit of DNA polymerase II (DNA polymerase epsilon) genetic 1 1 1 Negative Genetic
EMG1 YLR186W Methyltransferase for rRNA genetic 1 1 1 Negative Genetic
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator physical 1 1 1 Affinity Capture-RNA
CMD1 YBR109C Calmodulin genetic 1 1 1 Negative Genetic
GIM5 YML094W Subunit of the heterohexameric cochaperone prefoldin complex genetic 1 1 1 Synthetic Lethality
DIM1 YPL266W Essential 18S rRNA dimethylase (dimethyladenosine transferase) genetic 1 1 1 Negative Genetic
GPP1 YIL053W Constitutively expressed DL-glycerol-3-phosphate phosphatase physical 1 1 1 Affinity Capture-MS
ELM1 YKL048C Serine/threonine protein kinase genetic 1 1 1 Negative Genetic
GPP2 YER062C DL-glycerol-3-phosphate phosphatase involved in glycerol biosynthesis physical 1 1 1 Affinity Capture-MS
DEF1 YKL054C RNAPII degradation factor physical 1 1 1 Affinity Capture-MS
AFT1 YGL071W Transcription factor involved in iron utilization and homeostasis genetic 1 1 1 Negative Genetic
SPT15 YER148W TATA-binding protein (TBP) physical 1 1 1 Affinity Capture-MS
NAP1 YKR048C Histone chaperone and assembly chaperone for Rps6a/b physical 1 1 1 Affinity Capture-MS
SMP1 YBR182C MADS-box transcription factor involved in osmotic stress response physical 1 1 1 Two-hybrid
MSN2 YMR037C Stress-responsive transcriptional activator physical 1 1 1 Two-hybrid
MSN2 YMR037C Stress-responsive transcriptional activator genetic 1 1 1 Phenotypic Enhancement
MSN4 YKL062W Stress-responsive transcriptional activator physical 1 1 1 Two-hybrid
MSN4 YKL062W Stress-responsive transcriptional activator genetic 1 1 1 Phenotypic Enhancement
VAM3 YOR106W Syntaxin-like vacuolar t-SNARE physical 1 1 1 Two-hybrid
RPT5 YOR117W ATPase of the 19S regulatory particle of the 26S proteasome physical 1 1 1 Two-hybrid
HOT1 YMR172W Transcription factor for glycerol biosynthetic genes physical 1 1 1 Affinity Capture-Western
PUF3 YLL013C Protein of the mitochondrial outer surface physical 1 1 1 Affinity Capture-RNA
YRA1 YDR381W Nuclear polyadenylated RNA-binding protein physical 1 1 1 Affinity Capture-MS
YAP1 YML007W Basic leucine zipper (bZIP) transcription factor physical 1 1 1 Affinity Capture-MS
NSR1 YGR159C Nucleolin, nucleolar protein that binds nuclear localization sequences physical 1 1 1 Affinity Capture-MS
SUB2 YDL084W Component of the TREX complex required for nuclear mRNA export physical 1 1 1 Affinity Capture-MS
PBP1 YGR178C Component of glucose deprivation induced stress granules physical 1 1 1 Affinity Capture-MS
PBP4 YDL053C Pbp1p binding protein physical 1 1 1 Affinity Capture-MS
SUB1 YMR039C Transcriptional regulator genetic 1 1 1 Synthetic Growth Defect
YRB1 YDR002W Ran GTPase binding protein physical 1 1 1 Affinity Capture-MS
RPA49 YNL248C RNA polymerase I subunit A49 physical 1 1 1 Affinity Capture-MS
NSP1 YJL041W FG-nucleoporin component of central core of the nuclear pore complex physical 1 1 1 Affinity Capture-MS
NPL3 YDR432W RNA-binding protein physical 1 1 1 Affinity Capture-MS
NUP2 YLR335W Nucleoporin involved in nucleocytoplasmic transport physical 1 1 1 Affinity Capture-MS
SPT5 YML010W Spt4p/5p (DSIF) transcription elongation factor complex subunit physical 1 1 1 Affinity Capture-MS
SPT5 YML010W Spt4p/5p (DSIF) transcription elongation factor complex subunit genetic 1 1 1 Synthetic Growth Defect
RPO21 YDL140C RNA polymerase II largest subunit B220 physical 1 1 1 Co-localization
SSK2 YNR031C MAP kinase kinase kinase of HOG1 mitogen-activated signaling pathway genetic 1 1 1 Synthetic Rescue
PUB1 YNL016W Poly (A)+ RNA-binding protein genetic 1 1 1 Negative Genetic
PAC10 YGR078C Part of the heteromeric co-chaperone GimC/prefoldin complex genetic 1 1 1 Synthetic Growth Defect
ZAP1 YJL056C Zinc-regulated transcription factor genetic 1 1 1 Negative Genetic
STB5 YHR178W Transcription factor genetic 1 1 1 Negative Genetic
REI1 YBR267W Cytoplasmic pre-60S factor genetic 1 1 1 Negative Genetic
RSC1 YGR056W Component of the RSC chromatin remodeling complex genetic 1 1 1 Negative Genetic
MET18 YIL128W Component of cytosolic iron-sulfur protein assembly (CIA) machinery genetic 1 1 1 Negative Genetic
RIM11 YMR139W Protein kinase genetic 1 1 1 Negative Genetic
KCS1 YDR017C Inositol hexakisphosphate and inositol heptakisphosphate kinase genetic 1 1 1 Negative Genetic
VMA13 YPR036W Subunit H of the V1 peripheral membrane domain of V-ATPase genetic 1 1 1 Synthetic Haploinsufficiency
YJR084W YJR084W Protein that forms a complex with Thp3p genetic 1 1 1 Positive Genetic
URE2 YNL229C Nitrogen catabolite repression transcriptional regulator genetic 1 1 1 Positive Genetic
REB1 YBR049C RNA polymerase I enhancer binding protein genetic 1 1 1 Negative Genetic
PAN1 YIR006C Part of actin cytoskeleton-regulatory complex Pan1p-Sla1p-End3p genetic 1 1 1 Negative Genetic
RPB7 YDR404C RNA polymerase II subunit B16 genetic 1 1 1 Negative Genetic
SEC12 YNR026C Guanine nucleotide exchange factor (GEF) genetic 1 1 1 Negative Genetic
HRP1 YOL123W Subunit of cleavage factor I genetic 1 1 1 Negative Genetic
TBF1 YPL128C Telobox-containing general regulatory factor genetic 1 1 1 Negative Genetic
RPL23B YER117W Ribosomal 60S subunit protein L23B genetic 1 1 1 Negative Genetic
MIN10 YFR032C-B Mitochondrial protein of unknown function genetic 1 1 1 Negative Genetic
SPT4 YGR063C Spt4p/5p (DSIF) transcription elongation factor complex subunit genetic 1 1 1 Synthetic Growth Defect
PEX10 YDR265W Peroxisomal membrane E3 ubiquitin ligase genetic 1 1 1 Negative Genetic
PEX4 YGR133W Peroxisomal ubiquitin conjugating enzyme genetic 1 1 1 Negative Genetic
YKL069W YKL069W Methionine-R-sulfoxide reductase genetic 1 1 1 Negative Genetic
PEX13 YLR191W Peroxisomal importomer complex component genetic 1 1 1 Negative Genetic
RIM20 YOR275C Protein involved in proteolytic activation of Rim101p genetic 1 1 1 Negative Genetic
YPL039W YPL039W Putative protein of unknown function genetic 1 1 1 Negative Genetic
RPL36A YMR194W Ribosomal 60S subunit protein L36A genetic 1 1 1 Dosage Rescue
HRQ1 YDR291W 3'-5' DNA helicase of the conserved RecQ family genetic 1 1 1 Negative Genetic
SGS1 YMR190C RecQ family nucleolar DNA helicase genetic 1 1 1 Negative Genetic
DBP5 YOR046C Cytoplasmic ATP-dependent RNA helicase of the DEAD-box family physical 1 1 1 Affinity Capture-MS
AUR1 YKL004W Phosphatidylinositol:ceramide phosphoinositol transferase genetic 1 1 1 Positive Genetic
HOC1 YJR075W Alpha-1,6-mannosyltransferase genetic 1 1 1 Negative Genetic
DOM34 YNL001W Protein that facilitates ribosomal subunit dissociation genetic 1 1 1 Dosage Rescue
GAT2 YMR136W Protein containing GATA family zinc finger motifs genetic 1 1 1 Negative Genetic
GIS2 YNL255C Translational activator for mRNAs with internal ribosome entry sites physical 1 1 1 Affinity Capture-RNA