Standard name Systematic name Name description Description
MKC7 YDR144C GPI-anchored aspartyl protease GPI-anchored aspartyl protease; member of the yapsin family of proteases involved in cell wall growth and maintenance; shares functions with Yap3p and Kex2p; MKC7 has a paralog, YPS1, that arose from the whole genome duplication
Visualize the interactome of MKC7
Links to external databases:
  SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)

CYCLoPs localization & abundance

WT1 WT2 WT3
Cytoplasm 0.888 0.927 NaN
Mito 0.052 NaN NaN
Vac/Vac Memb 0.090 0.098 NaN

GFP localization & abundance

GFP localization GFP abundance
vacuole 538

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
MKC7 0 0 0 1 0

Enzyme information

Catalyzed reactions in Yeast8

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
YPS1 YLR120C Aspartic protease genetic 8 3 6 Phenotypic Enhancement, Synthetic Lethality, Synthetic Lethality, Phenotypic Enhancement, Phenotypic Enhancement, Synthetic Growth Defect, Synthetic Lethality, Phenotypic Enhancement
KEX2 YNL238W Kexin, a subtilisin-like protease (proprotein convertase) genetic 4 2 3 Dosage Rescue, Dosage Rescue, Synthetic Lethality, Dosage Rescue
GIM5 YML094W Subunit of the heterohexameric cochaperone prefoldin complex genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
SEC22 YLR268W R-SNARE protein genetic 2 2 2 Phenotypic Suppression, Negative Genetic
MED8 YBR193C Subunit of the RNA polymerase II mediator complex genetic 2 1 2 Negative Genetic, Negative Genetic
BRE5 YNR051C Ubiquitin protease cofactor genetic 2 1 2 Negative Genetic, Negative Genetic
RTG3 YBL103C bHLH/Zip transcription factor for retrograde (RTG) and TOR pathways genetic 2 1 2 Negative Genetic, Negative Genetic
ORC2 YBR060C Subunit of the origin recognition complex (ORC) genetic 2 1 2 Negative Genetic, Negative Genetic
RNA1 YMR235C GTPase activating protein (GAP) for Gsp1p genetic 2 1 2 Negative Genetic, Negative Genetic
ERG3 YLR056W C-5 sterol desaturase genetic 2 1 2 Negative Genetic, Negative Genetic
RPD3 YNL330C Histone deacetylase, component of both the Rpd3S and Rpd3L complexes regulation 1 1 1 chromatin immunoprecipitation-chip evidence
LEO1 YOR123C Component of the Paf1 complex genetic 1 1 1 Negative Genetic
KRE29 YER038C Subunit of the SMC5-SMC6 complex genetic 1 1 1 Negative Genetic
DBP7 YKR024C Putative ATP-dependent RNA helicase of the DEAD-box family genetic 1 1 1 Negative Genetic
CSL4 YNL232W Exosome non-catalytic core component genetic 1 1 1 Negative Genetic
DST1 YGL043W General transcription elongation factor TFIIS genetic 1 1 1 Negative Genetic
ACT1 YFL039C Actin, structural protein in cytoskeleton genetic 1 1 1 Synthetic Haploinsufficiency
CDC3 YLR314C Component of the septin ring that is required for cytokinesis genetic 1 1 1 Negative Genetic
CTK1 YKL139W Catalytic (alpha) subunit of C-terminal domain kinase I (CTDK-I) genetic 1 1 1 Negative Genetic
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator physical 1 1 1 Affinity Capture-RNA
ISW1 YBR245C ATPase subunit of imitation-switch (ISWI) class chromatin remodelers physical 1 1 1 Affinity Capture-RNA
LAS17 YOR181W Actin assembly factor genetic 1 1 1 Negative Genetic
LCB1 YMR296C Component of serine palmitoyltransferase genetic 1 1 1 Negative Genetic
MED1 YPR070W Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
MED6 YHR058C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
LPD1 YFL018C Dihydrolipoamide dehydrogenase genetic 1 1 1 Negative Genetic
CDC13 YDL220C Single stranded DNA-binding protein found at TG1-3 telomere G-tails genetic 1 1 1 Negative Genetic
AKL1 YBR059C Ser/Thr protein kinase genetic 1 1 1 Negative Genetic
HYP2 YEL034W Translation elongation factor eIF-5A genetic 1 1 1 Positive Genetic
CDC4 YFL009W F-box protein required for both the G1/S and G2/M phase transitions genetic 1 1 1 Negative Genetic
HIR2 YOR038C Subunit of HIR nucleosome assembly complex genetic 1 1 1 Negative Genetic
MAG1 YER142C 3-methyl-adenine DNA glycosylase genetic 1 1 1 Negative Genetic
CTF4 YPR135W Chromatin-associated protein genetic 1 1 1 Negative Genetic
CDC123 YLR215C Assembly factor for the eIF2 translation initiation factor complex genetic 1 1 1 Negative Genetic
ATG20 YDL113C Sorting nexin family member genetic 1 1 1 Negative Genetic
HAP3 YBL021C Subunit of the Hap2p/3p/4p/5p CCAAT-binding complex genetic 1 1 1 Negative Genetic
EAP1 YKL204W eIF4E-associated protein, competes with eIF4G for binding to eIF4E genetic 1 1 1 Positive Genetic
EXO70 YJL085W Subunit of the exocyst complex genetic 1 1 1 Negative Genetic
IRE1 YHR079C Serine-threonine kinase and endoribonuclease genetic 1 1 1 Synthetic Growth Defect
GCN4 YEL009C bZIP transcriptional activator of amino acid biosynthetic genes genetic 1 1 1 Positive Genetic
ACA1 YER045C ATF/CREB family basic leucine zipper (bZIP) transcription factor genetic 1 1 1 Negative Genetic
GPN2 YOR262W Putative GTPase with a specific role in RNA pol II and polIII biogenes genetic 1 1 1 Negative Genetic
COG4 YPR105C Essential component of the conserved oligomeric Golgi complex genetic 1 1 1 Negative Genetic
HPC2 YBR215W Subunit of the HIR complex genetic 1 1 1 Negative Genetic
BFR1 YOR198C Component of mRNP complexes associated with polyribosomes physical 1 1 1 Affinity Capture-RNA
ELO3 YLR372W Elongase genetic 1 1 1 Negative Genetic
MCM3 YEL032W Protein involved in DNA replication genetic 1 1 1 Positive Genetic
YOS9 YDR057W ER quality-control lectin physical 1 1 1 Affinity Capture-Western
PUF4 YGL014W Member of the PUF protein family physical 1 1 1 Affinity Capture-RNA
PAC10 YGR078C Part of the heteromeric co-chaperone GimC/prefoldin complex genetic 1 1 1 Synthetic Lethality
YPS7 YDR349C Putative GPI-anchored aspartic protease genetic 1 1 1 Phenotypic Enhancement
THR4 YCR053W Threonine synthase genetic 1 1 1 Negative Genetic
TRP2 YER090W Anthranilate synthase genetic 1 1 1 Negative Genetic
YCS4 YLR272C Subunit of the condensin complex genetic 1 1 1 Negative Genetic
TAF8 YML114C TFIID subunit (65 kDa) genetic 1 1 1 Positive Genetic
TMH18 YPR098C Mitochondrial protein of unknown function genetic 1 1 1 Negative Genetic
YPS3 YLR121C Aspartic protease genetic 1 1 1 Synthetic Lethality
YKE2 YLR200W Subunit of the heterohexameric Gim/prefoldin protein complex genetic 1 1 1 Synthetic Growth Defect
TRS85 YDR108W Component of transport protein particle (TRAPP) complex III genetic 1 1 1 Phenotypic Suppression
SBA1 YKL117W Co-chaperone that binds and regulates Hsp90 family chaperones genetic 1 1 1 Synthetic Lethality
VPS24 YKL041W One of four subunits of the ESCRT-III complex genetic 1 1 1 Negative Genetic
REB1 YBR049C RNA polymerase I enhancer binding protein genetic 1 1 1 Positive Genetic
TIF34 YMR146C eIF3i subunit of the eukaryotic translation initiation factor 3 (eIF3) genetic 1 1 1 Positive Genetic
SEC12 YNR026C Guanine nucleotide exchange factor (GEF) genetic 1 1 1 Positive Genetic
OAR1 YKL055C Mitochondrial 3-oxoacyl-[acyl-carrier-protein] reductase genetic 1 1 1 Positive Genetic
UBA3 YPR066W Protein that activates Rub1p (NEDD8) before neddylation genetic 1 1 1 Positive Genetic
YMR155W YMR155W Putative protein of unknown function genetic 1 1 1 Positive Genetic
SCM3 YDL139C Nonhistone component of centromeric chromatin genetic 1 1 1 Negative Genetic
PTI1 YGR156W Essential component of CPF (cleavage and polyadenylation factor) genetic 1 1 1 Negative Genetic
TIM54 YJL054W Component of the mitochondrial TIM22 complex genetic 1 1 1 Negative Genetic
RPC25 YKL144C RNA polymerase III subunit C25 genetic 1 1 1 Negative Genetic
PIK1 YNL267W Phosphatidylinositol 4-kinase genetic 1 1 1 Negative Genetic
RPL5 YPL131W Ribosomal 60S subunit protein L5 genetic 1 1 1 Negative Genetic
SHS1 YDL225W Component of the septin ring that is required for cytokinesis genetic 1 1 1 Negative Genetic
MSI1 YBR195C Subunit of chromatin assembly factor I (CAF-1) genetic 1 1 1 Negative Genetic
SWC5 YBR231C Component of the SWR1 complex genetic 1 1 1 Negative Genetic
RPS14A YCR031C Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
RPL13A YDL082W Ribosomal 60S subunit protein L13A genetic 1 1 1 Negative Genetic
MSH4 YFL003C Protein involved in meiotic recombination genetic 1 1 1 Negative Genetic
SKN1 YGR143W Protein involved in sphingolipid biosynthesis genetic 1 1 1 Negative Genetic
YTA7 YGR270W Chromatin-binding ATPase that regulates histone gene expression genetic 1 1 1 Negative Genetic
YOR1 YGR281W Plasma membrane ATP-binding cassette (ABC) transporter genetic 1 1 1 Negative Genetic
RPL17B YJL177W Ribosomal 60S subunit protein L17B genetic 1 1 1 Negative Genetic
PTK2 YJR059W Serine/threonine protein kinase genetic 1 1 1 Negative Genetic
MOG1 YJR074W Conserved nuclear protein that interacts with GTP-Gsp1p genetic 1 1 1 Negative Genetic
UBI4 YLL039C Ubiquitin genetic 1 1 1 Negative Genetic
UBP8 YMR223W Ubiquitin-specific protease component of the SAGA acetylation complex genetic 1 1 1 Negative Genetic
YGR237C YGR237C Putative protein of unknown function genetic 1 1 1 Negative Genetic
TEF4 YKL081W Gamma subunit of translational elongation factor eEF1B genetic 1 1 1 Negative Genetic
ZRT3 YKL175W Vacuolar membrane zinc transporter genetic 1 1 1 Negative Genetic
VPS38 YLR360W Part of a Vps34p phosphatidylinositol 3-kinase complex genetic 1 1 1 Negative Genetic
NUP188 YML103C Subunit of the inner ring of the nuclear pore complex (NPC) genetic 1 1 1 Negative Genetic
MLH1 YMR167W Protein required for mismatch repair in mitosis and meiosis genetic 1 1 1 Negative Genetic
PSK2 YOL045W PAS-domain containing serine/threonine protein kinase genetic 1 1 1 Negative Genetic
YOR186W YOR186W Putative protein of unknown function genetic 1 1 1 Negative Genetic
RLF2 YPR018W Largest subunit (p90) of the Chromatin Assembly Complex (CAF-1) genetic 1 1 1 Negative Genetic
KAR2 YJL034W ATPase involved in protein import into the ER genetic 1 1 1 Positive Genetic
COX17 YLL009C Copper metallochaperone that transfers copper to Sco1p and Cox11p genetic 1 1 1 Negative Genetic
FRA1 YLL029W Protein involved in negative regulation of iron regulon transcription genetic 1 1 1 Negative Genetic
BPH1 YCR032W Protein homologous to Chediak-Higashi syndrome and Beige proteins genetic 1 1 1 Negative Genetic
COQ11 YLR290C Putative oxidoreductase, subunit of Coenzyme Q biosynthetic complexes genetic 1 1 1 Negative Genetic
IRC3 YDR332W Double-stranded DNA-dependent helicase of the DExH/D-box family genetic 1 1 1 Negative Genetic
CWH43 YCR017C GPI lipid remodelase genetic 1 1 1 Negative Genetic
AVL9 YLR114C Conserved protein involved in exocytic transport from the Golgi genetic 1 1 1 Negative Genetic
FCY22 YER060W-A Putative purine-cytosine permease genetic 1 1 1 Negative Genetic
IFM1 YOL023W Mitochondrial translation initiation factor 2 genetic 1 1 1 Negative Genetic
GYP8 YFL027C GTPase-activating protein for yeast Rab family members genetic 1 1 1 Negative Genetic
ECM14 YHR132C Conserved fungal protein with similarity to zinc carboxypeptidases genetic 1 1 1 Negative Genetic