Standard name Systematic name Name description Description
RRP45 YDR280W Exosome non-catalytic core component Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp45p (PM/SCL-75, EXOSC9); protein abundance increases in response to DNA replication stress
Visualize the interactome of RRP45
Links to external databases:
  SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)

CYCLoPs localization & abundance

WT1 WT2 WT3
Nucleolus 0.255 0.176 0.244
Nucleus 0.711 0.810 0.730
Vac/Vac Memb 0.066 NaN NaN

GFP localization & abundance

GFP localization GFP abundance
nucleolus, nucleus 4800

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
RRP45 17 0 0 0 0

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
RRP6 YOR001W Nuclear exosome exonuclease component physical 15 4 11 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Reconstituted Complex, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS, Co-purification, Affinity Capture-MS
SKI6 YGR195W Exosome non-catalytic core component physical 13 3 8 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Two-hybrid, Two-hybrid, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-MS
DIS3 YOL021C Exosome core complex catalytic subunit physical 12 3 10 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-MS, Reconstituted Complex, Affinity Capture-Western
RRP46 YGR095C Exosome non-catalytic core component physical 12 3 8 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Co-purification, Affinity Capture-Western, Co-purification
CSL4 YNL232W Exosome non-catalytic core component physical 10 2 9 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS
SKI7 YOR076C GTP-binding protein that couples the Ski complex and exosome physical 8 3 7 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Reconstituted Complex, Affinity Capture-Western
RRP43 YCR035C Exosome non-catalytic core component physical 8 2 7 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Two-hybrid, Affinity Capture-MS
RRP4 YHR069C Exosome non-catalytic core component physical 6 1 5 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS
RRP40 YOL142W Exosome non-catalytic core component physical 6 1 5 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS
RRP42 YDL111C Exosome non-catalytic core component physical 6 1 5 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS
ECM16 YMR128W Essential DEAH-box ATP-dependent RNA helicase specific to U3 snoRNP physical 5 1 5 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS
MTR3 YGR158C Exosome non-catalytic core component physical 5 1 4 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS
UTP10 YJL109C Nucleolar protein physical 4 1 4 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS
MPP6 YNR024W Nuclear exosome-associated RNA binding protein physical 4 3 3 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Reconstituted Complex
LRP1 YHR081W Nuclear exosome-associated nucleic acid binding protein physical 4 1 3 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS
SKI2 YLR398C Ski complex component and putative RNA helicase physical 3 1 3 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS
SKI3 YPR189W Ski complex component and TPR protein physical 3 1 3 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS
UTP20 YBL004W Component of the small-subunit (SSU) processome physical 3 1 3 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS
DIS3 YOL021C Exosome core complex catalytic subunit genetic 3 2 2 Negative Genetic, Negative Genetic, Synthetic Rescue
UTP22 YGR090W Component of the small-subunit processome physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
RPA49 YNL248C RNA polymerase I subunit A49 physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
MPT5 YGL178W mRNA-binding protein of the PUF family physical 2 1 2 Affinity Capture-RNA, Affinity Capture-RNA
DBP9 YLR276C DEAD-box protein required for 27S rRNA processing genetic 2 1 1 Negative Genetic, Negative Genetic
RRP4 YHR069C Exosome non-catalytic core component genetic 2 1 1 Negative Genetic, Negative Genetic
SKI6 YGR195W Exosome non-catalytic core component genetic 2 1 1 Negative Genetic, Negative Genetic
YRA1 YDR381W Nuclear polyadenylated RNA-binding protein physical 2 1 1 Affinity Capture-Western, Affinity Capture-Western
RRP42 YDL111C Exosome non-catalytic core component genetic 2 1 1 Negative Genetic, Negative Genetic
ENP1 YBR247C Protein associated with U3 and U14 snoRNAs genetic 2 1 1 Negative Genetic, Negative Genetic
MOB2 YFL034C-B Activator of Cbk1p kinase genetic 2 1 1 Negative Genetic, Negative Genetic
MPP6 YNR024W Nuclear exosome-associated RNA binding protein genetic 2 1 1 Negative Genetic, Negative Genetic
REB1 YBR049C RNA polymerase I enhancer binding protein regulation 1 1 1 chromatin immunoprecipitation-chip evidence
RPL27A YHR010W Ribosomal 60S subunit protein L27A physical 1 1 1 Affinity Capture-MS
POP1 YNL221C Subunit of RNase MRP, nuclear RNase P and telomerase complexes genetic 1 1 1 Positive Genetic
MTR4 YJL050W RNA duplex-sensing translocase physical 1 1 1 Affinity Capture-MS
MTR4 YJL050W RNA duplex-sensing translocase genetic 1 1 1 Negative Genetic
CSL4 YNL232W Exosome non-catalytic core component genetic 1 1 1 Negative Genetic
LRP1 YHR081W Nuclear exosome-associated nucleic acid binding protein genetic 1 1 1 Negative Genetic
RRP45 YDR280W Exosome non-catalytic core component physical 1 1 1 Affinity Capture-MS
RRP6 YOR001W Nuclear exosome exonuclease component genetic 1 1 1 Negative Genetic
SRP1 YNL189W Karyopherin alpha homolog physical 1 1 1 Affinity Capture-MS
RRP5 YMR229C RNA binding protein involved in synthesis of 18S and 5.8S rRNAs physical 1 1 1 Affinity Capture-MS
RRP5 YMR229C RNA binding protein involved in synthesis of 18S and 5.8S rRNAs genetic 1 1 1 Phenotypic Enhancement
YRA1 YDR381W Nuclear polyadenylated RNA-binding protein genetic 1 1 1 Synthetic Lethality
YBL055C YBL055C 3'-->5' exonuclease and endonuclease with a possible role in apoptosis physical 1 1 1 Affinity Capture-MS
SBP1 YHL034C Protein that binds eIF4G and has a role in repression of translation physical 1 1 1 Affinity Capture-RNA
SSB2 YNL209W Cytoplasmic ATPase that is a ribosome-associated molecular chaperone physical 1 1 1 Co-purification
UTP14 YML093W Subunit of U3-containing Small Subunit (SSU) processome complex physical 1 1 1 Affinity Capture-MS
TFC3 YAL001C Subunit of RNA polymerase III transcription initiation factor complex genetic 1 1 1 Positive Genetic
STU1 YBL034C Microtubule plus-end-tracking non-motor protein genetic 1 1 1 Positive Genetic
SRP102 YKL154W Signal recognition particle (SRP) receptor beta subunit genetic 1 1 1 Positive Genetic
YBR184W YBR184W Putative protein of unknown function genetic 1 1 1 Positive Genetic
YDL057W YDL057W Putative protein of unknown function genetic 1 1 1 Positive Genetic
YEL076C YEL076C Putative protein of unknown function genetic 1 1 1 Positive Genetic
SLM2 YNL047C Phosphoinositide PI4,5P(2) binding protein, forms a complex with Slm1p genetic 1 1 1 Positive Genetic
SFB2 YNL049C Component of the Sec23p-Sfb2p heterodimer of the COPII vesicle coat genetic 1 1 1 Positive Genetic
SLA2 YNL243W Adaptor protein that links actin to clathrin and endocytosis genetic 1 1 1 Positive Genetic
SSL1 YLR005W Subunit of the core form of RNA polymerase transcription factor TFIIH genetic 1 1 1 Negative Genetic
TAO3 YIL129C Component of the RAM signaling network genetic 1 1 1 Negative Genetic
SPC42 YKL042W Central plaque component of spindle pole body (SPB) genetic 1 1 1 Negative Genetic
SNF5 YBR289W Subunit of the SWI/SNF chromatin remodeling complex genetic 1 1 1 Negative Genetic
THR4 YCR053W Threonine synthase genetic 1 1 1 Negative Genetic
XRN1 YGL173C Evolutionarily-conserved 5'-3' exonuclease genetic 1 1 1 Negative Genetic
SPE1 YKL184W Ornithine decarboxylase genetic 1 1 1 Negative Genetic
SUS1 YBR111W-A Global transcriptional regulator, component of SAGA, TREX-2 complexes genetic 1 1 1 Negative Genetic
RRP8 YDR083W Nucleolar S-adenosylmethionine-dependent rRNA methyltransferase genetic 1 1 1 Negative Genetic
SSF1 YHR066W Constituent of 66S pre-ribosomal particles genetic 1 1 1 Negative Genetic
RPC82 YPR190C RNA polymerase III subunit C82 physical 1 1 1 Affinity Capture-MS
RPA135 YPR010C RNA polymerase I second largest subunit A135 physical 1 1 1 Affinity Capture-MS
HPR1 YDR138W Subunit of THO/TREX complexes physical 1 1 1 Affinity Capture-Western
RPN5 YDL147W Subunit of the CSN and 26S proteasome lid complexes genetic 1 1 1 Negative Genetic
IMD3 YLR432W Inosine monophosphate dehydrogenase physical 1 1 1 Affinity Capture-MS
NAB2 YGL122C Nuclear polyadenylated RNA-binding protein physical 1 1 1 Affinity Capture-RNA
NUP82 YJL061W Linker nucleoporin component of the nuclear pore complex (NPC) genetic 1 1 1 Negative Genetic
APC1 YNL172W Largest subunit of the Anaphase-Promoting Complex/Cyclosome genetic 1 1 1 Negative Genetic
DCP2 YNL118C Catalytic subunit of Dcp1p-Dcp2p decapping enzyme complex genetic 1 1 1 Negative Genetic
ENP1 YBR247C Protein associated with U3 and U14 snoRNAs physical 1 1 1 Affinity Capture-MS
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator physical 1 1 1 Affinity Capture-RNA
KRR1 YCL059C Nucleolar protein required for rRNA synthesis and ribosomal assembly physical 1 1 1 Affinity Capture-MS
MCD1 YDL003W Essential alpha-kleisin subunit of the cohesin complex genetic 1 1 1 Positive Genetic
MOT1 YPL082C Essential protein involved in regulation of transcription genetic 1 1 1 Negative Genetic
ORC2 YBR060C Subunit of the origin recognition complex (ORC) genetic 1 1 1 Negative Genetic
DAM1 YGR113W Essential subunit of the Dam1 complex (aka DASH complex) genetic 1 1 1 Positive Genetic
NRD1 YNL251C RNA-binding subunit of Nrd1 complex physical 1 1 1 Affinity Capture-MS
NOC4 YPR144C Nucleolar protein physical 1 1 1 Affinity Capture-MS
RFC4 YOL094C Subunit of heteropentameric Replication factor C (RF-C) genetic 1 1 1 Negative Genetic
NUT2 YPR168W Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Positive Genetic
MTR3 YGR158C Exosome non-catalytic core component genetic 1 1 1 Negative Genetic
PRP9 YDL030W Subunit of the SF3a splicing factor complex genetic 1 1 1 Negative Genetic
MGA2 YIR033W ER membrane protein involved in regulation of OLE1 transcription genetic 1 1 1 Positive Genetic
RAD1 YPL022W Single-stranded DNA endonuclease (with Rad10p) genetic 1 1 1 Positive Genetic
DIM1 YPL266W Essential 18S rRNA dimethylase (dimethyladenosine transferase) genetic 1 1 1 Negative Genetic
PNO1 YOR145C Essential nucleolar protein required for pre-18S rRNA processing physical 1 1 1 Affinity Capture-MS
PUF3 YLL013C Protein of the mitochondrial outer surface physical 1 1 1 Affinity Capture-RNA
CDC53 YDL132W Cullin genetic 1 1 1 Negative Genetic
ACS2 YLR153C Acetyl-coA synthetase isoform genetic 1 1 1 Negative Genetic
GLE1 YDL207W Cytoplasmic nucleoporin required for polyadenylated mRNA export genetic 1 1 1 Negative Genetic
ERG6 YML008C Delta(24)-sterol C-methyltransferase genetic 1 1 1 Negative Genetic
CDC15 YAR019C Hippo-like kinase of the Mitotic Exit Network physical 1 1 1 Proximity Label-MS
NOP53 YPL146C Nucleolar protein physical 1 1 1 Reconstituted Complex
DEF1 YKL054C RNAPII degradation factor physical 1 1 1 Affinity Capture-MS
DUO1 YGL061C Essential subunit of the Dam1 complex (aka DASH complex) genetic 1 1 1 Positive Genetic
ENT3 YJR125C Protein containing an N-terminal epsin-like domain physical 1 1 1 Affinity Capture-MS
PEF1 YGR058W Penta-EF-hand protein genetic 1 1 1 Negative Genetic
IBD2 YNL164C Component of the BUB2-dependent spindle checkpoint pathway genetic 1 1 1 Positive Genetic
DBP5 YOR046C Cytoplasmic ATP-dependent RNA helicase of the DEAD-box family genetic 1 1 1 Negative Genetic
MEX67 YPL169C Poly(A)RNA binding protein involved in nuclear mRNA export genetic 1 1 1 Negative Genetic
MPS1 YDL028C Dual-specificity kinase genetic 1 1 1 Negative Genetic
MTR2 YKL186C mRNA transport regulator genetic 1 1 1 Negative Genetic
HMT1 YBR034C Nuclear SAM-dependent mono- and asymmetric methyltransferase physical 1 1 1 PCA
RPS18A YDR450W Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
IDS2 YJL146W Protein involved in modulation of Ime2p activity during meiosis genetic 1 1 1 Positive Genetic
PHO11 YAR071W One of three repressible acid phosphatases genetic 1 1 1 Positive Genetic
DCC1 YCL016C Subunit of a complex with Ctf8p and Ctf18p genetic 1 1 1 Positive Genetic
ADE16 YLR028C Enzyme of 'de novo' purine biosynthesis genetic 1 1 1 Positive Genetic
GCD14 YJL125C Subunit of tRNA (1-methyladenosine) methyltransferase genetic 1 1 1 Positive Genetic
ATG33 YLR356W Mitochondrial mitophagy-specific protein genetic 1 1 1 Negative Genetic
RPL20A YMR242C Ribosomal 60S subunit protein L20A physical 1 1 1 Affinity Capture-MS
ERG3 YLR056W C-5 sterol desaturase genetic 1 1 1 Positive Genetic
BCD1 YHR040W Essential protein required for the accumulation of box C/D snoRNA genetic 1 1 1 Positive Genetic
RPS29A YLR388W Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
NAR1 YNL240C Subunit of the cytosolic iron-sulfur (FeS) protein assembly machinery genetic 1 1 1 Negative Genetic
PZF1 YPR186C Transcription factor IIIA (TFIIIA) genetic 1 1 1 Negative Genetic
MAN2 YNR073C Mannitol dehydrogenase genetic 1 1 1 Positive Genetic