Standard name Systematic name Name description Description
TIF3 YPR163C Translation initiation factor eIF-4B Translation initiation factor eIF-4B; RNA recognition motif containing single-stranded RNA binding protein that possesses RNA annealing and strand-exchange activities; stimulates the ATPase and unwinding activities of the RNA helicase eIF4A, in a synergistic manner with eIF4G; promotes assembly of the translation initiation factor complex eIF4F and the 48S preinitiation complex; interacts with Rps20p at the head of the 40S ribosomal subunit and alters the structure of the mRNA entry channel
Visualize the interactome of TIF3
Links to external databases:
  SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)

CYCLoPs localization & abundance

WT1 WT2 WT3
Cytoplasm 0.993 0.986 0.936
ER NaN NaN 0.067

GFP localization & abundance

GFP localization GFP abundance
cytoplasm 24000

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
TIF3 5 0 0 0 0

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
TIF1 YKR059W Translation initiation factor eIF4A genetic 3 2 3 Synthetic Lethality, Dosage Rescue, Dosage Rescue
RPS20 YHL015W Protein component of the small (40S) ribosomal subunit physical 3 3 2 Two-hybrid, Affinity Capture-Western, Affinity Capture-MS
SSB2 YNL209W Cytoplasmic ATPase that is a ribosome-associated molecular chaperone physical 3 2 2 Affinity Capture-MS, Affinity Capture-MS, Co-purification
TIF4631 YGR162W Translation initiation factor eIF4G and scaffold protein physical 2 2 2 Affinity Capture-Western, Affinity Capture-MS
RPN11 YFR004W Metalloprotease subunit of 19S regulatory particle physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
CDC33 YOL139C Translation initiation factor eIF4E genetic 2 2 1 Synthetic Growth Defect, Synthetic Lethality
CAF20 YOR276W Phosphoprotein of the mRNA cap-binding complex genetic 2 2 1 Synthetic Rescue, Dosage Lethality
SSA1 YAL005C ATPase involved in protein folding and NLS-directed nuclear transport physical 2 1 1 Affinity Capture-MS, Affinity Capture-MS
YNG2 YHR090C Subunit of NuA4, an essential histone acetyltransferase complex genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
SSB1 YDL229W Cytoplasmic ATPase that is a ribosome-associated molecular chaperone physical 2 1 1 Affinity Capture-MS, Affinity Capture-MS
FKH1 YIL131C Forkhead family transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
SFP1 YLR403W Regulates transcription of ribosomal protein and biogenesis genes regulation 1 1 1 DNA to cDNA expression microarray evidence
FKH2 YNL068C Forkhead family transcription factor regulation 1 1 1 chromatin immunoprecipitation- exonuclease evidence
RGR1 YLR071C Subunit of the RNA polymerase II mediator complex regulation 1 1 1 chromatin immunoprecipitation-chip evidence
REB1 YBR049C RNA polymerase I enhancer binding protein regulation 1 1 1 chromatin immunoprecipitation-chip evidence
UME6 YDR207C Rpd3L histone deacetylase complex subunit regulation 1 1 1 chromatin immunoprecipitation-chip evidence
CHD1 YER164W Chromatin remodeler that regulates various aspects of transcription genetic 1 1 1 Positive Genetic
CDC40 YDR364C Pre-mRNA splicing factor genetic 1 1 1 Synthetic Rescue
DSN1 YIR010W Essential component of the outer kinetochore MIND complex physical 1 1 1 Affinity Capture-MS
ESA1 YOR244W Catalytic subunit of the histone acetyltransferase complex (NuA4) physical 1 1 1 Affinity Capture-MS
DED1 YOR204W ATP-dependent DEAD-box RNA helicase with strand-annealing activity genetic 1 1 1 Synthetic Lethality
RPN1 YHR027C Non-ATPase base subunit of the 19S RP of the 26S proteasome physical 1 1 1 Affinity Capture-MS
RPN10 YHR200W Proteasome polyubiquitin receptor physical 1 1 1 Affinity Capture-MS
CDC28 YBR160W Cyclin-dependent kinase (CDK) catalytic subunit physical 1 1 1 Affinity Capture-MS
EAF3 YPR023C Component of the Rpd3S histone deacetylase complex genetic 1 1 1 Negative Genetic
GTR2 YGR163W Subunit of a TORC1-stimulating GTPase and the EGO/GSE complex genetic 1 1 1 Synthetic Growth Defect
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator physical 1 1 1 Affinity Capture-RNA
CRM1 YGR218W Nuclear export factor, exportin physical 1 1 1 Affinity Capture-MS
HSC82 YMR186W Cytoplasmic chaperone of the Hsp90 family physical 1 1 1 Affinity Capture-MS
HSP82 YPL240C Hsp90 chaperone physical 1 1 1 Affinity Capture-MS
NOC4 YPR144C Nucleolar protein physical 1 1 1 Affinity Capture-MS
SAP30 YMR263W Component of Rpd3L histone deacetylase complex genetic 1 1 1 Positive Genetic
RPT5 YOR117W ATPase of the 19S regulatory particle of the 26S proteasome physical 1 1 1 Affinity Capture-MS
SBP1 YHL034C Protein that binds eIF4G and has a role in repression of translation physical 1 1 1 Affinity Capture-RNA
TEF2 YBR118W Translational elongation factor EF-1 alpha genetic 1 1 1 Positive Genetic
SPT5 YML010W Spt4p/5p (DSIF) transcription elongation factor complex subunit physical 1 1 1 Affinity Capture-MS
TIF1 YKR059W Translation initiation factor eIF4A physical 1 1 1 Reconstituted Complex
FIN1 YDR130C Spindle pole body-related intermediate filament protein physical 1 1 1 Affinity Capture-Western
PHO85 YPL031C Cyclin-dependent kinase genetic 1 1 1 Dosage Lethality
PMA1 YGL008C Plasma membrane P2-type H+-ATPase genetic 1 1 1 Negative Genetic
PET9 YBL030C Major ADP/ATP carrier of the mitochondrial inner membrane genetic 1 1 1 Dosage Rescue
MMS22 YLR320W Subunit of E3 ubiquitin ligase complex involved in replication repair physical 1 1 1 Affinity Capture-MS
NDC80 YIL144W Component of the kinetochore-associated Ndc80 complex physical 1 1 1 Affinity Capture-MS
RPS13 YDR064W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPS1A YLR441C Ribosomal protein of the small (40S) subunit physical 1 1 1 Affinity Capture-MS
RPS17A YML024W Ribosomal protein 51 (rp51) of the small (40s) subunit physical 1 1 1 Affinity Capture-MS
RPS7A YOR096W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPS22A YJL190C Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
MPT5 YGL178W mRNA-binding protein of the PUF family physical 1 1 1 Affinity Capture-RNA
NUP100 YKL068W FG-nucleoporin component of central core of the nuclear pore complex genetic 1 1 1 Positive Genetic
SNM1 YDR478W Ribonuclease MRP complex subunit genetic 1 1 1 Positive Genetic
ATP1 YBL099W Alpha subunit of the F1 sector of mitochondrial F1F0 ATP synthase genetic 1 1 1 Dosage Rescue
RPL31A YDL075W Ribosomal 60S subunit protein L31A physical 1 1 1 Affinity Capture-MS
TIF35 YDR429C eIF3g subunit of the eukaryotic translation initiation factor 3 (eIF3) physical 1 1 1 Two-hybrid
TIF4632 YGL049C Translation initiation factor eIF4G and scaffold protein physical 1 1 1 Affinity Capture-Western
TIF4632 YGL049C Translation initiation factor eIF4G and scaffold protein genetic 1 1 1 Synthetic Rescue
TIF4631 YGR162W Translation initiation factor eIF4G and scaffold protein genetic 1 1 1 Synthetic Rescue
YCF1 YDR135C Vacuolar glutathione S-conjugate transporter physical 1 1 1 PCA
TOM1 YDR457W E3 ubiquitin ligase of the hect-domain class physical 1 1 1 Affinity Capture-MS
TPK1 YJL164C cAMP-dependent protein kinase catalytic subunit genetic 1 1 1 Phenotypic Suppression
YME1 YPR024W Catalytic subunit of i-AAA protease complex genetic 1 1 1 Dosage Rescue
TOM70 YNL121C Component of the TOM (translocase of outer membrane) complex genetic 1 1 1 Dosage Rescue
YPC1 YBR183W Alkaline ceramidase genetic 1 1 1 Positive Genetic
RPS3 YNL178W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPS14A YCR031C Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
PXA2 YKL188C Subunit of heterodimeric peroxisomal ABC transport complex, with Pxa1p physical 1 1 1 PCA
SRS2 YJL092W DNA helicase and DNA-dependent ATPase genetic 1 1 1 Dosage Lethality
AEP3 YPL005W Peripheral mitochondrial inner membrane protein genetic 1 1 1 Negative Genetic
GIS2 YNL255C Translational activator for mRNAs with internal ribosome entry sites physical 1 1 1 Affinity Capture-RNA
RPS6A YPL090C Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPS9A YPL081W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPS10A YOR293W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPL26A YLR344W Ribosomal 60S subunit protein L26A physical 1 1 1 Affinity Capture-MS
RPS12 YOR369C Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
PUF2 YPR042C PUF family mRNA-binding protein physical 1 1 1 Affinity Capture-RNA
PUF2 YPR042C PUF family mRNA-binding protein genetic 1 1 1 Negative Genetic
SCH9 YHR205W AGC family protein kinase genetic 1 1 1 Synthetic Growth Defect
SCD6 YPR129W Repressor of translation initiation physical 1 1 1 Affinity Capture-MS
RPS27A YKL156W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
SAM50 YNL026W Component of the Sorting and Assembly Machinery (SAM) complex physical 1 1 1 Affinity Capture-MS
RPS15 YOL040C Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
MGR2 YPL098C Subunit of the TIM23 translocase complex genetic 1 1 1 Dosage Rescue
APQ12 YIL040W Nuclear envelope/ER integral membrane protein genetic 1 1 1 Negative Genetic