Standard name Systematic name Name description Description
YFH1 YDL120W Mitochondrial matrix iron chaperone Mitochondrial matrix iron chaperone; oxidizes and stores iron; interacts with Isu1p to promote Fe-S cluster assembly; mutation results in multiple Fe/S-dependent enzyme deficiencies; human frataxin homolog FXN is mutated in Friedrich's ataxia; human FTL gene can complement yeast yfh1 null mutant
Visualize the interactome of YFH1
Links to external databases:
  SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)

CYCLoPs localization & abundance

WT1 WT2 WT3
Endosome 0.050 NaN 0.091
Mito 0.923 0.985 0.785
Nuc Periphery 0.070 NaN NaN
Nucleolus 0.053 NaN NaN
Vac/Vac Memb 0.093 0.118 0.099
ER NaN 0.059 NaN
Golgi NaN NaN 0.058

GFP localization & abundance

GFP localization GFP abundance
mitochondrion 1560

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
YFH1 7 0 0 0 0

Enzyme information

Catalyzed reactions in Yeast8
r_4217 (Fe(II):oxygen oxidoreductase; Fe2+:oxygen oxidoreductase)

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
ISU1 YPL135W Conserved protein of the mitochondrial matrix physical 13 4 10 Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex, Co-fractionation, Affinity Capture-Western, Reconstituted Complex, Affinity Capture-Western, Reconstituted Complex, Reconstituted Complex, Co-crystal Structure, Reconstituted Complex, Reconstituted Complex
YFH1 YDL120W Mitochondrial matrix iron chaperone physical 9 3 8 Co-fractionation, Reconstituted Complex, Co-fractionation, Reconstituted Complex, Co-crystal Structure, Reconstituted Complex, Reconstituted Complex, Reconstituted Complex, Reconstituted Complex
ISU1 YPL135W Conserved protein of the mitochondrial matrix genetic 7 5 6 Synthetic Lethality, Synthetic Growth Defect, Negative Genetic, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Phenotypic Suppression
NFS1 YCL017C Cysteine desulfurase involved in iron-sulfur cluster biogenesis physical 6 4 5 Affinity Capture-Western, Co-fractionation, Reconstituted Complex, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-MS
HEM15 YOR176W Ferrochelatase physical 4 2 3 Reconstituted Complex, Co-crystal Structure, Reconstituted Complex, Co-crystal Structure
MRS4 YKR052C Iron transporter of the mitochondrial carrier family genetic 3 3 3 Synthetic Lethality, Synthetic Growth Defect, Positive Genetic
RAD51 YER095W Strand exchange protein genetic 2 2 2 Negative Genetic, Synthetic Lethality
AFT1 YGL071W Transcription factor involved in iron utilization and homeostasis genetic 2 2 2 Phenotypic Suppression, Synthetic Rescue
CCC1 YLR220W Vacuolar Fe2+/Mn2+ transporter genetic 2 2 2 Dosage Rescue, Phenotypic Enhancement
MRS3 YJL133W Iron transporter, mediates Fe2+ transport across inner mito membrane genetic 2 2 2 Synthetic Lethality, Synthetic Growth Defect
ISD11 YER048W-A Cysteine desulfurase (Nfs1p) activator physical 2 1 2 Affinity Capture-Western, Affinity Capture-Western
DNM1 YLL001W Dynamin-related GTPase involved in mitochondrial organization genetic 2 2 1 Synthetic Rescue, Phenotypic Suppression
CIT2 YCR005C Citrate synthase, peroxisomal isozyme involved in glyoxylate cycle genetic 2 2 1 Dosage Lethality, Synthetic Rescue
MDV1 YJL112W Peripheral protein of cytosolic face of mitochondrial outer membrane genetic 2 2 1 Phenotypic Suppression, Synthetic Rescue
MCA1 YOR197W Ca2+-dependent cysteine protease genetic 2 2 1 Synthetic Rescue, Phenotypic Suppression
YHB1 YGR234W Nitric oxide oxidoreductase physical 2 2 1 Two-hybrid, Affinity Capture-Western
ERG29 YMR134W Protein of unknown function involved in ergosterol biosynthesis genetic 2 2 1 Dosage Rescue, Phenotypic Suppression
SFP1 YLR403W Regulates transcription of ribosomal protein and biogenesis genes regulation 1 1 1 DNA to cDNA expression microarray evidence
MED2 YDL005C Subunit of the RNA polymerase II mediator complex regulation 1 1 1 chromatin immunoprecipitation-chip evidence
XBP1 YIL101C Transcriptional repressor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
STP1 YDR463W Transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
YAP6 YDR259C Basic leucine zipper (bZIP) transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
RPD3 YNL330C Histone deacetylase, component of both the Rpd3S and Rpd3L complexes regulation 1 1 1 chromatin immunoprecipitation-chip evidence
UGA3 YDL170W Transcriptional activator for GABA-dependent induction of GABA genes regulation 1 1 1 chromatin immunoprecipitation-chip evidence
CHD1 YER164W Chromatin remodeler that regulates various aspects of transcription genetic 1 1 1 Positive Genetic
AAH1 YNL141W Adenine deaminase (adenine aminohydrolase) genetic 1 1 1 Negative Genetic
CCR4 YAL021C Component of the CCR4-NOT transcriptional complex physical 1 1 1 Affinity Capture-RNA
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator physical 1 1 1 Affinity Capture-RNA
HSC82 YMR186W Cytoplasmic chaperone of the Hsp90 family genetic 1 1 1 Synthetic Growth Defect
LPD1 YFL018C Dihydrolipoamide dehydrogenase genetic 1 1 1 Phenotypic Enhancement
PDB1 YBR221C E1 beta subunit of the pyruvate dehydrogenase (PDH) complex genetic 1 1 1 Negative Genetic
HSP82 YPL240C Hsp90 chaperone genetic 1 1 1 Synthetic Growth Defect
MIR1 YJR077C Mitochondrial phosphate carrier genetic 1 1 1 Dosage Rescue
RPL23A YBL087C Ribosomal 60S subunit protein L23A genetic 1 1 1 Negative Genetic
MSH4 YFL003C Protein involved in meiotic recombination genetic 1 1 1 Negative Genetic
TEF2 YBR118W Translational elongation factor EF-1 alpha genetic 1 1 1 Negative Genetic
RAD1 YPL022W Single-stranded DNA endonuclease (with Rad10p) genetic 1 1 1 Negative Genetic
PUF3 YLL013C Protein of the mitochondrial outer surface physical 1 1 1 Affinity Capture-RNA
IDH1 YNL037C Subunit of mitochondrial NAD(+)-dependent isocitrate dehydrogenase genetic 1 1 1 Negative Genetic
SDH2 YLL041C Iron-sulfur protein subunit of succinate dehydrogenase physical 1 1 1 Affinity Capture-Western
SDH2 YLL041C Iron-sulfur protein subunit of succinate dehydrogenase genetic 1 1 1 Synthetic Growth Defect
RAD54 YGL163C DNA-dependent ATPase that stimulates strand exchange genetic 1 1 1 Negative Genetic
FET3 YMR058W Ferro-O2-oxidoreductase genetic 1 1 1 Positive Genetic
SOD1 YJR104C Cytosolic copper-zinc superoxide dismutase physical 1 1 1 Reconstituted Complex
RAD55 YDR076W Protein that stimulates strand exchange genetic 1 1 1 Negative Genetic
SOD2 YHR008C Mitochondrial manganese superoxide dismutase physical 1 1 1 Reconstituted Complex
SOD2 YHR008C Mitochondrial manganese superoxide dismutase genetic 1 1 1 Negative Genetic
RAS2 YNL098C GTP-binding protein genetic 1 1 1 Synthetic Rescue
MRE11 YMR224C Nuclease subunit of the MRX complex with Rad50p and Xrs2p genetic 1 1 1 Negative Genetic
SKI2 YLR398C Ski complex component and putative RNA helicase genetic 1 1 1 Positive Genetic
AIR1 YIL079C Zinc knuckle protein genetic 1 1 1 Positive Genetic
SEF1 YBL066C Putative transcription factor genetic 1 1 1 Negative Genetic
VPS13 YLL040C Lipid transport protein involved in prospore membrane morphogenesis genetic 1 1 1 Negative Genetic
ISU2 YOR226C Mitochondrial protein required for iron-sulfur protein synthesis genetic 1 1 1 Synthetic Rescue
MSB2 YGR014W Mucin family member involved in various signaling pathways genetic 1 1 1 Negative Genetic
SAP4 YGL229C Protein required for function of the Sit4p protein phosphatase genetic 1 1 1 Negative Genetic
VAM7 YGL212W Vacuolar SNARE protein genetic 1 1 1 Negative Genetic
TVP18 YMR071C Integral membrane protein physical 1 1 1 Two-hybrid
CDC27 YBL084C Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) genetic 1 1 1 Synthetic Rescue
RPS24A YER074W Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
BRE5 YNR051C Ubiquitin protease cofactor genetic 1 1 1 Positive Genetic
ARP6 YLR085C Actin-related protein that binds nucleosomes genetic 1 1 1 Negative Genetic
SWC5 YBR231C Component of the SWR1 complex genetic 1 1 1 Negative Genetic
RPS8A YBL072C Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
VPS71 YML041C Nucleosome-binding component of the SWR1 complex genetic 1 1 1 Negative Genetic
SSC1 YJR045C Hsp70 family ATPase physical 1 1 1 Affinity Capture-MS
APN1 YKL114C Major apurinic/apyrimidinic endonuclease genetic 1 1 1 Phenotypic Enhancement
RTG2 YGL252C Sensor of mitochondrial dysfunction genetic 1 1 1 Negative Genetic
NMD2 YHR077C Protein involved in the nonsense-mediated mRNA decay (NMD) pathway genetic 1 1 1 Positive Genetic
VPS41 YDR080W Subunit of the HOPS endocytic tethering complex genetic 1 1 1 Negative Genetic
HRB1 YNL004W Poly(A+) RNA-binding protein genetic 1 1 1 Positive Genetic
MPT5 YGL178W mRNA-binding protein of the PUF family physical 1 1 1 Affinity Capture-RNA
SWC3 YAL011W Protein of unknown function genetic 1 1 1 Negative Genetic
SSB2 YNL209W Cytoplasmic ATPase that is a ribosome-associated molecular chaperone physical 1 1 1 Co-purification
EAF7 YNL136W Subunit of the NuA4 histone acetyltransferase complex genetic 1 1 1 Negative Genetic
ILV6 YCL009C Regulatory subunit of acetolactate synthase genetic 1 1 1 Negative Genetic
ARO8 YGL202W Aromatic aminotransferase I genetic 1 1 1 Negative Genetic
SDH1 YKL148C Flavoprotein subunit of succinate dehydrogenase physical 1 1 1 Affinity Capture-Western
SDH1 YKL148C Flavoprotein subunit of succinate dehydrogenase genetic 1 1 1 Synthetic Growth Defect
GEF1 YJR040W Voltage-gated chloride channel genetic 1 1 1 Positive Genetic
CSF1 YLR087C Protein with structural similarity to lipid transport protein Vps13p genetic 1 1 1 Positive Genetic
YHB1 YGR234W Nitric oxide oxidoreductase genetic 1 1 1 Phenotypic Suppression
YJL070C YJL070C Putative metallo-dependent hydrolase superfamily protein genetic 1 1 1 Negative Genetic
YMD8 YML038C Putative nucleotide sugar transporter genetic 1 1 1 Negative Genetic
YMR160W YMR160W Protein of unknown function genetic 1 1 1 Negative Genetic
YVC1 YOR087W Vacuolar cation channel genetic 1 1 1 Negative Genetic
YTA6 YPL074W Putative ATPase of the CDC48/PAS1/SEC18 (AAA) family genetic 1 1 1 Negative Genetic
CIR1 YGR207C Mitochondrial protein that interacts with frataxin (Yfh1p) physical 1 1 1 Affinity Capture-Western
AIM45 YPR004C Putative ortholog of mammalian ETF-alpha physical 1 1 1 Affinity Capture-Western
PAM17 YKR065C Constituent of the TIM23 complex genetic 1 1 1 Negative Genetic
NFS1 YCL017C Cysteine desulfurase involved in iron-sulfur cluster biogenesis genetic 1 1 1 Synthetic Lethality
TSA1 YML028W Thioredoxin peroxidase genetic 1 1 1 Negative Genetic
GLG1 YKR058W Glycogenin glucosyltransferase genetic 1 1 1 Negative Genetic
FTR1 YER145C High affinity iron permease genetic 1 1 1 Positive Genetic
SHM2 YLR058C Cytosolic serine hydroxymethyltransferase genetic 1 1 1 Negative Genetic
RPL6B YLR448W Ribosomal 60S subunit protein L6B genetic 1 1 1 Negative Genetic
CTH1 YDR151C mRNA binding protein, member of the CCCH zinc finger family genetic 1 1 1 Negative Genetic
RCM1 YNL022C rRNA m5C methyltransferase genetic 1 1 1 Negative Genetic
NEJ1 YLR265C DNA end-binding protein required for nonhomologous end joining (NHEJ) genetic 1 1 1 Negative Genetic
PRX1 YBL064C Mitochondrial peroxiredoxin with thioredoxin peroxidase activity genetic 1 1 1 Negative Genetic
MDM38 YOL027C Membrane-associated mitochondrial ribosome receptor genetic 1 1 1 Negative Genetic
RAD57 YDR004W Protein that stimulates strand exchange genetic 1 1 1 Negative Genetic
TVP15 YDR100W Integral membrane protein physical 1 1 1 Two-hybrid
YCR007C YCR007C Putative integral membrane protein physical 1 1 1 Two-hybrid
FIT1 YDR534C Mannoprotein that is incorporated into the cell wall genetic 1 1 1 Negative Genetic
CCC2 YDR270W Cu(+2)-transporting P-type ATPase genetic 1 1 1 Positive Genetic
DPC25 YPL107W Putative mitochondrial protein of unknown function genetic 1 1 1 Negative Genetic
ARR1 YPR199C Transcriptional activator of the basic leucine zipper (bZIP) family genetic 1 1 1 Dosage Rescue
EFM4 YIL064W Lysine methyltransferase genetic 1 1 1 Negative Genetic
CHM7 YJL049W Yeast homolog of human CHMP7, localizes to the endoplasmic reticulum genetic 1 1 1 Negative Genetic
DPI34 YOR114W Putative mitochondrial protein of unknown function genetic 1 1 1 Negative Genetic
LEU2 YCL018W Beta-isopropylmalate dehydrogenase (IMDH) genetic 1 1 1 Dosage Rescue
TIS11 YLR136C mRNA-binding protein expressed during iron starvation genetic 1 1 1 Phenotypic Suppression
OCT1 YKL134C Mitochondrial intermediate peptidase genetic 1 1 1 Dosage Rescue
YCF1 YDR135C Vacuolar glutathione S-conjugate transporter genetic 1 1 1 Dosage Rescue
RDL2 YOR286W Protein with rhodanese activity genetic 1 1 1 Negative Genetic
UPF3 YGR072W Component of the nonsense-mediated mRNA decay (NMD) pathway genetic 1 1 1 Positive Genetic
RIM2 YBR192W Mitochondrial pyrimidine nucleotide transporter genetic 1 1 1 Dosage Rescue
SYC1 YOR179C Subunit of the APT subcomplex of cleavage and polyadenylation factor genetic 1 1 1 Positive Genetic
TRM44 YPL030W tRNA(Ser) Um(44) 2'-O-methyltransferase genetic 1 1 1 Negative Genetic